Your life, your thoughts, your diseases, and your health are all the function of cells.But what do you really know about what goes on inside you?The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant.The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world.Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover:A deeper understanding of how cells work and the basic nature of life on earth.Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research.The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells.The ability to make better decisions about health and to debunk the misinformation that comes in daily via media.Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.

    of Maryland School of Medicine), offers case histories of the health problems of a dozen long-dead famous figures diagnosed from modern medical perspectives. Illustrations depict patients including the odd-looking Pharaoh Akhenaten, C

    It was inside, inside my head, where all had become so wretchedly different. I had the night before been incontrovertibly a man of stable mood, of calm, of good cheer and unforced bonhomie. Now I had become changed, with dreadful suddenness, into another being altogether.”Simon Winchester has never shied away from big, even enormous, topics—as evidenced by his bestselling biography of the Atlantic Ocean, his account of the Krakatoa volcanic eruption, and his wildly popular “The Professor and the Madman,” about the making of the Oxford English Dictionary. In his Byliner Original “The Man with the Electrified Brain,” he takes on arguably his most daunting subject yet: his own flirtation with madness, and one of nature’s greatest and most enduring mysteries, the human brain. As a geology student in his second year at Oxford, Winchester was known as a young man of even temper and keen intellect, until one June morning when he woke to find himself “changed with dreadful suddenness into another being altogether,” his normal life “slumped into chasm” and “folded in the dirt.” For a period of nine days, he lived in immobilizing fear. Everyday items—familiar paintings, a pile of books, his own robe hanging from a hook—became objects of horror; the world lost color, purpose, all sense and safety. When the episode finally passed, he returned to normal, presuming that what had happened to him was a fluke. It wasn’t. The episode repeated itself at unpredictable and dangerous intervals for four years—always lasting for nine days—and very nearly caused the author’s death while he was on an expedition in the Arctic. What was wrong with him? Where could he find help? Would he spend the rest of his life anticipating the return of these mental blackouts? With the urgency of a whodunit, Winchester describes the coming and going of these terrifying dissociative states and the chance encounter that led to the controversial treatment of electroconvulsive therapy, which may or may not have cured him once and for all. Written by a consummate storyteller, “The Man with the Electrified Brain” locates that finest of lines between sanity and insanity and is Winchester’s most riveting and deeply personal work yet.

    But the most significant danger posed by socialism isn’t that its implementation would lead to greater poverty and fewer property rights, it’s that socialism would create numerous moral problems, including the limits it would place on individual liberty and religious freedom. In Socialism Is Evil: The Moral Case Against Marx’s Radical Dream, conservative columnist and think tank research fellow Justin Haskins examines the moral perils of Marx’s socialism and explains why if socialism were to be imposed in its fullest form, it wouldn’t just damage people’s freedoms, it would obliterate them. Haskins argues it would be dangerous to attempt to create Marx’s utopian socialist world, and even more importantly, that such an attempt would be so highly immoral that it could reasonably be called “evil.” In Socialism Is Evil, Haskins makes the moral case against socialism and also describes in detail what socialists believe, the differences between socialism and communism, why Marx’s socialism will never be completely adopted, and why even the more moderate European-style socialism, called “democratic socialism” by some, is highly immoral and anti-American. Many socialists are kind, generous people with good intentions, but sometimes, good intentions can create devastating results. Socialism Is Evil briefly tackles some of the most important moral controversies surrounding Marx’s socialism, providing supporters of individual liberty with the tools they need to stop the rise of socialism in its tracks.

    Villoldo shares some of their time-honored teachings that emphasize the sacred dream: an ephemeral, yet powerful vision that has the potential to guide us to our purpose and show us our place in the universe.The practices in this book will help you forge a sacred dream for yourself. They will help you craft a destiny infused with courage, and driven by vision. You’ll be invited to follow the footsteps of the luminous warrior and learn how to break out of the three nightmares surrounding love, death, and safety that have held you captive, and transform them into the experience of timeless freedom, known as the Primordial Light. This creative power exercised by shamans will lead you to create beauty and healing, and dream a new world into being.When you transform these dreams and accept that life is ever changing, that your mortality is a given and that no one except you can free you from fear —the chaos in your life turns to order, and beauty prevails.“Wake up from the slumber you are living in, and dream with your eyes open so that all the possibilities of the future are available to you.”

