Your life, your thoughts, your diseases, and your health are all the function of cells.But what do you really know about what goes on inside you?The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant.The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world.Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover:A deeper understanding of how cells work and the basic nature of life on earth.Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research.The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells.The ability to make better decisions about health and to debunk the misinformation that comes in daily via media.Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    But what does the brain have to say about the way we carry our hearts? As technology advances to allow us more focused examination of the intricate dance our brains do with our environment, we can use science to shed new light on humanity’s oldest question, “What is this thing called love?”In each chapter of this lively, edgy adventure through the romantic brain, Kayt Sukel dives into the latest neuroscientific research concerning love and sex (even getting her brain scanned while having an orgasm) and what it really means for the way we approach our relationships. Dirty Minds asks age-old questions such as: What parts of the brain are involved with love? Is there really a “seven-year itch”? Why do good girls like bad boys? Is monogamy practical? How thin is that line between love and hate? Do mothers have a stronger bond with children than their fathers do? How do our childhood experiences affect our emotional control and who is at risk for love addiction? Yet this book offers an entirely fresh approach, explaining all the ways the brain can make or break us in love.

    As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

    Bill Rawls understands Lyme disease sufferers seeking clarity and relief because, like myself, he has experienced the pain and frustration firsthand. Through this ground-breaking book, he shares everything he has discovered on his journey to reclaiming his health... it may just be the answer you've been waiting for." – Neil Spector, MD, Author of Gone in a Heartbeat Lyme disease is one of the most puzzling illnesses on the planet. Anyone who has suffered from its debilitating symptoms knows the frustrations of trying to find a cure. Many sufferers drag themselves from one doctor or alternative practitioner to the next, getting lost in a maze of lab tests, prescription drugs, and treatments. Thousands of dollars and months (or years) later, they realize they are no better off than where they started. Unlocking Lyme puts an end to this desperate quest. Written by Dr. Bill Rawls, a physician who overcame Lyme disease himself, this book is a comprehensive, practical resource full of solutions that work. What took Dr. Rawls 10 years to learn through intense research and personal experience, you can now learn and implement in a matter of months. DR. RAWLS’ STORY Dr. Rawls was in the middle of a successful OB/GYN career when Lyme disease interrupted his life. In his struggle to overcome it, he explored every treatment option – from conventional medicine to the full range of alternative therapies. Ultimately, he embraced modern herbal therapy as his preferred solution, but he recognizes that the path may be different for each person. INSIDE THE BOOK Unlocking Lyme is the sum of Dr. Rawls’ experience, research, and practical solutions to date. The book is divided into four parts, each part addressing a critical aspect of recovery: PART 1 - Provides an overview of common misconceptions about what Lyme disease is (hint: it’s more than just a tick bite and Borrelia infection) PART 2 - Provides information on how to obtain a diagnosis, despite current limitations in diagnostic testing for Lyme PART 3 - Discusses limitations of long-term antibiotic use, and offers an overview of holistic and non-toxic therapies for healing and symptom control (including pain, depression, insomnia) PART 4 - Explains how to embrace a healthier lifestyle so you can stay well; learn how to strengthen your immune system, microbiome, and balance in your body In the years since his recovery, Dr. Rawls has helped thousands of patients find their path to healing from Lyme disease. Unlocking Lyme brings together Dr. Rawls’ accumulated knowledge and is the key you need to get your life back. TESTIMONIALS “Dr. Rawls understands the misery of chronic Lyme disease firsthand. Unlocking Lyme shares the approaches that he used to successfully recover his own health, and helps the reader understand that there is so much that can be done to regain a state of wellness and optimal health.” – Scott Forsgren Editor & Founder, BetterHealthGuy.com “Dr. Rawls has spoken on his approach to Lyme disease for the past several years; his comprehensive approach and lifestyle guidance has helped many of our members. We heartily endorse his approach to helping deal with the symptoms of Lyme and other tick-borne illnesses.” – John Dorney, President NC Lyme Disease Foundation "Unlocking Lyme delves into the science behind Lyme disease, explaining what it is, but more importantly how it can be overcome. Dr. Rawls carefully explains the various treatments for Lyme, leaving the reader feeling informed and empowered.

