The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank.Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world.Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children.What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.From the Hardcover edition.

    How can we catch schools that cheat on standardized tests? How does Netflix know which movies you’ll like? What is causing the rising incidence of autism? As best-selling author Charles Wheelan shows us in Naked Statistics, the right data and a few well-chosen statistical tools can help us answer these questions and more.For those who slept through Stats 101, this book is a lifesaver. Wheelan strips away the arcane and technical details and focuses on the underlying intuition that drives statistical analysis. He clarifies key concepts such as inference, correlation, and regression analysis, reveals how biased or careless parties can manipulate or misrepresent data, and shows us how brilliant and creative researchers are exploiting the valuable data from natural experiments to tackle thorny questions.And in Wheelan’s trademark style, there’s not a dull page in sight. You’ll encounter clever Schlitz Beer marketers leveraging basic probability, an International Sausage Festival illuminating the tenets of the central limit theorem, and a head-scratching choice from the famous game show Let’s Make a Deal—and you’ll come away with insights each time. With the wit, accessibility, and sheer fun that turned Naked Economics into a bestseller, Wheelan defies the odds yet again by bringing another essential, formerly unglamorous discipline to life.

    Starting once again with fossils, he turns his gaze skyward, showing us how the entirety of the universe’s fourteen-billion-year history can be seen in our bodies. As he moves from our very molecular composition (a result of stellar events at the origin of our solar system) through the workings of our eyes, Shubin makes clear how the evolution of the cosmos has profoundly marked our own bodies. Fully illustrated with black and white drawings.

    For real.If you're like most people, geometry is a sterile and dimly remembered exercise you gladly left behind in the dust of ninth grade, along with your braces and active romantic interest in pop singers. If you recall any of it, it's plodding through a series of miniscule steps only to prove some fact about triangles that was obvious to you in the first place. That's not geometry. Okay, it is geometry, but only a tiny part, which has as much to do with geometry in all its flush modern richness as conjugating a verb has to do with a great novel.Shape reveals the geometry underneath some of the most important scientific, political, and philosophical problems we face. Geometry asks: Where are things? Which things are near each other? How can you get from one thing to another thing? Those are important questions. The word "geometry," from the Greek for "measuring the world." If anything, that's an undersell. Geometry doesn't just measure the world—it explains it. Shape shows us how.

    (The also-rans that year included Tom Wolfe, Verlyn Klinkenborg, and Oliver Sacks.) Hayes's work in this genre has also appeared in such anthologies as The Best American Magazine Writing, The Best American Science and Nature Writing, and The Norton Reader. Here he offers us a selection of his most memorable and accessible pieces--including "Clock of Ages"--embellishing them with an overall, scene-setting preface, reconfigured illustrations, and a refreshingly self-critical "Afterthoughts" section appended to each essay.

    Just how calculus makes these things possible and in doing so finds a correspondence between real numbers and the real world is the subject of this dazzling book by a writer of extraordinary clarity and stylistic brio. Even as he initiates us into the mysteries of real numbers, functions, and limits, Berlinski explores the furthest implications of his subject, revealing how the calculus reconciles the precision of numbers with the fluidity of the changing universe. "An odd and tantalizing book by a writer who takes immense pleasure in this great mathematical tool, and tries to create it in others."--New York Times Book Review

    Now, in The New Science of the Human Past, Reich describes just how the human genome provides not only all the information that a fertilized human egg needs to develop but also contains within it the history of our species. He delineates how the Genomic Revolution and ancient DNA are transforming our understanding of our own lineage as modern humans; how genomics deconstructs the idea that there are no biologically meaningful differences among human populations (though without adherence to pernicious racist hierarchies); and how DNA studies reveal the deep history of human inequality--among different populations, between the sexes, and among individuals within a population.

    It’s time we stand face-to-digital-face with the true powers and limitations of the algorithms that already automate important decisions in healthcare, transportation, crime, and commerce. Hello World is indispensable preparation for the moral quandaries of a world run by code, and with the unfailingly entertaining Hannah Fry as our guide, we’ll be discussing these issues long after the last page is turned.

    Yet today, science and its practitioners have come under political attack. In this fascinating history spanning continents and centuries, historian David Wootton offers a lively defense of science, revealing why the Scientific Revolution was truly the greatest event in our history.The Invention of Science goes back five hundred years in time to chronicle this crucial transformation, exploring the factors that led to its birth and the people who made it happen. Wootton argues that the Scientific Revolution was actually five separate yet concurrent events that developed independently, but came to intersect and create a new worldview. Here are the brilliant iconoclasts—Galileo, Copernicus, Brahe, Newton, and many more curious minds from across Europe—whose studies of the natural world challenged centuries of religious orthodoxy and ingrained superstition.From gunpowder technology, the discovery of the new world, movable type printing, perspective painting, and the telescope to the practice of conducting experiments, the laws of nature, and the concept of the fact, Wotton shows how these discoveries codified into a social construct and a system of knowledge. Ultimately, he makes clear the link between scientific discovery and the rise of industrialization—and the birth of the modern world we know.

