By 1988 she was living at home but was brain dead after a tragic cycle of misunderstanding, over-medication, and culture clash: "What the doctors viewed as clinical efficiency the Hmong viewed as frosty arrogance." The Spirit Catches You and You Fall Down is a tragedy of Shakespearean dimensions, written with the deepest of human feeling. Sherwin Nuland said of the account, "There are no villains in Fadiman's tale, just as there are no heroes. People are presented as she saw them, in their humility and their frailty—and their nobility.

    Aaron Berkowitz had just finished his neurology training when he was sent to Haiti on his first assignment with Partners In Health. There, he meets Janel, a 23-year-old man with the largest brain tumor Berkowitz or any of his neurosurgeon colleagues at Harvard Medical School have ever seen. Determined to live up to Partners In Health’s mission statement “to bring the benefits of modern medical science to those most in need,” Berkowitz tries to save Janel’s life by bringing him back to Boston for a 12-hour surgery.  In One by One by One, Berkowitz traces what he learns and grapples with as a young doctor trying to bridge the gap between one of the world’s richest countries and one of the world’s poorest to make the first big save of his medical career.As Janel and Berkowitz travel back and forth between the high-tech neurosurgical operating rooms of Harvard’s hospitals and Janel’s dirt-floored hut in rural Haiti, they face countless heart-wrenching twists and turns. Janel remains comatose for months after his surgery. It’s not clear he will recover enough to return to Haiti and be able to survive there. So he goes for a second brain surgery, a third, a fourth. Berkowitz brings the reader to the front lines of global humanitarian work as he struggles to overcome the challenges that arise when well-meaning intentions give rise to unintended consequences, when cultures and belief systems clash, and when it’s not clear what the right thing to do is, let alone the right way to do it. One by One by One is a gripping account of the triumphs, tragedies, and confusing spaces in between as an idealistic young doctor learns the hard but necessary lessons of living by the Haitian proverb tout moun se moun—every person is a person.

    Within a few short decades the most hostile of the world’s environments had all been conquered. Likewise, in the twentieth century, medicine transformed human life. Doctors took what was routinely fatal and made it survivable. As modernity brought us ever more into different kinds of extremis, doctors pushed the bounds of medical advances and human endurance. Extreme exploration challenged the body in ways that only the vanguard of science could answer. Doctors, scientists, and explorers all share a defining trait: they push on in the face of grim odds. Because of their extreme exploration we not only understand our physiology better; we have also made enormous strides in the science of healing.Drawing on his own experience as an anesthesiologist, intensive care expert, and NASA adviser, Dr. Kevin Fong examines how cuttingedge medicine pushes the envelope of human survival by studying the human body’s response when tested by physical extremes. Extreme Medicine explores different limits of endurance and the lens each offers on one of the systems of the body. The challenges of Arctic exploration created opportunities for breakthroughs in open heart surgery; battlefield doctors pioneered techniques for skin grafts, heart surgery, and trauma care; underwater and outer space exploration have revolutionized our understanding of breathing, gravity, and much more. Avant-garde medicine is fundamentally changing our ideas about the nature of life and death.Through astonishing accounts of extraordinary events and pioneering medicine, Fong illustrates the sheer audacity of medical practice at extreme limits, where human life is balanced on a knife’s edge. Extreme Medicine is a gripping debut about the science of healing, but also about exploration in its broadest sense—and about how, by probing the very limits of our biology, we may ultimately return with a better appreciation of how our bodies work, of what life is, and what it means to be human.

