Professors are asked to consider their demise and to ruminate on what matters most to them: What wisdom would we impart to the world if we knew it was our last chance? If we had to vanish tomorrow, what would we want as our legacy?When Randy Pausch, a computer science professor at Carnegie Mellon, was asked to give such a lecture, he didn't have to imagine it as his last, since he had recently been diagnosed with terminal cancer. But the lecture he gave, 'Really Achieving Your Childhood Dreams', wasn't about dying. It was about the importance of overcoming obstacles, of enabling the dreams of others, of seizing every moment (because time is all you have and you may find one day that you have less than you think). It was a summation of everything Randy had come to believe. It was about living.In this book, Randy Pausch has combined the humour, inspiration, and intelligence that made his lecture such a phenomenon and given it an indelible form. It is a book that will be shared for generations to come.

    A former girlfriend of Hugh Hefner describes how her years inside the Playboy Mansion went from a fairytale of A-list celebrity parties to an oppressive regime of strict rules, scheduled sex, and a total loss of identity, so much so that she even contemplated suicide.

    It was the last her family and friends saw of her for over eighteen years. On 26 August 2009, Dugard, her daughters, and Phillip Craig Garrido appeared in the office of her kidnapper's parole officer in California. Their unusual behaviour sparked an investigation that led to the positive identification of Jaycee Lee Dugard, living in a tent behind Garrido's home. During her time in captivity, at the age of fourteen and seventeen, she gave birth to two daughters, both fathered by Garrido. Dugard's memoir is written by the 30-year-old herself and covers the period from the time of her abduction in 1991 up until the present. In her stark, utterly honest and unflinching narrative, Jaycee opens up about what she experienced, including how she feels now, a year after being found. Garrido and his wife Nancy have since pleaded guilty to their crimes.

    Water pours from the faucet in crystalline patterns, numbers call to mind distinct geometric shapes, and intricate fractal patterns emerge from the movement of tree branches, revealing the intrinsic mathematical designs hidden in the objects around us.Yet Padgett wasn’t born this way. Twelve years ago, he had never made it past pre-algebra. But a violent mugging forever altered the way his brain works, giving him unique gifts. His ability to understand math and physics skyrocketed, and he developed the astonishing ability to draw the complex geometric shapes he saw everywhere. His stunning, mathematically precise artwork illustrates his intuitive understanding of complex mathematics.The first documented case of acquired savant syndrome with mathematical synesthesia, Padgett is a medical marvel. Struck by Genius recounts how he overcame huge setbacks and embraced his new mind. Along the way he fell in love, found joy in numbers, and spent plenty of time having his head examined. Like Born on a Blue Day and My Stroke of Insight, his singular story reveals the wondrous potential of the human brain.www.struckbygenius.com

    Doctors predicted that she would never intellectually develop beyond the abilities of a small child. Although she made some progress after years of intensive behavioral and communication therapy, Carly remained largely unreachable. Then, at the age of ten, she had a breakthrough. While working with her devoted therapists Howie and Barb, Carly reached over to their laptop and typed in "HELP TEETH HURT," much to everyone's astonishment. This was the beginning of Carly's journey toward self-realization. Although Carly still struggles with all the symptoms of autism, which she describes with uncanny accuracy and detail, she now has regular, witty, and profound conversations on the computer with her family, her therapists, and the many thousands of people who follow her via her blog, Facebook, and Twitter. In Carly's Voice, her father, Arthur Fleischmann, blends Carly's own words with his story of getting to know his remarkable daughter. One of the first books to explore firsthand the challenges of living with autism, it brings readers inside a once-secret world and in the company of an inspiring young woman who has found her voice and her mission.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    That simple act became a national news story because Abby was the director of a Planned Parenthood clinic in Texas who, after participating in her first actual abortion procedure, walked across the road to join the Coalition for Life. "Unplanned" is a heartstopping personal drama of life-and-death encounters, a courtroom battle, and spiritual transformation that speaks hope and compassion into the political controversy that surrounds this issue. Telling Abby’s story from both sides of the abortion clinic property line, this book is a must-read for anyone who cares about the life versus rights debate and helping women who face crisis pregnancies.

    Instead, he finds that he has joined a new world where race is front and center. The recipient of a scholarship designed to increase black student enrollment, Tweedy soon meets a professor who bluntly questions whether he belongs in medical school, a moment that crystallizes the challenges he will face throughout his career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds, "More common in blacks than in whites."Black Man in a White Coat examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine. As Tweedy transforms from student to practicing physician, he discovers how often race influences his encounters with patients. Through their stories, he illustrates the complex social, cultural, and economic factors at the root of many health problems in the black community. These issues take on greater meaning when Tweedy is himself diagnosed with a chronic disease far more common among black people. In this powerful, moving, and deeply empathic book, Tweedy explores the challenges confronting black doctors, and the disproportionate health burdens faced by black patients, ultimately seeking a way forward to better treatment and more compassionate care.

    He has kept a blog of his daily working life since 2003 and his award-winning writing is, by turn, moving, cynical, funny, heart-rending, and compassionate. From the tragic to the hilarious, the stories Tom tells give a fascinatingand at times alarming picture of life in inner-city Britain, and the people who are paid to mop up after it.

