is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. "A whole new crop of chemicals is radically changing the recreational drug landscape," writes Ben Westhoff. "These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs"--and all-too-often tragically lethal. Drugs like fentanyl, K2, and Spice--and those with arcane acronyms like 25i-NBOMe-- were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs' effects impossible to predict. Westhoff has infiltrated this shadowy world, becoming the first journalist to report from inside an illicit Chinese fentanyls lab and providing startling and original reporting on how China's vast chemical industry operates, and how the Chinese government subsidizes it. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Poignantly, Westhoff chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the U.S. and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    That judgment, implausible even to a casual fan, also contradicted the opinion of a growing cadre of neuroscientists who worked in vain to convince the NFL that it was facing a deadly new scourge: A chronic brain disease that was driving an alarming number of players -- including some of the all-time greats -- to madness.League of Denial reveals how the NFL, over a period of nearly two decades, sought to cover up and deny mounting evidence of the connection between football and brain damage.Comprehensively, and for the first time, award-winning ESPN investigative reporters Mark Fainaru-Wada and Steve Fainaru tell the story of a public health crisis that emerged from the playing fields of our 21st century pastime. Everyone knew that football is violent and dangerous. But what the players who built the NFL into a $10 billion industry didn’t know – and what the league sought to shield from them – is that no amount of padding could protect the human brain from the force generated by modern football; that the very essence of the game could be exposing these players to brain damage.In a fast-paced narrative that moves between the NFL trenches, America’s research labs and the boardrooms where the NFL went to war against science, League of Denial examines how the league used its power and resources to attack independent scientists and elevate its own flawed research -- a campaign with echoes of Big Tobacco’s fight to deny the connection between smoking and lung cancer. It chronicles the tragic fates of players like Hall of Fame Pittsburgh Steelers center Mike Webster, who was so disturbed at the time of his death he fantasized about shooting NFL executives; and former Chargers great Junior Seau, whose diseased brain became the target of an unseemly scientific battle between researchers and the NFL. Based on exclusive interviews, previously undisclosed documents and private emails, this is the story of what the NFL knew and when it knew it – questions at the heart of crisis that threatens football, from the highest levels all the way down to Pop Warner.

    

    Following a trail of police records, FBI files, cancer statistics, and medical journals, this revealing book presents evidence of a web of medical secret-keeping that began with the handling of evidence in the JFK assassination and continued apace, sweeping doctors into coverups of cancer outbreaks, contaminated polio vaccine, the arrival of the AIDS virus, and biological weapon research using infected monkeys.

    What seemed like a harmless cold morphed into a global pandemic that would wipe out as many as a hundred-million people - ten times as many as the Great War. German troops faltered lending the allies the winning advantage, India turned its sights to independence while South Africa turned to God. In Western Samoa a quarter of the population died; in some parts of Alaska, whole villages were wiped out. Civil unrest sparked by influenza shaped nations and heralded a new era of public health where people were no longer blamed for contracting disease. Using real case histories, we take a journey through the world in 1918, and look at the impact of Spanish flu on populations from America, to France, to the Arctic, and the scientific legacy this deadly virus has left behind.

    Explaining the truth behind the screening statistics and investigating the evidence behind the hype, Margaret McCartney, an award-winning writer and doctor, argues that this patient paradox - too much testing of well people and not enough care for the sick - worsens health inequalities and drains professionalism.

    Many people know there's something terribly broken about the industrial food, medical, and pharmaceutical systems, but they don't know what it is. It's no wonder because there is an intricate political and corporate apparatus in place to keep them from finding out. People think heart disease, cancer, and diabetes are inherited, not realizing that what they've actually inherited are the eating habits of their parents and grandparents. This stand-alone companion book expands upon the groundbreaking documentary, What The Health, in every way, putting foods that people buy – dairy, fish, eggs, meat – under the health microscope, while exposing the web of corporate and legislative machinations devised to confuse the public and keep Americans chronically – and profitably – ill. This is a jolting, sometimes hilarious, sometimes horrifying, but ultimately exhilarating adventure about reclaiming control of your health and the health of those you love.

    What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

    #1 New York Times bestselling author Douglas Preston takes readers on an adventure deep into the Honduran jungle in this riveting, danger-filled true story about the discovery of an ancient lost civilization.

