We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Whether you are studying chemistry forthe first time on your own, want to refresh your memory for a test, or need a little help for a course, this concise, interactive guidegives you a fresh approach to this fascinating subject. This fullyup-to-date edition of Chemistry: Concepts and Problems: * Has been tested, rewritten, and retested to ensure that you canteach yourself all about chemistry * Requires no prerequisites * Lets you work at your own pace with a helpful question-and-answerformat * Lists objectives for each chapter--you can skip ahead or findextra help if you need it * Reinforces what you learn with chapter self-tests

    Travel fast enough and you could weigh as much as a jumbo jet, be flattened thinner than a CD without feeling a thing-and live forever! As for the angles of a triangle, they do not always have to add up to 180 degrees. And then, of course, there are black holes. These are but a few of the extraordinary consequences of Einstein's theory of relativity. It is now over a hundred years since he made these discoveries, and yet the general public is still largely unaware of them. Filled with illuminating anecdotes and fascinating accounts of experiments, this book aims to introduce the interested lay person to the subject of relativity in a way which is accessible and engaging and at the same time scientifically rigorous. With relatively few mathematical equations--nothing more complicated than the Pythagoras's Theorem--this VSI packs a lot time into very little space, and for anyone who has felt intimidated by Einstein's groundbreaking theory, it offers the perfect place to start. About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    What does this unavoidable fact mean?For future generations, it won't mean anything very obvious. They will be so immersed in online life that questions about the Internet's basic purpose or meaning will vanish.But those of us who have lived both with and without the crowded connectivity of online life have a rare opportunity. We can still recognize the difference between Before and After. We catch ourselves idly reaching for our phones at the bus stop. Or we notice how, mid-conversation, a fumbling friend dives into the perfect recall of Google.In this eloquent and thought-provoking book, Michael Harris argues that amid all the changes we're experiencing, the most interesting is the one that future generations will find hardest to grasp. That is the end of absence-the loss of lack. The daydreaming silences in our lives are filled; the burning solitudes are extinguished. There's no true "free time" when you carry a smartphone. Today's rarest commodity is the chance to be alone with your own thoughts.

    WikiLeaks brought to light a new form of whistleblowing, using powerful cryptographic code to hide leakers’ identities while they spill the private data of government agencies and corporations. But that technology has been evolving for decades in the hands of hackers and radical activists, from the libertarian enclaves of Northern California to Berlin to the Balkans. And the secret-killing machine continues to evolve beyond WikiLeaks, as a movement of hacktivists aims to obliterate the world’s institutional secrecy.This is the story of the code and the characters—idealists, anarchists, extremists—who are transforming the next generation’s notion of what activism can be.With unrivaled access to such major players as Julian Assange, Daniel Domscheit-Berg, and WikiLeaks’ shadowy engineer known as the Architect, never before interviewed, reporter Andy Greenberg unveils the world of politically-motivated hackers—who they are and how they operate.

    This is how engineers calculate your quality of living, how corporations determine your needs, and how politicians estimate your opinions. These are the numbers you never think about-even though they play a crucial role in every single aspect of your life.What you learn may surprise you, amuse you, or even enrage you. But there's one thing you won't be able to deny: Numbers Rule Your World...An easy read with a big benefit. --Fareed Zakaria, CNNFor those who have anxiety about how organization data-mining is impacting their world, Kaiser Fung pulls back the curtain to reveal the good and the bad of predictive analytics. --Ian Ayres, Yale professor and author of Super Crunchers: Why Thinking By Numbers is the New Way to Be Smart A book that engages us with stories that a journalist would write, the compelling stories behind the stories as illuminated by the numbers, and the dynamics that the numbers reveal. --John Sall, Executive Vice President, SAS InstituteLittle did I suspect, when I picked up Kaiser Fung's book, that I would become so entranced by it - an illuminating and accessible exploration of the power of statistical analysis for those of us who have no prior training in a field that he explores so ably. --Peter Clarke, author of Keynes: The Rise, Fall, and Return of the 20th Century's Most Influential EconomistA tremendous book. . . . If you want to understand how to use statistics, how to think with numbers and yet to do this without getting lost in equations, if you've been looking for the book to unlock the door to logical thinking about problems, well, you will be pleased to know that you are holding that book in your hands. --Daniel Finkelstein, Executive Editor, The Times of LondonI thoroughly enjoyed this accessible book and enthusiastically recommend it to anyone looking to understand and appreciate the role of statistics and data analysis in solving problems and in creating a better world. --Michael Sherman, Texas A&M University, American Statistician

