With the assistance of a co-author, this popular student textbook has now been updated to include techniques such as membrane chromatography, aqueous phase partitioning, engineering recombinant proteins for purification and due to the rapid advances in bioinformatics/proteomics a discussion of the analysis of complex protein mixtures by 2D-electrophoresis and RPHPLC prior to sequencing by mass spectroscopy. Written with the student firmly in mind, no previous knowledge of biochemistry, and little of chemistry, is assumed. It is intended to provide an introduction to enzymology, and a balanced account of all the various theoretical and applied aspects of the subject which are likely to be included in a course.

    This is type of problems asked at the JEE (IIT). The purpose of this book is to show students how to handle such problems and give them sufficient practice in solving problems of this type, thus building their confidence. The main features of this book are:Each chapter begins with a summary of facts, formulate and working techniques. Trick, tips and techniques have been clearly marked with the icon.A large number of problems have been solved and explained in each chapter.The exercises contain short-answer, long-answer and objective type questions.Multiple-choice questions in which more than one option may be correct have also been given.Time-bound tests at the end of each chapter will help students practise answering questions in a given time.The book also includes integrated tests, bases on all the chapters.A chapter containing miscellaneous problems has been given at the end of the book. This will help students gain confidence in solving problems without prior knowledge of the chapter(s) to which the problems belong.Table of ContentsAlgebraProgressions, Related Inequalities and SeriesDeterminants and Cramer's RuleEquations, Inequations and ExpressionsComplex NumbersPermutation and CombinationBinomial Theorem for Positive Integral IndexPrinciple of Mathematical Induction (PMI)Infinite SeriesMatricesTrigonometryCircular Functions, IdentitiesSolution of EquationsInverse Circular FunctionsTrigonometrical Inequalities and InequationsLogarithmProperties of TriangleHeights and DistancesCoordinate GeometryCoordinates and Straight LinesPairs of Straight Lines and Transformation of AxesCirclesParabolaEllipse and HyperbolaCalculusFunctionDifferentiationLimit, Indeterminate FormContinuity, Differentiability and Graph of FunctionApplication of dy/dxMaxima and MinimaMonotonic Function and Lagrange's TheoremIndefinite In

    In Tree of Origin nine of the world's top primate experts read these clues and compose the most extensive picture to date of what the behavior of monkeys and apes can tell us about our own evolution as a species.It has been nearly fifteen years since a single volume addressed the issue of human evolution from a primate perspective, and in that time we have witnessed explosive growth in research on the subject. Tree of Origin gives us the latest news about bonobos, the make love not war apes who behave so dramatically unlike chimpanzees. We learn about the tool traditions and social customs that set each ape community apart. We see how DNA analysis is revolutionizing our understanding of paternity, intergroup migration, and reproductive success. And we confront intriguing discoveries about primate hunting behavior, politics, cognition, diet, and the evolution of language and intelligence that challenge claims of human uniqueness in new and subtle ways.Tree of Origin provides the clearest glimpse yet of the apelike ancestor who left the forest and began the long journey toward modern humanity.

    A stranger-than-fiction true story centered around a larger-than-life character who pursued a larger-than-life clam—the Geoduck—and then led wildlife police on a two-year-long chase, Shell Games is enthralling and remarkable from page one on.

    The new edition maintains the scope and expertise that made the book so popular while incorporating the latest research and updating the exquisite program of drawings.

