The books explores medical and scientific themes in a fictional way and it is difficult to think of an earlier book that does this. Although he was not a doctor, Sinclair Lewis's father was and he was greatly helped in the preparation of the manuscript by the science writer Paul de Kruif. It was de Kruif who brings a reality to the book that is almost biographical.This reality means that the books heralds the real impact of advances in drugs, public health, and immunology that were about to change the world. It also satirises those medical and scientific practitioners whose pursuit of fame and fortune, at the expense of truth, remains just as pertinent today.The book was first published in 1925 and was a popular and commercial success. It was awarded a Pulitzer Prize in 1926 which was refused by Sinclair Lewis. He was later to win the Nobel Prize for Literature—which he accepted.

    The unlikely thief, former child prodigy Benjamin Ziskind, is convinced that the painting once hung in his parents' living room. This work of art opens a door through which we discover his family's startling history--from an orphanage in Soviet Russia where Chagall taught to suburban New Jersey and the jungles of Vietnam.

    When his wife, Anna, comes to bring him home, she finds a man who remembers nothing, not even his own name. The removal of a small brain tumor saves his life, but his memories beyond the age of twelve are permanently lost.Here is the story of a keenly intelligent, sensitive man returned to a life in which everything is strange and new. An emigrant from his own life, set free from all that once defined him, Samson Greene believes he has nothing left to lose. So, when a charismatic scientist asks him to participate in a bold experiment, he agrees.Launched into a turbulent journey that takes him to the furthest extremes of solitude and intimacy, what he gains is nothing short of the revelation of what it means to be human.

    From Fourteenth Street to the Bowery, Delmonico's to the underbelly of the city waterfront, Dos Passos chronicles the lives of characters struggling to become a part of modernity before they are destroyed by it.More than seventy-five years after its first publication, Manhattan Transfer still stands as "a novel of the very first importance" (Sinclair Lewis). It is a masterpiece of modern fiction and a lasting tribute to the dual-edged nature of the American dream.

    Left to her own devices, Grady turns up the heat on the secret affair she's been having with a Brooklyn-born Jewish war veteran who works as a parking lot attendant. As the season passes, the romance turns more serious and morally ambiguous, and Grady must eventually make a series of decisions that will forever affect her life and the lives of everyone around her.

    Haunting, troubling, and mesmerizing, it shines a brilliant, unwavering light into the darkest recesses of a man’s psyche.To all appearances, John Wilder has all the trappings of success, circa 1960: a promising career in advertising, a loving family, a beautiful apartment, even a country home. John’s evenings are spent with associates at quiet Manhattan lounges and his weekends with friends at glittering cocktail parties. But something deep within this seemingly perfect life has long since gone wrong. Something has disturbed John’s fragile peace, and he can no longer find solace in fleeting affairs or alcohol. The anger, the drinking, and the recklessness are building to a crescendo—and they’re about to take down John’s family and his career. What happens next will send John on a long, strange journey—at once tragic and inevitable.

    In New Orleans in 1937, a man and a woman embark on a headlong flight into the wilderness of illicit passion, fleeing her husband and the temptations of respectability. In Mississippi ten years earlier, a convict sets forth across a flooded river, risking his own chance at freedom to rescue a pregnant woman. From these separate stories Faulkner composes a symphony of deliverance and damnation, survival and self-sacrifice, a novel in which elemental danger is juxtaposed wiht fatal injuries of the spirit. The Wild Palms is grandly inventive, heart-stopping in its prose, and suffused on every page with the physical presence of the country that Faulkner made his own.

    Set in a working-class Brooklyn neighborhood in 1947, this poignant tale revolves around two of the most endearing characters in recent fiction: an 11-year-old Irish Catholic boy named Michael Devlin and Rabbi Judah Hirsch, a refugee from Prague.

    Silicon Alley is a ghost town, Web 1.0 is having adolescent angst, Google has yet to IPO, Microsoft is still considered the Evil Empire. There may not be quite as much money around as there was at the height of the tech bubble, but there’s no shortage of swindlers looking to grab a piece of what’s left.Maxine Tarnow is running a nice little fraud investigation business on the Upper West Side, chasing down different kinds of small-scale con artists. She used to be legally certified but her license got pulled a while back, which has actually turned out to be a blessing because now she can follow her own code of ethics—carry a Beretta, do business with sleazebags, hack into people’s bank accounts—without having too much guilt about any of it. Otherwise, just your average working mom—two boys in elementary school, an off-and-on situation with her sort of semi-ex-husband Horst, life as normal as it ever gets in the neighborhood—till Maxine starts looking into the finances of a computer-security firm and its billionaire geek CEO, whereupon things begin rapidly to jam onto the subway and head downtown. She soon finds herself mixed up with a drug runner in an art deco motorboat, a professional nose obsessed with Hitler’s aftershave, a neoliberal enforcer with footwear issues, plus elements of the Russian mob and various bloggers, hackers, code monkeys, and entrepreneurs, some of whom begin to show up mysteriously dead. Foul play, of course.With occasional excursions into the DeepWeb and out to Long Island, Thomas Pynchon, channeling his inner Jewish mother, brings us a historical romance of New York in the early days of the internet, not that distant in calendar time but galactically remote from where we’ve journeyed to since.Will perpetrators be revealed, forget about brought to justice? Will Maxine have to take the handgun out of her purse? Will she and Horst get back together? Will Jerry Seinfeld make an unscheduled guest appearance? Will accounts secular and karmic be brought into balance?Hey. Who wants to know?