    Taking us on a journey through every fundamental field of science, as well as the history of civilization, art, moral values, and the theory of political institutions, Deutsch tracks how we form new explanations and drop bad ones, explaining the conditions under which progress—which he argues is potentially boundless—can and cannot happen. Hugely ambitious and highly original, The Beginning of Infinity explores and establishes deep connections between the laws of nature, the human condition, knowledge, and the possibility for progress.

    There are deep connections between stars and atoms, between the cosmos and the microworld. Just six numbers, imprinted in the "big bang," determine the essential features of our entire physical world. Moreover, cosmic evolution is astonishingly sensitive to the values of these numbers. If any one of them were "untuned," there could be no stars and no life. This realization offers a radically new perspective on our universe, our place in it, and the nature of physical laws.

    And of course she was supposed to win. How Hillary Clinton lost the 2016 election to Donald Trump is the tragic story of a sure thing gone off the rails. For every Comey revelation or hindsight acknowledgment about the electorate, no explanation of defeat can begin with anything other than the core problem of Hillary's campaign--the candidate herself. Through deep access to insiders from the top to the bottom of the campaign, political writers Jonathan Allen and Amie Parnes have reconstructed the key decisions and unseized opportunities, the well-intentioned misfires and the hidden thorns that turned a winnable contest into a devastating loss. Drawing on the authors' deep knowledge of Hillary from their previous book, the acclaimed biography HRC, Shattered will offer an object lesson in how Hillary herself made victory an uphill battle, how her difficulty articulating a vision irreparably hobbled her impact with voters, and how the campaign failed to internalize the lessons of populist fury from the hard-fought primary against Bernie Sanders. Moving blow-by-blow from the campaign's difficult birth through the bewildering terror of election night, Shattered tells an unforgettable story with urgent lessons both political and personal, filled with revelations that will change the way readers understand just what happened to America on November 8, 2016.

    Like when doctors prescribed morphine for crying infants. When snorting skull moss was a cure for a bloody nose. When consuming mail-order tapeworms was a latter-day fad diet. Or when snake oil salesmen peddled strychnine (used in rat poison) as an aphrodisiac in the '60s. Seamlessly combining macabre humor with hard science and compelling storytelling, Quackery is a visually rich and information-packed exploration of history's most outlandish cures, experiments, and scams.A humorous book that delves into some of the wacky but true ways that humans have looked to cure their ills. Leeches, mercury, strychnine, and lobotomies are a few of the topics that explore the lengths society has gone in the search for health.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    With the stroke of a pen the Jesuit fathers banned the doctrine of infinitesimals, announcing that it could never be taught or even mentioned. The concept was deemed dangerous and subversive, a threat to the belief that the world was an orderly place, governed by a strict and unchanging set of rules. If infinitesimals were ever accepted, the Jesuits feared, the entire world would be plunged into chaos.In Infinitesimal, the award-winning historian Amir Alexander exposes the deep-seated reasons behind the rulings of the Jesuits and shows how the doctrine persisted, becoming the foundation of calculus and much of modern mathematics and technology. Indeed, not everyone agreed with the Jesuits. Philosophers, scientists, and mathematicians across Europe embraced infinitesimals as the key to scientific progress, freedom of thought, and a more tolerant society. As Alexander reveals, it wasn't long before the two camps set off on a war that pitted Europe's forces of hierarchy and order against those of pluralism and change.The story takes us from the bloody battlefields of Europe's religious wars and the English Civil War and into the lives of the greatest mathematicians and philosophers of the day, including Galileo and Isaac Newton, Cardinal Bellarmine and Thomas Hobbes, and Christopher Clavius and John Wallis. In Italy, the defeat of the infinitely small signaled an end to that land's reign as the cultural heart of Europe, and in England, the triumph of infinitesimals helped launch the island nation on a course that would make it the world's first modern state.From the imperial cities of Germany to the green hills of Surrey, from the papal palace in Rome to the halls of the Royal Society of London, Alexander demonstrates how a disagreement over a mathematical concept became a contest over the heavens and the earth. The legitimacy of popes and kings, as well as our beliefs in human liberty and progressive science, were at stake-the soul of the modern world hinged on the infinitesimal.