    Margaret I. Cuomo is inspired to seek out new strategies for waging a smarter war on cancer.This year, about 1.6 million new cases of cancer will be diagnosed and more than 1,500 people will die "per day." We've been asked to accept the disappointing strategy to "manage cancer as a chronic disease." We've allowed pharmaceutical companies to position cancer drugs that extend life by just weeks and may cost $100,000 for a single course of treatment as breakthroughs. Where is the bold leadership that will transform our system from treatment to prevention? Have we forgotten the mission of the National Cancer Act of 1971 to "conquer cancer"?Through an analysis of more than 40 years of medical evidence and interviews with the top cancer researchers, drug company executives, and health policy advisers, Dr. Cuomo reveals intriguing answers to these questions. She shows us how all cancer stakeholders--the pharmaceutical industry, the government, physicians, and concerned Americans--can change the way we view and fight cancer in this country.

    His previous books include Before the Big Bang (St Martin's Griffin, 2011) and Inflight Science (Totem Books, 2011).

     An excerpt from Chapter 4 – A Force For Change “… In the grand scheme of diabetes self-management, I explain to patients and families that I (the doctor) don’t “manage” anyone’s diabetes. My role is more like that of a coach, occasional cheerleader, mentor, and at times role model I suppose. It truly is the sum of your choices; not mine or your doctor’s. Simply receiving diabetes education is often not enough. I see a three step process at work, and often times we barely get past the frst step. What we call “diabetes education” is intended to result in understanding on the part of the person(s) receiving it. But that is not the fnal element. Understanding should translate into behavior or actions for the education “loop” to be intact. There are many highly intelligent and understanding individuals in the criminal justice system who are well educated and understand all too well their actions, even the illegal ones. So what does all this have to do with using a CGM? In my opinion, it means all the difference in the world. It morphs a CGM device from a simple high or low blood alarm system (not a bad thing by itself) into the key for unlocking a vast new universe of diabetes self-realization that could once only be dreamed about. Basic diabetes self-care can be drawn as a decision loop. This loop is actually being executed daily by most persons with diabetes albeit often in a mindless fashion. Turning this chore into a more mindful action loop transforms this into an incredible tool for attaining the best blood sugar control possible for you. Like any loop, Sugar Surfing has no beginning or end. I tend to jump in at the point I call “monitoring”. This embodies many inputs both measurable and subjective. Most of us think of the act of measuring a blood sugar level with a meter or CGM device. But it’s more than that. It’s also being “in the moment”. That means being aware of recent, current and impending actions that are known to affect the ebb and fow of blood sugar levels in the body. Since blood sugar levels can be unpredictable, staying “in the moment” is a about the only approach that works for anticipating, or at least quickly reacting to unexpected shifts in BG. Once the status of the system (your body) has been sized up, either through the act of measuring a glucose level or glancing at the screen of your CGM device (or both), the next step is to analyze what is going on. This involves pulling in memories of recent actions (last insulin dose, most recent bout of exercise, what and how much was eaten (or will be soon) and more. The analysis step is where all of the little inputs come together for a final determination which is the next step: decision- making. Deciding is prioritizing one or more actions based on all the possible actions. The one that seems to be the best option is placed at the top of the list to be acted upon. Back up options are most likely numerous, but an initial action is required. The fnal part of our loop is execution: the act of following through on our decision. Immediately afterwards we are moving back into monitoring to determine the effect of our action and then modifying it as needed. You are probably saying “I already do this” and you would be right. But as has been written about by many authors, many of our decisions are mindless as opposed to mindful. This loop is a skill as much as it is a process. And as such, skills are practicable and can improve over time, or grow rusty with disuse.