    His theories on the evolutionary tensions between parent and offspring, sibling and sibling, man and woman, friend and friend, and a person and himself or herself have not only revolutionized genetics and evolutionary biology but have influenced disciplines from medicine and the social sciences to history, economics, and literary studies. But unlike other renowned scientists, Trivers has spent time behind bars, drove a getaway car for Huey P. Newton, and founded an armed group in Jamaica to protect gay men from mob violence. Now, in the entertaining tradition of Surely You're Joking Mr. Feynman, Trivers tell us in his inimitable voice about the inimitable life behind the revolutionary science. He comments with irreverent wit and penetrating insight on everything from American racism to the history of psychiatry to who killed Peter Tosh, musical heir to Bob Marley. Sprinkled with anecdotes about such luminaries as Richard Dawkins and Stephen Jay Gould, and with photographs throughout, this volume is sure to enlighten and entertain anyone with an interest in science, the human condition, or the nature of creative genius. PRAISE FOR WILD LIFE"To call Robert Trivers an acclaimed biologist is an understatement akin to calling the late Richard Feynman a popular professor of physics." -- PSYCHOLOGY TODAY"Who would have guessed that arguably today’s most original thinker in evolutionary theory could possibly have led the extraordinary life Robert Trivers recounts in these pages. We are taken on a wild trip from inspired meditations on the biology of self deception, through a steamy Jamaican underworld, to Black Panthers in California, to frank appraisals of distinguished or over-rated scientists, the whole adding up to a disarmingly frank and utterly unique memoir of a rollercoaster of a life. -- RICHARD DAWKINS, bestselling author of The Selfish Gene and The God Delusion“Robert Trivers is not just a brilliant evolutionary thinker but a world-class raconteur, adventurer, kibitzer, people-watcher, jester, and provocateur. This memoir is filled with sharp and hilarious observations about the living world, not least a certain species of hairless primate, not least a certain member of that species named Robert Trivers.” – STEVEN PINKER,best-selling author of How the Mind Works and The Better Angels of Our Nature: Why Violence Has Declined“It would not be hyperbole to say that Robert Trivers is one of the most important evolutionary theorists since Charles Darwin. But contrary to the image most people have of theoretical scientists as stodgy intellectuals holed up in their offices buried in paper, Trivers' memoir reveals a man whose life has been wild in every sense of the word. A lust for life doesn’t begin to sum up a career devoted to truth, courage, and the audacity to think what no one else has thought, and to act in ways few others would dare (you’ll even learn how to defend yourself in a knife fight). If that were not enough, Trivers is witty, clever, and compassionate. This book is destined to become a classic in scientific autobiography." -- MICHAEL SHERMER, Editor in Chief, The SkepticABOUT THE AUTHORRobert Trivers is a professor of anthropology and biological sciences at Rutgers University.

    Part One presents the general principles of pathophysiology and discusses the influence of the environment and the role of genetics in the development of disease. Part Two, organized by body system, examines normal anatomy and physiology, alterations of function in adults, and alterations of function in children.

    In Maneater, Nagami discusses the shocking and amazing cases of bacterial and viral infections she has encountered in her career as an infectious disease specialist. Through personal accounts, she reveals the facts about some of the deadliest diseases: the warning signs, treatments, and most compellingly, what it feels like to make the medical and ethical decisions that can mean the difference between life and death.

    The lion was not always king. From antiquity to the Middle Ages, the bear's centrality in cults and mythologies left traces in European languages, literatures, and legends from the Slavic East to Celtic Britain. Historian Michel Pastoureau considers how this once venerated creature was deposed by the advent of Christianity and continued to sink lower in the symbolic bestiary before rising again in Pyrrhic triumph as a popular toy.The early Church was threatened by pagan legends of the bear's power, among them a widespread belief that male bears were sexually attracted to women and would violate them, producing half-bear, half-human beings--invincible warriors who founded royal lines. Marked for death by the clergy, bears were massacred. During the Renaissance, the demonic prestige bears had been assigned in biblical allegory was lost to the goat, ass, bat, and owl, who were the devil's new familiars, while the lion was crowned as the symbol of nobility. Once the undefeated champions of the Roman arena, prized in princely menageries, bears became entertainers in the marketplace, trained to perform humiliating tricks or muzzled and devoured by packs of dogs for the amusement of humans. By the early twentieth century, however, the bear would return from exile, making its way into the hearts of children everywhere as the teddy bear.This compelling history reminds us that men and bears have always been inseparable, united by a kinship that gradually moved from nature to culture--a bond that continues to this day.

