The bestselling A Level text which contains advice from leading authorities in the field of geography research.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Download issues at no extra cost from Archived Items. The Economist is the premier source for the analysis of world business and current affairs, providing authoritative insight and opinion on international news, world politics, business, finance, science and technology, as well as overviews of cultural trends and regular Special reports on industries and countries. Established in 1843 to campaign against the protectionist corn laws, The Economist remains, in the second half of its second century, true to the liberal principles of its founder. James Wilson, a hat maker from the small Scottish town of Hawick, believed in free trade, internationalism and minimum interference by government, especially in the affairs of the market. The Economist also takes a fiercely independent stance on social issues, from gay marriage to the legalisation of drugs, but its main service to its readers is as a global newspaper: To uncover new ideas from all around the world. The Kindle Edition of The Economist contains all of the articles and graphics found in the print edition, but will not include all photos. For your convenience, issues are auto-delivered wirelessly to your Kindle each Friday at the same time the print edition hits the newsstand.

    An index and glossary are included.

    It's a game that's deceptively simple, yet within its easy framework you'll find truth and trickery, boredom and fear, skill and misfortune—in other words, all the things that make life fun and worth living! Texas Hold'em For Dummies introduces you to the fundamental concepts and strategies of this wildly popular game. It covers the rules for playing and betting, odds, etiquette, Hold'em lingo, and offers sound advice to avoid mistakes. This handy reference guide gives new and even seasoned players winning strategies and tactics not just for playing the game, but for winning. You'll learn: —Rules and strategies for limit, no-limit, tournament, and online play—How to play the other players—The importance of your bankroll—recommended sizes and more—Hands you should and should not play—How to camouflage your play and dodge traps—When, who, and how to bluff—How to maximize your win with check-raising and trapping—The different approaches for playing in private games, casinos, card rooms, tournaments, and on the Internet—How to use mathematics to your advantageTexas Hold 'Em is a game of both skill and chance. But it's a game that can be beaten, and whether you want to make money, sharpen your game, or just have a good time, Texas Hold 'Em for Dummies will give you the winning edge.

    

     Second Chances follows a single mother deserted by her adulterous ex-husband, a socialite who abandoned her family and fled to the Caribbean, a high-powered executive with a disconcerting fear of commitment and a questionable sense of judgment, and a privileged teenager plagued with a lecherous father and absentee mother while bewildered by an unforeseen opportunity with the most sought after boy in school. Although the women are each dealt cards they never expected, they find friendship, family and love in the least likely of places, and with those, they find hope.

    This new edition retains the basic format and pedagogical features of previous editions and provides an up-to-date foundation upon which more advanced and specialized knowledge can be built. This essential volume introduces and surveys the broad and complex interrelationships among food ingredients, processing, packaging, distribution and storage, and explores how these factors influence food quality and safety. Reflecting recent advances and emerging technologies in the area, this new edition includes updated commodity and ingredient chapters to emphasize the growing importance of analogs, macro-substitutions, fat fiber and sugar substitutes and replacement products, especially as they affect new product development and increasing concerns for a healthier diet. Revised processing chapters include changing attitudes toward food irradiation, greater use of microwave cooking and microwaveable products, controlled and modified atmosphere packaging and expanding technologies such a extrusion cooking, ohmic heating and supercritical fluid extraction, new information that addresses concerns about the responsible management of food technology, considering environmental, social and economic consequences, as well as the increasing globalization of the food industry. Discussions of food safety an consumer protection including newer phychrotropic pathogens; HAACP techniques for product safety and quality; new information on food additives; pesticides and hormones; and the latest information on nutrition labeling and food regulation. An outstanding text for students with little or no previous instruction in food science and technology, Food Science is also a valuable reference for professionals in food processing, as well as for those working in fields that service, regulate or otherwise interface with the food industry.

    Cave paintings of the giant beasts hint at the profound role they played in early human culture-our Ice Age ancestors built igloo-shaped huts out of mammoth bones and even feasted on mammoth tongues. Eager to uncover more clues to this mystical prehistoric age, explorers since the time of Peter the Great have scoured Siberia for mammoth remains. Now a new generation of explorers has taken to the tundra. Armed with GPS, ground-penetrating radar, and Soviet-era military helicopters, they seek an elusive prize: a mammoth carcass that will help determine how the creature lived, how it died-and how it might be brought back to life.In this adventure-filled narrative, science writer Richard Stone follows two teams of explorers-one Russian/Japanese, the other a French-led consortium-as they battle bitter cold, high winds, supply shortages, and the deeply rooted superstitions of indigenous peoples who fear the consequences of awakening the "rat beneath the ice." Stone travels from St. Petersburg to the Arctic Circle, from the North Sea to high-tech Japanese laboratories, as he traces the sometimes-surreal quest of these intrepid scientists, whose work could well rewrite our planet's evolutionary history. A riveting tale of high-stakes adventure and scientific hubris, Mammoth is also an intellectual voyage through uncharted moral terrain, as we confront the promise and peril of resurrecting creatures from the deep past.

