As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Pretending to work? That’s fudgelling, which may lead to rizzling if you feel sleepy after lunch, though by dinner time you will have become a sparkling deipnosophist.From Mark Forsyth, author of the bestselling The Etymologicon, this is a book of weird words for familiar situations. From ante-jentacular to snudge by way of quafftide and wamblecropt, at last you can say, with utter accuracy, exactly what you mean.

    When tragedy strikes, Rachel is separated from her brother Sam and sent to a Jewish orphanage where Dr. Mildred Solomon is conducting medical research. Subjected to X-ray treatments that leave her disfigured, Rachel suffers years of cruel harassment from the other orphans. But when she turns fifteen, she runs away to Colorado hoping to find the brother she lost and discovers a family she never knew she had.Though Rachel believes she’s shut out her painful childhood memories, years later she is confronted with her dark past when she becomes a nurse at Manhattan’s Old Hebrews Home and her patient is none other than the elderly, cancer-stricken Dr. Solomon. Rachel becomes obsessed with making Dr. Solomon acknowledge, and pay for, her wrongdoing. But each passing hour Rachel spends with the old doctor reveal to Rachel the complexities of her own nature. She realizes that a person’s fate—to be one who inflicts harm or one who heals—is not always set in stone.Lush in historical detail, rich in atmosphere and based on true events, Orphan #8 is a powerful, affecting novel of the unexpected choices we are compelled to make that can shape our destinies.

    Pisano answers this question by providing an incisive critique of the industry. Pisano not only reveals the underlying causes of biotech's problems; he offers the most sophisticated analysis yet on how the industry works. And he provides clear prescriptions for companies, investors, and policy makers seeking ways to improve the industry's performance. According to Pisano, the biotech industry's problems stem from its special character as a science-based business. This character poses three unique business challenges: how to finance highly risky investments under profound uncertainty and long time horizons for R&D, how to learn rapidly enough to keep pace with advances in drug science knowledge, and how to integrate capabilities across a broad spectrum of scientific and technological knowledge bases.The key to fixing the industry? Business models, organisational structures, and financing arrangements that place greater emphasis on integration and long-term learning over shorter—term 'monetisation' of intellectual property. Pisano maintains that all industry players—biotech firms, investors, universities, pharmaceutical companies, government regulators—can play a role in righting the industry. The payoff? Valuable improvements in health care, and a shinier future for human well-being.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    They became medical celebrities: every week, eager crowds arrived at the hospital to observe their symptoms; they were photographed, sculpted, painted, and transformed into characters in novels. The remarkable story of their lives as patients in the clinic is a strange amalgam of intimate details and public exposure, science and religion, medicine and the occult, hypnotism, love, and theater. But who were Blanche, Augustine, and Geneviève? What role did they play in their own peculiar form of stardom? And what exactly were they suffering from? Hysteria-with its dramatic seizures, hallucinations, and reenactments of past traumas-may be an illness of the past, but the notions of femininity that lie behind it offer insights into disorders of the present.

    The emotional, incredible true story of Neil White, a man who discovers the secret to happiness, leading a fulfilling life, and the importance of fatherhood in the most unlikely of places—the last leper colony in the continental United States.

    With a muckraker's passion, Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their efficacy. Tracing over three centuries of "cures" for madness, Whitaker shows how medical therapies have been used to silence patients and dull their minds. He tells of the eighteenth- and nineteenth-century practices of "spinning" the insane, extracting their teeth, ovaries, and intestines, and submerging patients in freezing water. The "cures" in the 1920s and 1930s were no less barbaric as eugenic attitudes toward the mentally ill led to brain-damaging lobotomies and electroshock therapy. Perhaps Whitaker's most damning revelation, however, is his report of how drug companies in the 1980s and 1990s skewed their studies in an effort to prove the effectiveness of their products. Based on exhaustive research culled from old patient medical records, historical accounts, numerous interviews, and hundreds of government documents, Mad in America raises important questions about our obligations to the mad, what it means to be "insane," and what we value most about the human mind.

    Wealthy tubercular patients live in private cure cottages; charity patients, mainly immigrants, fill the large public sanatorium. Prisoners of routine, they take solace in gossip, rumor, and—sometimes—secret attachments. But when the well-meaning efforts of one enterprising patient lead to a tragic accident and a terrible betrayal, the war comes home, bringing with it a surge of anti-immigrant prejudice and vigilante sentiment.

