There is every reason to believe that, within a few weeks of its onset, the infection was universally present in the nose and throat of the people, disseminated by mouth spray given off on talking by innumerable carriers and, in addition, by the coughing and sneezing of the sick. Susceptibility was very general, though it varied greatly in degree. Among those who escaped well marked sickness there are few who could not recall having had an occluded or running nose, or a raw feeling in the throat, or a cough, or aches and pains, at some time during the period of the prevalence of the disease, these probably representing the price such persons paid for their immunization." - Dr. Bernard Fantus In many ways, it is hard for modern people living in First World countries to conceive of a pandemic sweeping around the world and killing millions of people, and it is even harder to believe that something as common as influenza could cause such widespread illness and death. Although the flu still takes hundreds of lives each year, most of those lost are very young or old or ill with something else that had already weakened them. In fact, most people contract influenza at least once, and many suffer from the flu several times in their lives and survive it with a minimum amount of medical attention. In 1918, the world was still in the throes of the Great War, the deadliest conflict in human history at that point, but while World War I would be a catastrophic war surpassed only by World War II, an unprecedented influenza outbreak that same year inflicted casualties that would make both wars pale in comparison. An illness, or more likely a collection of illnesses, Spanish influenza quickly spread across the world and may have killed upwards of 100 million people, decimating populations across developed nations and possibly wiping out as much as 5% of the world’s population. If anything, the ongoing war and the censorship maintained by the countries fighting it may have resulted in the actual toll of the outbreak being underestimated based on the way soldiers’ deaths were categorized. World War I may have distracted people about the unprecedented nature of the outbreak, but the most alarming aspect of the outbreak in 1918 was the indiscriminate nature in which the scourge attacked young and old, healthy and unhealthy, and rich and poor alike. In fact, the popular name for the outbreak was a reference to the fact that Spain’s own king was stricken with the disease. While he and President Woodrow Wilson ended up surviving it, former First Lady Rose Cleveland did not. The staggering number of fatalities, and the way in which seemingly anybody could suffer during the outbreak, taught people in the early 20th century that regardless of the tremendous strides made by technology, and no matter how stalemated the war was, nobody was safe from nature itself. Of course, it also demonstrated how much more work could be done to prevent similar occurrences. The 1918 pandemic was neither the first nor the last outbreak of the flu, but it was by far the worst, and it forever changed the face of medicine and public health care in both North America and Europe. The 1918 Spanish Flu Pandemic: The History and Legacy of the World’s Deadliest Outbreak chronicles the devastating disease and the damage it wrought across the globe.

    Through fascinating portraits of a wide array of creatures, he introduces us to the many forms of sea life that humans have fished, hunted, and collected over the centuries, from charismatic whales and dolphins to the lowly menhaden, from sea turtles to cod, tuna, and coral.Rich in history, anecdote, and surprising fact, Richard Ellis’s descriptions bring to life the natural history of the various species, the threats they face, and the losses they have suffered. Killing has occurred on a truly stunning scale, with extinction all too often the result, leaving a once-teeming ocean greatly depleted. But the author also finds instances of hope and resilience, of species that have begun to make remarkable comebacks when given the opportunity.Written with passion and grace, and illustrated with Richard Ellis’s own drawings, The Empty Ocean brings to a wide audience a compelling view of the damage we have caused to life in the sea and what we can do about it. "

    It can be microscopic, yet also accounts for the largest organisms ever recorded, living for millennia and weighing tens of thousands of tonnes. Its ability to digest rock enabled the first life on land, it can survive unprotected in space, and thrives amidst nuclear radiation.In this captivating adventure, Merlin Sheldrake explores the spectacular and neglected world of fungi: endlessly surprising organisms that sustain nearly all living systems. They can solve problems without a brain, stretching traditional definitions of ‘intelligence’, and can manipulate animal behaviour with devastating precision. In giving us bread, alcohol and life-saving medicines, fungi have shaped human history, and their psychedelic properties, which have influenced societies since antiquity, have recently been shown to alleviate a number of mental illnesses. The ability of fungi to digest plastic, explosives, pesticides and crude oil is being harnessed in break-through technologies, and the discovery that they connect plants in underground networks, the ‘Wood Wide Web’, is transforming the way we understand ecosystems. Yet they live their lives largely out of sight, and over ninety percent of their species remain undocumented.Entangled Life is a mind-altering journey into this hidden kingdom of life, and shows that fungi are key to understanding the planet on which we live, and the ways we think, feel and behave. The more we learn about fungi, the less makes sense without them.

