Progressing logically from a molecular understanding of receptors and drug actions to the clinical uses of the most important groups of drugs, it delivers the latest information on cannabinoids and rimonabant, Cox 2 inhibitors, pharmacogenetics, biopharmaceuticals, and drug abuse-as well as "lifestyle drugs" such as performance-enhancing substances, botulinum toxin, and Viagra?. And now, online access via STUDENT CONSULT makes it an even more effective learning resource

    About The Author: Henry Gray, F.R.S., Fellow of the royal college of Surgeons: Lecturer on anatomy at St. George?s Hospital Medical School. Table Of Contents: Descriptive and Surgical Anatomy The Articulations Muscles and Fasclae The Blood-vascular system The Lymphatics The Nervous system The Organs of special sense The Organs of Digestion The Organs of voice and respiration The urinary organs The Male Organs of Generation The Female Organs of Generation The Surgical Anatomy of Hernia Surgical Anatomy of the Perinaeum General Anatomy or Histology Embryology

    Its unique 'Frontiers' chapters cover materials science, nanotechnology, catalysis, and biological inorganic chemistry, and have been fully updated to reflect advances in these key areas of contemporary research and industrial application.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    For five years in his mid-twenties, he sailed on the BEAGLE around the world, exploring jungles, climbing mountains, trekking across deserts. With every new landfall, he had new adventures: he rode through bandit country, was thrown into jail by revolutionaries, took part in an armed raid with marines, survived two earthquakes, hunted and fished. He suffered the terrible cold and rain of Tierra del Fuego, the merciless heat of the Australian outback and the inner pangs of heartbreak. He also made the discoveries that finally led him to formulate his theory of Natural Selection as the driving force of evolution. The five-year voyage of the BEAGLE was the basis for all Darwin's later work; but it also turned him from a friendly idler into the greatest scientist of his century. Kevin Jackson is a writer, broadcaster and film-maker. His most recent book is Constellation of Genius: 1922 and All That Jazz (Farrar Strauss Giroux, 2013). He lives in Cambridge, England.

    The beginning chapters introduce basic chemical and biological concepts to provide students with the framework they need to comprehend physiological principles. The chapters that follow promote conceptual understanding rather than rote memorization of facts. Health applications are included throughout the book to heighten interest, deepen understanding of physiological concepts, and help students relate the material to their individual career goals. Every effort has been made to help students integrate related concepts and understand the relationships between anatomical structures and their functions.

    For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

    In this groundbreaking analysis, over thirty of the most popular treatments—acupuncture, homeopathy, aromatherapy, reflexology, chiropractic, and herbal medicines—are examined for their benefits and potential dangers. Questions answered include: What works and what doesn't? What are the secrets, and what are the lies? Who can you trust, and who is ripping you off? Can science decide what is best, or do the old wives' tales really tap into ancient, superior wisdom?In their scrutiny of alternative and complementary cures, authors Simon Singh and Edzard Ernst also strive to reassert the primacy of the scientific method as a means for determining public health practice and policy.

    Volume One covers the head, neck, and upper extremities. Volume 2 covers the trunk and lower extremities. Many of the black-and-white illustrations have been converted to color in this edition, and chapter figures include orientational diagrams to give students much needed structural references.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    Hundreds of 3D images take you through each of the body's systems, from skeleton and muscles to the skin and nails. Discover how every aspect of the body functions, how the heart beats, how we breathe, and how the body defends itself. Find out what can go wrong, with descriptions of the ways in which common disorders affect the body's systems.

    The book's hallmark values-accuracy, currency, and passion for teaching and learning-have made Campbell/Reece the most successful book for readers for seven consecutive editions. More than 6 million readers have benefited from "BIOLOGY's"clear explanations, carefully crafted artwork, and student-friendly narrative style.Introduction: Themes in the Study of Life, The Chemical Context of Life, Water and the Fitness of the Environment, Carbon and the Molecular Diversity of Life, The Structure and Function of Large Biological Molecules, A Tour of the Cell, Membrane Structure and Function, An Introduction to Metabolism, Cellular Respiration: Harvesting Chemical Energy, Photosynthesis, Cell Communication, The Cell Cycle, Meiosis and Sexual Life Cycles, Mendel and the Gene Idea, The Chromosomal Basis of Inheritance, The Molecular Basis of Inheritance, From Gene to Protein, Control of Gene Expression, Viruses, Biotechnology, Genomes and Their Evolution, Descent with Modification: A Darwinian View of Life, The Evolution of Populations, The Origin of Species, The History of Life on Earth, Phylogeny and the Tree of Life, Bacteria and Archaea, Protists, Plant Diversity I: How Plants Colonized Land, Plant Diversity II: The Evolution of Seed Plants, Fungi, An Introduction to Animal Diversity, Invertebrates, Vertebrates, Plant Structure, Growth, and Development, Transport in Vascular Plants, Soil and Plant Nutrition, Angiosperm Reproduction and Biotechnology, Plant Responses to Internal and External Signals, Basic Principles of Animal Form and Function, Animal Nutrition, Circulation and Gas Exchange, The Immune System, Osmoregulation and Excretion, Hormones and the Endocrine System, Animal Reproduction, Animal Development, Neurons, Synapses, and Signaling, Nervous Systems, Sensory and Motor Mechanisms, Animal Behavior, An Introduction to Ecology and the Biosphere, Population Ecology, Community Ecology, Ecosystems, Conservation Biology and Restoration Ecology.For readers interested in learning the basics of Biology.

