But evolutionary biologists also point out many examples of contingency, cases where the tiniest change--a random mutation or an ancient butterfly sneeze--caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary freaks? And what does that say about life on other planets?Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be.Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.

    In this Very Short Introduction, eminent biologist and popular science writer Dorothy Crawford offers a fascinating portrait of these infinitesimally small but often highly dangerous creatures. Crawford first relates how viruses were discovered and she unravels the intricate structures of tiny parasites that are by far the most abundant life forms on the planet. Analyzing the threat of viral infections, Crawford recounts stories of renowned killer viruses such as Ebola and rabies as well as the less known bat-borne Nipah and Hendra viruses. She identifies wild animals as the source of the most recent pandemics, detailing the reasons behind the present increase in potentially fatal infections, and evaluating the evidence that suggests that long term viruses can eventually lead to cancer. Finally, Crawford looks to the future to ask whether we can ever live in harmony with viruses, and considers ways to prevent the emergence of new and devastating viruses.

    They made the world theirs long before the rise of dinosaurs. Travelling forward into the Permian and then Triassic periods, we learn how our ancient mammal ancestors evolved from large hairy beasts with accelerating metabolisms to exploit miniaturisation, which was key to unlocking the traits that define mammals as we now know them. Elsa criss-crosses the globe to explore the sites where discoveries are being made and meet the people who make them. In Scotland, she traverses the desert dunes of prehistoric Moray, where quarry workers unearthed the footprints of Permian creatures from before the time of dinosaurs. In South Africa, she introduces us to animals, once called 'mammal-like reptiles', that gave scientists the first hints that our furry kin evolved from a lineage of egg-laying burrowers. In China, new, complete fossilised skeletons reveal mammals that were gliders, shovel-pawed Jurassic moles, and flat-tailed swimmers.This book radically reframes the narrative of our mammalian ancestors and provides a counterpoint to the stereotypes of mighty dinosaur overlords and cowering little mammals. It turns out the earliest mammals weren't just precursors, they were pioneers.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    This man was a freediver, and his amphibious abilities inspired Nestor to seek out the secrets of this little-known discipline. In Deep, Nestor embeds with a gang of extreme athletes and renegade researchers who are transforming not only our knowledge of the planet and its creatures, but also our understanding of the human body and mind. Along the way, he takes us from the surface to the Atlantic’s greatest depths, some 28,000 feet below sea level. He finds whales that communicate with other whales hundreds of miles away, sharks that swim in unerringly straight lines through pitch-black waters, and seals who dive to depths below 2,400 feet for up to eighty minutes—deeper and longer than scientists ever thought possible. As strange as these phenomena are, they are reflections of our own species’ remarkable, and often hidden, potential—including echolocation, directional sense, and the profound physiological changes we undergo when underwater. Most illuminating of all, Nestor unlocks his own freediving skills as he communes with the pioneers who are expanding our definition of what is possible in the natural world, and in ourselves.

    From the minds of the world's leading physicists there flowed a river of ideas that would transport mankind to the pinnacle of wonderment and to the very depths of human despair. This was a century that began with the certainties of absolute knowledge and ended with the knowledge of absolute uncertainty. It was a century in which physicists developed weapons with the capacity to destroy our reality, whilst at the same time denying us the possibility that we can ever properly comprehend it.Almost everything we think we know about the nature of our world comes from one theory of physics. This theory was discovered and refined in the first thirty years of the twentieth century and went on to become quite simply the most successful theory of physics ever devised. Its concepts underpin much of the twenty-first century technology that we have learned to take for granted. But its success has come at a price, for it has at the same time completely undermined our ability to make sense of the world at the level of its most fundamental constituents.Rejecting the fundamental elements of uncertainty and chance implied by quantum theory, Albert Einstein once famously declared that 'God does not play dice'. Niels Bohr claimed that anybody who is not shocked by the theory has not understood it. The charismatic American physicist Richard Feynman went further: he claimed that nobody understands it.This is quantum theory, and this book tells its story.Jim Baggott presents a celebration of this wonderful yet wholly disconcerting theory, with a history told in forty episodes -- significant moments of truth or turning points in the theory's development. From its birth in the porcelain furnaces used to study black body radiation in 1900, to the promise of stimulating new quantum phenomena to be revealed by CERN's Large Hadron Collider over a hundred years later, this is the extraordinary story of the quantum world.Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