    But in her mother, a would-be artist burdened by the endless arrival of new babies, young Kate saw the consequences of a dream deferred. Determined to pursue her own no matter the cost, at 18 she left her small Midwestern town for New York, where, studying with the legendary Stella Adler, she learned the lesson that would define her as an actress: "Use it," Adler told her. Whatever disappointment, pain, or anger life throws in your path, channel it into the work.It was a lesson she would need. At twenty-two, just as her career was taking off, she became pregnant and gave birth to a daughter. Having already signed the adoption papers, she was allowed only a fleeting glimpse of her child. As her star continued to rise, her life became increasingly demanding and fulfilling, a whirlwind of passionate love affairs, life-saving friendships, and bone-crunching work. Through it all, Mulgrew remained haunted by the loss of her daughter, until, two decades later, she found the courage to face the past and step into the most challenging role of her life, both on and off screen.We know Kate Mulgrew for the strong women she's played--Captain Janeway on Star Trek; the tough-as-nails "Red" on Orange is the New Black. Now, we meet the most inspiring and memorable character of all: herself. By turns irreverent and soulful, laugh-out-loud funny and heart-piercingly sad, BORN WITH TEETH is the breathtaking memoir of a woman who dares to live life to the fullest, on her own terms.

    It left him sleepless, crippled, wracked with pain--a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which according to CDC definitions does not actually exist: the chronic form of Lyme disease, a hotly contested condition that devastates the lives of tens of thousands of people but has no official recognition--and no medically approved cure.From a rural dream house that now felt like a prison, Douthat's search for help takes him off the map of official medicine, into territory where cranks and conspiracies abound and patients are forced to take control of their own treatment and experiment on themselves. Slowly, against his instincts and assumptions, he realizes that many of the cranks and weirdos are right, that many supposed hypochondriacs are victims of an indifferent medical establishment, and that all kinds of unexpected experiences and revelations lurk beneath the surface of normal existence, in the places underneath.The Deep Places is a story about what happens when you are terribly sick and realize that even the doctors who are willing to treat you can only do so much. Along the way, Douthat describes his struggle back toward health with wit and candor, portraying sickness as the most terrible of gifts. It teaches you to appreciate the grace of ordinary life by taking that life away from you. It reveals the deep strangeness of the world, the possibility that the reasonable people might be wrong, and the necessity of figuring out things for yourself. And it proves, day by dreadful day, that you are stronger than you ever imagined, and that even in the depths there is always hope.

    Two years later, Clea Koff, a twenty-three-year-old forensic anthropologist, left the safe confines of a lab in Berkeley, California, to serve as one of sixteen scientists chosen by the United Nations to unearth the physical evidence of the Rwandan genocide. Over the next four years, Koff’s grueling investigations took her across geography synonymous with some of the worst crimes of the twentieth century. The Bone Woman is Koff’s unflinching, riveting account of her seven UN missions to Bosnia, Croatia, Kosovo, and Rwanda, as she shares what she saw, how it affected her, who was prosecuted based on evidence she found, and what she learned about the world. Yet even as she recounts the hellish nature of her work and the heartbreak of the survivors, she imbues her story with purpose, humanity, and a sense of justice. A tale of science in service of human rights, The Bone Woman is, even more profoundly, a story of hope and enduring moral principles.

    Forever. But here’s the thing about crazy: It. Wants. Out.” In Scrappy Little Nobody, she invites readers inside her brain, sharing extraordinary and charmingly ordinary stories with candor and winningly wry observations.With her razor-sharp wit, Anna recounts the absurdities she’s experienced on her way to and from the heart of pop culture as only she can—from her unusual path to the performing arts (Vanilla Ice and baggy neon pants may have played a role) to her double life as a middle-school student who also starred on Broadway to her initial “dating experiments” (including only liking boys who didn’t like her back) to reviewing a binder full of butt doubles to her struggle to live like an adult woman instead of a perpetual “man-child.”Enter Anna’s world and follow her rise from “scrappy little nobody” to somebody who dazzles on the stage, the screen, and now the page—with an electric, singular voice, at once familiar and surprising, sharp and sweet, funny and serious (well, not that serious).

    Michelle was a young single mother when she was kidnapped by a local school bus driver named Ariel Castro. For more than a decade afterward, she endured unimaginable torture at the hand of her abductor. In 2003 Amanda Berry joined her in captivity, followed by Gina DeJesus in 2004. Their escape on May 6, 2013, made headlines around the world.Barely out of her own tumultuous childhood, Michelle was estranged from her family and fighting for custody of her young son when she disappeared. Local police believed she had run away, so they removed her from the missing persons lists fifteen months after she vanished. Castro tormented her with these facts, reminding her that no one was looking for her, that the outside world had forgotten her. But Michelle would not be broken.In Finding Me, Michelle will reveal the heartbreaking details of her story, including the thoughts and prayers that helped her find courage to endure her unimaginable circumstances and now build a life worth living. By sharing both her past and her efforts to create a future, Michelle becomes a voice for the voiceless and a powerful symbol of hope for the thousands of children and young adults who go missing every year.

    This book will equally deepen the awareness of clinicians and enlighten the lay reader. It is a gift to both.' Donald M. Berwick, MD, MPPIn this highly articulate, down-to-earth, generous book, Dr David Galler tells stories of life and death from his position as Intensive Care specialist at Middlemore Hospital. Written lyrically and warmly, these stories are based on real life events describing the everyday dilemmas and challenges that doctors and patients commonly face.It aims to explain and demystify much of the work doctors do, cast light on the workings of the medical establishment and how medicine operates, in the hope that it will encourage patients to seek to be better informed and play a greater role in the decisions that will affect them and their loved ones.It speaks to the resilience of individuals and families and their extraordinary generosity and dignity under the most extreme pressure. This book is about realistic optimism and is a celebration of life.It is also a very personal story about David Galler's life, his family and about his own slow coming of age as a doctor, from the sadness and helplessness he felt about his father's death to at last feeling that he was of some use to his most important patient, his mother.