     From USA history to silly facts about American presidents, from laws you can’t believe are laws to facts about U.S. inventions, this book is the perfect solution to any moment of boredom. It has facts about religion and sports, facts about U.S. geography and nature, facts about food and drinks, and facts about language, animals, and American education. There are facts about science, facts about the military, facts about modes of transportation, facts about business and money, and facts about how big the United States really is. According to one American, “This book of trivia is the greatest thing that’s been written since the Nevada state Constitution. Did you know that was the longest message ever sent via Morse code telegram?” With this book of 1,000 trivia facts, you’ll impress even the most knowledgeable friends you have. Use the interesting facts to start a great conversation. Pull out the random facts to make someone smile. Be the center of any party with all the funny facts you’ll find in this book. Got a pub quiz or trivia night to go to? Prepare with this book! With this many fun facts about the United States, you’ll win every time.

    They both have a God-given talent and skill...' - Ray Martin'If I've done one thing in life I'm proud of, it's launching Ruit into the world'. - Fred Hollows'One of the greatest people I've ever met.' - Joel Edgerton'I've known Dr Sanduk Ruit for over thirty years. He is one of our greatest living eye surgeons and humanitarians... Watching him give the gift of sight is like watching someone give a second life.' - Richard GereInspiring and uplifting, this is the extraordinary story of Dr Sanduk Ruit who, like his mentor Fred Hollows, took on the world's medical establishment to give the life-changing gift of sight to hundreds and thousands of the world's poorest and most isolated people. It is the story of a boy from the lowest tiers of a rigid caste system who grew up in a tiny, remote Himalayan village with no school to become one of the most respected ophthalmologists in the world and a medical giant of Asia.Compelling and compassionate, it is also the story of a young doctor who became Fred Hollows' medical soul mate and who chose to defy the world's medical establishment and the lure of riches to make the world a better place.

    As gripping as CSI and as eye-opening as Mary Roach’s Stiff, Carney’s The Red Market sheds a blazing new light on the disturbing, billion-dollar business of trading in human body parts, bodies, and child trafficking, raising issues and exposing corruptions almost too bizarre and shocking to imagine.

     ""It’s an astonishing performance. Wise goes through every piece of evidence, every report, every word and comes to the conclusion that investigators were deliberately and brilliantly misled by whoever took over the plane to look in the wrong place. Read this stunning piece of investigative journalism and see if he convinces you." -- John Podhoretz, Commentary magazine. Five years after a state-of-the-art Boeing 777 vanished into the night over the South China Sea, renowned science and aviation author Jeff Wise offers a compelling and detailed account of what happened that night and in the months and years that followed. In his follow-up to "The Plane That Wasn't There," named the Best Kindle Single of 2015, Wise walks readers through the many developments that have taken place in the meantime and explains why despite spending hundreds of millions of dollars and searching an area of seabed the size of Great Britain, authorities were unable to locate the plane's wreckage. Officials and independent experts were stunned by their failure, but Wise predicted it four years ago. Here he distills the fruits of exhaustive research and arrives at a conclusion that upends our understanding of what humans are capable of, both technologically and morally. Jeff Wise is a science journalist specializing in aviation and psychology. A licensed pilot of gliders and light airplanes, he has also written for New York, the New York Times, Time, Businessweek, Esquire, Popular Mechanics, and many others. He is also the author of Extreme Fear: The Science of Your Mind in Danger. A native of Massachusetts, he lives outside New York City with his wife and two sons.

    Now they can stop worrying, take charge of their brain health, and begin enjoying a sharper mind quickly and for years to come. In 2 Weeks to a Younger Brain, Dr. Gary Small and Gigi Vorgan translate the latest brain science into practical strategies and exercises that everyone can use to get immediate and long-lasting benefits. Dr. Small's studies have found that the sooner each of us gets started on a younger brain program, the greater the potential benefits. Following the authors' advice will not only improve your memory, but will also strengthen your physical health by reducing your risk for diabetes, heart disease, and stroke. In a new study published by the journal Psychological Science, researchers at MIT and Massachusetts General Hospital reported that the ability to reason, learn, and remember information ebbs and flows over our lifespan Although some forms of rapid recall peak in our late teens, our ability to evaluate another person's emotions by just viewing their eyes is strongest in midlife. And, vocabulary skills may not decline until well into our 60s. Remarkably, their data showed that since the late-1970s and early 1980s, our peak-ability to define words has gradually increased from age 40 to age 60. After three decades of helping thousands of patients improve their mental acuity, Dr. Small has shown that our daily lifestyle habits are directly linked to brain health. 2 Weeks to a Younger Brain reveals how you can rapidly form new habits that bolster cognitive abilities and help prevent, and reverse, brain aging. 2 Weeks to a Younger Brain makes sense of the latest scientific discoveries showing that: • Brain aging starts as young as age 20 • Sex is good for your brain • Memory exercises can erase senior moments from your brain scan • Aerobic conditioning can overcome even a genetic risk for Alzheimer's disease