    It's the most miraculous substance on earth, responsible for our food, our weather, our water, and our ability to hear. In this exuberant book, gifted science writer Gabrielle Walker peels back the layers of our atmosphere with the stories of the people who uncovered its secrets: - A flamboyant Renaissance Italian discovers how heavy our air really is: The air filling Carnegie Hall, for example, weighs seventy thousand pounds. - A one-eyed barnstorming pilot finds a set of winds that constantly blow five miles above our heads. - An impoverished American farmer figures out why hurricanes move in a circle by carving equations with his pitchfork on a barn door. - A well-meaning inventor nearly destroys the ozone layer. - A reclusive mathematical genius predicts, thirty years before he's proved right, that the sky contains a layer of floating metal fed by the glowing tails of shooting stars.

    Thanks to the introduction of free-roaming cattle, ponies, pigs and deer – proxies of the large animals that once roamed Britain – the 3,500 acre project has seen extraordinary increases in wildlife numbers and diversity in little over a decade.Once-common species, including turtle doves, nightingales, peregrine falcons, lesser spotted woodpeckers and purple emperor butterflies, are now breeding at Knepp, and populations of other species are rocketing. The Burrells’ degraded agricultural land has become a functioning ecosystem again, heaving with life – all by itself.This recovery has taken place against a backdrop of catastrophic loss elsewhere. According to the 2016 ‘State of Nature’ report, the UK is ranked 29th in the world for biodiversity loss: 56% of species in the UK are in decline and 15% are threatened with extinction. We are living in a desert, compared with our gloriously wild past.In Wilding, Isabella Tree tells the story of the ‘Knepp experiment’ and what it reveals of the ways in which we might regain that wilder, richer country. It shows how rewilding works across Europe; that it has multiple benefits for the land; that it can generate economic activity and employment; how it can benefit both nature and us – and that all of this can happen astonishingly quickly. Part gripping memoir, part fascinating account of the ecology of our countryside, Wilding is, above all, an inspiring story of hope.

    But when a new admission to the critical care unit almost died his first night on call, he found himself scrambling. Visions of mastery quickly gave way to hopes of simply surviving hospital life, where confidence was hard to come by and no amount of med school training could dispel the terror of facing actual patients.This funny, candid memoir of McCarthy’s intern year at a New York hospital provides a scorchingly frank look at how doctors are made, taking readers into patients’ rooms and doctors’ conferences to witness a physician's journey from ineptitude to competence. McCarthy's one stroke of luck paired him with a brilliant second-year adviser he called “Baio” (owing to his resemblance to the Charles in Charge star), who proved to be a remarkable teacher with a wicked sense of humor. McCarthy would learn even more from the people he cared for, including a man named Benny, who was living in the hospital for months at a time awaiting a heart transplant. But no teacher could help McCarthy when an accident put his own health at risk, and showed him all too painfully the thin line between doctor and patient.The Real Doctor Will See You Shortly offers a window on to hospital life that dispenses with sanctimony and self-seriousness while emphasizing the black-comic paradox of becoming a doctor: How do you learn to save lives in a job where there is no practice?

