With humor and insight, Melissa Mohr takes readers on a journey to discover how "swearing" has come to include both testifying with your hand on the Bible and calling someone a *#$&!* when they cut you off on the highway. She explores obscenities in ancient Rome and unearths the history of religious oaths in the Middle Ages, when swearing (or not swearing) an oath was often a matter of life and death. Holy Sh*t also explains the advancement of civility and corresponding censorship of language in the 18th century, considers the rise of racial slurs after World War II, examines the physiological effects of swearing and answers a question that preoccupies the FCC, the US Senate, and anyone who has recently overheard little kids at a playground: are we swearing more now than people did in the past?A gem of lexicography and cultural history, Holy Sh*t is a serious exploration of obscenity.

    That’s a mistake, Tim Harford says in The Data Detective. We shouldn’t be suspicious of statistics—we need to understand what they mean and how they can improve our lives: they are, at heart, human behavior seen through the prism of numbers and are often “the only way of grasping much of what is going on around us.” If we can toss aside our fears and learn to approach them clearly—understanding how our own preconceptions lead us astray—statistics can point to ways we can live better and work smarter.As “perhaps the best popular economics writer in the world” (New Statesman), Tim Harford is an expert at taking complicated ideas and untangling them for millions of readers. In The Data Detective, he uses new research in science and psychology to set out ten strategies for using statistics to erase our biases and replace them with new ideas that use virtues like patience, curiosity, and good sense to better understand ourselves and the world. As a result, The Data Detective is a big-idea book about statistics and human behavior that is fresh, unexpected, and insightful.

    In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?

    Peter Watson's hugely ambitious and stimulating history of ideas from deep antiquity to the present day—from the invention of writing, mathematics, science, and philosophy to the rise of such concepts as the law, sacrifice, democracy, and the soul—offers an illuminated path to a greater understanding of our world and ourselves.

    The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    Told here for the first time, the dramatic tale of how the secrets of the brain were discovered in seventeenth-century England unfolds against a turbulent backdrop of civil war, the Great Fire of London, and plague. At the beginning of that chaotic century, no one knew how the brain worked or even what it looked like intact. But by the century's close, even the most common conceptions and dominant philosophies had been completely overturned, supplanted by a radical new vision of man, God, and the universe. Presiding over the rise of this new scientific paradigm was the founder of modern neurology, Thomas Willis, a fascinating, sympathetic, even heroic figure at the center of an extraordinary group of scientists and philosophers known as the Oxford circle. Chronicled here in vivid detail are their groundbreaking revelations and the often gory experiments that first enshrined the brain as the physical seat of intelligence -- and the seat of the human soul. Soul Made Flesh conveys a contagious appreciation for the brain, its structure, and its many marvelous functions, and the implications for human identity, mind, and morality.

    My Family and Other Animals was intended to embrace the natural history of the island but ended up as a delightful account of Durrell’s family’s experiences, from the many eccentric hangers-on to the ceaseless procession of puppies, toads, scorpions, geckoes, ladybugs, glowworms, octopuses, bats, and butterflies into their home.

    He first revisits the old stories--Hermes in Greece, Eshu in West Africa, Krishna in India, Coyote in North America, among others--and then holds them up against the life and work of more recent creators: Picasso, Duchamp, Ginsberg, John Cage, and Frederick Douglass. Authoritative in its scholarship, loose-limbed in its style, Trickster Makes This World ranks among the great works of modern cultural criticism.

    Yet despite the devastation, this catastrophic event seems but a forgotten moment in the United States.American Pandemic offers a much-needed corrective to the silence surrounding the influenza outbreak. It sheds light on the social and cultural history of Americans during the pandemic, uncovering both the causes of the nation's public amnesia and the depth of the quiet remembering that endured. Focused on the primary players in this drama--patients and their families, friends, and community, public health experts, and health care professionals--historian Nancy K. Bristow draws on multiple perspectives to highlight the complex interplay between social identity, cultural norms, memory, and the epidemic. Bristow has combed a wealth of primary sources, including letters, diaries, oral histories, memoirs, novels, newspapers, magazines, photographs, government documents, and health care literature. She shows that though the pandemic caused massive disruption in the most basic patterns of American life, influenza did not create long-term social or cultural change, serving instead to reinforce the status quo and the differences and disparities that defined American life.As the crisis waned the pandemic slipped from the nation's public memory. The helplessness and despair Americans had suffered during the pandemic, Bristow notes, was a story poorly suited to a nation focused on optimism and progress. For countless survivors, though, the trauma never ended, shadowing the remainder of their lives with memories of loss. This book lets us hear these long-silent voices, reclaiming an important chapter in the American past.

    Growing up in Bangladesh in the 1980s, where the concept of women’s healthcare hardly existed, she understood how lucky she was to access the best in the world. But she couldn’t have been more wrong. Things started to go awry from the minute she stepped in the hospital, and after thirty hours of labor (two of which she spent pushing), Hossain’s epidural slipped. Her pain was so severe that she ran a fever of 104 degrees, and as she shook and trembled uncontrollably, the doctors finally performed an emergency C-section. Giving birth in the richest country on earth, Hossain never imagined she could die in labor. But she almost did. The experience put her on a journey to explore, understand, and share how women—especially women of color—are dismissed to death by systemic sexism in American healthcare. Following in the footsteps of feminist manifestos such as The Feminine Mystique and Rage Becomes Her, The Pain Gap is an eye-opening and stirring call to arms that encourages women to flip their “hysteria complex” on its head and use it to revolutionize women’s healthcare. This book tells the story of Hossain’s experiences—from growing up in South Asia surrounded by staggering maternal mortality rates to lobbying for global health legislation on Capitol Hill to nearly becoming a statistic herself. Along the way, she realized that a little fury might be just what the doctor ordered. Meticulously researched and deeply reported, this book explores real women’s traumatic experiences with America’s healthcare system—and empowers everyone to use their experiences to bring about the healthcare revolution women need.

