Peter Stark offers a harrowing saga in which a band of explorers battled nature, starvation, and madness to establish the first American settlement in the Pacific Northwest and opened up what would become the Oregon trail, permanently altering the nation's landscape and its global standing.Six years after Lewis and Clark began their journey to the Pacific Northwest, two of the Eastern establishment's leading figures, John Jacob Astor and Thomas Jefferson, turned their sights to founding a colony akin to Jamestown on the West Coast and transforming the nation into a Pacific trading power. Author and correspondent for Outside magazine Peter Stark recreates this pivotal moment in American history for the first time for modern readers, drawing on original source material to tell the amazing true story of the Astor Expedition.Unfolding over the course of three years, from 1810 to 1813, Astoria is a tale of high adventure and incredible hardship in the wilderness and at sea. Of the more than one hundred-forty members of the two advance parties that reached the West Coast—one crossing the Rockies, the other rounding Cape Horn—nearly half perished by violence. Others went mad. Within one year, the expedition successfully established Fort Astoria, a trading post on the Columbia River. Though the colony would be short-lived, it opened provincial American eyes to the potential of the Western coast and its founders helped blaze the Oregon Trail.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    In only a few decades, the medical system has been overrun by organizations seeking to exploit for profit the trust that vulnerable and sick Americans place in their healthcare. Our politicians have proven themselves either unwilling or incapable of reining in the increasingly outrageous costs faced by patients, and market-based solutions only seem to funnel larger and larger sums of our money into the hands of corporations. Impossibly high insurance premiums and inexplicably large bills have become facts of life; fatalism has set in. Very quickly Americans have been made to accept paying more for less. How did things get so bad so fast?Breaking down this monolithic business into the individual industries--the hospitals, doctors, insurance companies, and drug manufacturers--that together constitute our healthcare system, Rosenthal exposes the recent evolution of American medicine as never before. How did healthcare, the caring endeavor, become healthcare, the highly profitable industry? Hospital systems, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Patients receive bills in code, from entrepreneurial doctors they never even saw.The system is in tatters, but we can fight back. Dr. Elisabeth Rosenthal doesn't just explain the symptoms, she diagnoses and treats the disease itself. In clear and practical terms, she spells out exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship and to hospital C-suites, explaining step-by-step the workings of a system badly lacking transparency. This is about what we can do, as individual patients, both to navigate the maze that is American healthcare and also to demand far-reaching reform. An American Sickness is the frontline defense against a healthcare system that no longer has our well-being at heart.

    Washington trusted them; relied on them. But unbeknownst to Washington, some of them were part of a treasonous plan. In the months leading up to the Revolutionary War, these traitorous soldiers, along with the Governor of New York William Tryon and Mayor David Mathews, launched a deadly plot against the most important member of the military: George Washington himself.This is the story of the secret plot and how it was revealed. It is a story of leaders, liars, counterfeiters, and jailhouse confessors. It also shows just how hard the battle was for George Washington—and how close America was to losing the Revolutionary War.Taking place during the most critical period of our nation’s birth, The First Conspiracy tells a remarkable and previously untold piece of American history that not only reveals George Washington’s character, but also illuminates the origins of America’s counterintelligence movement that led to the modern day CIA.

    Army and Navy from small towns and elite colleges, more than ten thousand women served as codebreakers during World War II. While their brothers and boyfriends took up arms, these women moved to Washington and learned the meticulous work of code-breaking. Their efforts shortened the war, saved countless lives, and gave them access to careers previously denied to them. A strict vow of secrecy nearly erased their efforts from history; now, through dazzling research and interviews with surviving code girls, bestselling author Liza Mundy brings to life this riveting and vital story of American courage, service, and scientific accomplishment.

