What happened, how it happened, and what it means to you today. A colorful cast of characters whose discoveries were often driven not only by personal tragedy, curiosity, and hard work, but petty bickering, dumb luck, and a healthy dose of humor. For anyone interested in science, medicine, and beyond... Why are you alive right now? Chances are, you owe your life to one of the remarkable medical discoveries in this book. Maybe it was vaccines. Or antibiotics. Or X-rays. Revolutionary medical breakthroughs like these haven’t just changed the way we treat disease, they’ve transformed how we understand ourselves and the world we live in. In Breakthrough!, Jon Queijo tells the hidden stories behind 10 of history’s most amazing medical discoveries. This isn’t dry history: These are life-and-death mysteries uncovered, tales of passionate, often-mocked individuals who stood their ground and were proven right. From germs to genetics, the ancient Hippocrates to the cutting edge, these are stories that have changed the world—and, quite likely, saved your life.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Czerski provides the tools to alter the way we see everything around us by linking ordinary objects and occurrences, like popcorn popping, coffee stains, and fridge magnets, to big ideas like climate change, the energy crisis, or innovative medical testing. She provides answers to vexing questions: How do ducks keep their feet warm when walking on ice? Why does it take so long for ketchup to come out of a bottle? Why does milk, when added to tea, look like billowing storm clouds? In an engaging voice at once warm and witty, Czerski shares her stunning breadth of knowledge to lift the veil of familiarity from the ordinary.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    Bacevich provides a searing reassessment of U.S. military policy in the Middle East over the past four decades. From the end of World War II until 1980, virtually no American soldiers were killed in action while serving in the Greater Middle East. Since 1990, virtually no American soldiers have been killed in action anywhere else. What caused this shift? Andrew J. Bacevich, one of the country’s most respected voices on foreign affairs, offers an incisive critical history of this ongoing military enterprise—now more than thirty years old and with no end in sight. During the 1980s, Bacevich argues, a great transition occurred. As the Cold War wound down, the United States initiated a new conflict—a War for the Greater Middle East—that continues to the present day. The long twilight struggle with the Soviet Union had involved only occasional and sporadic fighting. But as this new war unfolded, hostilities became persistent. From the Balkans and East Africa to the Persian Gulf and Central Asia, U.S. forces embarked upon a seemingly endless series of campaigns across the Islamic world. Few achieved anything remotely like conclusive success. Instead, actions undertaken with expectations of promoting peace and stability produced just the opposite. As a consequence, phrases like “permanent war” and “open-ended war” have become part of everyday discourse. Connecting the dots in a way no other historian has done before, Bacevich weaves a compelling narrative out of episodes as varied as the Beirut bombing of 1983, the Mogadishu firefight of 1993, the invasion of Iraq in 2003, and the rise of ISIS in the present decade. Understanding what America’s costly military exertions have wrought requires seeing these seemingly discrete events as parts of a single war. It also requires identifying the errors of judgment made by political leaders in both parties and by senior military officers who share responsibility for what has become a monumental march to folly. This Bacevich unflinchingly does. A twenty-year army veteran who served in Vietnam, Andrew J. Bacevich brings the full weight of his expertise to this vitally important subject. America’s War for the Greater Middle East is a bracing after-action report from the front lines of history. It will fundamentally change the way we view America’s engagement in the world’s most volatile region.Advance praise for America’s War for the Greater Middle East“In one arresting book after another, Bacevich has relentlessly laid bare the failings of American foreign policy since the Cold War. This one is his sad crowning achievement: the story of our long and growing military entanglement in the region of the most tragic, bitter, and intractable of conflicts.”—Richard K. Betts, director, Saltzman Institute of War and Peace Studies, Columbia University “An unparalleled historical tour de force certain to affect the formation of future U.S. foreign policy . . . Every citizen aspiring to high office needs not only to read but to study and learn from this important book. This is one of the most serious and essential books I have read in more than half a century of public service.”—Lieutenant General Paul K. Van Riper, U.S. Marine Corps (Ret.) “Bacevich asks and answers a provocative, inconvenient question: In a multigenerational war in the Middle East, ‘Why has the world’s mightiest military achieved so little?’ ”—Graham Allison, director, Belfer Center for Science and International Affairs, and Douglas Dillon Professor of Government at Harvard’s John F. Kennedy School of GovernmentFrom the Hardcover edition.

    Like you, the elements have lives: personalities and attitudes, talents and shortcomings, stories rich with meaning. You may think of them as the inscrutable letters of the periodic table but you know them much better than you realise. Welcome to a dazzling tour through history and literature, science and art. Here you'll meet iron that rains from the heavens and noble gases that light the way to vice. You'll learn how lead can tell your future while zinc may one day line your coffin. You'll discover what connects the bones in your body with the Whitehouse in Washington, the glow of a streetlamp with the salt on your dinner table. From ancient civilisations to contemporary culture, from the oxygen of publicity to the phosphorus in your pee, the elements are near and far and all around us. Unlocking their astonishing secrets and colourful pasts, Periodic Tales will take you on a voyage of wonder and discovery, excitement and novelty, beauty and truth. Along the way, you'll find that their stories are our stories, and their lives are inextricable from our own.

    He set records, he developed the techniques, and he maintained the highest standards of excellence.Sheck lived a life of adventure, danger, and excitement of a degree that few people can ever dream of, or, if they do, those dreams are nightmares. Cave diving is the world's most dangerous sport. If you participate on the highest level, you know that some of your best friends are going to die. If you continue to push yourself and your equipment to the limits--if you persist in being a world class diver as Sheck was--the chances are very high that you, too, will die.This book may terrify you, but it will unquestionably fascinate you, and in the end, Sheck Exley will convince you that his death came to him in the midst of the incredibly intense joy he took in diving into the depths of the earth.

