Even worse, it seemed to be inevitably progressive – but no longer.Professor Roy Taylor is one of the world’s leading experts on type 2, the man who in 2006 finally found the missing piece of the jigsaw explaining that it was actually a reversible condition. With his team of researchers at Newcastle University, he launched a series of studies leading to a remarkable, multi-million-pound trial, which in 2019 confirmed that simple advice about diet could bring about lasting remission.In this book, Taylor brings all the knowledge and experience of four decades of treating people with diabetes. He explains exactly what is happening in the body as type 2 diabetes develops and shows how you can live a full and healthy life beyond it.** Includes the 3-step Newcastle weight loss programme, as well as delicious tried-and-tested recipes from participants of the diabetes reversal trials **

    But there was nothing inherently special about them! They only knew to abide by an ancient rule of nature. Nature, in turn, rewarded them with strength, agility, and health.Your lifelong health is largely determined by what goes on inside your body at the microscopic level. Every meal you eat, beverage you drink, and moment of exertion or rest impacts your internal machinery. With the right intake of food, regular exercise, and an occasional break from both, your body begins to experience autophagy. And that is what this book is going show you!This book will teach you about: What is Autophagy and how it works How to age slower and be vigorous throughout your life Which foods make you live longer and build muscle How to promote health and longevity with intermittent fasting the various ways to fast the weight loss effects of fasting How to use autophagic processes to delay or prevent signs of aging Autophagy mistakes to avoid This manual is for everyone who values their life and health. It is for who is young and old alike who value healthy living and would like to keep their bodies and immune systems resilient to all forms of disease attack. The teachings of this manual are your ticket to a long, good life, without the fear of your body failing you any time soon. Buy this book right now and invest in your own health. You don’t have a second to lose! Just Click on “Buy now button” And Start Your Journey Toward a Healthier You Today!

    This elegant, humane, and engaging book "captures what we know of the development of what makes us human" (Nature).Visit Armand Marie Leroi on the web: http: //armandleroi.com/index.htmlStepping effortlessly from myth to cutting-edge science,