    At its center stood two former military comrades locked in a struggle that tested the boundaries of our fledgling democracy. Jacksonland is their story. One man we recognize: Andrew Jackson—war hero, populist, and exemplar of the expanding South—whose first major initiative as president instigated the massive expulsion of Native Americans known as the Trail of Tears. The other is a half-forgotten figure: John Ross—a mixed-race Cherokee politician and diplomat—who used the United States’ own legal system and democratic ideals to oppose Jackson. Representing one of the Five Civilized Tribes who had adopted the ways of white settlers—cultivating farms, publishing a newspaper in their own language, and sending children to school—Ross championed the tribes’ cause all the way to the Supreme Court. He gained allies like Senator Henry Clay, Chief Justice John Marshall, and even Davy Crockett. In a fight that seems at once distant and familiar, Ross and his allies made their case in the media, committed civil disobedience, and benefited from the first mass political action by American women. Their struggle contained ominous overtures of later events like the Civil War and set the pattern for modern-day politics. At stake in this struggle was the land of the Five Civilized Tribes. In shocking detail, Jacksonland reveals how Jackson, as a general, extracted immense wealth from his own armies’ conquest of native lands. Later, as president, Jackson set in motion the seizure of tens of millions of acres—“Jacksonland”—in today’s Deep South. Jacksonland is the work of renowned journalist Steve Inskeep, cohost of NPR’s Morning Edition, who offers here a heart-stopping narrative masterpiece, a tragedy of American history that feels ripped from the headlines in its immediacy, drama, and relevance to our lives. Harrowing, inspiring, and deeply moving, Inskeep’s Jacksonland is the story of America at a moment of transition, when the fate of states and nations was decided by the actions of two heroic yet tragically opposed men.  CANDICE MILLARD, author of Destiny of the Republic and The River of Doubt “Inskeep tells this, one of the most tragic and transformative stories in American history, in swift, confident, colorful strokes. So well, and so intimately, does he know his subject that the reader comes away feeling as if Jackson and Ross’s epic struggle for the future of their nations took place yesterday rather than nearly two hundred years ago.”

    She was repeatedly hospitalized in excruciating pain, but the doctors insisted it was a urinary tract infection and sent her home with antibiotics. Unable to get out of bed, much less attend class, Norman dropped out of college and embarked on what would become a years-long journey to discover what was wrong with her. It wasn't until she took matters into her own hands--securing a job in a hospital and educating herself over lunchtime reading in the medical library--that she found an accurate diagnosis of endometriosis.In Ask Me About My Uterus, Norman describes what it was like to have her pain dismissed, to be told it was all in her head, only to be taken seriously when she was accompanied by a boyfriend who confirmed that her sexual performance was, indeed, compromised. Putting her own trials into a broader historical, sociocultural, and political context, Norman shows that women's bodies have long been the battleground of a never-ending war for power, control, medical knowledge, and truth. It's time to refute the belief that being a woman is a preexisting condition.

     Giving shape to the deep depression that pervaded Lincoln's adult life, Joshua Wolf Shenk's Lincoln's Melancholy reveals how this illness influenced both the president's character and his leadership. Lincoln forged a hard path toward mental health from the time he was a young man. Shenk draws from historical record, interviews with Lincoln scholars, and contemporary research on depression to understand the nature of his unhappiness. In the process, he discovers that the President's coping strategies—among them, a rich sense of humor and a tendency toward quiet reflection—ultimately helped him to lead the nation through its greatest turmoil.

    It was like roaring surf, one of them said later. Like a runaway two-horse team smashing through a fence, said another. A third firefighter jumped up from his chair to look out a window-"Oh my God!" he shouted to the other men, "Run!"A 50-foot-tall steel tank filled with 2.3 million gallons of molasses had just collapsed on Boston's waterfront, disgorging its contents as a 15-foot-high wave of molasses that at its outset traveled at 35 miles an hour. It demolished wooden homes, even the brick fire station. The number of dead wasn't known for days. It would be years before a landmark court battle determined who was responsible for the disaster.

     A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation s disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

