In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing.   When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud.   But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes.   Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.

    How did the table fork acquire a fourth tine?  What advantage does the Phillips-head screw have over its single-grooved predecessor? Why does the paper clip look the way it does? What makes Scotch tape Scotch?   In this delightful book Henry Petroski takes a microscopic look at artifacts that most of us count on but rarely contemplate, including such icons of the everyday as pins, Post-its, and fast-food "clamshell" containers.  At the same time, he offers a convincing new theory of technological innovation as a response to the perceived failures of existing products—suggesting that irritation, and not necessity, is the mother of invention.

    Gut, an international bestseller, gives the alimentary canal its long-overdue moment in the spotlight. With quirky charm, rising science star Giulia Enders explains the gut’s magic, answering questions like: Why does acid reflux happen? What’s really up with gluten and lactose intolerance? How does the gut affect obesity and mood? Communication between the gut and the brain is one of the fastest-growing areas of medical research—on par with stem-cell research. Our gut reactions, we learn, are intimately connected with our physical and mental well-being. Enders’s beguiling manifesto will make you finally listen to those butterflies in your stomach: they’re trying to tell you something important.

    Today, more than sixty years later, members of a new generation of scientists are attempting to create life from the ground up. Science has moved forward in leaps and bounds since Schrodinger's time, but our understanding of what does and does not constitute life has only grown more complex. An era that has already seen computer chip-implanted human brains, genetically engineered organisms, genetically modified foods, cloned mammals, and brain-dead humans kept alive by machines is one that demands fresh thinking about the concept of life. While a segment of our national debate remains stubbornly mired in moral quandaries over abortion, euthanasia, and other right to life issues, the science writer Ed Regis demonstrates how science can and does provide us with a detailed understanding of the nature of life. Written in a lively and accessible style, and synthesizing a wide range of contemporary research, What Is Life? is a brief and illuminating contribution to an age-old debate.

    In all the current highly publicized debates about creationism and its descendant "intelligent design," there is an element of the controversy that is rarely mentioned—the "evidence," the empirical truth of evolution by natural selection. Even Richard Dawkins and Stephen Jay Gould, while extolling the beauty of evolution and examining case studies, have not focused on the evidence itself. Yet the proof is vast, varied, and magnificent, drawn from many different fields of science. Scientists are observing species splitting into two and are finding more and more fossils capturing change in the past—dinosaurs that have sprouted feathers, fish that have grown limbs. Why Evolution Is True weaves together the many threads of modern work in genetics, paleontology, geology, molecular biology, and anatomy that demonstrate the "indelible stamp" of the processes first proposed by Darwin. In crisp, lucid prose accessible to a wide audience, Why Evolution Is True dispels common misunderstandings and fears about evolution and clearly confirms that this amazing process of change has been firmly established as a scientific truth.

    Reveals how to run an online business profitably in spite of the Internet's inherently free culture, disseminating the principles of a ''priceless economy'' in six categories that pertain to advertising, labor exchange, and advanced-version fees.

    But what happens when we hit a wall and weight loss stalls, energy flags, or we're tired of restricted eating? We're not cavemen anymore, so why should we follow a strict caveman diet? In YOUR PERSONAL PALEO CODE, Chris Kresser uses the Paleo diet as a baseline from which you can tailor the ideal three-step program-Reset, Rebuild, Revive-to fit your lifestyle, body type, genetic blueprint, and individual needs. Kresser helps further personalize your prescription for specific health conditions, from heart disease and high blood pressure to thyroid disorders and digestive problems. Along with a 7-day meal plan and delectable, nutritious recipes, YOUR PERSONAL PALEO CODE offers natural solutions and an avalanche of groundbreaking advice on how to restore a healthy gut and immune system; how to eliminate toxins; which fats to eat liberally; how to choose the healthiest proteins; and much more. Best of all, you only have to follow the program 80% of the time; there's room to indulge in moderation while still experiencing dramatic results. Based on cutting-edge scientific research, YOUR PERSONAL PALEO CODE is designed to be flexible and user-friendly, with helpful charts, quizzes, and effective action steps to help you lose weight, reverse disease, and stay fit and healthy for life.

