An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    From butterfly gardens to zoo exhibitions, they are one of the few insects we’ve encouraged to infiltrate our lives. Yet, what has drawn us to these creatures in the first place? And what are their lives really like? In this groundbreaking book, New York Times bestselling author and science journalist Wendy Williams reveals the inner lives of these “flying flowers”—creatures far more intelligent and tougher than we give them credit for. Monarch butterflies migrate thousands of miles each year from Canada to Mexico. Other species have learned how to fool ants into taking care of them. Butterflies’ scales are inspiring researchers to create new life-saving medical technology. Williams takes readers to butterfly habitats across the globe and introduces us to not only various species, but to the scientists who have dedicated their lives to studying them. Coupled with years of research and knowledge gained from experts in the field, this accessible “butterfly biography” explores the ancient partnership between these special creatures and humans, and why they continue to fascinate us today. Touching, eye-opening, and incredibly profound, The Language of Butterflies reveals the critical role they play in our world.

    The most fatal virus known to science, rabies — a disease that spreads avidly from animals to humans — kills nearly one hundred percent of its victims once the infection takes root in the brain. In this critically acclaimed exploration, journalist Bill Wasik and veterinarian Monica Murphy chart four thousand years of the history, science, and cultural mythology of rabies. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh and often wildly entertaining look at one of humankind’s oldest and most fearsome foes.

    Buried there lie answers about the origins of humankind. After a century of investigation, scientists have transformed our understanding about the beginnings of human life. But vital clues still remain hidden. In Born in Africa, Martin Meredith follows the trail of discoveries about human origins made by scientists over the last hundred years, recounting their intense rivalry, personal feuds, and fierce controversies as well as their feats of skill and endurance.The results have been momentous. Scientists have identified more than twenty species of extinct humans. They have firmly established Africa as the birthplace not only of humankind but also of modern humans. They have revealed how early technology, language ability, and artistic endeavour all originated in Africa; and they have shown how small groups of Africans spread out from Africa in an exodus sixty thousand years ago to populate the rest of the world. We have all inherited an African past.

    Inspired by her own feline's instinct to hunt and supported by her studies abroad, Thomas examines the life actions, as well as the similarities and differences of these majestic creatures. Lions, tigers, pumas and housecats: Her observations shed light on their social lives, thought processes, eating habits, and communication techniques, and reveal how they survive and coexist with each other and with humans.

    In late 2017, scientists at a Hawaiian observatory glimpsed an object soaring through our inner solar system, moving so quickly that it could only have come from another star. Avi Loeb, Harvard’s top astronomer, showed it was not an asteroid; it was moving too fast along a strange orbit, and left no trail of gas or debris in its wake. There was only one conceivable explanation: the object was a piece of advanced technology created by a distant alien civilization.   In Extraterrestrial, Loeb takes readers inside the thrilling story of the first interstellar visitor to be spotted in our solar system. He outlines his controversial theory and its profound implications: for science, for religion, and for the future of our species and our planet. A mind-bending journey through the furthest reaches of science, space-time, and the human imagination, Extraterrestrial challenges readers to aim for the stars—and to think critically about what’s out there, no matter how strange it seems.

    From the mythical beasts of ancient Greece to the hormonal vampires of the Twilight saga, monsters have captivated us for millennia. Matt Kaplan, a noted science journalist and monster-myth enthusiast, employs an entertaining mix of cutting-edge research and a love of lore to explore the history behind these fantastical fictions and our hardwired obsession with things that go bump in the night. Ranging across history, Medusa’s Gaze and Vampire’s Bite tackles the enduring questions that arise on the frontier between fantasy and reality. What caused ancient Minoans to create the tale of the Minotaur and its subterranean maze? Did dragons really exist? What inspired the creation of vampires and werewolves, and why are we so drawn to them? With the eye of a journalist and the voice of a storyteller, Kaplan takes readers to the forefront of science, where our favorite figures of horror may find real-life validation. Does the legendary Kraken, a squid of epic proportions, really roam the deep? Are we close to making Jurassic Park a reality by replicating a dinosaur from fossilized DNA? As our fears evolve, so do our monsters, and Medusa’s Gaze and Vampire’s Bite charts the rise of the ultimate beasts, humans themselves.

