But ambition quickly took wing. The house swelled to 225 rooms and became - until 2012 when it was topped by the home of a billionaire in Mumbai, India – the world’s largest residence ever built for a private citizen. Here’s the story of the house that Vanderbilt built - from the gardens by Frederick Law Olmsted to the John Singer Sargent portraits that adorn its walls.

    The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    This book will equally deepen the awareness of clinicians and enlighten the lay reader. It is a gift to both.' Donald M. Berwick, MD, MPPIn this highly articulate, down-to-earth, generous book, Dr David Galler tells stories of life and death from his position as Intensive Care specialist at Middlemore Hospital. Written lyrically and warmly, these stories are based on real life events describing the everyday dilemmas and challenges that doctors and patients commonly face.It aims to explain and demystify much of the work doctors do, cast light on the workings of the medical establishment and how medicine operates, in the hope that it will encourage patients to seek to be better informed and play a greater role in the decisions that will affect them and their loved ones.It speaks to the resilience of individuals and families and their extraordinary generosity and dignity under the most extreme pressure. This book is about realistic optimism and is a celebration of life.It is also a very personal story about David Galler's life, his family and about his own slow coming of age as a doctor, from the sadness and helplessness he felt about his father's death to at last feeling that he was of some use to his most important patient, his mother.

    Nancy Butcher has gathered together some of the most unusual natural cures that have been proven effective today, and even throws in some unbelievable and-thankfully-abandoned therapies from times past.Filled with case histories of unique illnesses, historic documentation of strange medical practices, and the author's own insightful commentary, this book explains not only how to cure headaches, sleep better, and improve your sex life, but also that people with Cotard's syndrome actually believe they are dead.

    president's daughter?Brimming with answers to popular questions like these, The Best Bar Trivia Book Ever arms you with the knowledge your team needs to annihilate your bar trivia competition. This must-have guide features hundreds of facts, covering everything from sports and pop culture to history and science, so that you're always ready to deliver the ultimate trivia smackdown. You'll also get all the ins and outs of your favorite event with information on important bar trivia rules, assembling a team, and claiming victories week after week.Whether you're new to the scene or want to dominate at your local bar, this book will help your team outsmart the competition every single week!

    This is incidental as it is about neither of those industries in particular. It is about the magic and wonderment of those days as seen through the eyes of a child – my eyes! It is about the days when imagination was the biggest plaything that we possessed. The days when a plastic football provided a whole summer's play. It is about the scrapes that I found myself in and the things that I observed around me, and how they made me feel. All the stories are true and I personally experienced every one of them. The names of the characters have been changed. The reason being that I have no idea of the whereabouts of many of the characters contained within my stories, so I have no way of asking them for their permission to include them in this book. Some have possibly passed away, and it would be unfair of me to mention them without their blessing. Anyone who knows me will know who they are though.

    Based on the latest scientific discoveries, Dr Mosley provides a fascinating and detailed understanding of the secrets of this coronavirus, how it spreads, how it infects your body and how your immune system tries to fight back. With access to leading experts, he reports on the battle to find treatments and a safe and effective vaccine (ultimately, the only way to defeat the virus). Armed with the facts about Covid-19 you'll be in a better position to protect yourself and your family as the world begins to reopen. Eating well, sleeping soundly, exercising and managing stress are all vital for keeping your body and immune system in the best possible shape to fight the virus. These are areas where Dr Mosley, creator of the 5:2 diet, is well known for his science-based and practical approach.

    All three astronauts were experienced pilots and had dreams of one day walking on the moon, but little did they know, nor did anyone else, that once they entered the spacecraft that cold winter day they would never leave it alive. The Apollo program would be perilously close to failure before it ever got off the ground. But rather than dooming the space program, this tragedy caused the spacecraft to be completely overhauled, creating a stellar flying machine to achieve the program’s primary goal: putting man on the moon. Apollo 1 is a candid portrayal of the astronauts, the disaster that killed them, and its aftermath. In it, readers will learn: How the Apollo 1 spacecraft was doomed from the start, with miles of uninsulated wiring and tons of flammable materials in a pure oxygen atmosphere, along with a hatch that wouldn’t open How, due to political pressure, the government contract to build the Apollo 1 craft went to a bidder with an inferior plan How public opinion polls were beginning to turn against the space control before the tragedy and got much worse after Apollo 1 is about America fulfilling its destiny of man setting foot on the moon. It’s also about the three American heroes who lost their lives in the tragedy, but whose lives were not lost in vain.