    The Extreme Life of the Sea takes readers to the absolute limits of the ocean world--the fastest and deepest, the hottest and oldest creatures of the oceans. It dives into the icy Arctic and boiling hydrothermal vents--and exposes the eternal darkness of the deepest undersea trenches--to show how marine life thrives against the odds. This thrilling book brings to life the sea's most extreme species, and tells their stories as characters in the drama of the oceans. Coauthored by Stephen Palumbi, one of today's leading marine scientists, The Extreme Life of the Sea tells the unforgettable tales of some of the most marvelous life forms on Earth, and the challenges they overcome to survive. Modern science and a fluid narrative style give every reader a deep look at the lives of these species.The Extreme Life of the Sea shows you the world's oldest living species. It describes how flying fish strain to escape their predators, how predatory deep-sea fish use red searchlights only they can see to find and attack food, and how, at the end of her life, a mother octopus dedicates herself to raising her batch of young. This wide-ranging and highly accessible book also shows how ocean adaptations can inspire innovative commercial products--such as fan blades modeled on the flippers of humpback whales--and how future extremes created by human changes to the oceans might push some of these amazing species over the edge.An enhanced edition is also available and includes eleven videos.

    In the words of Edward O. Wilson, the museum stands as both "cabinet of wonder and temple of science." Its rich and unlikely history involves literary figures, creationists, millionaires, and visionary scientists from Asa Gray to Stephen Jay Gould. Its mastodon skeleton -- still on display -- is even linked to one of the nineteenth century's most bizarre and notorious murders. The Rarest of the Rare tells the fascinating stories behind the extinct butterflies, rare birds, lost plants, dazzling meteorites, and other scientific and historic specimens that fill the museum's halls. You'll learn about the painting that catches Audubon in a shameful lie, the sand dollar collected by Darwin during the voyage of the Beagle, and dozens of other treasures in this surprising, informative, and often amusing tour of the natural world.

    Random genetic mutation, long believed to be the main source of variation, is only a marginal factor. As the authors demonstrate in this book, the more important source of speciation, by far, is the acquisition of new genomes by symbiotic merger. The result of thirty years of delving into a vast, mostly arcane literature, this is the first book to go beyond -- and reveal the severe limitations of -- the "Modern Synthesis" that has dominated evolutionary biology for almost three generations. Lynn Margulis, whom E. O. Wilson called "one of the most successful synthetic thinkers in modern biology," and her co-author Dorion Sagan have written a comprehensive and scientifically supported presentation of a theory that directly challenges the assumptions we hold about the variety of the living world.

    Thanks to cartoons and folk accounts we have a distorted view of these other humans - for that is what they were. We think of them as crude and clumsy and not very bright, easily driven to extinction by the lithe, smart modern humans that came out of Africa some 100,000 years ago.But was it really as simple as that? Clive Finlayson reminds us that the Neanderthals were another kind of human, and their culture was not so very different from that of our own ancestors. In this book, he presents a wider view of the events that led to the migration of the moderns into Europe, what might have happened during the contact of the two populations, and what finally drove the Neanderthals to extinction. It is a view that considers climate, ecology, and migrations of populations, as well as culture and interaction.His conclusion is that the destiny of the Neanderthals and the Moderns was sealed by ecological factors and contingencies. It was a matter of luck that we survived and spread while the Neanderthals dwindled and perished. Had the climate not changed in our favour some 50 million years ago, things would have been very different.There is much current research interest in Neanderthals, much of it driven by attempts to map some of their DNA. But it's not just a question of studying the DNA. The rise and fall of populations is profoundly moulded by the larger scale forces of climate and ecology. And it is only by taking this wider view that we can fully understand the course of events that led to our survival and their demise. The fact that Neanderthals survived until virtually yesterday makes our relationship with them and their tragedy even more poignant. They almost made it, after all.

    Our fortunes were once founded on sheep, and this book tells a story of wool and money and history, of merchants and farmers and shepherds, of English yeomen and how they got their freedom, and above all, of the soil. Sheep have helped define our culture and topography, impacting on everything from accent and idiom, architecture, roads and waterways, to social progression and wealth. With his eye for the idiosyncratic, Philip meets the native breeds that thrive in this country; he tells stories about each breed, meets their shepherds and owners, learns about their past - and confronts the present realities of sheep farming. Along the way, Philip meets the people of the countryside and their many professions: the mole-catchers, the stick-makers, the tobacco-twisters and clog-wrights. He explores this artisan heritage as he re-discovers the countryside, and finds a lifestyle parallel to modern existence, struggling to remain unchanged - and at its heart, always sheep.