These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Coffee. Sunscreen. Vapes. George Zaidan reveals what will kill you, what won't, and why--explained with high-octane hilarity, hysterical hijinks, and other things that don't begin with the letter H. INGREDIENTS offers the perspective of a chemist on the stuff we eat, drink, inhale, and smear on ourselves. Apart from the burning question of whether you should eat that Cheeto, Zaidan explores a range of topics. Here's a helpful guide:Stuff in this book: - How bad is processed food? How sure are we?- Is sunscreen safe? Should you use it?- Is coffee good or bad for you?- What's your disease horoscope?- What is that public pool smell made of?- What happens when you overdose on fentanyl in the sun?- What do cassava plants and Soviet spies have in common?- When will you die?Stuff in other books: - Your carbon footprint- Food sustainability- GMOs- CEO pay- Science funding- Politics- Football- Baseball- Any kind of ball reallyZaidan, an MIT-trained chemist who cohosted CNBC's hit Make Me a Millionaire Inventor and wrote and voiced several TED-Ed viral videos, makes chemistry more fun than Hogwarts as he reveals exactly what science can (and can't) tell us about the packaged ingredients sold to us every day. Sugar, spinach, formaldehyde, cyanide, the ingredients of life and death, and how we know if something is good or bad for us--as well as the genius of aphids and their butts--are all discussed in exquisite detail at breakneck speed.

    He's a man on a mission to save the world's most endangered plants from destruction and thieves hunting for wealthy collectors. He is a plant messiah.From the planet's tiniest waterlily - the Nymphaea thermarum - to Huarango trees with roots over 50 metres long, Carlos has a miraculous ability to bring breathtakingly beautiful plants back from the brink of extinction. He has travelled to the most remote and dangerous parts of the world - from the mountains of Peru to isolated Indian Ocean islands to the deepest Australian outback - in search of the rarest exotic species. Then, back in the Tropical Nursery at Kew, he uses pioneering, left-field techniques to help them grow.Now he's here to spread the gospel. The Plant Messiah is the inspirational story of a man who has devoted - and risked - his life to save incredible species, all in the name of making this Earth a greener and happier place. Amen to that.

    Wilczek’s groundbreaking work in quantum physics was inspired by his intuition to look for a deeper order of beauty in nature. In fact, every major advance in his career came from this intuition: to assume that the universe embodies beautiful forms, forms whose hallmarks are symmetry—harmony, balance, proportion—and economy. There are other meanings of “beauty,” but this is the deep logic of the universe—and it is no accident that it is also at the heart of what we find aesthetically pleasing and inspiring.Wilczek is hardly alone among great scientists in charting his course using beauty as his compass. As he reveals in A Beautiful Question, this has been the heart of scientific pursuit from Pythagoras, the ancient Greek who was the first to argue that “all things are number,” to Galileo, Newton, Maxwell, Einstein, and into the deep waters of twentiethcentury physics. Though the ancients weren’t right about everything, their ardent belief in the music of the spheres has proved true down to the quantum level. Indeed, Wilczek explores just how intertwined our ideas about beauty and art are with our scientific understanding of the cosmos.Wilczek brings us right to the edge of knowledge today, where the core insights of even the craziest quantum ideas apply principles we all understand. The equations for atoms and light are almost literally the same equations that govern musical instruments and sound; the subatomic particles that are responsible for most of our mass are determined by simple geometric symmetries. The universe itself, suggests Wilczek, seems to want to embody beautiful and elegant forms. Perhaps this force is the pure elegance of numbers, perhaps the work of a higher being, or somewhere between. Either way, we don’t depart from the infinite and infinitesimal after all; we’re profoundly connected to them, and we connect them. When we find that our sense of beauty is realized in the physical world, we are discovering something about the world, but also something about ourselves.Gorgeously illustrated, A Beautiful Question is a mind-shifting book that braids the age-old quest for beauty and the age-old quest for truth into a thrilling synthesis. It is a dazzling and important work from one of our best thinkers, whose humor and infectious sense of wonder animate every page. Yes: The world is a work of art, and its deepest truths are ones we already feel, as if they were somehow written in our souls.

