By exploring both the public actions and private papers of key figures such as Thomas Jefferson, Aaron Burr, and Alexander Hamilton, Freeman reveals an alien and profoundly unstable political world grounded on the code of honor. In the absence of a party system and with few examples to guide America’s experiment in republican governance, the rituals and rhetoric of honor provided ground rules for political combat. Gossip, print warfare, and dueling were tools used to jostle for status and form alliances in an otherwise unstructured political realm. These political weapons were all deployed in the tumultuous presidential election of 1800—an event that nearly toppled the new republic. By illuminating this culture of honor, Freeman offers new understandings of some of the most perplexing events of early American history, including the notorious duel between Burr and Hamilton. A major reconsideration of early American politics, Affairs of Honor offers a profoundly human look at the anxieties and political realities of leaders struggling to define themselves and their role in the new nation.

    Serendipity, timing, and luck played a part in the discovery of unintentional cures and breakthroughs:A plastic shard in an RAF pilot’s eye leads to the use of plastic for contact lenses.The inability to remove a titanium chamber from rabbit’s bone leads to dental implants.Viagra was discovered by a group of chemists, working in the lab to find a new drug to alleviate the pain of angina pectoris.A stretch of five weeks of unusually warm weather in 1928 played a role in assisting Dr. Alexander Fleming in his analysis of bacterial growth and the discovery of penicillin.After studying the effects of the venom injected by the bite of a deadly pit viper snake, chemists developed a groundbreaking drug that works to control blood pressure. Accidental Medical Discoveries is an entertaining and enlightening look at the creation of 25 medical inventions that have changed the world – unintentionally. The book is presented in a lively and engaging way, and will appeal to a wide variety of readers, from history buffs to trivia fanatics to those in the medical profession.

    The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern tobacco plantations to the dense immigrant neighborhoods of northern cities to far-flung villages on the edges of the nascent American empire. In Pox, award-winning historian Michael Willrich offers a gripping chronicle of how the nation's continentwide fight against smallpox launched one of the most important civil liberties struggles of the twentieth century.At the dawn of the activist Progressive era and during a moment of great optimism about modern medicine, the government responded to the deadly epidemic by calling for universal compulsory vaccination. To enforce the law, public health authorities relied on quarantines, pesthouses, and "virus squads"-corps of doctors and club-wielding police. Though these measures eventually contained the disease, they also sparked a wave of popular resistance among Americans who perceived them as a threat to their health and to their rights.At the time, anti-vaccinationists were often dismissed as misguided cranks, but Willrich argues that they belonged to a wider legacy of American dissent that attended the rise of an increasingly powerful government. While a well-organized anti-vaccination movement sprang up during these years, many Americans resisted in subtler ways-by concealing sick family members or forging immunization certificates. Pox introduces us to memorable characters on both sides of the debate, from Henning Jacobson, a Swedish Lutheran minister whose battle against vaccination went all the way to the Supreme Court, to C. P. Wertenbaker, a federal surgeon who saw himself as a medical missionary combating a deadly-and preventable-disease.As Willrich suggests, many of the questions first raised by the Progressive-era antivaccination movement are still with us: How far should the government go to protect us from peril? What happens when the interests of public health collide with religious beliefs and personal conscience? In Pox, Willrich delivers a riveting tale about the clash of modern medicine, civil liberties, and government power at the turn of the last century that resonates powerfully today.

    . . If what we want in this moment is insight from this brilliant doctor about pandemics, he wants us to see that they do not occur in isolation. --Carolyn Kellogg, The Boston GlobeIn 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it?Paul Farmer, the internationally renowned doctor and anthropologist, experienced the Ebola outbreak firsthand--Partners in Health, the organization he founded, was among the international responders. In Fevers, Feuds, and Diamonds, he offers the first substantive account of this frightening, fast-moving episode and its implications. In vibrant prose, Farmer tells the harrowing stories of Ebola victims while showing why the medical response was slow and insufficient. Rebutting misleading claims about the origins of Ebola and why it spread so rapidly, he traces West Africa's chronic health failures back to centuries of exploitation and injustice. Under formal colonial rule, disease containment was a priority but care was not - and the region's health care woes worsened, with devastating consequences that Farmer traces up to the present.This thorough and hopeful narrative is a definitive work of reportage, history, and advocacy, and a crucial intervention in public-health discussions around the world.