    But while this medieval medicine now seems archaic, it also made a critical contribution to modern science.Medieval Bodies guides us on a head-to-heel journey through this era’s revolutionary advancements and disturbing convictions. We learn about the surgeons who dissected a living man’s stomach, then sewed him up again; about the geographers who delineated racial groups by skin color; and about the practice of fasting to gain spiritual renown. Encompassing medicine and mysticism, politics and art—and complete with vivid, full-color illustrations—Medieval Bodies shows us how it felt to live and die a thousand years ago.

    Unable to stand, barely able to think, he waited for hours in an emergency room before being correctly diagnosed and rushed into surgery. Over the next few days, as he clung to life and the first light of a new year came through his window, he found himself reflecting on the fragility of health, not recognized in America as a human right but without which all rights and freedoms have no meaning.And that was before the pandemic. We have since watched American hospitals, long understaffed and undersupplied, buckling under waves of coronavirus patients. The federal government made matters worse through willful ignorance, misinformation, and profiteering. Our system of commercial medicine failed the ultimate test, and thousands of Americans died.In this eye-opening cri de coeur, Snyder traces the societal forces that led us here and outlines the lessons we must learn to survive. In examining some of the darkest moments of recent history and of his own life, Snyder finds glimmers of hope and principles that could lead us out of our current malaise. Only by enshrining healthcare as a human right, elevating the authority of doctors and medical knowledge, and planning for our children's future can we create an America where everyone is truly free.

    Fascinating... may presage a paradigm shift in medicine." --Kirkus Reviews (starred review)Teeming with information and big ideas... Outstanding."--Booklist (starred review) The origin of asthma, autism, Alzheimer's, allergies, cancer, heart disease, obesity, and even some kinds of depression is now clear. Award-winning researcher on the microbiome, professor Rodney Dietert presents a new paradigm in human biology that has emerged in the midst of the ongoing global epidemic of noncommunicable diseases.The Human Superorganism makes a sweeping, paradigm-shifting argument. It demolishes two fundamental beliefs that have blinkered all medical thinking until very recently: 1) Humans are better off as pure organisms free of foreign microbes; and 2) the human genome is the key to future medical advances. The microorganisms that we have sought to eliminate have been there for centuries supporting our ancestors. They comprise as much as 90 percent of the cells in and on our bodies--a staggering percentage! More than a thousand species of them live inside us, on our skin, and on our very eyelashes. Yet we have now significantly reduced their power and in doing so have sparked an epidemic of noncommunicable diseases--which now account for 63 percent of all human deaths.Ultimately, this book is not just about microbes; it is about a different way to view humans. The story that Dietert tells of where the new biology comes from, how it works, and the ways in which it affects your life is fascinating, authoritative, and revolutionary. Dietert identifies foods that best serve you, the superorganism; not new fad foods but ancient foods that have made sense for millennia. He explains protective measures against unsafe chemicals and drugs. He offers an empowering self-care guide and the blueprint for a revolution in public health. We are not what we have been taught. Each of us is a superorganism. The best path to a healthy life is through recognizing that profound truth.

    In a book of unprecedented scope, McGilchrist draws on a vast body of recent brain research, illustrated with case histories, to reveal that the difference is profound—not just this or that function, but two whole, coherent, but incompatible ways of experiencing the world. The left hemisphere is detail oriented, prefers mechanisms to living things & is inclined to self-interest. The right hemisphere has greater breadth, flexibility & generosity. This division helps explain the origins of music & language, & casts new light on the history of philosophy, as well as on some mental illnesses. The 2nd part of the book takes a journey thru the history of Western culture, illustrating the tension between these two worlds as revealed in the thought & belief of thinkers & artists, from Aeschylus to Magritte. He argues that, despite its inferior grasp of reality, the left hemisphere is increasingly taking precedence in the modern world, with potentially disastrous consequences.List of IllustrationsAcknowledgmentsIntroductionAsymmetry and the brain --What do the two hemispheres 'do'? --Language, truth and music --The nature of the two worlds --The primacy of the right hemisphere --The triumph of the left hemisphere --Imitation and the evolution of culture --The ancient world --The Renaissance and the Reformation --The Enlightenment --Romanticism and the Industrial Revolution --The modern and post-modern worldsConclusionNotes BibliographyIndex