    It was Aaron Sorkin versus Tina Fey, and it was clear which series critics thought was more promising. The Baltimore Sun called it a competition 30 Rock “can’t win.” By November, the New York Times was noting lackluster ratings for both shows, and adding that 30 Rock was “perilously close to a flop.” But while Studio 60 was canceled after 22 episodes, Fey’s madcap buddy comedy lasted 138 episodes. It resurrected the career of Alec Baldwin, survived an extended absence by Tracy Morgan, and permeated the culture—it’s breakneck pacing, oddball characters, and extremely rich joke writing are deeply beloved by millions of fans. In this combination of narrative and oral history, culture writer and editor Mike Roe brings to life the history of the gloriously goofy show through interviews with the creators, stars, writers, and bit players.

    Today, says Dale Purves, the dominant research agenda may have taken us as far as it can--and neuroscientists may be approaching a paradigm shift. In this highly personal book, Purves reveals how we got to this point and offers his notion of where neuroscience may be headed next. Purves guides you through a half-century of the most influential ideas in neuroscience and introduces the extraordinary scientists and physicians who created and tested them. Purves offers a critical assessment of the paths that neuroscience research has taken, their successes and their limitations, and then introduces an alternative approach for thinking about brains. Building on new research on visual perception, he shows why common ideas about brain networks can't be right and uncovers the factors that determine our subjective experience. The resulting insights offer a deeper understanding of what it means to be human. - Why we need a better conception of what brains are trying to do and how they do it Approaches to understanding the brain over the past several decades may be at an impasse - The surprising lessons that can be learned from what we see How complex neural processes owe more to trial-and-error experience than to logical principles - Brains--and the people who think about them Meet some of the extraordinary individuals who've shaped neuroscience - The -ghost in the machine- problem The ideas presented further undermine the concept of free will

    Oz ShowTwo top doctors present a comprehensive, light-hearted guide for the hypochondriac in all of us.Christopher Kelly, MD, and Marc Eisenberg, MD, FACC, are both highly accomplished physicians and health experts from UNC Health and Columbia University Medical Center. In Am I Dying?!, Dr. Kelly and Dr. Eisenberg walk you through common symptoms and medical myths to provide a helpful, conversational guide on what to do when you experience symptoms – offering advice on whether to chill out, make a doctor’s appointment, or go to the hospital.Most new symptoms turn out to be minor. Most likely, a stuffy nose isn’t a sign of cancer. But sometimes a headache isn’t just a temporary nuisance and could be a sign of a serious condition. The internet can offer a wealth of data, but it can also be a source of harmful misinformation. So if you have a new symptom, how worried should you be?This down-to-earth, humorous symptom guide covers over forty different symptoms, organized into eight body areas – including head/neck, chest/back, belly, skin, and more. Some examples include:·          Belly:  When is bloating a sign of a serious problem? Why do some people feel nauseated all the time?·          Lady Parts :  How often do you really need a mammogram? When is a lump likely to be serious?·          Bathroom Trouble:  Why do some people pee so often (and can a bladder explode from holding it)? Packed with practical information and organized in a fun, easy-to-access format, Am I Dying?! is a perfect gift, medical resource, and must-have addition to your home library.

    Finding out where it came from and how it first jumped into people is an urgent priority, but early expectations that this would prove an easy question to answer have been dashed. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened.In this uniquely insightful book, a scientist and a writer join forces to try to get to the bottom of how a virus whose closest relations live in bats in subtropical southern China somehow managed to begin spreading among people more than 1,500 kilometres away in the city of Wuhan. They grapple with the baffling fact that the virus left none of the expected traces that such outbreaks usually create: no infected market animals or wildlife, no chains of early cases in travellers to the city, no smouldering epidemic in a rural area, no rapid adaptation of the virus to its new host--human beings.To try to solve this pressing mystery, Viral delves deep into the events of 2019 leading up to 2021, the details of what went on in animal markets and virology laboratories, the records and data hidden from sight within archived Chinese theses and websites, and the clues that can be coaxed from the very text of the virus's own genetic code.The result is a gripping detective story that takes the reader deeper and deeper into a metaphorical cave of mystery. One by one the authors explore promising tunnels only to show that they are blind alleys, until, miles beneath the surface, they find themselves tantalisingly close to a shaft that leads to the light.