    New emphasis has been given to complexity, networks, and patterns of organisation, leading to a novel kind of 'systemic' thinking. This volume integrates the ideas, models, and theories underlying the systems view of life into a single coherent framework. Taking a broad sweep through history and across scientific disciplines, the authors examine the appearance of key concepts such as autopoiesis, dissipative structures, social networks, and a systemic understanding of evolution. The implications of the systems view of life for health care, management, and our global ecological and economic crises are also discussed. Written primarily for undergraduates, it is also essential reading for graduate students and researchers interested in understanding the new systemic conception of life and its implications for a broad range of professions - from economics and politics to medicine, psychology and law.

    H. Freeman and Company.  Visit the  Life, Eighth Edition preview site.  LIFE HAS EVOLVED. . . from its original publication to this dramatically revitalized Eighth Edition. LIFE has always shown students how biology works, offering an engaging and coherent presentation of the fundamentals of biology by describing the landmark experiments that revealed them. This edition builds on those strengths and introduces several innovations.As with previous editions, the Eighth Edition will also be available in three paperback volumes:  • Volume I: The Cell and Heredity, Chapters 1-20  • Volume II: Evolution, Diversity and Ecology, Chapters 1, 21-33, 52-57  • Volume III: Plants and Animals, Chapters 1, 34-51

    This remarkable book describes Fout's odyssey from novice researcher to celebrity scientist to impassioned crusader for the rights of animals. Living and conversing with these sensitive creatures has given him a profound appreciation of what they can teach us about ourselves. It has also made Fouts an outspoken opponent of biomedical experimentation on chimpanzees. A voyage of scientific discovery and interspecies communication, this is a stirring tale of friendship, courage, and compassion that will change forever the way we view our biological--and spritual--next of kin. Fouts is a professor of Psychology.

    He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.In Ravenous, Sam Apple reclaims Otto Warburg as a forgotten, morally compromised genius who pursued cancer single-mindedly even as Europe disintegrated around him. While the vast majority of Jewish scientists fled Germany in the anxious years leading up to World War II, Warburg remained in Berlin, working under the watchful eye of the dictatorship. With the Nazis goose-stepping their way across Europe, systematically rounding up and murdering millions of Jews, Warburg awoke each morning in an elegant, antiques-filled home and rode horses with his partner, Jacob Heiss, before delving into his research at the Kaiser Wilhelm Society.Hitler and other Nazi leaders, Apple shows, were deeply troubled by skyrocketing cancer rates across the Western world, viewing cancer as an existential threat akin to Judaism or homosexuality. Ironically, they viewed Warburg as Germany’s best chance of survival. Setting Warburg’s work against the absorbing history of cancer science, Apple follows him as he arrived at his central belief that cancer is a problem of metabolism. Though Warburg’s metabolic approach to cancer was considered groundbreaking, his work was soon eclipsed in the early postwar era, after the discovery of the structure of DNA set off a search for the genetic origins of cancer.Remarkably, Warburg’s theory has undergone a resurgence in our own time, as scientists have begun to investigate the dangers of sugar and the link between obesity and cancer, finding that the way we eat can influence how cancer cells take up nutrients and grow. Rooting his revelations in extensive archival research as well as dozens of interviews with today’s leading cancer authorities, Apple demonstrates how Warburg’s midcentury work may well hold the secret to why cancer became so common in the modern world and how we can reverse the trend. A tale of scientific discovery, personal peril, and the race to end a disastrous disease, Ravenous would be the stuff of the most inventive fiction were it not, in fact, true.

