They are the powerhouses of our cells, essential for the production and management of energy at cell level. Dr Sarah Myhill, together with Dr John McLaren Howard of Acumen Laboratories and Dr Norman Booth of Mansfield College Oxford, has spent many years studying the relationship between their malfunction and the commonest problem seen by GPs in the UK – fatigue. Their research findings have been published in three scientific papers in the International Journal of Clinical and Experimental Medicine, in 2009, 2012 and 2013. These studies showed that poor functioning of the mitochondria is the central problem in CFS. Patients with the worst mitochondrial function had the worst fatigue and vice versa. This is solid scientific evidence that CFS is a problem with mitochondria and has allowed the objective measurement of fatigue for the first time. With the publication of the third study, which showed that mitochondrial function tests and symptoms improved in patients who took measures to address their mitochondrial problems, Dr Myhill was ready to write this book. Here she explains the importance of healthy mitochondria, how we can measure their functioning and what we can do to keep them healthy, or restore them to health if problems arise. CFS is all in our cells, not in our minds!

    His guitarist is trying to get them all killed. Fans are stealing his things. Mechanics are rebuking his lifestyle. Even his own fragile, uptight psyche is antagonizing him. But despite having every odd stacked against him, Project 86's frontman is living the dream and loving it. In It's All Downhill From Here, Andrew Schwab chronicles the highs and lows, the struggles and triumphs of this underground, independent rock band's rocky road to stardom. From a hostage situation on their first day on the road, to a drummer's crushed hand, a haunting female fan and an '80s rocker's halitosis problem, Schwab tells it like it is, with biting wit and rock star charm. This insider's look at the real life of a rock band not only reaffirms that everyone's human, but makes you hungry for a dream of your own to chase after.

    This book integrates clinical examples throughout each chapter and covers important physiologic concepts. It includes 630 multiple choice questions. It covers topics such as: Regulation of food intake; Mitochondria and molecular motors; Renal function; and, Estrogen receptors.

    Leptin is your body’s natural weight-loss mechanism: it curbs your appetite, jump-starts your metabolism, and when working properly makes you literally fat resistant—you will lose weight effortlessly and efficiently and never gain those pounds back.If you’re struggling to lose weight, chances are you are “leptin resistant”—your body no longer responds to leptin, making it impossible for you to slim down. The Fat Resistance Diet is the first and only eating plan designed specifically to combat leptin resistance and reprogram your body to start melting away the pounds. Using a breakthrough combination of anti-inflammatory and hormone-balancing foods, the three-phase regimen delivers:A loss of six to ten pounds in the first two weeks.A loss of at least two pounds a week thereafter. Fun, flavorful meals that make sticking with the plan a breeze.An easy maintenance program that keeps you fat resistant for life.With over 100 delicious recipes designed for maximum satisfaction and eating pleasure, the Fat Resistance Diet is the only diet you’ll ever need—a brand new way to eat that will transform your body into a lean, fat-fighting machine.

    French women know the intrinsic value of classic basics and integrate their favorite clothes and accessories based upon years of experience perfecting their unique sense of style. French women know how to create a sense of intrigue. And it’s not achieved by wearing a barrage of latest trends or designers. It’s about having the confidence to dress up a simple white button-down, incorporating their signature flair, for a far more interesting and sophisticated look. Most women tend to buy everything that catches their eye. There’s not much discernment, just buying power. And these women have the overstuffed closets to show for it. I must warn you – This book is not just another simplistic buying guide to achieve a French chic look. Nor will I insult you with cliché advice on incorporating scarves into your daily wardrobe. I would like to offer you a different perspective. This book includes advice and insights about making empowering choices when it comes to what is hanging in your closet. The choice to simplify, buy less, and keep only fabulous items. The choice to honor your body first and foremost. And the choice to invest in your wardrobe.

    It is not the original book nor is it intended to replace the original book. You may purchase the original book here: http://bit.ly/mansonsartIn this fast guide, you'll be taken by the hand through a summary and analysis of The main points made by the author An organized chapter by chapter synopsis References to noteworthy people mentioned The author's most important tips, websites, books, and tools Most CompanionReads may be read in 30 minutes.This book is meant for anyone who is interested in enhancing their reading experience. It will give you deeper insight, fresher perspectives, and help you squeeze more enjoyment out of your book. Perfect for a quick refresh on the main ideas or when you want to use it as a topic of conversation at your next meeting.Enjoy this edition instantly on your Kindle device!Now available in paperback, digital, and audio editions.Sign up for our newsletter to get notified about our new books at www.companionreads.com/gift

    He chronicles some of the most formative calls of his career in this autobiography that reads like crime fiction. McCarthy demonstrates with detail and clarity that the difficult choice is often the right choice. While not for the faint of heart, each entry in this collection provides poignant insight into the bonds between medics and the people and city they serve.