    Much like human families, tree parents live together with their children, communicate with them, and support them as they grow, sharing nutrients with those who are sick or struggling and creating an ecosystem that mitigates the impact of extremes of heat and cold for the whole group. As a result of such interactions, trees in a family or community are protected and can live to be very old. In contrast, solitary trees, like street kids, have a tough time of it and in most cases die much earlier than those in a group.Drawing on groundbreaking new discoveries, Wohlleben presents the science behind the secret and previously unknown life of trees and their communication abilities; he describes how these discoveries have informed his own practices in the forest around him. As he says, a happy forest is a healthy forest, and he believes that eco-friendly practices not only are economically sustainable but also benefit the health of our planet and the mental and physical health of all who live on Earth.

    In The Ends of the World, Peter Brannen dives into deep time, exploring Earth’s past dead ends, and in the process, offers us a glimpse of our possible future.Many scientists now believe that the climate shifts of the twenty-first century have analogs in these five extinctions. Using the visible clues these devastations have left behind in the fossil record, The Ends of the World takes us inside “scenes of the crime,” from South Africa to the New York Palisades, to tell the story of each extinction. Brannen examines the fossil record—which is rife with creatures like dragonflies the size of sea gulls and guillotine-mouthed fish—and introduces us to the researchers on the front lines who, using the forensic tools of modern science, are piecing together what really happened at the crime scenes of the Earth’s biggest whodunits.Part road trip, part history, and part cautionary tale, The Ends of the World takes us on a tour of the ways that our planet has clawed itself back from the grave, and casts our future in a completely new light.

     With rivalries, reversals, and a race against time, the struggle to eradicate polio is one of the great tales of modern history. It begins with the birth of Jonas Salk, shortly before one of the worst polio epidemics in United States history. At the time, the disease was a terrifying enigma: striking from out of nowhere, it afflicted tens of thousands of children in this country each year and left them-literally overnight-paralyzed, and sometimes at death's door. Salk was in medical school just as a president crippled by the disease, Franklin D. Roosevelt, was taking office-and providing the impetus to the drive for studies on polio. By the early 1950s, Salk had already helped create an influenza vaccine, and was hot on the trail of the polio virus. He was nearly thwarted, though, by the politics of medicine and by a rival researcher eager to discredit his proposed solution. Meanwhile, in 1952, polio was spreading in record numbers, with 57,000 cases in the United States that summer alone. In early 1954, Salk was weighing the possibility of trials of a not-yet-perfected vaccine against-as the summer approached-the prospect of thousands more children being struck down by the disease. The results of the history-making trials were announced at a press conference on April 12, 1955: "The vaccine works." The room-and an entire nation-erupted in cheers for this singular medical achievement. Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program-and as humanity is tantalizingly close to eradicating polio worldwide-comes this unforgettable chronicle. Salk's work was an unparalleled achievement-and it makes for a magnificent read.

    Now she builds on those insights to show us how to give our animals the best and happiest life—on their terms, not ours.It’s usually easy to pinpoint the cause of physical pain in animals, but to know what is causing them emotional distress is much harder. rawing on the latest research and her own work,Grandin identifies the core emotional needs of animals. Then she explains how to fulfill them for dogs and cats, horses, farm animals, and zoo animals.Whether it’s how to make the healthiest environment for the dog you must leave alone most of the day, how to keep pigs from being bored, or how to know if the lion pacing in the zoo is miserable or just exercising, Grandin teaches us to challenge our assumptions about animal contentment and honor our bond with our fellow creatures.Animals Make Us Human is the culmination of almost thirty years of research, experimentation, and experience.This is essential reading for anyone who’s ever owned, cared for, or simply cared about an animal.

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    Berra, whose "Darwin: The Man" lectures are in high demand worldwide, tells the fascinating story of the person and the idea that changed everything. Berra discusses Darwin’s revolutionary scientific work, its impact on modern-day biological science, and the influence of Darwin’s evolutionary theory on Western thought. But Berra digs deeper to reveal Darwin the man by combining anecdotes with carefully selected illustrations and photographs.This small gem of a book includes 20 color plates and 60 black-and-white illustrations, along with an annotated list of Darwin’s publications and a chronology of his life.