    The facts surrounding how male-centric medicine impacts women's health every day are chilling: in the ER, women are more likely to receive a psychiatric diagnosis with regard to opioid use, while men are more likely to be referred for detoxification; the more vocal women become about their pain, the more likely their providers are to prescribe either inadequate or inappropriate pain relief medication; women often present with nontraditional symptoms of stroke, which causes delays in recognition by both them and their health professionals; and a government accountability study found that 80% of drugs that are withdrawn from the market are due to side effects that happen to women (a result of testing drugs mostly on men).Leading expert on sex and gender medicine Dr. Alyson McGregor focuses on the key areas where these differences are most potentially harmful, addressing:Cardiac and stroke diagnosis and treatment in women;Prescription and dosing of pharmaceuticals;Subjective evaluation of women's symptoms;Pain and pain management;Hormones and female biochemistry (including prescribed hormones);How economic status, race, and gender identity are additional critical factors.Not only does Dr. McGregor explore these disparities in depth, she shares clear, practical suggestions for what we can do. A work of riveting expose, revelatory insights into the medical establishment and actionable guidance for putting this information to use, Sex Matters is an empowering roadmap for reinventing modern medicine -- and for self-care.

    In this new book Hawking takes us to the cutting edge of theoretical physics, where truth is often stranger than fiction, to explain in laymen's terms the principles that control our universe. Like many in the community of theoretical physicists, Professor Hawking is seeking to uncover the grail of science - the elusive Theory of Everything that lies at the heart of the cosmos. In his accessible and often playful style, he guides us on his search to uncover the secrets of the universe - from supergravity to supersymmetry, from quantum theory to M-theory, from holography to duality. He takes us to the wild frontiers of science, where superstring theory and p-branes may hold the final clue to the puzzle. And he lets us behind the scenes of one of his most exciting intellectual adventures as he seeks "to combine Einstein's General Theory of Relativity and Richard Feynman's idea of multiple histories into one complete unified theory that will describe everything that happens in the universe." With characteristic exuberance, Professor Hawking invites us to be fellow travelers on this extraordinary voyage through space-time. Copious four-color illustrations help clarify this journey into a surreal wonderland where particles, sheets, and strings move in eleven dimensions; where black holes evaporate and disappear, taking their secret with them; and where the original cosmic seed from which our own universe sprang was a tiny nut. The Universe in a Nutshell is essential reading for all of us who want to understand the universe in which we live. Like its companion volume, A Brief History of Time, it conveys the excitement felt within the scientific community as the secrets of the cosmos reveal themselves.

    Medieval dentists burned candles in patients' mouths to kill invisible worms gnawing at their teeth. Renaissance physicians, by law, timed surgical procedures with the position of the stars, and instructed epileptics to collect fresh blood from the newly beheaded. Highlighting bad science, oafish behavior, and stomach-turning procedures that hurt more than helped, Strange Medicine presents extraordinary but true facts and an honor roll of doctors, scientists, and dreamers who gave a whole new meaning to clinical trials!

    Astrophysicist Adam Frank traces the question of alien life and intelligence from the ancient Greeks to the leading thinkers of our own time, and shows how we as a civilization can only hope to survive climate change if we recognize what science has recently discovered: that we are just one of ten billion trillion planets in the Universe, and it’s highly likely that many of those planets hosted technologically advanced alien civilizations. What’s more, each of those civilizations must have faced the same challenge of civilization-driven climate change.Written with great clarity and conviction, Light of the Stars builds on the inspiring work of pioneering scientists such as Frank Drake and Carl Sagan, whose work at the dawn of the space age began building the new science of astrobiology; Jack James, the Texas-born engineer who drove NASA’s first planetary missions to success; Vladimir Vernadsky, the Russian geochemist who first envisioned the Earth’s biosphere; and James Lovelock and Lynn Margulis, who invented Gaia theory. Frank recounts the perilous journey NASA undertook across millions of miles of deep space to get its probes to Venus and Mars, yielding our first view of the cosmic laws of planets and climate that changed our understanding of our place in the universe.Thrilling science at the grandest of scales, Light of the Stars explores what may be the largest question of all: What can the likely presence of life on other worlds tell us about our own fate?

    Both Nick and his character, Ron Swanson, are known for their humor and patriotism in equal measure.After the great success of his autobiography, Paddle Your Own Canoe, Offerman now focuses on the lives of those who inspired him. From George Washington to Willie Nelson, he describes twenty-one heroic figures and why they inspire in him such great meaning. He combines both serious history with light-hearted humor—comparing, say, Benjamin Franklin’s abstinence from daytime drinking to his own sage refusal to join his construction crew in getting plastered on the way to work. The subject matter also allows Offerman to expound upon his favorite topics, which readers love to hear—areas such as religion, politics, woodworking and handcrafting, agriculture, creativity, philosophy, fashion, and, of course, meat.