    When Elizabeth begins to suffer terrible migraines and backaches, her aunt takes her to the doctor, then to a psychiatrist. But slowly, and with Jackson's characteristic chill, we learn that Elizabeth is not just one girl—but four separate, self-destructive personalities. The Bird's Nest, Jackson's third novel, develops hallmarks of the horror master's most unsettling work: tormented heroines, riveting familial mysteries, and a disquieting vision inside the human mind.

    It is the story of Nedra and Viri, whose favored life is centered around dinners, ingenious games with their children, enviable friends, and near-perfect days passed skating on a frozen river or sunning on the beach. But even as he lingers over the surface of their marriage, Salter lets us see the fine cracks that are spreading through it, flaws that will eventually mar the lovely picture beyond repair. Seductive, witty, and elegantly nuanced, Light Years is a classic novel of an entire generation that discovered the limits of its own happiness—and then felt compelled to destroy it.

    The novel follows a young man, living in Manhattan as if he owned it, through nightclubs, fashion shows, editorial offices, and loft parties as he attempts to outstrip mortality and the recurring approach of dawn. With nothing but goodwill, controlled substances, and wit to sustain him in this anti-quest, he runs until he reaches his reckoning point, where he is forced to acknowledge loss and, possibly, to rediscover his better instincts. This remarkable novel of youth and New York remains one of the most beloved, imitated, and iconic novels in America.

    In Englander's amazingly taut and ambitious "The Twenty-seventh Man," a clerical error lands earnest, unpublished Pinchas Pelovits in prison with twenty-six writers slated for execution at Stalin's command, and in the grip of torture Pinchas composes a mini-masterpiece, which he recites in one glorious moment before author and audience are simultaneously annihilated. In "The Gilgul of Park Avenue," a Protestant has a religious awakening in the back of a New York taxi. In the collection's hilarious title story, a Hasidic man incensed by his wife's interminable menstrual cycle gets a dispensation from his rabbi to see a prostitute. The stories in For the Relief of Unbearable Urges are powerfully inventive and often haunting, steeped in the weight of Jewish history and in the customs of Orthodox life. But it is in the largeness of their spirit-- a spirit that finds in doubt a doorway to faith, that sees in despair a chance for the heart to deepen--and in the wisdom that so prodigiously transcends the author's twenty-eight years, that these stories are truly remarkable. Nathan Englander envisions a group of Polish Jews herded toward a train bound for Auschwitz and in a deft imaginative twist turns them into acrobats tumbling out of harm's way; he takes an elderly wigmaker and makes her, for a single moment, beautiful. Again and again, Englander does what feels impossible: he finds, wherever he looks, a province beyond death's dominion.For the Relief of Unbearable Urges is a work of stunning authority and imagination--a book that is as wondrous and joyful as it is wrenchingly sad, and that heralds the arrival of a profoundly gifted new storyteller.

    Was it an accident, a murder, a suicide? The circumstances of her death were never resolved, but O’Hara seized upon the tragedy to imagine the woman’s down-and-out life in New York City in the early 1930s. “O’Hara understood better than any other American writer how class can both reveal and shape character,” Fran Lebowitz writes in her Introduction. With brash honesty and a flair for the unconventional, BUtterfield 8 lays bare the unspoken and often shocking truths that lurked beneath the surface of a society still reeling from the effects of the Great Depression. The result is a masterpiece of American fiction.

    Unfolding over four tumultuous weeks in present-day Washington, D.C., Here I Am is the story of a fracturing family in a moment of crisis. As Jacob and Julia Bloch and their three sons are forced to confront the distances between the lives they think they want and the lives they are living, a catastrophic earthquake sets in motion a quickly escalating conflict in the Middle East. At stake is the meaning of home - and the fundamental question of how much aliveness one can bear. Showcasing the same high-energy inventiveness, hilarious irreverence, and emotional urgency that readers loved in his earlier work, Here I Am is Foer's most searching, hard-hitting, and grandly entertaining novel yet. It not only confirms Foer's stature as a dazzling literary talent but reveals a novelist who has fully come into his own as one of our most important writers.