    Known for its complete coverage of concepts and principles along with a more systematic and descriptive treatment of mineralogy, the revised edition now includes a CD-ROM to let readers see the minerals and crystals, while also viewing chemical composition, symmetry, and morphological crystallography.

    The latest version is far superior, both in content and presentation, to previous versions. I give it my highest recommendation."--"Doody's Review Service"From the authors of "Basic and Clinical Pharmacology," the leading pharmacology textbook, here is the newest edition of the best review book available for medical pharmacology course exams and board examinations. This skill-building guide comes with over 1000 review questions and answers -- far more than most other pharmacology reviews -- and a chapter-based approach that facilitates use with course notes or larger texts. Features: A new full-color presentation Organized to reflect course syllabi, focusing on the clinical use and pharmacology of drug categories, rather than individual drugs Two complete practice exams A valuable appendix of test-taking strategies Chapters that include valuable learning aids such as: --Short discussion of the major concepts that underlie basic principles or drug groups--Explanatory figures and tables--Review questions followed by answers and explanations--Drug Trees in drug-oriented chapters that visually organize drug groups--A list of high-yield terms and definitions you need to know Skill Keeper questions that prompt you to review previous material to understand links between related topics A checklist of tasks you should be able to do, once you have finished the chapter Summary Tables that list the important drugs and include key information about their mechanisms of action, effects, clinical uses, pharmacokinetics, drug interactions, and toxicities

    This book gives you a step-by-step guide to adjust your routine so you can be your best self." - Darin Suthapong, CEO of Indy Dish "The simplicity in message and actionable advice is packed to the brim in this book. I've found myself using this framework consistently at least once a day." - Kiran Pathakota, Senior Technical Product Manager at AmazonChange Your Default Settings and Change Your Course in LifeAt any given moment you're following pre-existing settings that direct your life along a certain path. They are your patterns of actions, words, and thoughts that have become ingrained over the years. The problem is that they may be taking your life in an unintended direction, limiting your growth both personally and professionally.In this short, visual, and action-oriented book, user experience expert Rad Wendzich offers a three-step guide to changing your recurring behaviors that too often go unexamined. Why change now? Most people don't change their defaults. When you do, you will stand out more from your peers. And the sooner you make the updates, the sooner you can reap the benefits.

    As our prehistoric ancestors spread throughout the globe, they began the most deadly epoch the planet's fauna have experienced since the demise of the dinosaurs. And following the dawn of the age of exploration five hundred years ago, the rate of extinction has accelerated ever more rapidly." In A Gap in Nature, scientist and historian Tim Flannery, in collaboration with internationally acclaimed wildlife artist Peter Schouten, catalogues 103 creatures that have vanished from the face of the earth since Columbus first set foot in the New World. From the colorful Carolina parakeet to the gigantic Steller's sea cow, Flannery evocatively tells the story of each animal and its habitat, how it lived and how it succumbed to its terrible destiny. Accompanying every entry is a beautifully rendered color representation by Schouten, who has devoted years of his life to this project. His portraits - life size in their original form - are exquisitely reproduced in this extraordinary book and include animals from every continent: American passenger pigeons, Tasmanian thylacines, Mauritian dodos, African bluebucks, and dozens more.

    New chapters cover criminal behavior theories and psychological profiling; autoerotic deaths, and occult crimes, plus two new chapters detailing infamous unsolved crimes/criminals: Jack the Ripper and the Jon Benet Ramsey case. The authors′ continuing research and activities in the field result in a multitude of new case studies for this book, often included as boxed inserts.

    is an American Board of Emergency Medicine certified ED doctor. His journey began in the mid-1970s, when he chose to pursue a career in medicine. In his youthful perspective, he came to regard doctors as the good guys, the ones who healed people and saved lives. He knew he’d be one of those good guys one day. Now, with a career spanning more than thirty years, he works as an emergency-room physician in North Carolina. In A License to Heal: Random Memories of an ER Doctor, Bentley describes the real world of emergency medicine from the viewpoint of a practicing physician. This memoir is filled with real-life stories of the ER, including life and death, triumph and tragedy. Meet a man named Solomon Darby, who spoke to long-dead relatives during his own near-death experience. Bentley also recalls the heartbreaking story of a young widow who desperately needed to understand and cope with the death of her husband. Amid the grief, there are also episodes of great humor and human comedy. In the dynamic world of emergency medicine, there is a great deal of pain, blood, and tragedy, but there is also hope, compassion, and excitement—for both the patients and the staff."