    On playing fields across America, lives are being derailed by seemingly innocuous jolts to the head. From the peewees to the pros, concussions are reaching epidemic proportions. This book brings that hidden epidemic and its consequences out of the shadows. As frightening as the numbers are—estimates of sports-related concussions range from 1.6 million to 3.8 million annually in the United States—they can’t begin to explain the profound impact of a hidden health problem that can strike any of us. It is becoming increasingly clear that concussions, like severe head traumas, can rob us of our memory, our mental abilities, our very sense of self. Because the damage caused by a concussion is rarely visible to the naked eye or even on a brain scan, no one knows how many millions might be living lives devastated by an invisible injury too often shrugged off as “just a bump on the head.” This book puts a human face on a huge public health crisis. Through narratives that chronicle the poignant experiences of real people struggling with this invisible and often unrecognized brain injury, Linda Carroll and David Rosner bring home its potentially devastating consequences. Among those you will meet are a high school football player whose college dreams were derailed by a series of undiagnosed concussions, a hard-driving soccer star whose own struggles with concussions pushed her to crusade for safety reform as a coach and soccer mom, and an economist who lost her career because of lingering concussion symptoms from a fender bender. The Concussion Crisis weaves these human dramas with compelling stories of scientists and doctors who are unraveling the mysteries of how an invisible injury can wreak such havoc. It takes readers into the top labs, where scientists are teasing out what goes wrong in the brain after a jolt to the head, and into the nation’s leading concussion clinic, where patients get cutting-edge management and treatment. Carroll and Rosner analyze the cultural factors that allowed this burgeoning epidemic to fester unseen and untreated. They chronicle the growing public awareness sparked by the premature retirements of superstars like NFL quarterbacks Troy Aikman and Steve Young. And they argue for an immediate change in a macho culture that minimizes the dangers inherent in repeated jolts to the head. The Concussion Crisis sounds an urgent wake-up call to parents, coaches, trainers, doctors, and the athletes themselves. The book will stand as the definitive exploration of this heretofore-silent health crisis. It should be required reading for every parent with a child playing sports—in fact, by everyone who has ever suffered a hard bump on the head.

    Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission, to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.Ramey's pursuit of a diagnosis and cure for her own mysterious illness is a medical mystery that she says reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet, and social connection to the state of our microbiomes.

    Jonathan B. Tucker traces the history of the smallpox virus from its first recorded outbreak around 3700 B.C. through its use as the first biological warfare agent in human history, and draws some decisively important lessons for the future. In a timely debate, Tucker addresses the ever-growing concerns about the proliferation of the deadly smallpox virus and its use by terrorist organizations. Explaining how the eradication of the disease in the late 1970s encouraged military research and production of the virus, he exposes the failure of the Russian government to secure its remaining cold-war stockpiles, and evaluates the past and present measures undertaken by the United States to counter the existing dangers of a smallpox attack. Ultimately, he passionately argues for the strengthening of the existing legal ban on the development and possession of biological weapons. Impeccably researched, Scourge is as arresting as it is indispensable, and as William Beatty in Booklist raves, Tucker has a sense of ... history that helps him make the story of smallpox as disease and ... weapon fascinating and frightening. Scourge has been acclaimed as a concise, suspenseful and scientifically accurate narrative. -- The New York Times Book Review Tucker's fascinating, revealing book affords the reader a sobering look at this new type of warfare.... -- Chris Patsilelis, Houston Chronicle -- [Tucker] reports the debate evenhandedly and with telling detail. -- David Brown, The Washington Post Book World