An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Civilization, we are told, could be achieved only by sacrificing those original freedoms or, alternatively, by taming our baser instincts. David Graeber and David Wengrow show how such theories first emerged in the eighteenth century as a conservative reaction to powerful critiques of European society posed by Indigenous observers and intellectuals. Revisiting this encounter has startling implications for how we make sense of human history today, including the origins of farming, property, cities, democracy, slavery, and civilization itself.Drawing on pathbreaking research in archaeology and anthropology, the authors show how history becomes a far more interesting place once we learn to throw off our conceptual shackles and perceive what's really there. If humans did not spend 95 percent of their evolutionary past in tiny bands of hunter-gatherers, what were they doing all that time? If agriculture, and cities, did not mean a plunge into hierarchy and domination, then what kinds of social and economic organization did they lead to? The answers are often unexpected, and suggest that the course of human history may be less set in stone, and more full of playful, hopeful possibilities, than we tend to assume.The Dawn of Everything fundamentally transforms our understanding of the human past and offers a path toward imagining new forms of freedom, new ways of organizing society. This is a monumental book of formidable intellectual range, animated by curiosity, moral vision, and a faith in the power of direct action.

    Genetic manipulation and artificial intelligence shape an astounding destiny for our species. With these wondrous changes come unexpected new truths of heart and mind that challenge the very definition of human—and that threaten not only our existence but the universe itself as our surprising powers—both miraculous and monstrous—evolve through the centuries.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    Is Earth Warming? 2. Butterflies, Glaciers, and Hurricanes 3. Ice Ages and Beyond 4. In the Greenhouse 5. A Tale of Three Planets 6. Global Recycling 7. The Human Factor 8. Computing the Future 9. Impacts of Climate Change 10. Energy and Climate 11. EnergyResources and Alternatives 12. Sustainable Futures?

    It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.

     This book is not for those who want to continue in the energy draining cycle of losing weight only to gain it back again.  This book is for those who want the TRUTH.  Everything You’ve Been Told about Weight Loss Is A Big Fat Lie! Seriously, it really is. You’ve tried it all haven’t you? Weight-Loss fads, challenges, and every other diet out there—but nothing seems to stick. Finally, someone has the courage to tell you why.  Kaelin Tuell Poulin, the woman who lost 65 pounds in 7 months while still eating pizza and ice cream, cuts through the B.S. She debunks the MYTHS and reveals the TRUTHS about losing weight and creating a lasting healthy lifestyle that will TRANSFORM your life.  No more weight loss tips from people who haven't lost any weight. On her own personal journey, Kaelin discovered that the reason her and other women had a hard time losing weight and keeping it off was because the weight-loss industry was lying about how to actually get healthy and have long-term success. To help you discover your own incredible story, the founder of the LadyBoss movement now shares her inspiring personal journey from being clinically obese and hopeless to fit and confident.  Kaelin’s award-winning achievements in fitness and health , backed by careful research, led her to develop the Lady Boss Formula for weight loss success that tens of thousands of women around the world—housewives, executives, athletes, students, and busy moms—have used to lose weight and keep it off forever. How is your health holding you back? What would life be like if it wasn't? Through this book you will lay the foundation to create YOUR story so it becomes one you love to tell. You deserve the life of your dreams. It's time to start living it.  Kaelin will show you the way as you become part of the most powerful community of women on the planet. Are you ready for the truth?

    There is no better way to study the big questions in philosophy than to compare how the world's greatest minds have analyzed these questions, defined the terms, and then reasoned out potential solutions. Once you've compared the arguments, the final step is always deciding for yourself whether you find an explanation convincing.This course gives you the tools to follow and create logical arguments while exploring famous philosophers' viewpoints on these important questions. Although progress has been made toward answers, brilliant thinkers have continued to wrestle with many big questions that inspire thoughtful people everywhere. These questions include: What is knowledge? Does God exist? Do humans have free will? What is right and wrong? How should society be organized?Given the complexity of these big questions, it should be no surprise that many controversies are far from settled. In fact, by the end of these 36 lectures, you may be even less sure of the right answers to some of the questions than you were at the beginning. But being a philosopher means constantly testing your views - giving a reasoned defense if you believe you are right and modifying your ideas when you realize you are wrong. You'll discover that great thinkers before you have offered convincing answers to hard questions, philosophers after them have made equally persuasive objections, and then still others have refined the debate even further - causing the issues to come into sharper and sharper focus.Join Plato, St. Anselm, Descartes, Locke, Hume, Kant, Mill, Smith, Marx, Rawls, and many others in an exploration of fundamental questions. Get ready to think big!

