Many of the most highly regarded citizens leaped from windows or jumped into the Rhone, screaming that their heads were made of copper, their bodies wrapped in snakes, their limbs swollen to gigantic size or shrunken to tiny appendages. Others ran through the streets, claiming to be chased by "bandits with donkey ears", by tigers, lions & other terrifying apparitions. Animals went berserk. Dogs ripped bark from trees until their teeth fell out. Cats dragged themselves along the floor in grotesque contortions. Ducks strutted like penguins. Villagers & animals died right & left. Bit by bit, the story behind the tragedy in Pont-St-Esprit--a tiny Provencial village of twisted streets that looks much today as it did in the Middle Ages--unfolded to doctors & toxcologists. That story, one of the most bizarre in modern medical history, is movingly recounted in The Day of St. Anthony's Fire. Throughout the Middle Ages & during other times in history, similar hallucinatory outbreaks occurred. They were called St. Anthony's Fire because it was believed that only prayers to the saint could hold the disease in check. Even modern medicine could find no way to check the disease. Drugs failed to bring even temporary relief. Hundreds in the village suffered for weeks, with total agonizing insomnia, never knowing when they might once more suddenly go berserk. The cause of St. Anthony's Fire was known since early history to be ergot, a mold found on rye grain that at rare times inexplicably became posionous enough to create monstrous hallucinations & death. In '51 little significance was attached to the fact that the base of ergot was lysergic acid, also the base for LSD, a drug just coming to the attention of scientists at the time--a drug so powerful that one eye-dropperful could cause as many as 5000 people to hallucinate for hours. At this point, the story becomes a vividly absorbing medical detective story demonstrating the possibility that a strange, spontaneous form of LSD might have caused the human tragedy that came to the hapless villagers of Pont-St-Esprit.

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change.Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code.Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

    The most up-to-date and beautifully illustrated text on the market, it has a strong molecular and cellular approach, firmly relating the molecular and cellular biological underpinnings of physiology to the study of human physiology and disease. Contributions from leading physiologists ensure authoritative, cutting-edge information, and thorough and consistent editing have produced a readable and student-friendly text.The smart way to study!Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

    The newly revised Fifth Edition has been significantly updated throughout and features substantially revised art and Running Problems in the book and on the reader Companion Website. Recognized as an extraordinary educator and active learning enthusiast, Dr. Silverthorn incorporates time-tested classroom techniques throughout the book and presents thorough, up-to-date coverage of new scientific discoveries, biotechnology techniques, and treatments of disorders. Dr. Silverthorn also co-authored the accompanying Student Workbook and Instructor Manual, ensuring that these ancillaries reinforce the pedagogical approach of the book.The Fifth Edition includes access to Interactive Physiology(R) 10-System Suite (IP-10), PhysioEx(TM) 8.0, A&P Flix animations in 3D, and The Physiology Place Companion Website. Key Topics: Introduction to Physiology, Molecular Interactions, Compartmentation: Cells and Tissues, Energy and Cellular Metabolism, Membrane Dynamics, Communication, Integration, Homeostasis, Introduction to the Endocrine System, Neurons: Cellular and Network Properties, The Central Nervous System, Sensory Physiology, Efferent Division: Autonomic and Somatic Motor Control, Muscles, Integrative Physiology I: Control of Body Movement, Cardiovascular Physiology, Blood Flow and the Control of Blood Pressure, Blood, Mechanics of Breathing, Gas Exchange and Transport, The Kidneys, Integrative Physiology II: Fluid and Electrolyte Balance, Digestion, Energy Balance and Metabolism, Endocrine Control of Growth and Metabolism, The Immune System, Integrative Physiology III: Exercise, Reproduction and DevelopmentMarket: Intended for those interested in learning the basics of human physiology

    In his delightfully down-to-earth style, he explores & explains a mind-boggling future of intelligent robots, extraterrestrial life & its consquences, & other provocative, fascinating quandries of the future we want to see today.

    Each bodily function is discussed from a variety of viewpoints: scientific, anthropological, historical, mythological, sociological, and artistic. Topics include constipation, the history and evolution of toilet paper, farting, urine, earwax, smegma, and many other engrossing topics!You think you know shit? How about: Scatological Lives of the Greats; Thomas Crapper, Closet Genius; Excrement in Psychoanalysis; Excretal Customs Worldwide; Bodily Functions in Literature & Cinema; Historical Applications of Excrement....Spend a little time getting to know yourself! Read all about Feces, Flatus, Vomit, Urine, Mucus, Menstruation, Saliva, Sweat, & more!