    It is also no secret that these nineteenth-century gynecologists performed experimental caesarean sections, ovariotomies, and obstetric fistula repairs primarily on poor and powerless women. Medical Bondage breaks new ground by exploring how and why physicians denied these women their full humanity yet valued them as "medical superbodies" highly suited for medical experimentation.In Medical Bondage, Cooper Owens examines a wide range of scientific literature and less formal communications in which gynecologists created and disseminated medical fictions about their patients, such as their belief that black enslaved women could withstand pain better than white "ladies." Even as they were advancing medicine, these doctors were legitimizing, for decades to come, groundless theories related to whiteness and blackness, men and women, and the inferiority of other races or nationalities. Medical Bondage moves between southern plantations and northern urban centers to reveal how nineteenth-century American ideas about race, health, and status influenced doctor-patient relationships in sites of healing like slave cabins, medical colleges, and hospitals. It also retells the story of black enslaved women and of Irish immigrant women from the perspective of these exploited groups and thus restores for us a picture of their lives.

    Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    Would you know one if you held it in your hand?In Dark Archives, Megan Rosenbloom seeks out the historic and scientific truths behind anthropodermic bibliopegy--the practice of binding books in this most intimate covering. Dozens of such books live on in the world's most famous libraries and museums. Dark Archives exhumes their origins and brings to life the doctors, murderers, innocents, and indigents whose lives are sewn together in this disquieting collection. Along the way, Rosenbloom tells the story of how her team of scientists, curators, and librarians test rumored anthropodermic books, untangling the myths around their creation and reckoning with the ethics of their custodianship.A librarian and journalist, Rosenbloom is a member of The Order of the Good Death and a cofounder of their Death Salon, a community that encourages conversations, scholarship, and art about mortality and mourning. In Dark Archives--captivating and macabre in all the right ways--she has crafted a narrative that is equal parts detective work, academic intrigue, history, and medical curiosity: a book as rare and thrilling as its subject.

    A city of gas lamps, cobblestone streets, and horse-drawn carriages—and home to the controversial surgeon Dr. Spencer Black. The son of a grave robber, young Dr. Black studies at Philadelphia’s esteemed Academy of Medicine, where he develops an unconventional hypothesis: What if the world’s most celebrated mythological beasts—mermaids, minotaurs, and satyrs—were in fact the evolutionary ancestors of humankind?  The Resurrectionist offers two extraordinary books in one. The first is a fictional biography of Dr. Spencer Black, from a childhood spent exhuming corpses through his medical training, his travels with carnivals, and the mysterious disappearance at the end of his life. The second book is Black’s magnum opus: The Codex Extinct Animalia, a Gray’s Anatomy for mythological beasts—dragons, centaurs, Pegasus, Cerberus—all rendered in meticulously detailed anatomical illustrations. You need only look at these images to realize they are the work of a madman. The Resurrectionist tells his story.

      The autumn of 1922 found F. Scott Fitzgerald at the height of his fame, days from turning twenty-six years old, and returning to New York for the publication of his fourth book, Tales of the Jazz Age. A spokesman for America’s carefree younger generation, Fitzgerald found a home in the glamorous and reckless streets of New York. Here, in the final incredible months of 1922, Scott and Zelda Fitzgerald drank and quarreled and partied amid financial scandals, literary milestones, car crashes, and celebrity disgraces. Yet the Fitzgeralds’ triumphant return to New York coincided with another event: the discovery of a brutal double murder in nearby New Jersey, a crime made all the more horrible by the farce of a police investigation—which failed to accomplish anything beyond generating enormous publicity for the newfound celebrity participants. Proclaimed the "crime of the decade" even as its proceedings dragged on for years, the Mills-Hall murder has been wholly forgotten today. But the enormous impact of this bizarre crime can still be felt in The Great Gatsby, a novel Fitzgerald began planning that autumn of 1922 and whose plot he ultimately set within that fateful year.Careless People is a unique literary investigation: a gripping double narrative that combines a forensic search for clues to an unsolved crime and a quest for the roots of America’s best loved novel. Overturning much of the received wisdom of the period, Careless People blends biography and history with lost newspaper accounts, letters, and newly discovered archival materials. With great wit and insight, acclaimed scholar of American literature Sarah Churchwell reconstructs the events of that pivotal autumn, revealing in the process new ways of thinking about Fitzgerald’s masterpiece. Interweaving the biographical story of the Fitzgeralds with the unfolding investigation into the murder of Hall and Mills, Careless People is a thrilling combination of literary history and murder mystery, a mesmerizing journey into the dark heart of Jazz Age America.

    Arranged chronologically for easy reference and illustrated throughout with artwork, photographs, and documents, this is a information-packed overview of the lives and legacies of America's first ladies. What's more, The First Ladies Fact Book features selections of the most intimate correspondence of all the first ladies. Delightful surprises abound, including little-known information about the women's hobbies, styles of dress, habits of socializing, and quirks. With more than 700 photographs and illustrations, this is a eye-catching history of the nation's first ladies.