    Lou Grant from The Mary Tyler Moore Show—reclaims the Constitution from the right-wingers who think that they and only they know how to interpret it.Ed Asner, a self-proclaimed dauntless Democrat from the old days, figured that if the right-wing wackos are wrong about voter fraud, Obama’s death panels, and climate change, they are probably just as wrong about what the Constitution says. There’s no way that two hundred-plus years later, the right-wing ideologues know how to interpret the Constitution. On their way home from Philadelphia the people who wrote it couldn’t agree on what it meant. What was the president’s job? Who knew? All they knew was that the president was going to be George Washington and as long as he was in charge, that was good enough. When Hamilton wanted to start a national bank, Madison told him that it was unconstitutional. Both men had been in the room when the Constitution was written. And now today there are politicians and judges who claim that they know the original meaning of the Constitution. Are you kidding? In The Grouchy Historian, Ed Asner leads the charge for liberals to reclaim the Constitution from the right-wingers who use it as their justification for doing whatever terrible thing they want to do, which is usually to comfort the comfortable and afflict the afflicted. It’s about time someone gave them hell and explained that progressives can read, too.

    Soon enough, she is happily ensconced in the daily workings of his family. And not only that: Stella is treated like a family member—in ways that dogs of his youth were not. Spending humanlike sums on vet bills, questioning her diet and exercise regimens, contemplating her happiness—how had this all come to pass, when the dogs from Homans’s childhood seemed quite content living mostly out in the yard?In What’s a Dog For?, Homans explores the dog’s complex and prominent place in our world and how it came to be. Evolving from wild animals to working animals to nearly human members of our social fabric, dogs are now the subject of serious scientific studies concerning pet ownership, evolutionary theory, and even cognitive science. From new insights into what makes dogs so appealing to humans to the health benefits associated with owning a dog, Homans investigates why the human-canine relationship has evolved so rapidly—how dogs moved into our families, our homes, and sometimes even our beds in the span of a generation, becoming a $53 billion industry in the United States in the process.As dogs take their place as coddled family members and their numbers balloon to more than seventy-seven million in the United States alone, it’s no surprise that canine culture at large is also undergoing a massive transformation. They are now subject to many of the same questions of rights and ethics as people, and the politics of dogs are more tumultuous and public than ever— with fierce moral battles raging over kill shelters, puppy mills, and breed standards. Incorporating interviews and research from scientists, activists, breeders, and trainers, What’s a Dog For? investigates how dogs have reached this exalted status and why they hold such fascination for us. With one paw in the animal world and one paw in the human world, it turns out they have much to teach us about love, death, and morality—and ultimately, in their closeness and difference, about what it means to be human.

    Federal Election Commission trust in our government has reached an all-time low. More than ever before, Americans believe that money buys results in Congress, and that business interests wield control over our legislature.With heartfelt urgency and a keen desire for righting wrongs, Harvard law professor Lawrence Lessig takes a clear-eyed look at how we arrived at this crisis: how fundamentally good people, with good intentions, have allowed our democracy to be co-opted by outside interests, and how this exploitation has become entrenched in the system. Rejecting simple labels and reductive logic-and instead using examples that resonate as powerfully on the Right as on the Left-Lessig seeks out the root causes of our situation. He plumbs the issues of campaign financing and corporate lobbying, revealing the human faces and follies that have allowed corruption to take such a foothold in our system. He puts the issues in terms that nonwonks can understand, using real-world analogies and real human stories. And ultimately he calls for widespread mobilization and a new Constitutional Convention, presenting achievable solutions for regaining control of our corrupted-but redeemable-representational system. In this way, Lessig plots a roadmap for returning our republic to its intended greatness. While America may be divided, Lessig vividly champions the idea that we can succeed if we accept that corruption is our common enemy and that we must find a way to fight against it. In REPUBLIC, LOST, he not only makes this need palpable and clear-he gives us the practical and intellectual tools to do something about it.