    Someday, we know, we will all die. And, we know, so too will the universe itself.Until the End of Time is Brian Greene's breathtaking new exploration of the cosmos and our quest to understand it. Greene takes us on a journey across time, from our most refined understanding of the universe's beginning, to the closest science can take us to the very end. He explores how life and mind emerged from the initial chaos, and how our minds, in coming to understand their own impermanence, seek in different ways to give meaning to experience: in story, myth, religion, creative expression, science, the quest for truth, and our longing for the timeless, or eternal. Through a series of nested stories that explain distinct but interwoven layers of reality-from the quantum mechanics to consciousness to black holes-Greene provides us with a clearer sense of how we came to be, a finer picture of where we are now, and a firmer understanding of where we are headed.Yet all this understanding, which arose with the emergence of life, will dissolve with its conclusion. Which leaves us with one realization: during our brief moment in the sun, we are tasked with the charge of finding our own meaning.Let us embark.

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.

    Heath in the 1950s and '60s has been described as among the most controversial experiments in US history. His work was alleged at the time to be part of MKUltra, the CIA's notorious "mind control" project. His research subjects included incarcerated convicts and gay men who wished to be "cured" of their sexual preference. Yet his cutting-edge research and legacy were quickly buried deep in Tulane University's archives. Investigative science journalist Lone Frank now tells the complete sage of this passionate, determined doctor and his groundbreaking neuroscience.More than fifty years after Heath's experiments, this very same treatment is becoming mainstream practice in modern psychiatry for everything from schizophrenia, anorexia, and compulsive behavior to depression, Parkinson's, and even substance addiction.Lone Frank uncovered lost documents and accounts of Heath's trailblazing work. She tracked down surviving colleagues and patients, and she delved into the current support for deep brain stimulation by scientists and patients alike. What has changed? Why do we today unquestioningly embrace this technology as a cure? How do we decide what is a disease of the brain to be cured and what should be allowed to remain unprobed and unprodded? And how do we weigh the decades of criticism against the promise of treatment that could be offered to millions of patients?Elegantly written and deeply fascinating, The Pleasure Shock weaves together biography, scientific history, and medical ethics. It is an adventure into our ever-shifting views of the mind and the fateful power we wield when we tinker with the self.

    William Maples can deduce the age, gender, and ethnicity of a murder victim, the manner in which the person was dispatched, and, ultimately, the identity of the killer.  In Dead Men Do Tell Tales, Dr. Maples revisits his strangest, most interesting, and most horrific investigations, from the baffling cases of conquistador Francisco Pizarro and Vietnam MIAs to the mysterious deaths of President Zachary Taylor and the family of Czar Nicholas II.

    Every person alive today is descended from him. How did this real-life Adam wind up as the father of us all? What happened to the descendants of other men who lived at the same time? And why, if modern humans share a single prehistoric ancestor, do we come in so many sizes, shapes, and races?Examining the hidden secrets of human evolution in our genetic code, Spencer Wells reveals how developments in the revolutionary science of population genetics have made it possible to create a family tree for the whole of humanity. Replete with marvelous anecdotes and remarkable information, from the truth about the real Adam and Eve to the way differing racial types emerged, The Journey of Man is an enthralling, epic tour through the history and development of early humankind.

    New technologies have revealed secrets locked in prehistoric bones that no one could have previously predicted. We can now work out the color of dinosaurs, the force of their bite, their top speeds, and even how they cared for their young.Remarkable new fossil discoveries—giant sauropod dinosaur skeletons in Patagonia, dinosaurs with feathers in China, and a tiny dinosaur tail in Burmese amber—remain the lifeblood of modern paleobiology. Thanks to advances in technologies and methods, however, there has been a recent revolution in the scope of new information gleaned from such fossil finds.In Dinosaurs Rediscovered, leading paleontologist Michael J. Benton gathers together all the latest paleontological evidence, tracing the transformation of dinosaur study from its roots in antiquated natural history to an indisputably scientific field. Among other things, the book explores how dinosaur remains are found and excavated, and especially how paleontologists read the details of dinosaurs’ lives from their fossils—their colors, their growth, and even whether we will ever be able to bring them back to life. Benton’s account shows that, though extinct, dinosaurs are still very much a part of our world.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