    A young man is murdered for his prized pet fish. An Asian tycoon buys a single specimen for $150,000. Meanwhile, a pet detective chases smugglers through the streets of New York. Delving into an outlandish world of obsession, paranoia, and criminality, The Dragon Behind the Glass tells the story of a fish like none other. Treasured as a status symbol believed to bring good luck, the Asian arowana, or “dragon fish,” is a dramatic example of a modern paradox: the mass-produced endangered species. While hundreds of thousands are bred in captivity, the wild fish has become a near-mythical creature. From the South Bronx to Borneo and beyond, journalist Emily Voigt follows the trail of the arowana to learn its fate in nature. With a captivating blend of personal reporting, history, and science, Voigt traces our fascination with aquarium fish back to the era of exploration when intrepid naturalists stood on the cutting edge of modern science, discovering new species around the globe. In an age when freshwater fish now comprise one of the most rapidly vanishing groups of animals, she unearths a surprising truth behind the arowana’s rise to fame—one that calls into question how we protect the world’s rarest species. An elegant examination of the human conquest of nature, The Dragon Behind the Glass revels in the sheer wonder of life’s diversity and lays bare our deepest desire—to hold on to what is wild.

    Every field, forest, and park is full of living organisms adapted for relationships with creatures that are now extinct. In a vivid narrative, Connie Barlow shows how the idea of "missing partners" in nature evolved from isolated, curious examples into an idea that is transforming how ecologists understand the entire flora and fauna of the Americas. This fascinating book will enrich and deepen the experience of anyone who enjoys a stroll through the woods or even down an urban sidewalk. But this knowledge has a dark side too: Barlow's "ghost stories" teach us that the ripples of biodiversity loss around us now are just the leading edge of what may well become perilous cascades of extinction.

    In The Botany of Desire, Michael Pollan ingeniously demonstrates how people and domesticated plants have formed a similarly reciprocal relationship. He masterfully links four fundamental human desires—sweetness, beauty, intoxication, and control—with the plants that satisfy them: the apple, the tulip, marijuana, and the potato. In telling the stories of four familiar species, Pollan illustrates how the plants have evolved to satisfy humankind’s most basic yearnings. And just as we’ve benefited from these plants, we have also done well by them. So who is really domesticating whom?

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    Lavishly illustrated with over sixty original artworks, All Yesterdays aims to challenge our notions of how prehistoric animals looked and behaved. As a critical exploration of palaeontological art, All Yesterdays asks questions about what is probable, what is possible, and what is commonly ignored.Written by palaeozoologist Darren Naish, and palaeontological artists John Conway and C.M. Kosemen, All Yesterdays is scientifically rigorous and artistically imaginative in its approach to fossils of the past - and those of the future.

    Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee(2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answerage-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past.In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their sourceamong our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations fromour common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomicbases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution inorder to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.