    Jeffrey Tucker, CLO of Liberty.me and Distinguished Fellow of the Foundation for Economic Education, argues that peer-to-peer technology is forging a new and brighter social, economic, and political order. People tend to look at innovations in isolation. Here is my new e-reader. Here is an app I like. Here is my new mobile device and computer. Even bitcoin is routinely analyzed and explained in terms of its properties as an alternative to national currencies, as if there were no more than that at stake.But actually there is a historical trajectory at work here, one that we can trace through its logic, implementation, and spread. It’s the same logic that led from the dial phone at the county store, operated by people pulling and plugging in wires, to the wireless smartphone in your pocket that contains the whole store of human knowledge. It’s all about technology in the service of individuation.Once you understand the driving ethos — voluntarism, creativity, networks, individual initiative — you can see the outlines of a new social structure emerging within our time, an order that defies a century of top-down planning and nation-state restrictionism.It is coming about not because of political reform. It is not any one person’s creation. It is not happening because a group of elite intellectuals advocated it. The new world is emerging organically, and messily, from the ground up, as an extension of unrelenting creativity and experimentation. In the end, it is emerging out of an anarchist order that no one in particular controls and no one in particular can fully understand."The building of universal prosperity is a process that unfolds bit by bit through decentralized decision making and improvements at the margin through trial-and-error. To continue this process, we need understanding, patience, and dreams. Jeffrey Tucker’s book is an excellent guide to all three.” ~ Patrick Byrne, CEO of Overstock.com, from the introduction. “In Bitcoin’s brief existence Jeffrey Tucker has become one of its leading proponents. In this book we can see exactly why. Many people think of bitcoin as just money, but Mr. Tucker is able to explain, in a way that is easily understandable by all, the tsunami of innovation that bitcoin is about to release upon the world.” ~ Roger Ver, Bitcoin investor, from the Foreword

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    From the start, the drug's manufacturer aggressively marketed its patented time-release formula as a breakthrough in the effort to reduce prescription drug abuse. It wasn't long, however, before thrill-seeking teenagers shattered that illusion of safety; by simply crushing an "Oxy," they were able to tap into a high so seductive it would come to dominate their lives. Some patients, seeking relief from pain, also found themselves drawn to the drug's dark side. Pain Killer takes readers on a journey of discovery that begins with the true story of Lindsay, a high-school cheerleader in Virginia who gets hooked on Oxys, and expands outward to explore the critical issues of legitimate pain management, prescription drug abuse, and how the misuse of science by the drug industry threatens the public good. With the fast-rising abuse of prescription drugs by young people ringing alarm bells within government, the how and why behind the OxyContin disaster is a gripping read not only for parents, but also for medical professionals, community leaders, business executives, and all those concerned with this crisis. The dangers described in Pain Killer also reverberate far beyond the threat from a single drug at a particular moment in time. The focus of our government's war on drugs has clearly misled many of us into thinking that only illegal drugs smuggled from beyond our borders can be abused. As Meier tells the dramatic story, some of the most deadly substances are produced and sold legally right here at home.THE EXTRAORDINARY AND TRUE STORY OF OXYCONTIN EQUAL PARTS crime thriller, medical detective story, and business exposé, Pain Killer takes a hard-hitting look at how a powerful drug touted as the salvation for millions triggered a national tragedy. At its inception, the legal narcotic OxyContin was seen as a pharmaceutical dream, a "wonder" drug that would herald a sea change in medical care while reaping vast profits for its maker. It did do that; but it also unleashed a public health crisis that cut a swath of despair and crime through unsuspecting small towns, suburbs, and cities across the country. As reports of OxyContin overdoses made front-page and network news, doctors, narcotics agents, regulators, industry executives, and lawmakers raced in, scrambling to slow the damage. Behind it all stood one of America's wealthiest families, and a drug company whose relentless promotion helped fuel the problem Written by award-winning journalist Barry Meier, whose special report in the New York Times triggered national interest in OxyContin, Pain Killer chronicles the rise of the multibillion dollar pain management industry and lays bare its excesses and abuses.