    Sixty-six million years ago, the Earth’s most fearsome creatures vanished. Today they remain one of our planet’s great mysteries. Now The Rise and Fall of the Dinosaurs reveals their extraordinary, 200-million-year-long story as never before.In this captivating narrative (enlivened with more than seventy original illustrations and photographs), Steve Brusatte, a young American paleontologist who has emerged as one of the foremost stars of the field—naming fifteen new species and leading groundbreaking scientific studies and fieldwork—masterfully tells the complete, surprising, and new history of the dinosaurs, drawing on cutting-edge science to dramatically bring to life their lost world and illuminate their enigmatic origins, spectacular flourishing, astonishing diversity, cataclysmic extinction, and startling living legacy. Captivating and revelatory, The Rise and Fall of the Dinosaurs is a book for the ages.Brusatte traces the evolution of dinosaurs from their inauspicious start as small shadow dwellers—themselves the beneficiaries of a mass extinction caused by volcanic eruptions at the beginning of the Triassic period—into the dominant array of species every wide-eyed child memorizes today, T. rex, Triceratops, Brontosaurus, and more. This gifted scientist and writer re-creates the dinosaurs’ peak during the Jurassic and Cretaceous, when thousands of species thrived, and winged and feathered dinosaurs, the prehistoric ancestors of modern birds, emerged. The story continues to the end of the Cretaceous period, when a giant asteroid or comet struck the planet and nearly every dinosaur species (but not all) died out, in the most extraordinary extinction event in earth’s history, one full of lessons for today as we confront a “sixth extinction.”Brusatte also recalls compelling stories from his globe-trotting expeditions during one of the most exciting eras in dinosaur research—which he calls “a new golden age of discovery”—and offers thrilling accounts of some of the remarkable findings he and his colleagues have made, including primitive human-sized tyrannosaurs; monstrous carnivores even larger than T. rex; and paradigm-shifting feathered raptors from China.An electrifying scientific history that unearths the dinosaurs’ epic saga, The Rise and Fall of the Dinosaurs will be a definitive and treasured account for decades to come.

    It's a story that takes in prehistoric geography, human evolution, the agrarian age, the Black Death, the voyages of Columbus, the Industrial Revolution and global warming.

    Uses everyday examples to introduce the principles of chemistry to the nonscientist, and includes experiments that can be conducted using common household products.

    At the dawn of the Industrial Revolution in eighteenth-century England, standards of measurement were established, giving way to the development of machine tools—machines that make machines. Eventually, the application of precision tools and methods resulted in the creation and mass production of items from guns and glass to mirrors, lenses, and cameras—and eventually gave way to further breakthroughs, including gene splicing, microchips, and the Hadron Collider.Simon Winchester takes us back to origins of the Industrial Age, to England where he introduces the scientific minds that helped usher in modern production: John Wilkinson, Henry Maudslay, Joseph Bramah, Jesse Ramsden, and Joseph Whitworth. It was Thomas Jefferson who later exported their discoveries to the fledgling United States, setting the nation on its course to become a manufacturing titan. Winchester moves forward through time, to today’s cutting-edge developments occurring around the world, from America to Western Europe to Asia.As he introduces the minds and methods that have changed the modern world, Winchester explores fundamental questions. Why is precision important? What are the different tools we use to measure it? Who has invented and perfected it? Has the pursuit of the ultra-precise in so many facets of human life blinded us to other things of equal value, such as an appreciation for the age-old traditions of craftsmanship, art, and high culture? Are we missing something that reflects the world as it is, rather than the world as we think we would wish it to be? And can the precise and the natural co-exist in society?

    Craig Venter became the first to successfully create synthetic life putting humankind at the threshold of the most important and exciting phase of biological research, one that will enable us to actually write the genetic code for designing new species to help us adapt and evolve for long-term survival. The science of synthetic genomics will have a profound impact on human existence, including chemical and energy generation, health, clean water and food production, environmental control, and possibly even our evolution. In "Life at the Speed of Light," Venter presents a fascinating and authoritative study of this emerging field from the inside detailing its origins, current challenges and controversies, and projected effects on our lives. This scientific frontier provides an opportunity to ponder anew the age-old question What is life? and examine what we really mean by playing God. " Life at the Speed of Light "is a landmark work, written by a visionary at the dawn of a new era of biological engineering."

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    Examines the effects of rapid industrial and technological changes upon the individual, the family, and society.

    Yet The Origin of Species (1859) is also a humane and inspirational vision of ecological interrelatedness, revealing the complex mutual interdependencies between animal and plant life, climate and physical environment, and—by implication—within the human world. Written for the general reader, in a style which combines the rigour of science with the subtlety of literature, The Origin of Species remains one of the founding documents of the modern age.

    With his trademark clarity and humor, Holt probes the mysteries of quantum mechanics, the quest for the foundations of mathematics, and the nature of logic and truth. Along the way, he offers intimate biographical sketches of celebrated and neglected thinkers, from the physicist Emmy Noether to the computing pioneer Alan Turing and the discoverer of fractals, Benoit Mandelbrot. Holt offers a painless and playful introduction to many of our most beautiful but least understood ideas, from Einsteinian relativity to string theory, and also invites us to consider why the greatest logician of the twentieth century believed the U.S. Constitution contained a terrible contradiction--and whether the universe truly has a future.