    

    Authors Peter Tompkins and Christopher Bird suggest that the most far-reaching revolution of the 20th century — one that could save or destroy the planet — may come from the bottom of your garden."Almost incredible ... bristles with plenty of hard facts and astounding scientific and practical lore." —S. K. Oberbeck, Newsweek“This fascinating book roams ... over that marvelous no man's land of mystical glimmerings into the nature of science and life itself." —Henry Mitchell, Washington Post Book World“If I can't ‘get inside a plant’ or ‘feel emanations’ from a plant and don't know anyone else who can. that doesn't detract one whit from the possibility that some people can and do. . . .According to The Secret Life of Plants, plants and men do inter-relate, with plants exhibiting empathetic and spiritual relationships and showing reactions interpreted as demonstrating physical-force connections with men. As my students say, ‘hey, wow!’"—Richard M. Klein, Professor of Botany, University of Vermont (in Smithsonian)

    Contributions from Michael Pollan, Andrew Weil, Eugenia Bone, and many more experts make Fantastic Fungi an awe-inspiring visual journey through the exotic, little-known realm of fungi and its amazing potential to positively influence our lives.An all-star team of professional and amateur mycologists, artists, foodies, ecologists, doctors, and explorers joined forces with time-lapse master Louie Schwartzberg to create Fantastic Fungi, the life-affirming, mind-bending film about mushrooms and their mysterious interwoven rootlike filaments called mycelium. What this team reveals will blow your mind and possibly save the planet. This visually compelling companion book of the same name, edited by preeminent mycologist Paul Stamets, will expand upon the film in every way through extended transcripts, new essays and interviews, and additional facts about the fantastic realm of fungi.Fantastic Fungi is at the forefront of a mycological revolution that is quickly going mainstream. In this book, learn about the incredible communication network of mycelium under our feet, which has the proven ability to restore the planet’s ecosystems, repair our health, and resurrect our symbiotic relationship with nature. Fantastic Fungi aspires to educate and inspire the reader in three critical areas: First, the text showcases research that reveals mushrooms as a viable alternative to Western pharmacology. Second, it explores studies pointing to mycelium as a solution to our gravest environmental challenges. And, finally, it details fungi’s marvelous proven ability to shift consciousness. Motivating both the visually stunning film and this follow-up book is an urgent mission to change human consciousness and restore our planet.

    From the research biologist who stung himself with every conceivable insect to the world's most murderous mammals, this book explores oft-ignored but alluring facets of biology, anatomy, space exploration, nature, and more. Featuring interviews with leading researchers in the field and a large dose of wit, the author reveals the most intriguing real-world applications of science in all their glory.

    The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences?Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine.Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

    Somehow, within each of our brains, billions of neurons work to create our conscious experience. How does this happen? Why do we experience life in the first person? After over twenty years researching the brain, world-renowned neuroscientist Anil Seth puts forward a radical new theory of consciousness and self. His unique theory of what it means to 'be you' challenges our understanding of perception and reality and it turns what you thought you knew about yourself on its head.'Awe-inspiring and humane.' NEW STATESMAN (Books of the Year)'Fascinating.' FINANCIAL TIMES (Books of the Year)'Profound.' GUARDIAN (Books of the Year)'Brilliant.' CLAIRE TOMALIN, NEW YORK TIMES'Outstanding.' PSYCHOLOGY TODAY 'Amazing . . . a brilliant read.'RUSSELL BRAND'Beautifully written, crystal clear, deeply insightful.'DAVID EAGLEMAN, Pulitzer Prize-nominated author of Livewired'Offers us new cause for astonishment and wonder.'ANNAKA HARRIS, author of Conscious'A fascinating book. A joy to read.'NIGEL WARBURTON'Truly compelling.'PROFESSOR KARL FRISTON, Universty College London'A wonderfully accessible and comprehensive account.'SEAN CARROLL, author of Something Deeply Hidden

    Weed. Grass. Mary Jane. We all think we know what cannabis is and what we use it for. But do we? Our collective understanding of this surprising plant has been muddled by politics and morality; what we think we know isn’t the real story.A war on cannabis has been waged in the United States since the early years of the twentieth century, yet in the past decade, society has undergone a massive shift in perspective that has allowed us to reconsider our beliefs. In Brave New Weed, Joe Dolce travels the globe to "tear down the cannabis closet" and de-mystify this new frontier, seeking answers to the questions we didn’t know we should ask.Dolce heads to a host of places, including Amsterdam, Israel, California, and Colorado, where he skillfully unfolds the odd, shocking, and wildly funny history of this complex plant. From the outlandish stories of murder trials where defendants claimed "insanity due to marijuana consumption" to the groundbreaking success stories about the plant’s impressive medicinal benefits, Dolce paints a fresh and much-needed portrait of cannabis, our changing attitudes toward it, and the brave new direction science and cultural acceptance are leading us.Enlightening, entertaining, and thought-provoking, Brave New Weed is a compelling read that will surprise and educate proponents on both sides of the cannabis debate.

    In transcribing the 150-year-old manuscript’s cryptic handwriting and complex notations, Thoreau specialist Bradley Dean has performed a "heroic feat of decipherment" (Booklist) to bring this great work to light. Readers will discover "passages that reach for the transcendentalist ideal of writing new scriptures, yet grounding this Bible in a vision of practical ecology" (Boston). Beautifully illustrated throughout with line drawings of the natural life Thoreau considers on his walks, Wild Fruits is "well worth any nature lover’s attention" (Christian Science Monitor).