    Even the oddities—the entire state of Maryland(!)—have become so engrained that our map might as well be a giant jigsaw puzzle designed by Divine Providence. But that's where the real mystery begins. Every edge of the familiar wooden jigsaw pieces of our childhood represents a revealing moment of history and of, well, humans drawing lines in the sand.How the States Got Their Shapes is the first book to tackle why our state lines are where they are. Here are the stories behind the stories, right down to the tiny northward jog at the eastern end of Tennessee and the teeny-tiny (and little known) parts of Delaware that are not attached to Delaware but to New Jersey.How the States Got Their Shapes examines:Why West Virginia has a finger creeping up the side of PennsylvaniaWhy Michigan has an upper peninsula that isn't attached to MichiganWhy some Hawaiian islands are not HawaiiWhy Texas and California are so outsized, especially when so many Midwestern states are nearly identical in sizePacked with fun oddities and trivia, this entertaining guide also reveals the major fault lines of American history, from ideological intrigues and religious intolerance to major territorial acquisitions. Adding the fresh lens of local geographic disputes, military skirmishes, and land grabs, Mark Stein shows how the seemingly haphazard puzzle pieces of our nation fit together perfectly.

    Gas lamps still flicker in the city streets, but the miracle of electric light is in its infancy. The person who controls the means to turn night into day will make history--and a vast fortune. A young untested lawyer named Paul Cravath, fresh out of Columbia Law School, takes a case that seems impossible to win. Paul's client, George Westinghouse, has been sued by Thomas Edison over a billion-dollar question: Who invented the light bulb and holds the right to power the country? The case affords Paul entry to the heady world of high society--the glittering parties in Gramercy Park mansions, and the more insidious dealings done behind closed doors. The task facing him is beyond daunting. Edison is a wily, dangerous opponent with vast resources at his disposal--private spies, newspapers in his pocket, and the backing of J. P. Morgan himself. Yet this unknown lawyer shares with his famous adversary a compulsion to win at all costs. How will he do it?In obsessive pursuit of victory, Paul crosses paths with Nikola Tesla, an eccentric, brilliant inventor who may hold the key to defeating Edison, and with Agnes Huntington, a beautiful opera singer who proves to be a flawless performer on stage and off. As Paul takes greater and greater risks, he'll find that everyone in his path is playing their own game, and no one is quite who they seem.

    Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep.In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children’s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers’ odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder?This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You’ll never look at your pillow the same way again.

    Now, with the intellectual curiosity and emotional wisdom that make his columns among the most read in the nation, Brooks turns to the building blocks of human flourishing in a multilayered, profoundly illuminating work grounded in everyday life.This is the story of how success happens. It is told through the lives of one composite American couple, Harold and Erica—how they grow, push forward, are pulled back, fail, and succeed. Distilling a vast array of information into these two vividly realized characters, Brooks illustrates a fundamental new understanding of human nature. A scientific revolution has occurred—we have learned more about the human brain in the last thirty years than we had in the previous three thousand. The unconscious mind, it turns out, is most of the mind—not a dark, vestigial place but a creative and enchanted one, where most of the brain’s work gets done. This is the realm of emotions, intuitions, biases, longings, genetic predispositions, personality traits, and social norms: the realm where character is formed and where our most important life decisions are made. The natural habitat of The Social Animal. Drawing on a wealth of current research from numerous disciplines, Brooks takes Harold and Erica from infancy to school; from the “odyssey years” that have come to define young adulthood to the high walls of poverty; from the nature of attachment, love, and commitment, to the nature of effective leadership. He reveals the deeply social aspect of our very minds and exposes the bias in modern culture that overemphasizes rationalism, individualism, and IQ. Along the way, he demolishes conventional definitions of success while looking toward a culture based on trust and humility.The Social Animal is a moving and nuanced intellectual adventure, a story of achievement and a defense of progress. Impossible to put down, it is an essential book for our time, one that will have broad social impact and will change the way we see ourselves and the world.

    A New York Times Notable Book of 2011. One of NPR's Best Books of 2011. One of Janet Maslin's Ten Picks for 2011. When the writer Donovan Hohn heard of the mysterious loss of thousands of bath toys at sea, he figured he would interview a few oceanographers, talk to a few beachcombers, and read up on Arctic science and geography. But questions can be like ocean currents: wade in too far, and they carry you away. Hohn's accidental odyssey pulls him into the secretive world of shipping conglomerates, the daring work of Arctic researchers, the lunatic risks of maverick sailors, and the shadowy world of Chinese toy factories. Moby-Duck is a journey into the heart of the sea and an adventure through science, myth, the global economy, and some of the worst weather imaginable. With each new discovery, Hohn learns of another loose thread, and with each successive chase, he comes closer to understanding where his castaway quarry comes from and where it goes. In the grand tradition of Tony Horwitz and David Quammen, Moby-Duck is a compulsively readable narrative of whimsy and curiosity.

    As Professor of Anatomy and Forensic Anthropology, she focuses on mortal remains in her lab, at burial sites, at scenes of violence, murder and criminal dismemberment, and when investigating mass fatalities due to war, accident or natural disaster. In All that Remains she reveals the many faces of death she has come to know, using key cases to explore how forensic science has developed, and what her work has taught her. Do we expect a book about death to be sad? Macabre? Sue’s book is neither. There is tragedy, but there is also humour in stories as gripping as the best crime novel. Our own death will remain a great unknown. But as an expert witness from the final frontier, Sue Black is the wisest, most reassuring, most compelling of guides.