    Over the next 3 centuries, it would grow to become one of the mightiest empires in the world, the Vijayanagara Empire. An empire dazzling in it's achievements, in it's riches, in it's arts. From it's founding, to it's fall after the Battle of Tallikota to the heights it achieved under Sri Krishna Deva Raya, City of Victory aims to recreate the splendor and glory of one of the most magnificent empires ev

    The Drive-By Truckers, as they named themselves, grew into one of the best and most consequential rock bands of the twenty-first century, a great live act whose songs deliver the truth and nuance rarely bestowed on Southerners, so often reduced to stereotypes.Where the Devil Don’t Stay tells the band’s unlikely story not chronologically but geographically. Seeing the Truckers’ albums as roadmaps through a landscape that is half-real, half-imagined, their fellow Southerner Stephen Deusner travels to the places the band’s members have lived in and written about. Tracking the band from Muscle Shoals, Alabama, to Richmond, Virginia, to the author’s hometown in McNairy County, Tennessee, Deusner explores the Truckers’ complex relationship to the South and the issues of class, race, history, and religion that run through their music. Drawing on new interviews with past and present band members, including Jason Isbell, Where the Devil Don’t Stay is more than the story of a great American band; it’s a reflection on the power of music and how it can frame and shape a larger culture.

    So what comes next? Growth will resume. But economic uncertainty will worsen, making what comes next not just a boom but a nerve-shattering SONIC BOOM. Gregg Easterbrook - who "writes nothing that is not brilliant" ("Chicago Tribune") - is a fount of unconventional wisdom, and over time, he is almost always proven right. Throughout 2008 and 2009, as the global economy was contracting and the experts were panicking, Easterbrook worked on a book saying prosperity is about to make its next big leap. Will he be right again? SONIC BOOM: Globalization at Mach Speed presents three basic insights. First, if you don't like globalization, brace yourself, because globalization has barely started. Easterbrook contends the world is about to become "far "more globally linked. Second, the next wave of global change will be primarily positive: economic prosperity, knowledge and freedom will increase more in the next 50 years than in all of human history to this point. But before you celebrate, Easterbrook further warns that the next phase of global change is going to drive us crazy. Most things will be good for most people - but nothing will seem certain for anyone. Each SONIC BOOM chapter is based on examples of cities around the world - in the United States, Europe, Russia, China, South America - that represent a significant Sonic Boom trend. With a terrific sense of humor, pitch-perfect reporting and clear, elegant prose, Easterbrook explains why economic recovery is on the horizon but why the next phase of global change will also give everyone one hell of a headache. "Forbes" calls Easterbrook "the best writer on complex topics in the United States" and SONIC BOOM will show you why.

    Furthermore, the current epidemic of chronic illness demands a new care standard that can break down the existing structural barriers to full resolution. It requires functional medicine. The Evolution of Medicine provides step-by-step instruction for building a successful "community micropractice," one that engages both the patient and practitioner in a therapeutic partnership focused on the body as a whole rather than isolated symptoms. This invaluable handbook will awaken health professionals to exciting new career possibilities. At the same time, it will alleviate the fear of abandoning a conventional medical system that is bad for doctors, patients, and payers, as well as being ineffectual in the treatment of chronic ailments. Welcome to a new world of modern medical care, delivered in a community setting. It's time to embrace the Evolution of Medicine and reignite your love for the art of healing.

    Among the women she profiles are Supreme Court Justice Sandra Day O'Connor, architect and urban planner Denise Scott Brown, and Mileva Maric Einstein, the scientist whose marriage to Einstein ended in tragedy.

    The title of his most famous work, Ab Urbe Condita ("From the Founding of the City"), expresses the scope and magnitude of Livy's undertaking. He wrote in a mixture of annual chronology and narrative. Livy claims that lack of historical data prior to the sacking of Rome in 387 BC by the Gauls made his task more difficult. He wrote the majority of his works during the reign of Augustus. However, he is often identified with an attachment to the Roman Republic and a desire for its restoration. His writing style was poetic and archaic in contrast to Caesar's and Cicero's styles. Also, he often wrote from the Romans' opponent's point of view in order to accent the Romans' virtues in their conquest of Italy and the Mediterranean.

    Still, this first-hand account does shed much light on what it was really like to come under the charge of many different Indian tribes.Although Brayton’s treatment was not entirely negative or positive, his frank and blunt story does much to dispel the romantic stories that have been perpetuated about young settlers’ children who became Indian chattel. It does much to tell true history and dispel any deliberate or accidental revisions. In many cases the Indians treated Brayton well, but there can be no doubt that they stole from him and his family a life that would end up confused and stuck between two worlds. Although Brayton did finally unite with many of his natural family, he never stopped identifying with Native Americans, and he was forced to leave an Indian wife and child behind. In fact, when the War of Rebellion or Civil War broke out, Brayton enlisted and served in an American Indian brigade. Chet DembeckPublisher of One