This is the story of a fateful year that prefigured the events of 1776.In The Fever of 1721, Stephen Coss brings to life an amazing cast of characters in a year that changed the course of medical history, American journalism, and colonial revolution, including Cotton Mather, the great Puritan preacher, son of the president of Harvard College; Zabdiel Boylston, a doctor whose name is on one of Boston's grand avenues; James and his younger brother Benjamin Franklin; and Elisha Cooke and his protegee; Samuel Adams.During the worst smallpox epidemic in Boston history Mather convinced Doctor Boylston to try a procedure that he believed would prevent death--by making an incision in the arm of a healthy person and implanting it with smallpox. Inoculation led to vaccination, one of the most profound medical discoveries in history. Public outrage forced Boylston into hiding, and Mather's house was firebombed.A political fever also raged. Elisha Cooke was challenging the Crown for control of the colony and finally forced Royal Governor Samuel Shute to flee Massachusetts. Samuel Adams and the Patriots would build on this to resist the British in the run-up to the American Revolution. And a bold young printer James Franklin (who was on the wrong side of the controversy on inoculation), launched America's first independent newspaper and landed in jail. His teenage brother and apprentice, Benjamin Franklin, however, learned his trade in James' shop and became a father of the Independence movement.One by one, the atmosphere in Boston in 1721 simmered and ultimately boiled over, leading to the full drama of the American Revolution.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    With a tremendous cracking and splintering of oak, it struck the ship just beneath the anchor secured at the cat-head on the port bow..." In the Heart of the Sea brings to new life the incredible story of the wreck of the whaleship Essex - an event as mythic in its own century as the Titanic disaster in ours, and the inspiration for the climax of Moby-Dick. In a harrowing page-turner, Nathaniel Philbrick restores this epic story to its rightful place in American history.In 1820, the 240-ton Essex set sail from Nantucket on a routine voyage for whales. Fifteen months later, in the farthest reaches of the South Pacific, it was repeatedly rammed and sunk by an eighty-ton bull sperm whale. Its twenty-man crew, fearing cannibals on the islands to the west, made for the 3,000-mile-distant coast of South America in three tiny boats. During ninety days at sea under horrendous conditions, the survivors clung to life as one by one, they succumbed to hunger, thirst, disease, and fear.Philbrick interweaves his account of this extraordinary ordeal of ordinary men with a wealth of whale lore and with a brilliantly detailed portrait of the lost, unique community of Nantucket whalers. Impeccably researched and beautifully told, the book delivers the ultimate portrait of man against nature, drawing on a remarkable range of archival and modern sources, including a long-lost account by the ship's cabin boy.At once a literary companion and a page-turner that speaks to the same issues of class, race, and man's relationship to nature that permeate the works of Melville, In the Heart of the Sea will endure as a vital work of American history.

    Barbara Tuchman anatomizes the century, revealing both the great rhythms of history and the grain and texture of domestic life as it was lived.

    But the so-called Dark Ages also gave us the first universities, eyeglasses, and mechanical clocks, proving that the Middle Ages were home to a vibrant scientific culture.In The Light Ages, Cambridge science historian Seb Falk takes us on an immersive tour of medieval science through the story of one fourteenth-century monk, John of Westwyk. From multiplying Roman numerals to navigating by the stars, curing disease, and telling time with an ancient astrolabe, we learn emerging science alongside Westwyk, while following the gripping story of the struggles and successes of an ordinary man in a precarious world. An enlightening history that argues that these times weren’t so dark after all, The Light Ages shows how medieval ideas continue to color how we see the world today.

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.

    Four days later, the B-17 assigned to the search-and-rescue mission became lost in a blinding storm and also crashed. Miraculously, all nine men on board survived, and the US military launched a daring rescue operation. But after picking up one man, the Grumman Duck amphibious plane flew into a severe storm and vanished.Frozen in Time tells the story of these crashes and the fate of the survivors, bringing vividly to life their battle to endure 148 days of the brutal Arctic winter, until an expedition headed by famed Arctic explorer Bernt Balchen brought them to safety. Mitchell Zuckoff takes the reader deep into the most hostile environment on earth, through hurricane-force winds, vicious blizzards, and subzero temperatures.Moving forward to today, he recounts the efforts of the Coast Guard and North South Polar Inc. – led by indefatigable dreamer Lou Sapienza – who worked for years to solve the mystery of the Duck’s last flight and recover the remains of its crew.A breathtaking blend of mystery and adventure Mitchell Zuckoff's Frozen in Time: An Epic Story of Survival and a Modern Quest for Lost Heroes of World War II is also a poignant reminder of the sacrifices of our military personnel and a tribute to the everyday heroism of the US Coast Guard.