    The story starts in earnest 3.8 billion years ago, with the earliest-known form of life on Earth, a bacteria that still exists today, and journeys through action-packed millennia, charting the appearance of new life forms as well as devastating extinction events. Of course, the ever-popular and endlessly intriguing dinosaurs feature large, but Prehistoric Life gives you the whole picture, and the plants, invertebrates, amphibians, birds, reptiles, and mammals that are the ancestors of today's species also populate its pages, making this book unprecedented in its coverage of prehistory. Specially commissioned artworks use cutting-edge technology to render species in breathtakingly realistic fashion, with astonishing images of prehistoric remains, such as skeletons and fossils, to complete the story. To put all the evidence in context, the concept of geological time is explored, as is the classification of species and how the evidence for their evolution is preserved and can be deciphered.New technologies have brought new life to inanimate fossils. CT scanning, for example, unlocks a 3D image of a plant or animal from a piece of rock, which can then be viewed from all angles revealing never-before-seen details. From this researchers can fill in missing pieces and even simulate how an animal might have moved. Panels explore these and numerous other scientific techniques for recovering, dating, and reconstructing, as well as profiling individuals, key excavations and discoveries, and some of the unique anatomical features that nature has developed over the course of time.The last section of the book looks at the development of humans and the eventual rise to dominance of Homo sapiens, exploring not only their changing anatomy as revealed by the fossils but also the evidence for culture and society as evidenced by extraordinary cave paintings and intricately worked tools.In combination, the stunning visuals, captivating, authoritative text, and comprehensive approach make Prehistoric Life a fascinating and revealing encyclopedia that will appeal to the whole family.TABLE OF CONTENTS1. LIVING PLANET (38 pp)Foundations of a living planet. The Earth's structure. Plate tectonics, formation of oceans and continents.Changing climate. factors that contribute to climate change, how those can be seen in the geological record, and how that has affected life on Earth.Reconstructing the past. Using the present to understand the past (rocks and the rock cycle, layers of rock and dating)Fossils. Types of fossils, how they form, reconstructing the past from them (digging up, analysis), reconstructing past environments, dating using fossils.Geological timescale. Explanation of geological time.Life on Earth. What is life? Natural selection, DNA, molecular clocks, mass extinctions.Timeline of Evolution. Broad-scale look at major evolutionary markers through time.Classification. How we classify living organisms. The kingdoms of life.2. ON EARTH (398 PP) This chapter will be organized so that pages can be removed to leave a section of 360pp.his consists of a catalog divided into geological periods. Each period introduction covers the conditions on Earth at the time (geology and climate) and includes a chart showing the evolution of the main forms of life. The subsequent catalog entries are organized into groups: Microscopic life; Plants and Fungi; Invertebrates; and Vertebrates, with each having an introduction detailing the main evolutionary developments within the group.Archean 3.8-2.5 billion years ago (4pp)Period introduction. (1p)Archean life intro - (1p) the rise of life. Biology of cells; prokaryotes, cyanobacteria, stromatolites.Catalog of species.Proterozoic 2.5 billion-543 mya (6pp)Period introduction. (2pp)Microscopic life intro. (1p)Catalog of species. (1p)Invertebrates intro. (1p)Catalog of species. (1p)Cambrian 543-490 mya (20pp)Period introduction (4pp)Microscopic life intro. (1p)Catalog of species. (3pp)Invertebrates intro. (2pp)Catalog of species. (8pp)Vertebrates intro. (1p)Catalog of species. (1p)Ordovician 490-443 mya (14pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species.(1p)Invertebrates intro. (1p)Catalog of species. (3pp)Vertebrates intro. (1p)Catalog of species. (1p)Silurian 443-417 mya (20pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (1p)Invertebrates intro. (1p)Catalog of species. (7pp)Vertebrates intro. (1p)Catalog of species. (3p)Devonian 417-354 mya (34pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (7pp)Invertebrates intro. (1p)Catalog of species. (7pp)Vertebrates intro. (2p)Catalog of species. (10pp)Carboniferous 354-290 mya (38pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (2pp)Catalog of species. (8pp)Invertebrates intro. (1p)Catalog of species. (9pp)Vertebrates intro. (2pp)Catalog of species. (10pp)Permian 290-248 mya (26pp)Period introduction. (Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (3pp)Invertebrates intro. (1p)Catalog of species. (7pp)Vertebrates intro. (1p)Catalog of species. (7pp)Triassic 248-206 mya (30pp)Period introduction. (Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (5pp)Invertebrates intro. (1p)Catalog of species. (3pp)Vertebrates intro. (1pp)Catalog of species. (13pp)Jurassic 206-144 mya (56pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (5pp)Invertebrates intro. (1p)Catalog of species. (9pp)Vertebrates intro. (2pp)Catalog of species. (24pp)Cretaceous 144-65 mya (54pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (2pp)Catalog of species. (10pp)Invertebrates intro. (1p)Catalog of species. (9pp)Vertebrates intro. (2pp)Catalog of species. (24pp)Paleogene 65-23.8 mya (34pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (6pp)Invertebrates intro. (1p)Catalog of species. (6pp)Vertebrates intro. (2pp)Catalog of species. (12pp)Neogene 23.8-1.8 mya (32pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (6pp)Invertebrates intro. (1p)Catalog of species. (7pp)Vertebrates intro. (1p)Catalog of species. (10pp)Quaternary 1.8 mya-Present (26pp)Period introduction. (4pp)Microscopic life intro. (1p)Catalog of species. (1p)Plants and fungi intro. (1p)Catalog of species. (Invertebrates intro. (1p)Catalog of species. (5pp)Vertebrates intro. (1p)Catalog of species. (8pp)3. THE RISE OF HUMANS (44PP)Timeline of human evolution.Coverage of: Sahelanthropus tchadensis, Orrorin tugenesis, Ardipithecus kadabba, Ardipithecus ramidus, Australopithecus anamensis, Australopithecus afarensis, Kenyanthropus platyops, Australopithecus africanus, Australopithecus aethiopicus, Australopithecus garhi, Homo habilis, Homo rudolfensis, Paranthropus boisei, Homo ergaster, Paranthropus robustus, Homo erectus, Homo heidelbergensis, Homo neanderthalensis, Homo sapiens.Themes of anatomy, DNA, global expansion, tool use, diet, communication, ecology, society, and culture run through the section.Glossary/Index/Acknowledgements

    Traveling through the dizzying expanse of geologic time—from prehistoric art in Norwegian sea caves, to the blue depths of the Greenland ice cap, to a deep-sunk "hiding place" where nuclear waste will be stored for 100,000 years to come—Underland takes us on an extraordinary journey into our relationship with darkness, burial, and what lies beneath the surface of both place and mind.Global in its geography and written with great lyricism, Underland speaks powerfully to our present moment. At once ancient and urgent, this is a book that will change the way you see the world.