    And survival is never a given. Somehow, a blind, defenseless tiger kitten must evolve into a deadly, efficient predator; a chimp must learn to distinguish edible plants from lethal poisons; a baby buffalo must be able to pick its mother out of a herd of hundreds. Contrary to common belief, not everything is "hardwired" -- or instinctual -- in the animal kingdom. Many skills a wild animal needs to thrive, to grow, to be what nature intended, must be developed through play, painstaking teaching, and often treacherous trial and error. The coming-of-age processes of the myriad creatures of plain, forest, ocean, and jungle are truly fascinating and often astonishing natural events.In Becoming a Tiger, Susan McCarthy, co-author of the critically acclaimed New York Times bestseller When Elephants Weep, offers readers an in-depth look into the amazing ways baby animals learn not only about themselves, but about their world and ours -- and how to survive in both. Based on extensive scientific research done in the lab, in controlled "natural" settings, as well as in the wild, her findings provide stunning new insights into the lives and development of Earth's nonhuman inhabitants -- not only tigers, but lions, bears, bats, rats, birds, dolphins, whales, apes, elephants, and dozens of other species.Sharing stories and discoveries at once captivating, funny, breathtaking, provocative, and heartwarming, Susan McCarthy carries us on a remarkable journey into untamed places, immersing us in the fascinating, complex, and hitherto unimagined societies and cultures of the beasts and birds. Along the way she shines a brilliant new light on subjects scientists, biologists, and zoologists have only begun to explore, revealing startling truths about the behavior, and sometimes humanlike foibles, of creatures great and small.Warm, informative, and beautifully written, Becoming a Tiger is an enthralling reading experience for animal lovers everywhere. In the transformation tales of playful pups, big-footed cubs, and scrawny chicks becoming deadly hunters, able foragers, and deft nest-builders are valuable and enriching life lessons for members of our own inquisitive, ever-developing species.

    Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences. Key Features of the Sixth Edition Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners More than 1,200 high-quality, full-color illustrations A concise appendix reviewing important Organic Chemistry Concepts New to the Sixth Edition: Fully Updated with a significant revision of all chapters and major topics Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

     Three and a half billion years ago, Mars resembled earth. It was warm and wet and could have supported primitive organisms. If life once existed on Mars, might it have originated there and traveled to earth inside meteorites blasted into space by cosmic impacts? Davies builds on recent scientific discoveries and theories to address larger questions of existence: What, exactly, is life? Is it the inevitable by-product of physical laws, as many scientists maintain, or an almost miraculous accident? Are we alone in the universe, or will life emerge on all earthlike planets? And if there is life elsewhere in the universe, is it preordained to evolve toward greater complexity and intelligence? Through his search for answers to these questions, Davies explores the ultimate mystery of mankind's existence -- who we are and what our place might be in the unfolding drama of the cosmos.

    By the author of Gorgon. 35,000

    We get cancer because we can't avoid it—it's a bug in the system of life itself.Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us.Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy.We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move.Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

    It is essentially a death sentence. The only accepted form of treatment - starvation - whittles her down to forty-five pounds skin and bones. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases - a miracle soon marred by scientific jealousy, intense business competition and fistfights. In a race against time and a ravaging disease, Elizabeth becomes one of the first diabetics to receive insulin injections - all while its discoverers and a little known pharmaceutical company struggle to make it available to the rest of the world.Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    Now, on the 150th anniversary of its publication, acclaimed science writer and master of narrative nonfiction Bill Hayes has written the fascinating, never-before-told true story of how this seminal volume came to be. A blend of history, science, culture, and Hayes’s own personal experiences, The Anatomist is this author’s most accomplished and affecting work to date.With passion and wit, Hayes explores the significance of Gray’s Anatomy and explains why it came to symbolize a turning point in medical history. But he does much, much more. Uncovering a treasure trove of forgotten letters and diaries, he illuminates the astonishing relationship between the fiercely gifted young anatomist Henry Gray and his younger collaborator H. V. Carter, whose exquisite anatomical illustrations are masterpieces of art and close observation. Tracing the triumphs and tragedies of these two extraordinary men, Hayes brings an equally extraordinary era–the mid 1800s–unforgettably to life.But the journey Hayes takes us on is not only outward but inward–through the blood and tissue and organs of the human body–for The Anatomist chronicles Hayes’s year as a student of classical gross anatomy, performing with his own hands the dissections and examinations detailed by Henry Gray 150 years ago. As Hayes’s acquaintance with death deepens, he finds his understanding and appreciation of life deepening in unexpected and profoundly moving ways. The Anatomist is more than just the story of a book. It is the story of the human body, a story whose beginning and end we all know and share but that, like all great stories, is infinitely rich in between.