    For any student of the city and its secret life, it is indispensable reading." -Peter Ackroyd, The Times (London)Before his murder in 1831, the "Italian boy" was one of thousands of orphans on the streets of London, begging among the livestock, hawkers, and con men. When his body was sold to a medical college, the suppliers were arrested for murder. Their high-profile trial would unveil a furtive trade in human corpses carried out by "resurrection men" who killed to satisfy the first rule of the cadaver market: the fresher the body, the higher the price. Historian Sarah Wise reconstructs not only the boy's murder but the chaos and squalor of his world. In 1831 London, the poor were desperate and the wealthy petrified, the population swelling so fast that class borders could not hold. All the while, early humanitarians were attempting to protect the disenfranchised, the courts were establishing norms of punishment, and doctors were pioneering the science of anatomy.As vivid and intricate as a novel by Charles Dickens, The Italian Boy restores to history the lives of the very poorest Londoners and offers an unparalleled account of England's great metropolis at the brink of a major transformation.

    In handsomely crafted prose, and with the grace and authority of his extraordinary gift for narrative history, William Manchester leads us from a civilization tottering on the brink of collapse to the grandeur of its rebirth - the dense explosion of energy that spawned some of history's greatest poets, philosophers, painters, adventurers, and reformers, as well as some of its most spectacular villains - the Renaissance.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    In his capital at Constantinople he built the world's most beautiful building, married its most powerful empress, and wrote its most enduring legal code, seemingly restoring Rome's fortunes for the next five hundred years. Then, in the summer of 542, he encountered a flea. The ensuing outbreak of bubonic plague killed five thousand people a day in Constantinople and nearly killed Justinian himself. In Justinian's Flea, William Rosen tells the story of history's first pandemic plague seven centuries before the Black Death that killed tens of millions, devastated the empires of Persia and Rome, left a path of victims from Ireland to Iraq, and opened the way for the armies of Islam. Weaving together evolutionary microbiology, economics, military strategy, ecology, and ancient and modern medicine, Rosen offers a sweeping narrative of one of the great hinge moments in history, one that will appeal to readers of John Kelly's The Great Mortality, John Barry's The Great Influenza, and Jared Diamond's Collapse .

    Liberated from home and hearth by World War I, politically enfranchised and ready to work, women arrived to take their place in the dazzling new skyscrapers of Manhattan. But they did not want to stay in uncomfortable boarding houses. They wanted what men already had—exclusive residential hotels with maid service, workout rooms, and private dining. Built in 1927, at the height of the Roaring Twenties, the Barbizon Hotel was designed as a luxurious safe haven for the “Modern Woman” hoping for a career in the arts. Over time, it became the place to stay for any ambitious young woman hoping for fame and fortune. Sylvia Plath fictionalized her time there in The Bell Jar, and, over the years, it’s almost 700 tiny rooms with matching floral curtains and bedspreads housed, among many others, Titanic survivor Molly Brown; actresses Grace Kelly, Liza Minnelli, Ali MacGraw, Jaclyn Smith; and writers Joan Didion, Gael Greene, Diane Johnson, Meg Wolitzer. Mademoiselle magazine boarded its summer interns there, as did Katharine Gibbs Secretarial School its students and the Ford Modeling Agency its young models. Before the hotel’s residents were household names, they were young women arriving at the Barbizon with a suitcase and a dream. Not everyone who passed through the Barbizon’s doors was destined for success—for some, it was a story of dashed hopes—but until 1981, when men were finally let in, the Barbizon offered its residents a room of their own and a life without family obligations. It gave women a chance to remake themselves however they pleased; it was the hotel that set them free. No place had existed like it before or has since. “Poignant and intriguing” (The New Republic), The Barbizon weaves together a tale that has, until now, never been told. It is both a vivid portrait of the lives of these young women looking for something more and a “brilliant many-layered social history of women’s ambition and a rapidly changing New York through the 20th century” (The Guardian).

