Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.

    In Me, Myself, and Why, Jennifer Ouellette dives into the miniscule ranges of variation to understand just what sets us apart. She draws on cutting-edge research in genetics, neuroscience, and psychology-enlivened as always with her signature sense of humor-to explore the mysteries of human identity and behavior. Readers follow her own surprising journey of self-discovery as she has her genome sequenced, her brain mapped, her personality typed, and even samples a popular hallucinogen. Bringing together everything from Mendel's famous pea plant experiments and mutations in The X-Men to our taste for cilantro and our relationships with virtual avatars, Ouellette takes us on an endlessly thrilling and illuminating trip into the science of ourselves

    Yet she spent much of her life disassociated from her own body—a disconnection brought on by her father’s sexual abuse and her mother’s remoteness. “Because I did not, could not inhabit my body or the Earth,” she writes, “I could not feel or know their pain.”But Ensler is shocked out of her distance. While working in the Congo, she is shattered to encounter the horrific rape and violence inflicted on the women there. Soon after, she is diagnosed with uterine cancer, and through months of harrowing treatment, she is forced to become first and foremost a body—pricked, punctured, cut, scanned. It is then that all distance is erased. As she connects her own illness to the devastation of the earth, her life force to the resilience of humanity, she is finally, fully—and gratefully—joined to the body of the world.Unflinching, generous, and inspiring, Ensler calls on us all to embody our connection to and responsibility for the world.http://us.macmillan.com/inthebodyofth...

    Here, nurses remember their first “sticks,” first births, and first deaths, and reflect on what gets them though long, demanding shifts, and keeps them in the profession. The stories reveal many voices from nurses at different stages of their careers: One nurse-in-training longs to be trusted with more “important” procedures, while another questions her ability to care for nursing home residents. An efficient young emergency room nurse finds his life and career irrevocably changed by a car accident. A nurse practitioner wonders whether she has violated professional boundaries in her care for a homeless man with AIDS, and a home care case manager is the sole attendee at a funeral for one of her patients. What connects these stories is the passion and strength of the writers, who struggle against burnout and bureaucracy to serve their patients with skill, empathy, and strength.

    By combining analysis of the historical evidence with the latest psychiatric research, Ghaemi demonstrates how he thinks these qualities have produced brilliant leadership under the toughest circumstances.individuals and society at large-however high the price for those who endure these illnesses.

    This is an incredible true account of investigative journalism and a devastating indictment of energy politics in America.Stacey Haney, a lifelong resident of Amity, Pennsylvania, is struggling to support her children when the fracking boom comes to town. Like most of her neighbors, she sees the energy companies' payments as a windfall. Soon trucks are rumbling down her unpaved road and a fenced-off fracking site rises on adjacent land. But her annoyance gives way to concern and then to fear as domestic animals and pets begin dying and mysterious illnesses strike her family--despite the companies' insistence that nothing is wrong.Griswold masterfully chronicles Haney's transformation into an unlikely whistle-blower as she launches her own investigation into corporate wrongdoing. As she takes her case to court, Haney inadvertently reveals the complex rifts in her community and begins to reshape its attitudes toward outsiders, corporations, and the federal government. Amity and Prosperity uses her gripping and moving tale to show the true costs of our energy infrastructure and to illuminate the predicament of rural America in the twenty-first century.

    And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    After vague, initial reports of terrified Chinese boiling vinegar to "purify" the air, Greenfeld and his staff soon found themselves immersed in the story of a lifetime.Deftly tracking a mysterious viral killer from the bedside of one of the first victims to China's overwhelmed hospital wards—from cutting-edge labs where researchers struggle to identify the virus to the war rooms at the World Health Organization headquarters in Geneva—China Syndrome takes readers on a gripping ride that blows through the Chinese government's effort to cover up the disease . . . and sounds a clarion call warning of a catastrophe to come: a great viral storm potentially more deadly than any respiratory disease since the influenza of 1918.

    Teresi introduces us to brain-death experts, hospice workers, undertakers, coma specialists and those who have recovered from coma, organ transplant surgeons and organ procurers, anesthesiologists who study pain in legally dead patients, doctors who have saved living patients from organ harvests, nurses who care for beating-heart cadavers, ICU doctors who feel subtly pressured to declare patients dead rather than save them, and many others. Much of what they have to say is shocking. Teresi also provides a brief history of how death has been determined from the times of the ancient Egyptians and the Incas through the twenty-first century. And he draws on the writings and theories of celebrated scientists, doctors, and researchers—Jacques-Bénigne Winslow, Sherwin Nuland, Harvey Cushing, and Lynn Margulis, among others—to reveal how theories about dying and death have changed. With The Undead, Teresi makes us think twice about how the medical community decides when someone is dead.

    However, in a country of more than 325 million people, addressing everyone's issues is challenging. How can we effect beneficial change for everyone so we all can thrive? What is the great equalizer?In this book, Daniel E. Dawes argues that political determinants of health create the social drivers--including poor environmental conditions, inadequate transportation, unsafe neighborhoods, and lack of healthy food options--that affect all other dynamics of health. By understanding these determinants, their origins, and their impact on the equitable distribution of opportunities and resources, we will be better equipped to develop and implement actionable solutions to close the health gap.Dawes draws on his firsthand experience helping to shape major federal policies, including the Affordable Care Act, to describe the history of efforts to address the political determinants that have resulted in health inequities. Taking us further upstream to the underlying source of the causes of inequities, Dawes examines the political decisions that lead to our social conditions, makes the social determinants of health more accessible, and provides a playbook for how we can address them effectively. A thought-provoking and evocative account that considers both the policies we think of as health policy and those that we don't, The Political Determinants of Health provides a novel, multidisciplinary framework for addressing the systemic barriers preventing the United States from becoming the healthiest nation in the world.

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    The facts surrounding how male-centric medicine impacts women's health every day are chilling: in the ER, women are more likely to receive a psychiatric diagnosis with regard to opioid use, while men are more likely to be referred for detoxification; the more vocal women become about their pain, the more likely their providers are to prescribe either inadequate or inappropriate pain relief medication; women often present with nontraditional symptoms of stroke, which causes delays in recognition by both them and their health professionals; and a government accountability study found that 80% of drugs that are withdrawn from the market are due to side effects that happen to women (a result of testing drugs mostly on men).Leading expert on sex and gender medicine Dr. Alyson McGregor focuses on the key areas where these differences are most potentially harmful, addressing:Cardiac and stroke diagnosis and treatment in women;Prescription and dosing of pharmaceuticals;Subjective evaluation of women's symptoms;Pain and pain management;Hormones and female biochemistry (including prescribed hormones);How economic status, race, and gender identity are additional critical factors.Not only does Dr. McGregor explore these disparities in depth, she shares clear, practical suggestions for what we can do. A work of riveting expose, revelatory insights into the medical establishment and actionable guidance for putting this information to use, Sex Matters is an empowering roadmap for reinventing modern medicine -- and for self-care.

    Blending personal stories from Martin's own history with accessible social science, cultural theory, and interviews with sex researchers, psychologists, primatologists, anthropologists, and real women from all walks of life, she reveals startling insights about female sexuality.

    The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard.Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.