    On playing fields across America, lives are being derailed by seemingly innocuous jolts to the head. From the peewees to the pros, concussions are reaching epidemic proportions. This book brings that hidden epidemic and its consequences out of the shadows. As frightening as the numbers are—estimates of sports-related concussions range from 1.6 million to 3.8 million annually in the United States—they can’t begin to explain the profound impact of a hidden health problem that can strike any of us. It is becoming increasingly clear that concussions, like severe head traumas, can rob us of our memory, our mental abilities, our very sense of self. Because the damage caused by a concussion is rarely visible to the naked eye or even on a brain scan, no one knows how many millions might be living lives devastated by an invisible injury too often shrugged off as “just a bump on the head.” This book puts a human face on a huge public health crisis. Through narratives that chronicle the poignant experiences of real people struggling with this invisible and often unrecognized brain injury, Linda Carroll and David Rosner bring home its potentially devastating consequences. Among those you will meet are a high school football player whose college dreams were derailed by a series of undiagnosed concussions, a hard-driving soccer star whose own struggles with concussions pushed her to crusade for safety reform as a coach and soccer mom, and an economist who lost her career because of lingering concussion symptoms from a fender bender. The Concussion Crisis weaves these human dramas with compelling stories of scientists and doctors who are unraveling the mysteries of how an invisible injury can wreak such havoc. It takes readers into the top labs, where scientists are teasing out what goes wrong in the brain after a jolt to the head, and into the nation’s leading concussion clinic, where patients get cutting-edge management and treatment. Carroll and Rosner analyze the cultural factors that allowed this burgeoning epidemic to fester unseen and untreated. They chronicle the growing public awareness sparked by the premature retirements of superstars like NFL quarterbacks Troy Aikman and Steve Young. And they argue for an immediate change in a macho culture that minimizes the dangers inherent in repeated jolts to the head. The Concussion Crisis sounds an urgent wake-up call to parents, coaches, trainers, doctors, and the athletes themselves. The book will stand as the definitive exploration of this heretofore-silent health crisis. It should be required reading for every parent with a child playing sports—in fact, by everyone who has ever suffered a hard bump on the head.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    This new edition continues its tradition of providing the most comprehensive and up-to-date content available today. New chapters on medical nutrition therapy for psychiatric disease and developmental disorders spotlight the advances made in these areas. Extensive appendices, tables, illustrations, figures, and clinical insight boxes give practical hands-on procedures and clinical tools with the most current information, including brand-new guidelines on food intake and physical activity, and highlight the inclusion of the new food guide pyramid, MyPyramid, to use in everyday practice.Edited by two leading experts in nutrition, L. Kathleen Mahan and Sylvia Escott-Stump, and written by nationally recognized contributors to ensure that all information is comprehensive and current.Hundreds of full-color illustrations bring nutrition therapy to life and provide a realistic representation of clinical practice.UNIQUE! Pathophysiology algorithms present the cause, pathophysiology, and the medical nutrition management for a variety of disorders and conditions, helping you better understand the illness process and provide optimum nutritional care.Clinical Insight, New Directions, and Focus On... boxes provide additional information and suggest further discussion, study, or research.Clinical Scenarios offer case studies that help you apply what you've learned to real-world situations.Relevant websites direct you to online resources for further information on specific chapter topics.Key Terms are defined at the beginning of each chapter and highlighted within the text to help you focus your study and test your mastery of the information.Evolve Student Resource contains WebLinks and more than 1,000 self-assessment study questions that provide instant feedback.Medical Nutrition Therapy for Psychiatric Conditions chapter explores recent research into the links between nutrition and mental disorders such as Alzheimer's disease, anxiety disorder, bipolar disorder, dementia, depression, and schizophrenia.Medical Nutrition Therapy for Developmental Disabilities chapter looks at the unique nutritional needs of individuals with ADHD, Downs syndrome, cerebral palsy, and muscular dystrophy and the role medical nutrition therapy plays in providing effective care.Information on energy, macronutrients, vitamins, and minerals is now summarized in easy-to-read, need-to-know tables and bulleted lists, providing a quick review of basic nutrition.Updated information on the Dietary Guidelines for Americans 2005 and MyPyramid presents information on the newest recommendations for nutrients and physical activity throughout the text, while integrating the customizable MyPyramid into plans of care.Sample Nutrition Diagnosis boxes in each chapter present a problem, its etiology, and its signs and symptoms before concluding with a sample nutrition diagnosis, providing you with real-life scenarios you may encounter in practice.Nutritional Facts in the appendices put the content of the chapter into a practical and convenient format that students and dietetics professionals can use in their education of the client on necessary nutritional care.Updated content is provided on the new Dietary Reference Intakes, the 2000 Dietary Guidelines and Healthy People 2010.New information is included on type 2 diabetes and prediabetes.The newest guidelines released by the National Institute of Health to assist with implementing the DASH diet for effective management of hypertension.The latest information is presented on dietary supplementation and integrative care, with cutting-edge evidence of how the nursing care process is changing to provide better care.

    The beginning chapters introduce basic chemical and biological concepts to provide students with the framework they need to comprehend physiological principles. The chapters that follow promote conceptual understanding rather than rote memorization of facts. Health applications are included throughout the book to heighten interest, deepen understanding of physiological concepts, and help students relate the material to their individual career goals. Every effort has been made to help students integrate related concepts and understand the relationships between anatomical structures and their functions.

    In Heart 411, two renowned experts, heart surgeon Marc Gillinov and cardiologist Steven Nissen, tackle the questions their patients have raised over their decades of practice: Can the stress of my job really lead to a heart attack? How does exercise help my heart, and what is the right amount and type of exercise? What are the most important tests for my heart, and when do I need them? How do symptoms and treatments differ among men, women, and children?Backed by decades of clinical experience and up-to-the-minute research, yet written in the accessible, down-to-earth tone of your trusted family doctor, Heart 411 cuts through the confusion to give you the knowledge and tools you need to live a long and heart-healthy life.