    They distributed anti-Nazi leaflets, printed subversive newspapers, hid resisters, secreted Jews to safety, transported weapons, and conveyed clandestine messages. The youngest was a schoolgirl of fifteen who scrawled "V" for victory on the walls of her lycée; the eldest, a farmer's wife in her sixties who harbored escaped Allied airmen. Strangers to each other, hailing from villages and cities from across France, these brave women were united in hatred and defiance of their Nazi occupiers.Eventually, the Gestapo hunted down 230 of these women and imprisoned them in a fort outside Paris. Separated from home and loved ones, these disparate individuals turned to one another, their common experience conquering divisions of age, education, profession, and class, as they found solace and strength in their deep affection and camaraderie.In January 1943, they were sent to their final destination: Auschwitz. Only forty-nine would return to France.A Train in Winter draws on interviews with these women and their families; German, French, and Polish archives; and documents held by World War II resistance organizations to uncover a dark chapter of history that offers an inspiring portrait of ordinary people, of bravery and survival—and of the remarkable, enduring power of female friendship.

    That, of course, is a matter of opinion. And there are other layers to the story.With a combination of novelistic flair and historical accuracy, Kate Williams begins by relating the heartbreaking story of Princess Charlotte, the Queen who never was, and her impact on the young Victoria. Our perception of Victoria the Queen is coloured by portraits of her older, widowed self - her dour expression embodying the repressive morality propagated in her time. But Becoming Queen reveals an energetic and vibrant woman, determined to battle for power. It also documents the Byzantine machinations behind Victoria's quest to occupy the throne, and shows how her struggles did not end when finally the crown was placed on her head.In the late eighteenth century, monarchies were in crisis across Europe. Discontented with their mad King, George III, and his spendthrift offspring, the English pinned their hopes on the only legitimate grandchild: Princess Charlotte, daughter of George, Prince of Wales. But Charlotte died at the age of twenty-two, a few hours after giving birth to a stillborn son. A grieving nation immediately began venerating her as someone who would have made an ideal Queen while Charlotte's rackety uncles embarked on a race to produce the next heir.No one thought that little Victoria, daughter of the Duke of Kent, would ascend the throne. She, in turn, became increasingly determined to take control of her own destiny, and clashed constantly not only with her hugely ambitious mother but with her protégé and household comptroller, the Irish adventurer, John Conroy. After she became Queen, ministers, even her beloved Prince Albert, still attempted to steal power away from her.Revealing how Charlotte's death shaped Victoria's reign and laying bare the passions that swirled around the throne, Becoming Queen is an absorbingly dramatic tale of secrets, sexual repression and endless conflict. After her lauded biography of Emma Hamilton, England's Mistress, Kate Williams has produced a most original and intimate portrait of Great Britain's longest reigning monarch.

    When she was married at sixteen to a German count far below her rank, it was with the understanding that her father would help her husband achieve the kingship of Bohemia. The terrible betrayal of this commitment would ruin "the Winter Queen," as Elizabeth would forever be known, imperil the lives of those she loved, and launch a war that would last for thirty years. Forced into exile, the Winter Queen and her family found refuge in Holland, where the glorious art and culture of the Dutch Golden Age indelibly shaped her daughters' lives. Her eldest, Princess Elizabeth, became a scholar who earned the respect and friendship of the philosopher René Descartes. Louisa was a gifted painter whose engaging manner and appealing looks provoked heartache and scandal. Beautiful Henrietta Maria would be the only sister to marry into royalty, although at great cost. But it was the youngest, Sophia, a heroine in the tradition of a Jane Austen novel, whose ready wit and good-natured common sense masked immense strength of character, who fulfilled the promise of her great-grandmother Mary and reshaped the British monarchy, a legacy that endures to this day.Brilliantly researched and captivatingly written, filled with danger, treachery, and adventure but also love, courage, and humor, Daughters of the Winter Queen follows the lives of five remarkable women who, by refusing to surrender to adversity, changed the course of history.