    The book has the hallmark features for which Lippincott's Illustrated Reviews volumes are so popular: an outline format, over 600 full-color illustrations, end-of-chapter summaries, review questions, plus an entire section of clinical case studies with full-color illustrations. This edition's medical/clinical focus has been sharpened to provide a high-yield review. Five additional case studies have been included, bringing the total to nineteen. Review questions have been reformatted to comply with USMLE Step 1 style, with clinical vignettes.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    In the past, discoveries often had to wait for the rise of the next generation to see questions in a new light and let go of old truisms. Today, in a world that is defined by a rapid rate of change, staying on the cutting edge has as much to do with shedding outdated notions as adopting new ones. In this spirit, John Brockman, publisher of the online salon Edge.org ("the world's smartest website"—The Guardian), asked 175 of the world's most influential scientists, economists, artists, and philosophers: What scientific idea is ready for retirement?Jared Diamond explores the diverse ways that new ideas emerge * Nassim Nicholas Taleb takes down the standard deviation * Richard Thaler and novelist Ian McEwan reveal the usefulness of "bad" ideas * Steven Pinker dismantles the working theory of human behavior * Richard Dawkins renounces essentialism * Sherry Turkle reevaluates our expectations of artificial intelligence * Physicist Andrei Linde suggests that our universe and its laws may not be as unique as we think * Martin Rees explains why scientific understanding is a limitless goal * Alan Guth rethinks the origins of the universe * Sam Harris argues that our definition of science is too narrow * Nobel Prize winner Frank Wilczek disputes the division between mind and matter * Lawrence Krauss challenges the notion that the laws of physics were preordained * plus contributions from Daniel Goleman, Mihaly Csikszentmihalyi, Nicholas Carr, Rebecca Newberger Goldstein, Matt Ridley, Stewart Brand, Sean Carroll, Daniel C. Dennett, Helen Fisher, Douglas Rushkoff, Lee Smolin, Kevin Kelly, Freeman Dyson, and others.

    Algorithms have made our lives more efficient, more entertaining, and, sometimes, better informed. At the same time, complex algorithms are increasingly violating the basic rights of individual citizens. Allegedly anonymized datasets routinely leak our most sensitive personal information; statistical models for everything from mortgages to college admissions reflect racial and gender bias. Meanwhile, users manipulate algorithms to "game" search engines, spam filters, online reviewing services, and navigation apps.Understanding and improving the science behind the algorithms that run our lives is rapidly becoming one of the most pressing issues of this century. Traditional fixes, such as laws, regulations and watchdog groups, have proven woefully inadequate. Reporting from the cutting edge of scientific research, The Ethical Algorithm offers a new approach: a set of principled solutions based on the emerging and exciting science of socially aware algorithm design. Michael Kearns and Aaron Roth explain how we can better embed human principles into machine code - without halting the advance of data-driven scientific exploration. Weaving together innovative research with stories of citizens, scientists, and activists on the front lines, The Ethical Algorithm offers a compelling vision for a future, one in which we can better protect humans from the unintended impacts of algorithms while continuing to inspire wondrous advances in technology.

    In 1-2-3 Magic Teen, internationally renowned parenting expert Thomas W. Phelan explains how to better understand your teenager, which problems are not worth fighting over, and why your child's behavior likely matches the definition of a normal adolescent. With helpful, straightforward advice backed up by research and parent-tested strategies, 1-2-3 Magic Teen will help you establish a calmer, more respectful home and family life and show you how to guide your teenager into healthy, functional young adulthood. In this book, you'll find tools and advice tailored for the challenges of a teen lifestyle, including: Forgetting to do chores Absence in family outings Drop in grades Missed curfews Parties and drinking Work responsibilities

    Devastated by his betrayal, Maggie struggles to protect herself and her children from stigma, keeping the circumstances of her husband's death a secret for nearly twenty-five years. It is only when a journey of self-discovery aligns with her children's coming of age and a new world of sexual tolerance that she can finally embrace the truth and set herself free.With a foreword by Wall Street Journal editor Laura Landro and an afterword by Today show psychologist Dr. Dale Atkins, Now Everyone Will Know is an honest, unflinching look at the damaging nature of family secrets and an inspiring call to embrace every truth--the good, the bad, the ugly--that makes us who we are.

    Now, in a tour-de-force narrative twenty years in the making, Ashton leads us on a journey through humanity’s greatest creations to uncover the surprising truth behind who creates and how they do it. From the crystallographer’s laboratory where the secrets of DNA were first revealed by a long forgotten woman, to the electromagnetic chamber where the stealth bomber was born on a twenty-five-cent bet, to the Ohio bicycle shop where the Wright brothers set out to “fly a horse,” Ashton showcases the seemingly unremarkable individuals, gradual steps, multiple failures, and countless ordinary and usually uncredited acts that lead to our most astounding breakthroughs.Creators, he shows, apply in particular ways the everyday, ordinary thinking of which we are all capable, taking thousands of small steps and working in an endless loop of problem and solution. He examines why innovators meet resistance and how they overcome it, why most organizations stifle creative people, and how the most creative organizations work. Drawing on examples from art, science, business, and invention, from Mozart to the Muppets, Archimedes to Apple, Kandinsky to a can of Coke, How to Fly a Horse is a passionate and immensely rewarding exploration of how “new” comes to be.

    Genealogy is the second most popular hobby in the United States, and the outpouring of interest in it from the African American community has been remarkable. After personally and professionally delving into the phenomenon for more than a decade, Alondra Nelson realized that genetic testing is being used to grapple with the unfinished business of slavery. It is being used for reconciliation, to establish ties with African ancestral homelands, to rethink citizenship, and to make unprecedented legal claims for slavery reparations based on genetic ancestry. Arguing that DNA offers a new tool for enduring issues, Nelson shows that the social life of DNA is affecting and transforming twenty-first-century racial politics.