    As recently as 1918, a pandemic of influenza claimed over 50 million lives worldwide. The advent of drugs and vaccines led to an era of hope when we thought our battles with infectious disease were won, but our optimism has been eroded by the recognition that many pathogens have the capacity to transform themselves and escape our efforts to eradicate them. Are we now facing an inevitable repeat of a calamity such as the 1918 influenza pandemic or the Black Death? Can we anticipate and thwart such an event, or are we wilfully creating the conditions that would promote the emergence of new and highly virulent human infectious disease?Sunetra Gupta is Professor of Theoretical Epidemiology at the University of Oxford specialising in infectious diseases. She holds a bachelor's degree from Princeton University and a Ph.D. from the University of London. She has been awarded the Scientific Medal by the Zoological Society of London and the Royal Society Rosalind Franklin Award for her scientific research. She is also a novelist whose books have been awarded the Sahitya Akademi Award, the Southern Arts Literature Prize, shortlisted for the Crossword Award, and longlisted for the DSC and Orange Prizes.

    Too bad. Because medicine isn't an industry, it's practically witchcraft. Despite the growth of big pharma, HMOs, and hospital chains, medicine remains the isolated work of individual doctors—and the system is going broke fast.So why is Andy Kessler—the man who told you outrageous stories of Wall Street analysts gone bad in Wall Street Meat and tales from inside a hedge fund in Running Money—poking around medicine for the next big wave of technology?It's because he smells change coming. Heart attacks, strokes, and cancer are a huge chunk of medical spending, yet there's surprisingly little effort to detect disease before it's life threatening. How lame is that—especially since the technology exists today to create computer-generated maps of your heart and colon?Because it's too expensive—for now. But Silicon Valley has turned computing, telecom, finance, music, and media upside down by taking expensive new technologies and making them ridiculously cheap. So why not the $1.8 trillion health care business, where the easiest way to save money is to stop folks from getting sick in the first place?Join Kessler's bizarre search for the next big breakthrough as he tries to keep from passing out while following cardiologists around, cracks jokes while reading mammograms, and watches twitching mice get injected with radioactive probes. Looking for a breakthrough, Kessler even selflessly pokes, scans, and prods himself.CT scans of your heart will identify problems before you have a heart attack or stroke; a nanochip will search your blood for cancer cells--five years before they grow uncontrollably and kill you; and baby boomers can breathe a little easier because it's all starting to happen now.Your doctor can't be certain what's going on inside your body, but technology will. Embedding the knowledge of doctors in silicon will bring a breakout technology to health care, and we will soon see an end of medicine as we know it.

    New York Times bestselling author Roger Stone lashes out with a blistering indictment, exposing the true history and monumental hypocrisy of the Bushes. In Stone’s usual “go for the jugular” style, this is a no-holds-barred history of the Bush family, comprised of smug, entitled autocrats who both use and hide behind their famous name. They got a long-overdue taste of defeat and public humiliation when Jeb’s 2016 presidential bid went down in flames.Besides detailing the vast litany of Jeb’s misdeeds — including receiving a $4 million taxpayer bailout when his father was vice president as well as his startlingly-close alignment with supposed “enemy” Hillary Clinton — Stone travels back to Bush patriarchs Samuel and Prescott, right on through to presidents George H. W. and George W. Bush to weave an epic story of privilege, greed, corruption, drug profiteering, assassination, and lies. A new preface to this paperback edition features explosive information, including the family’s Machiavellian plan to propel Jeb’s son George Prescott Bush forward as the family’s next political contender.The Bush Crime Family will have readers asking, “Why aren’t these people in prison?”

    Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses —deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak.Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.” Warren Andiman, MD is professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health.

    But its roots stretch back as far as ancient Greece, when medicine first departed from the divine and the mystical and moved toward observation and logic. Its early development was slow, constrained by the taboo around dissection (only external symptoms could be used for diagnosis), as well as superstition and mysticism (illness was the work of demons and pixies and curable only by penitence). Paul Strathern steers us skillfully through the maze of discoveries, diseases, and wrong turns that have made medicine what it is today—super efficient, high tech, and increasingly costly. A Brief History of Medicine offers an accessible history of the arguments, missteps, and dumb luck that led to the world's most important medical breakthroughs—from anatomy, grave robbing, the plague, and germ theory to vaccination, quackery, microorganisms, and penicillin.

    Dumb crooks, celebrities gone bad, unsolved mysteries, odd laws, and more—Strange Crime has plenty of stories that will make you ask yourself, “What could they possibly have been thinking?” This easily portable paperback book is ideal for readers on the go. Take it to school, to work, to jury duty!

    Immerse yourself in the history of medicine - a colourful story of skill, serendipity, trial and error, moments of genius, and dogged determination.From traditional chinese medicine to today's sophisticated gene therapies and robotic surgery, A Short History of Medicine combines riveting storytelling and beautiful images, historical accounts and lucid explanations, to illuminate the story of medicine through time.Witness early, bloody, anaesthetic-free operations; see the first crude surgical instruments; trace the mapping of the circulatory system; follow the painstaking detective work that led to the decoding of the human genome; and understand the role that potions, cures, therapies, herbal medicines, and drugs have played in the human quest to tame and conquer disease, injury, and death.A Short History of Medicine is an engrossing illustrated history and tale of drama and discovery that celebrates the milestones of medical history across generations and cultures.

    The fourth edition includes revised content on muscles, tendons, bones, and joints and further updates in the breast chapter describe benign breast disease and the classification of cancer staging.This edition includes numerous illustrations, with additional photographs showing the more subtle surgical signs and demonstrating new approaches to surgical examination. The authors also place a greater emphasis on the doctor-patient relationship and patient confidentiality.