    The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern tobacco plantations to the dense immigrant neighborhoods of northern cities to far-flung villages on the edges of the nascent American empire. In Pox, award-winning historian Michael Willrich offers a gripping chronicle of how the nation's continentwide fight against smallpox launched one of the most important civil liberties struggles of the twentieth century.At the dawn of the activist Progressive era and during a moment of great optimism about modern medicine, the government responded to the deadly epidemic by calling for universal compulsory vaccination. To enforce the law, public health authorities relied on quarantines, pesthouses, and "virus squads"-corps of doctors and club-wielding police. Though these measures eventually contained the disease, they also sparked a wave of popular resistance among Americans who perceived them as a threat to their health and to their rights.At the time, anti-vaccinationists were often dismissed as misguided cranks, but Willrich argues that they belonged to a wider legacy of American dissent that attended the rise of an increasingly powerful government. While a well-organized anti-vaccination movement sprang up during these years, many Americans resisted in subtler ways-by concealing sick family members or forging immunization certificates. Pox introduces us to memorable characters on both sides of the debate, from Henning Jacobson, a Swedish Lutheran minister whose battle against vaccination went all the way to the Supreme Court, to C. P. Wertenbaker, a federal surgeon who saw himself as a medical missionary combating a deadly-and preventable-disease.As Willrich suggests, many of the questions first raised by the Progressive-era antivaccination movement are still with us: How far should the government go to protect us from peril? What happens when the interests of public health collide with religious beliefs and personal conscience? In Pox, Willrich delivers a riveting tale about the clash of modern medicine, civil liberties, and government power at the turn of the last century that resonates powerfully today.

    The disaster not only changed the world’s perception of nuclear power and the science that spawned it, but also our understanding of the planet’s delicate ecology. With the images of the abandoned homes and playgrounds beyond the barbed wire of the 30-kilometer Exclusion Zone, the rusting graveyards of contaminated trucks and helicopters, the farmland lashed with black rain, the event fixed for all time the notion of radiation as an invisible killer.Chernobyl was also a key event in the destruction of the Soviet Union, and, with it, the United States’ victory in the Cold War. For Moscow, it was a political and financial catastrophe as much as an environmental and scientific one. With a total cost of 18 billion rubles—at the time equivalent to $18 billion—Chernobyl bankrupted an already teetering economy and revealed to its population a state built upon a pillar of lies. The full story of the events that started that night in the control room of Reactor No.4 of the V.I. Lenin Nuclear Power Plant has never been told—until now. Through two decades of reporting, new archival information, and firsthand interviews with witnesses, journalist Adam Higginbotham tells the full dramatic story, including Alexander Akimov and Anatoli Dyatlov, who represented the best and worst of Soviet life; denizens of a vanished world of secret policemen, internal passports, food lines, and heroic self-sacrifice for the Motherland. Midnight in Chernobyl, award-worthy nonfiction that reads like sci-fi, shows not only the final epic struggle of a dying empire but also the story of individual heroism and desperate, ingenious technical improvisation joining forces against a new kind of enemy.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    In addition to offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its effects, she suggests concrete steps we can take to cure it.

    C. Gwynne’s Empire of the Summer Moon spans two astonishing stories. The first traces the rise and fall of the Comanches, the most powerful Indian tribe in American history. The second entails one of the most remarkable narratives ever to come out of the Old West: the epic saga of the pioneer woman Cynthia Ann Parker and her mixed-blood son Quanah, who became the last and greatest chief of the Comanches. Although readers may be more familiar with the tribal names Apache and Sioux, it was in fact the legendary fighting ability of the Comanches that determined just how and when the American West opened up. Comanche boys became adept bareback riders by age six; full Comanche braves were considered the best horsemen who ever rode. They were so masterful at war and so skillful with their arrows and lances that they stopped the northern drive of colonial Spain from Mexico and halted the French expansion westward from Louisiana. White settlers arriving in Texas from the eastern United States were surprised to find the frontier being rolled backward by Comanches incensed by the invasion of their tribal lands. So effective were the Comanches that they forced the creation of the Texas Rangers and account for the advent of the new weapon specifically designed to fight them: the six-gun. The war with the Comanches lasted four decades, in effect holding up the development of the new American nation. Gwynne’s exhilarating account delivers a sweeping narrative that encompasses Spanish colonialism, the Civil War, the destruction of the buffalo herds, and the arrival of the railroads—a historical feast for anyone interested in how the United States came into being. Against this backdrop Gwynne presents the compelling drama of Cynthia Ann Parker, a lovely nine-year-old girl with cornflower-blue eyes who was kidnapped by Comanches from the far Texas frontier in 1836. She grew to love her captors and became infamous as the "White Squaw" who refused to return until her tragic capture by Texas Rangers in 1860. More famous still was her son Quanah, a warrior who was never defeated and whose guerrilla wars in the Texas Panhandle made him a legend. S. C. Gwynne’s account of these events is meticulously researched, intellectually provocative, and, above all, thrillingly told.