The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    

    Over five decades, Star Trek's celebration of mankind's technical achievements and positive view of the future have earned it an enduring place in our global culture. Its scientific vision has also had a profound effect on the past thirty years of technological breakthroughs. Join William Shatner, the original captain of the Starship Enterprise, as he reveals how Star Trek has influenced and inspired some of our greatest scientific minds -- the people behind the future we will all share. In interviews with dozens of scientists we learn about the inventions that will revolutionise our lives and the discoveries that will make it truly possible to explore the last great frontier -- space. As one Nobel Laureate commented on being shown a wood and plastic model of the engine core from a Star Trek: The Next Generation starship: I'm working on that. From the technicalities of warp speed to real-life replicators to the likelihood of our being able to beam across continents, this always-informative book takes us on a fascinating and eye-opening voyage to

    This book--newly revised in 1995--systematically describes each of the primary characteristics of the tongue (body color, shape and coating) and their significance in the clinic. It traces the historical development of tongue diagnosis and its relationship to externally- contracted disorders and the eight principals. Featured in this revised edition are 59 color plates and accompanying case histories from the author's own practice. Other aspects of tongue diagnosis newly described in this edition include the integration of tongue and pulse diagnosis; the use of the tongue in diagnosing emotional problems; tongue diagnosis and herbal treatment; the tongue in prognosis; and special considerations regarding tongue diagnosis in children.

    Michael Mosley'This book is marvellous: buy it, share it, recommend it.... We are fortunate to have dedicated, caring and humble folks such as Doc Morgan on the Critical Care front line. We are even better off when a writer can capture all that this exciting, mad, glorious and even exasperating job means. If you work in healthcare, know somebody that does, or simply inhabit a body then this book is for you: in fact it's critical.' Peter Brindley, Professor of Critical Care Medicine, Anesthesiology, Medical Ethics University of Alberta'Just wonderful. I love the exploration of what it means to survive, at what cost and so on. Such an important factor and it's a real problem with what we do. An old surgeon once told me ‘just because we can, doesn’t mean we should. Operating is the easiest thing in the world, not doing so is incredibly challenging’. A lovely book.' Dr Nikki Stamp FRACS Cardiothoracic and Transplant Surgeon and author of Can You Die of a Broken Heart?‘An illuminating, compassionate insight into the fascinating world of intensive care.’ Leah Hazzard, author of Hard PushedCritical is an intelligent, compelling and profoundly insightful journey into the world of intensive care medicine and the lives of people who have forever been changed by it. Being critically ill means one or more of your vital organs have failed – this could be your lungs, your heart, your kidneys, gut or even your brain. Starting with the first recognised case in which a little girl was saved by intensive care in 1952 in Copenhagen, Matt writes brilliantly about the fascinating history, practices and technology in this newest of all the major medical specialties. Matt guides us around the ICU by guiding us around the body and the different organs, and in this way, we learn not only the stories of many of the patients he’s treated over the years, but also about the various functions different parts of the body.   He draws on his time spent with real patients, on the brink of death, and explains how he and his colleagues fight against the odds to help them live. Happily many of his cases have happy endings, but Matt also writes movingly about those cases which will always remain with him – the cases where the mysteries of the body proved too hard to solve, or diagnoses came too late or made no difference to the outcome.

    The new edition is thoroughly updated, including most notably a new chapter on innate immunity, a capstone chapter on immune responses in time and space, and many new focus boxes drawing attention to exciting clinical, evolutionary, or experimental connections that help bring the material to life.See what's in the LaunchPad

    Immerse yourself in the history of medicine - a colourful story of skill, serendipity, trial and error, moments of genius, and dogged determination.From traditional chinese medicine to today's sophisticated gene therapies and robotic surgery, A Short History of Medicine combines riveting storytelling and beautiful images, historical accounts and lucid explanations, to illuminate the story of medicine through time.Witness early, bloody, anaesthetic-free operations; see the first crude surgical instruments; trace the mapping of the circulatory system; follow the painstaking detective work that led to the decoding of the human genome; and understand the role that potions, cures, therapies, herbal medicines, and drugs have played in the human quest to tame and conquer disease, injury, and death.A Short History of Medicine is an engrossing illustrated history and tale of drama and discovery that celebrates the milestones of medical history across generations and cultures.

    David B. Agus shared what he has learned from his work as a pioneering cancer doctor, revealing the innovative steps he takes to prolong the lives of not only cancer patients, but all those who want to enjoy a vigorous, lengthy life. Now Dr. Agus has turned his research into a practical and concise illustrated handbook for everyday living. A Short Guide to a Long Life is divided into three sections (What to Do, What to Avoid, and Doctor's Orders) that provide the definitive answers to many common and not-so-common questions: Who should take a baby aspirin daily? Are flu shots safe? What constitutes "healthy" foods? Are airport scanners hazardous? Dr. Agus believes optimal health begins with our daily routines. His book will help you develop new patterns of personal health care, using inexpensive and widely available tools that are based on the latest and most reliable science.

