Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    In his new book, Aslan takes on a subject even more immense: God, writ large.  In layered prose and with thoughtful, accessible scholarship, Aslan narrates the history of religion as a remarkably cohesive attempt to understand the divine by giving it human traits and emotions. According to Aslan, this innate desire to humanize God is hardwired in our brains, making it a central feature of nearly every religious tradition. As Aslan writes, “Whether we are aware of it or not, and regardless of whether we’re believers or not, what the vast majority of us think about when we think about God is a divine version of ourselves.”   But this projection is not without consequences. We bestow upon God not just all that is good in human nature—our compassion, our thirst for justice—but all that is bad in it: our greed, our bigotry, our penchant for violence. All these qualities inform our religions, cultures, and governments.   More than just a history of our understanding of God, this book is an attempt to get to the root of this humanizing impulse in order to develop a more universal spirituality. Whether you believe in one God, many gods, or no god at all, God: A Human History will challenge the way you think about the divine and its role in our everyday lives.Praise for God   “Breathtaking in its scope and controversial in its claims, God: A Human History shows how humans from time immemorial have made God in their own image, and argues that they should now stop. Writing with all the verve and brilliance we have come to expect from his pen, Reza Aslan has once more produced a book that will prompt reflection and shatter assumptions.”—Bart D. Ehrman, author of How Jesus Became God   “Reza Aslan offers so much to relish in his excellent ‘human history’ of God. In tracing the commonalities that unite religions, Aslan makes truly challenging arguments that believers in many traditions will want to mull over, and to explore further. This rewarding book is very ambitious in its scope, and it is thoroughly grounded in an impressive body of reading and research.”—Philip Jenkins, author of Crucible of Faith

    Here, acclaimed scholar Stephen Greenblatt explores it with profound appreciation for its cultural and psychological power as literature. From the birth of the Hebrew Bible to the awe-inspiring contributions of Augustine, Dürer, and Milton in bringing Adam and Eve to vivid life, Greenblatt unpacks the story’s many interpretations and consequences over time. Rich allegory, vicious misogyny, deep moral insight, narrow literalism, and some of the greatest triumphs of art and literature: all can be counted as children of our “first” parents.

    Being a journalist, she dove into the research and uncovered neurodiversity—a framework that moves away from pathologizing “abnormal” versus “normal” brains and instead recognizes the vast diversity of our mental makeups. When it comes to women, sensory processing differences are often overlooked, masked, or mistaken for something else entirely. Between a flawed system that focuses on diagnosing younger, male populations, and the fact that girls are conditioned from a young age to blend in and conform to gender expectations, women often don’t learn about their neurological differences until they are adults, if at all. As a result, potentially millions live with undiagnosed or misdiagnosed neurodivergences, and the misidentification leads to depression, anxiety, low self-esteem, and shame. Meanwhile, we all miss out on the gifts their neurodivergent minds have to offer.Divergent Mind is a long-overdue, much-needed answer for women who have a deep sense that they are “different.” Sharing real stories from women with high sensitivity, ADHD, autism, misophonia, dyslexia, SPD and more, Nerenberg explores how these brain variances present differently in women and dispels widely-held misconceptions (for example, it’s not that autistic people lack sensitivity and empathy, they have an overwhelming excess of it).Nerenberg also offers us a path forward, describing practical changes in how we communicate, how we design our surroundings, and how we can better support divergent minds. When we allow our wide variety of brain makeups to flourish, we create a better tomorrow for us all.

    Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Both men were practicing medicine at the same time in the 1880s: Freud at the Vienna General Hospital, Halsted at New York’s Bellevue Hospital. Markel writes that Freud began to experiment with cocaine as a way of studying its therapeutic uses—as an antidote for the overprescribed morphine, which had made addicts of so many, and as a treatment for depression.  Halsted, an acclaimed surgeon even then, was curious about cocaine’s effectiveness as an anesthetic and injected the drug into his arm to prove his theory. Neither Freud nor Halsted, nor their colleagues, had any idea of the drug’s potential to dominate and endanger their lives. Addiction as a bona fide medical diagnosis didn’t even exist in the elite medical circles they inhabited.  In An Anatomy of Addiction, Markel writes about the life and work of each man, showing how each came to know about cocaine; how Freud found that the drug cured his indigestion, dulled his aches, and relieved his depression. The author writes that Freud, after a few months of taking the magical drug, published a treatise on it, Über Coca, in which he described his “most gorgeous excitement.” The paper marked a major shift in Freud’s work: he turned from studying the anatomy of the brain to exploring the human psyche.  Halsted, one of the most revered of American surgeons, became the head of surgery at the newly built Johns Hopkins Hospital and then professor of surgery, the hospital’s most exalted position, committing himself repeatedly to Butler Hospital, an insane asylum, to withdraw from his out-of control cocaine use.  Halsted invented modern surgery as we know it today: devising new ways to safely invade the body in search of cures and pioneering modern surgical techniques that controlled bleeding and promoted healing. He insisted on thorough hand washing, on scrub-downs and whites for doctors and nurses, on sterility in the operating room—even inventing the surgical glove, which he designed and had the Goodyear Rubber Company make for him—accomplishing all of this as he struggled to conquer his unyielding desire for cocaine.  An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction as he conquered his own world with his visionary healing gifts. Here is the full story, long overlooked, told in its rich historical context.