    Among the Union soldiers, doctors, wounded men from both sides, freed slaves, politicians, speculators, and spies who passed through the hospital in the crossroads of the Civil War, were nurses who gave their time freely and willingly to save lives and aid the wounded. These women saw casualties on a scale Americans had never seen before, and medicine was at a turning point. HEROINES OF MERCY STREET follows the lives of women like Dorothea Dix, Mary Phinney, Anne Reading, and more before, during, and after their epic struggle in Alexandria and reveals their personal contributions to this astounding period in the advancement of medicine.

    Handsome and charismatic, he was known to frequent the dive bars and gin joints of the Five Points, the most dangerous neighborhood in maritime Manhattan. For years, he operated out of the public eye, rambling from crime to crime, working on the water, in ships, sleeping in the nickel-a-night flops, drinking in barrooms where rat-baiting and bear-baiting were great entertainments.Hicks's criminal career reached its peak in 1860, when he was hired, under an alias, as an extra hand on an oyster sloop. His plan was to rob the ship, make his getaway, and disappear in the teeming streets of lower Manhattan, as he'd done numerous times before. But the plan went awry, and the voyage turned into a massacre. In the straits of Coney Island, on a foggy night, the ghost sloop, adrift and unmanned, was rammed by another vessel. When police boarded the ship to investigate, they found blood and gore everywhere, no bodies, only the grisly signs of struggle. A manhunt was launched for the mysterious merchant seaman on the manifest.Long fascinated by gangster legends, Rich Cohen tells the story of this notorious underworld figure for the first time, from his humble origins to his incarnation as a demon who terrorized the Five Points and became the gangster most feared by other gangsters, at a time when pirates anchored off of 14th street.

    Anyone who started a business, marketed a new invention, ran for office, formed an association, or wrote for publication was helping to fashion the world's first liberal society. These are the people we encounter in Inheriting the Revolution, a vibrant tapestry of the lives, callings, decisions, desires, and reflections of those Americans who turned the new abstractions of democracy, the nation, and free enterprise into contested realities. Through data gathered on thousands of people, as well as hundreds of memoirs and autobiographies, Joyce Appleby tells myriad intersecting stories of how Americans born between 1776 and 1830 reinvented themselves and their society in politics, economics, reform, religion, and culture. They also had to grapple with the new distinction of free and slave labor, with all its divisive social entailments; the rout of Enlightenment rationality by the warm passions of religious awakening; the explosion of small business opportunities for young people eager to break out of their parents' colonial cocoon. Few in the nation escaped the transforming intrusiveness of these changes. Working these experiences into a vivid picture of American cultural renovation, Appleby crafts an extraordinary--and deeply affecting--account of how the first generation established its own culture, its own nation, its own identity.The passage of social responsibility from one generation to another is always a fascinating interplay of the inherited and the novel; this book shows how, in the early nineteenth century, the very idea of generations resonated with new meaning in the United States.

    Drawing on the diaries of a midwife and healer in eighteenth-century Maine, this intimate history illuminates the medical practices, household economies, religious rivalries, and sexual mores of the New England frontier.

    Some prospered and rose to the highest levels of United States government, while others had their homes and farms seized by British soldiers. Signer George Wythe was poisoned by his nephew; Button Gwinnett was killed in a duel; Robert Morris went to prison; Thomas Lynch was lost at sea; and of course Sam Adams achieved fame as a patriot/brewer. Complete with portraits of the signers as well as a facsimile of the Declaration of Independence, Signing Their Lives Away provides an entertaining and enlightening narrative for history buffs of all ages.