    Confusing messages from health authorities and ineffective treatments have left many people desperate for reliable solutions. An enormous alternative industry is filling the void, selling products that are often of questionable safety and totally unknown effectiveness.In Clean, doctor and journalist James Hamblin explores how we got here, examining the science and culture of how we care for our skin today. He talks to dermatologists, microbiologists, allergists, immunologists, aestheticians, bar-soap enthusiasts, venture capitalists, Amish people, theologians, and straight-up scam artists, trying to figure out what it really means to be clean. He even experiments with giving up showers entirely, and discovers that he is not alone.Along the way he realizes that most of our standards of cleanliness are less related to health than most people think. A major part of the picture has been missing: a little-known ecosystem known as the skin microbiome--the trillions of microbes that live on our skin and in our pores. These microbes are not dangerous; they're more like an outer layer of skin that no one knew we had, and they influence everything from acne, eczema, and dry skin to how we smell. The new goal of skin care will be to cultivate a healthy biome--and to embrace the meaning of "clean" in the natural sense. This can mean doing much less, saving time, money, energy, water, and plastic bottles in the process.Lucid, accessible, and deeply researched, Clean explores the ongoing, radical change in the way we think about our skin, introducing readers to the emerging science that will be at the forefront of health and wellness conversations in coming years.

    Internationally recognized low back specialist Stuart McGill presents original research to quantify the forces that specific movements and exercises impose on the low back, dispels myths regarding spine stabilization exercises, and suggests prevention approaches and strategies to offset injuries and restore function.Low Back Disorders: Evidence-Based Prevention and Rehabilitation, Second Edition, presents a clear exposition of back anatomy and biomechanics and demonstrates how to interpret the latest research on low back involvement for clinical applications. The text also contains detailed information on injuries associated with seated work and sport and ergonomic issues related to manual handling of materials. With Low Back Disorders: Evidence-Based Prevention and Rehabilitation, Second Edition, you will-gain valuable information on measured loading of the back during specific activities and apply it to avoid common--but counterproductive--practices in back rehabilitation;-learn how to analyze each patient's or client's unique physical characteristics and lifestyle factors to tailor preventive measures and treatments to individual needs;-learn how to help patients and clients progress through the stages of rehabilitation: corrective exercise, stability or mobility, endurance, and strength; and-acquire the information necessary to design an effective injury-prevention program.This fully updated second edition expands knowledge of low back disorders and best practices in several areas. Enhanced algorithms guide progessive therapeutic exercise, and specially designed patient assessment provocation tests aid you in determining the cause of back troubles, guide your choices in the best ways to eliminate problems, and improve the development of appropriate activities for functional gain. Whereas the first edition focused on increasing spine stability, the second edition provides new information on dealing with both regional instability or mobility and regional stiffness present in individuals where most of the motion occurs at a single spinal segment.With an expanded repertoire of pain-free motion exercises and additional information on ways to find and adjust stabilization exercises, Low Back Disorders: Evidence-Based Prevention and Rehabilitation, Second Edition, offers you new tools to help your patients and clients achieve pain-free exertion.The text includes exercises and activities that provide a solid foundation of physical work in preparation for more advanced activities in sports and occupations. Also, the process of transitioning into performance exercise is outlined with an explanation of the critical stages of the performance pyramid, including the design of appropriate corrective exercise, building joint and whole-body stability, enhancing endurance, training true strength, and transitioning to ultimate performance.Low Back Disorders: Evidence-Based Prevention and Rehabilitation, Second Edition, presents foundational information and corresponding clinical applications in a clear, well-sequenced format. Part I builds your knowledge of lumbar function and injury. Part II demonstrates how to use this knowledge to build evidence-based injury-prevention programs by assessing risks, creating ergonomic interventions, and training personnel. Part III focuses on improving rehabilitation techniques, including specific diagnostic and provocative tests, with specific therapeutic exercises proven to enhance performance and reduce pain through a continuum from corrective exercise to stability and mobility, endurance, strength, and power.Additionally, the text offers these practical features to guide your learning and inform your practice:-More than 475 photos, graphs, and charts support the research and the scientific basis for the text's conclusions.-More than 50 tests and exercises with step-by-step instructions help you develop successful programs for your patients and clients.-Special sections highlight how the anatomical, biomechanical, and research results can be applied to clinical situations.-Extensive discussions on individualizing treatment for clients or patients help you improve your assessment skills by learning what questions to ask and what avenues of investigation to pursue with each patient or client.-Reproducible handout sheets for each of the 25 basic rehabilitation exercises, which include photos and blank lines for instructions, enable the creation of instruction sheets tailored to the current needs and progress rates of each patient or client.Cutting-edge research and evidence-based application strategies from the leading spine specialist in North America make Low Back Disorders: Evidence-Based Prevention and Rehabilitation, Second Edition, the authoritative text for study, care, and treatment of the low back. Its unique approach to back care will guide you in developing intervention, rehabilitation, and prevention programs to address the unique needs of each patient or client and develop a strong scientific foundation for your practice.