    Drawing on evidence from archaeology, history, cognitive neuroscience, psychopharmacology, social psychology, literature, and genetics, Slingerland shows that our taste for chemical intoxicants is not an evolutionary mistake, as we are so often told. In fact, intoxication helps solve a number of distinctively human challenges: enhancing creativity, alleviating stress, building trust, and pulling off the miracle of getting fiercely tribal primates to cooperate with strangers. Our desire to get drunk, along with the individual and social benefits provided by drunkenness, played a crucial role in sparking the rise of the first large-scale societies. We would not have civilization without intoxication. From marauding Vikings and bacchanalian orgies to sex-starved fruit flies, blind cave fish, and problem-solving crows, Drunk is packed with fascinating case studies and engaging science, as well as practical takeaways for individuals and communities. The result is a captivating and long overdue investigation into humanity's oldest indulgence—one that explains not only why we want to get drunk, but also how it might actually be good for us to tie one on now and then.

    He demonstrates how the explosion of rational thought and scientific innovation during the Enlightenment began to change our understanding of the flesh and its relation to the soul. No longer simply a "mortal coil," the body eventually became the location, and source, of our conscious selves. Porter examines this paradigm shift through the eyes of the great thinkers of history, from Descartes to Voltaire to Lord Byron, summarizing and explicating their beliefs "in a prose that leaps resplendently from the page" (Harper's).

    In Four Lost Cities, acclaimed science journalist Annalee Newitz takes readers on an entertaining and mind-bending adventure into the deep history of urban life. Investigating across the centuries and around the world, Newitz explores the rise and fall of four ancient cities, each the center of a sophisticated civilization: the Neolithic site of Çatalhöyük in Central Turkey, the Roman vacation town of Pompeii on Italy’s southern coast, the medieval megacity of Angkor in Cambodia, and the indigenous metropolis Cahokia, which stood beside the Mississippi River where East St. Louis is today.Newitz travels to all four sites and investigates the cutting-edge research in archaeology, revealing the mix of environmental changes and political turmoil that doomed these ancient settlements. Tracing the early development of urban planning, Newitz also introduces us to the often anonymous workers—slaves, women, immigrants, and manual laborers—who built these cities and created monuments that lasted millennia.Four Lost Cities is a journey into the forgotten past, but, foreseeing a future in which the majority of people on Earth will be living in cities, it may also reveal something of our own fate.

    Soon enough, she is happily ensconced in the daily workings of his family. And not only that: Stella is treated like a family member—in ways that dogs of his youth were not. Spending humanlike sums on vet bills, questioning her diet and exercise regimens, contemplating her happiness—how had this all come to pass, when the dogs from Homans’s childhood seemed quite content living mostly out in the yard?In What’s a Dog For?, Homans explores the dog’s complex and prominent place in our world and how it came to be. Evolving from wild animals to working animals to nearly human members of our social fabric, dogs are now the subject of serious scientific studies concerning pet ownership, evolutionary theory, and even cognitive science. From new insights into what makes dogs so appealing to humans to the health benefits associated with owning a dog, Homans investigates why the human-canine relationship has evolved so rapidly—how dogs moved into our families, our homes, and sometimes even our beds in the span of a generation, becoming a $53 billion industry in the United States in the process.As dogs take their place as coddled family members and their numbers balloon to more than seventy-seven million in the United States alone, it’s no surprise that canine culture at large is also undergoing a massive transformation. They are now subject to many of the same questions of rights and ethics as people, and the politics of dogs are more tumultuous and public than ever— with fierce moral battles raging over kill shelters, puppy mills, and breed standards. Incorporating interviews and research from scientists, activists, breeders, and trainers, What’s a Dog For? investigates how dogs have reached this exalted status and why they hold such fascination for us. With one paw in the animal world and one paw in the human world, it turns out they have much to teach us about love, death, and morality—and ultimately, in their closeness and difference, about what it means to be human.

    Ballet dancers and rock musicians, professors and thieves-"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul.