    The DOs chronicles the development of this controversial medical movement from the nineteenth century to the present. Historian Norman Gevitz describes the philosophy and practice of osteopathy, as well as its impact on medical care. From the theories underlying the use of spinal manipulation developed by osteopathy's founder, Andrew Taylor Still, Gevitz traces the movement's early success, despite attacks from the orthodox medical community, and details the internal struggles to broaden osteopathy's scope to include the full range of pharmaceuticals and surgery. He also recounts the efforts of osteopathic colleges to achieve parity with institutions granting M.D. degrees and looks at the continuing effort by osteopathic physicians and surgeons to achieve greater recognition and visibility.In print continuously since 1982, The DOs has now been thoroughly updated and expanded to include two new chapters addressing recent and current challenges and to bring the history of the profession up to the beginning of the new millennium.

    * A large cross-section of organic reactions/mechanisms given with stereochemical implications. * Relationship between conformation and reactivity specially highlighted. * Instrumentation techniques relating to stereochemical investigation discussed in simple language.ABOUT THE BOOK:During recent years, stereochemistry has undergone a phenomenal growth both in theory and practice, with a concomitant increase of interest among the organic chemists, biological chemists, medicinal chemists, and pharmacologists. The present text provides an up-to-date, coherent, and comprehensive account of the subject starting from the fundamentals and leading up to the latest developments as far as practicable. Emphasis has been placed on a symmetry-based approach to molecular chirality, stereochemical terminologies (modern stereochemistry is replete with them), topicity and prostereoisomerism, conformational analysis, dynamic stereochemistry, chiroptical properties, and assignment of absolute configuration to chiral molecules. Dynamic stereochemistry has been discussed with reference to conformation-reactivity correlation, stereoselective synthesis, and pericyclic reactions. A large cross-section of organic reactions with stereochemical implication has been incorporated. Attempts have been made to familiarise the readers with modern instrumental techniques, nuclear magnetic resonance in particular, used for stereochemical investigation. Each chapter is provided with a summary which highlights the main points of the text. CONTENTS: * Molecular Geometry and Chemical Bonding * Molecular Symmetry and Chirality * Stereoisomerism: Definitions and Classifications * Stereoisomerism and Centre of Chirality * Stereoisomerism: Axial Chirality, Planar Chirality and Helicity * Topicity and Prostereoisomerism * Racemisation and Methods of Resolution * Determination of Configuration * Conformations of Acyclic Molecules * Conformations of Cyclic Systems: Monocyclic Compounds * Conformations of Cyclic Systems: Fused Ring and Bridged Ring Compounds * Dynamic Stereochemistry I: Conformation and Reactivity * Dynamic Stereochemistry II:Stereoselective Reactions * Dynamic Stereochemistry III:Pericyclic Reactions * Molecular Dissymmetry and Chiroptical Properties * Molecular Recognition: Chemical and Stereochemical AspectsREADERSHIP: * Graduate and postgraduate students of Chemistry courses * University and college libraries * Biochemists, Medical and Pharmacology students and other related professionalsNew Academic Science is a newly established Science, Technical and Medical publisher.We offer high level text and reference titles to the academic community. Written by leading scientists and academic professionals affiliated to prestigious institutions worldwide, our books bring into focus innovative research and the latest teaching theories and concepts. Some of the many areas we publish in include: -Electrical Engineering -Mechanical Engineering-Chemistry-Mathematics-Physics-Computer ScienceAbout the AuthorL.P. Singh, was a Professor in the Department of Electrical Engineering at Indian Institute of Technology, Kanpur. He obtained his Ph.D.degree in Electrical Engineering from I.I.T. Kanpur. Prof. Singh has got an experience of more than 40 years in teaching undergraduate as well as graduate classes in the areas of Electrical Science, Electrical Machines, Power System Analysis, Power System Dynamics, Advanced Protective Relaying, Power System Simulation and Modelling and Digital Protection etc. He has visited a number of reputed foreign universities and research organizations and has conducted seminars and has also worked as Research Associate at some places such as at BPAORE(USA). He has published more than 125 research papers in reputed international journals.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.