    S. Ramachandran is at the forefront of his field-so much so that Richard Dawkins dubbed him the "Marco Polo of neuroscience." Now, in a major new work, Ramachandran sets his sights on the mystery of human uniqueness. Taking us to the frontiers of neurology, he reveals what baffling and extreme case studies can teach us about normal brain function and how it evolved. Synesthesia becomes a window into the brain mechanisms that make some of us more creative than others. And autism--for which Ramachandran opens a new direction for treatment--gives us a glimpse of the aspect of being human that we understand least: self-awareness. Ramachandran tackles the most exciting and controversial topics in neurology with a storyteller's eye for compelling case studies and a researcher's flair for new approaches to age-old questions. Tracing the strange links between neurology and behavior, this book unveils a wealth of clues into the deepest mysteries of the human brain.

    After years of failed diets Dr Nadja Hermann weighed over 23 stone at the age of 30. All her life, she had heard and read about hundreds of reasons why diets wouldn't work for her. But when her weight started to seriously affect her health, she took a hard look at the science and realised that most of what she believed about dieting was a myth. What was more, those very myths were preventing her from losing weight.Forget clean eating, paleo, or fasting — it was conquering these elements of ‘Fat Logic’ that finally led to Hermann achieving a healthy weight. One and a half years later, she weighed 10 stone, and has maintained that weight to this day. Now, using humour, the insight she’s acquired, and a dose of science, Hermann debunks widespread lies about weight loss, and shows how it is possible to attain a healthy weight.

    We heeded almost none of them. The result is a pandemic on a scale never before seen in our lifetimes. In this captivating, authoritative, and eye-opening book, science journalist Debora MacKenzie lays out the full story of how and why it happened: the previous viruses that should have prepared us, the shocking public health failures that paved the way, the failure to contain the outbreak, and most importantly, what we must do to prevent future pandemics.Debora MacKenzie has been reporting on emerging diseases for more than three decades, and she draws on that experience to explain how COVID-19 went from a potentially manageable outbreak to a global pandemic. Offering a compelling history of the most significant recent outbreaks, including SARS, MERS, H1N1, Zika, and Ebola, she gives a crash course in Epidemiology 101--how viruses spread and how pandemics end--and outlines the lessons we failed to learn from each past crisis. In vivid detail, she takes us through the arrival and spread of COVID-19, making clear the steps that governments knew they could have taken to prevent or at least prepare for this. Looking forward, MacKenzie makes a bold, optimistic argument: this pandemic might finally galvanize the world to take viruses seriously. Fighting this pandemic and preventing the next one will take political action of all kinds, globally, from governments, the scientific community, and individuals--but it is possible.No one has yet brought together our knowledge of COVID-19 in a comprehensive, informative, and accessible way. But that story can already be told, and Debora MacKenzie's urgent telling is required reading for these times and beyond. It is too early to say where the COVID-19 pandemic will go, but it is past time to talk about what went wrong and how we can do better.

    The Doctors Mayo (Minnesota)

    Spoiled Rachel struggles to establish her independence and learns to love across the cultural divide; conservative Seema attempts to end a relationship that has become increasingly abusive; and street-savvy Nomsa finally accepts a past that she has spent a lifetime denying. Coping with rogue snakes, gang assassinations, and the public's denial of AIDS, these women demonstrate what it takes to be a doctor in South Africa.