    A Biography of Loneliness offers a radically new interpretation of loneliness as an emotional language and experience. Using letters and diaries, philosophical tracts, political discussions, and medical literature from the eighteenth century to the present, historian of the emotions Fay Bound Alberti argues that loneliness is not an ahistorical, universal phenomenon. It is, in fact, a modern emotion: before 1800, its language did not exist. And where loneliness is identified, it is not always bad, but a complex emotional state that differs according to class, gender, ethnicity and experience.Looking at informative case studies such as Sylvia Plath, Queen Victoria, and Virginia Woolf, A Biography of Loneliness charts the emergence of loneliness as a modern and embodied emotional state.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    In You Are the Placebo, Dr. Joe Dispenza shares numerous documented cases of those who reversed cancer, heart disease, depression, crippling arthritis, and even the tremors of Parkinson’s disease by believing in a placebo. Similarly, Dr. Joe tells of how others have gotten sick and even died the victims of a hex or voodoo curse—or after being misdiagnosed with a fatal illness. Belief can be so strong that pharmaceutical companies use double- and triple-blind randomized studies to try to exclude the power of the mind over the body when evaluating new drugs.     Dr. Joe does more than simply explore the history and the physiology of the placebo effect. He asks the question: “Is it possible to teach the principles of the placebo, and without relying on any external substance, produce the same internal changes in a person’s health and ultimately in his or her life?” Then he shares scientific evidence (including color brain scans) of amazing healings from his workshops, in which participants learn his model of personal transformation, based on practical applications of the so-called placebo effect. The book ends with a “how-to” meditation for changing beliefs and perceptions that hold us back—the first step in healing.     You Are the Placebo combines the latest research in neuroscience, biology, psychology, hypnosis, behavioral conditioning, and quantum physics to demystify the workings of the placebo effect . . . and show how the seemingly impossible can become possible.

    Medication Madness is a fascinating, frightening, and dramatic look at the role that psychiatric medications have played in fifty cases of suicide, murder, and other violent, criminal, and bizarre behaviors.  As a psychiatrist who believes in holding people responsible for their conduct, the weight of scientific evidence and years of clinical experience eventually convinced Dr. Breggin that psychiatric drugs frequently cause individuals to lose their judgment and their ability to control their emotions and actions. Medication Madness raises and examines the issues surrounding personal responsibility when behavior seems driven by drug-induced adverse reactions and intoxication. Dr. Breggin personally evaluated the cases in the book in his role as a treating psychiatrist, consultant or medical expert.  He interviewed survivors and witnesses, and reviewed extensive medical, occupational, educational and police records. The great majority of individuals lived exemplary lives and committed no criminal or bizarre actions prior to taking the psychiatric medications. Medication Madness reads like a medical thriller, true crime story, and courtroom drama; but it is firmly based in the latest scientific research and dozens of case studies. The lives of the children and adults in these stories, as well as the lives of their families and their victims, were thrown into turmoil and sometimes destroyed by the unanticipated effects of psychiatric drugs.  In some cases our entire society was transformed by the tragic outcomes. Many categories of psychiatric drugs can cause potentially horrendous reactions. Prozac, Paxil, Zoloft, Adderall, Ritalin, Concerta, Xanax, lithium, Zyprexa and other psychiatric medications may spellbind patients into believing they are improved when too often they are becoming worse.  Psychiatric drugs drive some people into psychosis, mania, depression, suicide, agitation, compulsive violence and loss of self-control without the individuals realizing that their medications have deformed their way of thinking and feeling.  This book documents how the FDA, the medical establishment and the pharmaceutical industry have over-sold the value of psychiatric drugs.  It serves as a cautionary tale about our reliance on potentially dangerous psychoactive chemicals to relieve our emotional problems and provides a positive approach to taking personal charge of our lives.

    Yet this is the first book to tell the story of rain. Cynthia Barnett's  Rain begins four billion years ago with the torrents that filled the oceans, and builds to the storms of climate change. It weaves together science—the true shape of a raindrop, the mysteries of frog and fish rains—with the human story of our ambition to control rain, from ancient rain dances to the 2,203 miles of levees that attempt to straitjacket the Mississippi River. It offers a glimpse of our "founding forecaster," Thomas Jefferson, who measured every drizzle long before modern meteorology. Two centuries later, rainy skies would help inspire Morrissey’s mopes and Kurt Cobain’s grunge. Rain is also a travelogue, taking readers to Scotland to tell the surprising story of the mackintosh raincoat, and to India, where villagers extract the scent of rain from the monsoon-drenched earth and turn it into perfume. Now, after thousands of years spent praying for rain or worshiping it; burning witches at the stake to stop rain or sacrificing small children to bring it; mocking rain with irrigated agriculture and cities built in floodplains; even trying to blast rain out of the sky with mortars meant for war, humanity has finally managed to change the rain. Only not in ways we intended. As climate change upends rainfall patterns and unleashes increasingly severe storms and drought, Barnett shows rain to be a unifying force in a fractured world. Too much and not nearly enough, rain is a conversation we share, and this is a book for everyone who has ever experienced it.