    Police captains took hefty bribes to see nothing while reformers writhed in frustration.     In Island of Vice, bestselling author Richard Zacks paints a vivid picture of the lewd underbelly of 1890s New York, and of Theodore Roosevelt, the cocksure crusading police commissioner who resolved to clean up the bustling metropolis, where the silk top hats of Wall Street bobbed past teenage prostitutes trawling Broadway.     Writing with great wit and zest, Zacks explores how Roosevelt went head-to-head with corrupt Tammany Hall, took midnight rambles with muckraker Jacob Riis, banned barroom drinking on Sundays, and tried to convince 2 million New Yorkers to enjoy wholesome family fun. In doing so, Teddy made a ruthless enemy of police captain “Big Bill” Devery, who grew up in the Irish slums and never tired of fighting “tin soldier” reformers. Roosevelt saw his mission as a battle of good versus evil; Devery saw prudery standing in the way of fun and profit.     When righteous Roosevelt’s vice crackdown started to succeed all too well, many of his own supporters began to turn on him. Cynical newspapermen mocked his quixotic quest, his own political party abandoned him, and Roosevelt discovered that New York loves its sin more than its salvation.     Zacks’s meticulous research and wonderful sense of narrative verve bring this disparate cast of both pious and bawdy New Yorkers to life. With cameos by Stephen Crane, J. P. Morgan, and Joseph Pulitzer, plus a horde of very angry cops, Island of Vice is an unforgettable portrait of turn-of-the-century New York in all its seedy glory, and a brilliant portrayal of the energetic, confident, and zealous Roosevelt, one of America’s most colorful public figures.From the Hardcover edition.

    Building upon his talent for logistics, Knox engineered Washington's famous Christmas night passage to safety across the Delaware River. And it was the general's tactical successes that made the final victory at Yorktown possible. With riveting battle scenes, inspiring patriotism, and vivid prose, Puls breathes new life into the American Revolution and firmly re-establishes Knox in his deserved place in history.

    But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

     Giving shape to the deep depression that pervaded Lincoln's adult life, Joshua Wolf Shenk's Lincoln's Melancholy reveals how this illness influenced both the president's character and his leadership. Lincoln forged a hard path toward mental health from the time he was a young man. Shenk draws from historical record, interviews with Lincoln scholars, and contemporary research on depression to understand the nature of his unhappiness. In the process, he discovers that the President's coping strategies—among them, a rich sense of humor and a tendency toward quiet reflection—ultimately helped him to lead the nation through its greatest turmoil.

    During the war, approximately 620,000 soldiers lost their lives. An equivalent proportion of today's population would be six million. This Republic of Suffering explores the impact of this enormous death toll from every angle: material, political, intellectual, and spiritual. The eminent historian Drew Gilpin Faust delineates the ways death changed not only individual lives but the life of the nation and its understanding of the rights and responsibilities of citizenship. She describes how survivors mourned and how a deeply religious culture struggled to reconcile the slaughter with its belief in a benevolent God, pondered who should die and under what circumstances, and reconceived its understanding of life after death. Faust details the logistical challenges involved when thousands were left dead, many with their identities unknown, on the fields of places like Bull Run, Shiloh, Antietam, and Gettysburg. She chronicles the efforts to identify, reclaim, preserve, and bury battlefield dead, the resulting rise of undertaking as a profession, the first widespread use of embalming, the gradual emergence of military graves registration procedures, the development of a federal system of national cemeteries for Union dead, and the creation of private cemeteries in the South that contributed to the cult of the Lost Cause. She shows, too, how the war victimized civilians through violence that extended beyond battlefields-from disease, displacement, hardships, shortages, emotional wounds, and conflicts connected to the disintegration of slavery.

    The Lady and Her Monsters by Roseanne Motillo brings to life the fascinating times, startling science, and real-life horrors behind Mary Shelley’s gothic masterpiece, Frankenstein.Montillo recounts how—at the intersection of the Romantic Age and the Industrial Revolution—Shelley’s Victor Frankenstein was inspired by actual scientists of the period: curious and daring iconoclasts who were obsessed with the inner workings of the human body and how it might be reanimated after death.With true-life tales of grave robbers, ghoulish experiments, and the ultimate in macabre research—human reanimation—The Lady and Her Monsters is a brilliant exploration of the creation of Frankenstein, Mary Shelley’s horror classic.