    Michael Swango: a deadly doctor who took genuine pleasure in poisoning his patients and colleagues. Killed at least 60 in an intercontinental murder spree.The Lainz Angels of Death: four lethal nurses who turned the geriatric ward at an Austrian hospital into their private killing field. Gwendolyn Graham & Cathy Wood: lesbian lovers who got their kicks by suffocating the elderly patients under their care. Teet Haerm: police pathologist who spent his nights hunting prostitutes in Stockholm, Sweden. Haerm actually performed autopsies on many of the women he’d killed.Orville Lynn Majors: an ICU nurse with a deep-seated hatred for his elderly patients, Majors is suspected of over 100 murders.Kimberly Saenz: addicted to prescription drugs and with her life falling apart around her, Saenz struck out at helpless patients, injecting them with bleach.Donald Harvey: dubbed the “Angel of Death,” Harvey killed at least seventy hospital patients by suffocation, poisoning, drug overdoses and other methods.Thomas Neill Cream: London's East End had barely recovered from Jack the Ripper when Dr. Cream arrived on the scene, dispensing agonizing death with his special little pills.˃˃˃ Plus 10 more sensational true crime cases….Scroll up and grab a copy today. Book Series by Robert Keller Most of my works cover serial killers, while the “Murder Most Vile” series covers individual true crime stories. These are the main collections; American Monsters 50 American Serial Killers You’ve Probably Never Heard Of Murder Most Vile Human Monsters British Monsters Australian Monsters Canadian Monsters German Monsters Cannibal Killers Plus various other standalone books, including the The Deadly Dozen, which is available as a free download on Amazon, and Serial Killers Unsolved, which you can get for free when signing up to my mailing list. Robert Keller’s True Crime eBook Categories: Serial Killers True Crime Serial Killer Biographies Murder and Mayhem True Murder Cases Serial Killer Case Files True Crime Short Stories

    As the current CEO of Children's National in Washington, D.C., the author presents an argument to place children's medical requirements and their need to thrive well into adulthood at the forefront of American medicine, and he admits that 'these kids have been my real teachers

    A school cafeteria lunch is infected with a drug-resistant strain of E. coli.... Thousands in a bustling shopping mall inhale a lethal mist of smallpox, turning each individual into a highly infectious agent of suffering and death....Dr. Michael Osterholm knows all too well the horrifying scenarios he describes. In this eye-opening account, the nation’s leading expert on bioterrorism sounds a wake-up call to the terrifying threat of biological attack — and America’s startling lack of preparedness. He demonstrates the havoc these silent killers can wreak, exposes the startling ease with which they can be deployed, and asks probing questions about America’s ability to respond to such attacks. Are most doctors and emergency rooms able to diagnose correctly and treat anthrax, smallpox, and other potential tools in the bioterrorist’s arsenal? Is the government developing the appropriate vaccines and treatments? The answers are here in riveting detail — what America has and hasn’t done to prevent the coming bioterrorist catastrophe. Impeccably researched, grippingly told, Living Terrors presents the unsettling truth about the magnitude of the threat. And more important, it presents the ultimate insider’s prescription for change: what we must do as a nation to secure our freedom, our future, our lives.

    This is the story of a surgeon in training and his adventures during the years of his residency.

    An unpopular war. A military and diplomatic team in disarray. Those are the challenges President Obama has faced as he attempts to make a success of U.S involvement in Afghanistan. They are also the challenges President Truman surmounted in the winter of 1950 as he began managing a war in Korea that risked becoming bigger and more costly. It was the first significant armed conflict of the Cold War: United States troops under the command of General Douglas MacArthur came to the aid of the South Koreans after North Korea invaded. When Communist China entered the conflict on the side of the North Koreans, the crisis seemed on the verge of flaring into a world war. Truman was determined not to let that happen. MacArthur kept urging a widening of the war into China itself and ignoring his Commander in Chief. On April 11, 1951, after MacArthur had “shot his mouth off,” as one diplomat put it, one too many times, Truman fired him. The story of their showdown—one of the most dramatic in U.S. history between a Commander in Chief and his top soldier in the field—is captured in all its detail by David McCullough in his biography Truman, and presented here in a e-book called Truman Fires MacArthur (an excerpt of Truman, McCullough’s Pulitzer Prize-winning biography), which was the headline carried in many newspapers around the country the next day. Truman Fires MacArthur will continue to ride the headlines. It will go on sale as an ebook just as the Rolling Stone profile that exposed General Stanley McChrystal’s insurrection and forced his resignation hits newsstands, and media coverage of the showdown continues to draw historical analogies between Truman and Obama.

    Then he caught a group of travellers stealing from his warehouse. A car chase, petrol bombing and court case later, and everything had changed.A marked man, Mike was forced to leave everything behind and move to the Peak District for a fresh start. But his old life was never far behind and when he fell for Rhoda, a Romany Gypsy, kin to the very people he was hiding from, he knew he wouldn't be safe for much longer . . .The Gypsy Code is a story of secret identity, revenge and forbidden love that's perfect for fans of Running with the Firm, Undercover and Soldier Spy.