    Radiometric dating of nearby rocks indicated the skeleton, classified as Ardipithecus ramidus, was 4.4 million years old, more than a million years older than "Lucy," then the oldest known human ancestor. The findings challenged many assumptions about human evolution--how we started walking upright, how we evolved our nimble hands, and, most significantly, whether we were descended from an ancestor that resembled today's chimpanzee--and repudiated a half-century of paleoanthropological orthodoxy.Fossil Men is the first full-length exploration of Ardi, the fossil men who found her, and her impact on what we know about the origins of the human species. It is a scientific detective story played out in anatomy and the natural history of the human body. Kermit Pattison brings into focus a cast of eccentric, obsessive scientists, including one of the world's greatest fossil hunters, Tim White--an exacting and unforgiving fossil hunter whose virtuoso skills in the field were matched only by his propensity for making enemies; Gen Suwa, a Japanese savant who sometimes didn't bother going home at night to devote more hours to science; Owen Lovejoy, a onetime creationist-turned-paleoanthropologist; Berhane Asfaw, who survived imprisonment and torture to become Ethiopia's most senior paleoanthropologist and who fought for African scientists to gain equal footing in the study of human origins; and the Leakeys, for decades the most famous family in paloanthropology.An intriguing tale of scientific discovery, obsession and rivalry that moves from the sun-baked desert of Africa and a nation caught in a brutal civil war, to modern high-tech labs and academic lecture halls, Fossil Men is popular science at its best, and a must read for fans of Jared Diamond, Richard Dawkins, and Edward O. Wilson.

    John Snow. It's the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure—garbage removal, clean water, sewers—necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action—and ultimately solve the most pressing medical riddle of their time. In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories and inter-connectedness of the spread of disease, contagion theory, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.

    Nature hailed it as a book of grand and daunting sweep.... A splendid and rewarding tour de force. And New Scientist wrote that it captured the essence of modern biology, calling it an extremely significant book which, as a bonus, is very readable. Now, in The Origins of Life, Maynard Smith and Szathmary have completely rewritten Transitions to bring their ideas to a wider audience of general readers. Here is a brilliant, state-of-the-art account of how life evolved on earth, focusing primarily on six major transitions--dramatic breakthroughs in the way that information was passed between generations. The authors offer illuminating explorations of the origin of life itself, the arrival of the first cells with nuclei, the first reproduction by sexual means, the appearance of multicellular plants and animals, the emergence of cooperation and of animal societies, and the birth of language. The Origins of Life represents the thinking of two leading scientists on questions that engage us all--how life began and how it gradually evolved from tiny invisible cells into whales and trees and human beings.

    In movies, in novels, in comic strips, and on television, we’ve all seen dinosaurs—or at least somebody’s educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur, without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on Jurassic Park, and a pioneer in bringing paleontology into the twenty-first century, teams up with the editor of The New York Times’s Science Times section to reveal exactly what’s in store. In the 1980s, Horner began using CAT scans to look inside fossilized dinosaur eggs, and he and his colleagues have been delving deeper ever since. At North Carolina State University, Mary Schweitzer has extracted fossil molecules—proteins that survived 68 million years—from a Tyrannosaurus rex fossil excavated by Horner. These proteins show that T. rex and the modern chicken are kissing cousins. At McGill University, Hans Larsson is manipulating a chicken embryo to awaken the dinosaur within: starting by growing a tail and eventually prompting it to grow the forelimbs of a dinosaur. All of this is happening without changing a single gene. This incredible research is leading to discoveries and applications so profound they’re scary in the power they confer on humanity. How to Build a Dinosaur is a tour of the hot rocky deserts and air-conditioned laboratories at the forefront of this scientific revolution.