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    Bored and Brilliant builds on that experiment to show us how to rethink our gadget use to live better and smarter in this new digital ecosystem. Manoush explains the connection between boredom and original thinking, exploring how we can harness boredom’s hidden benefits to become our most productive and creative selves without totally abandoning our gadgets in the process.Grounding the book in the neuroscience and cognitive psychology of “mind wandering”—what our brains do when we’re doing nothing at all—Manoush includes practical steps you can take to ease the nonstop busyness and enhance your ability to dream, wonder, and gain clarity in your work and life. The outcome is mind-blowing. Unplug and read on.

    We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning. And yet our skin and the fascinating way it functions is largely unknown to us. In prose as lucid as his research underlying it is rigorous, blending in memorable stories from the past and from his own medical experience, Monty Lyman has written a revelatory book exploring our outer surface that will surprise and enlighten in equal measure. Through the lenses of science, sociology, and history--on topics as diverse as the mechanics and magic of touch (how much goes on in the simple act of taking keys out of a pocket and unlocking a door is astounding), the close connection between the skin and the gut, what happens instantly when one gets a paper cut, and how a midnight snack can lead to sunburn--Lyman leads us on a journey across our most underrated and unexplored organ and reveals how our skin is far stranger, more wondrous, and more complex than we have ever imagined.

    Lennon's final pivotal year would climax in several moments of creative triumph as he rediscovered his artistic self in dramatic fashion. With the bravura release of the Double Fantasy album with wife Yoko Ono, he was poised and ready for an even brighter future only to be wrenched from the world by an assassin's bullets. John Lennon, 1980 isn't about how the gifted songwriter died; but rather, about how he lived.

    Uber had catapulted to the top of the tech world, yet for many came to symbolize everything wrong with Silicon Valley.Award-winning New York Times technology correspondent Mike Isaac’s Super Pumped presents the dramatic rise and fall of Uber, set against an era of rapid upheaval in Silicon Valley. Backed by billions in venture capital dollars and led by a brash and ambitious founder, Uber promised to revolutionize the way we move people and goods through the world. A near instant “unicorn,” Uber seemed poised to take its place next to Amazon, Apple, and Google as a technology giant.What followed would become a corporate cautionary tale about the perils of startup culture and a vivid example of how blind worship of startup founders can go wildly wrong. Isaac recounts Uber’s pitched battles with taxi unions and drivers, the company’s toxic internal culture, and the bare-knuckle tactics it devised to overcome obstacles in its quest for dominance. With billions of dollars at stake, Isaac shows how venture capitalists asserted their power and seized control of the startup as it fought its way toward its fateful IPO.Based on hundreds of interviews with current and former Uber employees, along with previously unpublished documents, Super Pumped is a page-turning story of ambition and deception, obscene wealth, and bad behavior that explores how blistering technological and financial innovation culminated in one of the most catastrophic twelve-month periods in American corporate history.

    The Psychopath Test is a fascinating journey through the minds of madness. Jon Ronson's exploration of a potential hoax being played on the world's top neurologists takes him, unexpectedly, into the heart of the madness industry. An influential psychologist who is convinced that many important CEOs and politicians are, in fact, psychopaths teaches Ronson how to spot these high-flying individuals by looking out for little telltale verbal and nonverbal clues. And so Ronson, armed with his new psychopath-spotting abilities, enters the corridors of power. He spends time with a death-squad leader institutionalized for mortgage fraud in Coxsackie, New York; a legendary CEO whose psychopathy has been speculated about in the press; and a patient in an asylum for the criminally insane who insists he's sane and certainly not a psychopath. Ronson not only solves the mystery of the hoax but also discovers, disturbingly, that sometimes the personalities at the helm of the madness industry are, with their drives and obsessions, as mad in their own way as those they study. And that relatively ordinary people are, more and more, defined by their maddest edges.

    But now, someone is eliminating the Gentian line. Campion and Purslane—two shatterlings who have fallen in love and shared forbidden experiences—must determine exactly who, or what, their enemy is, before they are wiped out of existence.