    Like when doctors prescribed morphine for crying infants. When snorting skull moss was a cure for a bloody nose. When consuming mail-order tapeworms was a latter-day fad diet. Or when snake oil salesmen peddled strychnine (used in rat poison) as an aphrodisiac in the '60s. Seamlessly combining macabre humor with hard science and compelling storytelling, Quackery is a visually rich and information-packed exploration of history's most outlandish cures, experiments, and scams.A humorous book that delves into some of the wacky but true ways that humans have looked to cure their ills. Leeches, mercury, strychnine, and lobotomies are a few of the topics that explore the lengths society has gone in the search for health.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    Christian W. McMillen provides a concise yet comprehensive account of pandemics throughout human history, illustrating how pandemic disease has shaped history and, at the same time, social behavior has influenced pandemic disease. Extremely interesting from a medical standpoint, the study of pandemics also provides unexpected, broader insights into culture and politics.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    I'm writing this third person like I give a shit. I don't. This is my therapy book. I'm writing it for me, and for every other nurse out there who is angry at how last year went down. I see you. You are not alone. In addition to being a nurse, I'm a professional author, and I kept track of last year as it was happening. So maybe laypeople can peek in a bit and understand what it was like to have portions of your country and family betray you while you went and risked your life. Here's how it begins: On April 25th, 2021 at 10:55 in the morning I messaged my girl’s chat group from where I work as a nurse on an ICU floor: “Nothing like feeling strongly suicidal at a job where you’re supposed to be keeping people alive,” and then tweeted that my “mental health wasn’t great” and deleted the twitter app off of my phone because I didn’t want to “overshare.” That I felt like dying. That I would’ve rather died than still be at work. *** There were roughly four million nurses in America, as of last year. Only 2.7 million soldiers fought in the Vietnam War. Soldiers who came back from Vietnam, after having witnessed -- and in some cases, participated in – atrocities were changed forever. It would be foolhardy to believe that you could send four million people into a wartime equivalent, without there being psychological consequences. And yet, that’s what America has done. We spent a year battling a largely unknown assailant, running low on gear, haunted by the fact that we could bring something deadly home, and getting coughed on by people who pretended that our fights were imaginary and, worse yet, that our struggles – watching people die, day after day, no matter what we did -- were literally unreal. Nurses are fucked up. We are going to continue to be fucked up for quite some time. And unless there’s an acknowledgement and a reckoning, healthcare as we know it in America’s going to be hamstrung for the next decade. I do not know a single nurse who doesn’t want another job right now. (If you don’t and you’re reading this, if you’re a pedi-nurse or something, congrats. Know that I am very jealous of you and your job satisfaction.) Even before covid, burn out levels in nurses were epic. In 2018 31.5% of those 4 million nurses changed jobs due to burn out. A fleeing brain drain is happening right now as I type, as nurses across the nation figure out what their safety and well-being looks like for them. Some people will wind up being stay-at-home-parents, some will go into R&D, and others will just retire a few years earlier then they had planned to, because there’s nothing like watching people die for year to make you think maybe you should go and live. (Unless you’re me, and yeah, we’ll get to that.) And? A large number of us hate a large number of you. (Although likely not the ‘you’ reading this book.) If you spent your pandemic fighting masks, voting for Trump, or going on vacation? Those of us with the blood you caused on our hands actively wish you ill. I’m just being honest. We’re going to remember, as we all go into this, our first safe summer. Because, unlike you, some of us will never get to forget. This really is a therapy book, and I really was (am?) suicidal. But unlike many in my nursing cohort who got through 2020, I am also a professional writer. I don’t know what I’m thinking half the time unless I write it down -- so I do. And I kept track of what was happening with me last year. I’m going to go back and cull through my personal journals, emails, and tweets, and share what being a nurse in 2020 was like with you. This book is going to be a kind of scrapbook in that sense, in that I have ancillary material that I’ll quote and share here, in addition to my original thoughts upon it. (Note: I won’t be cleaning up the grammar and spelling mistakes in my tweets, as they’re a matter of public record.) A lot of it is going to be immediate, and a lot of it is going to be raw. I’m not here to make apologies about how angry this book will be. I can’t, not when that’s the reason I’m writing it. Because I need to do something, anything, to quench this ember of hate I have in my heart. Jesus can’t touch it and neither can love. I need someone – you, if you’re reading this – to try and go there with me. I want to take you along and show you what it was like. I want to make you feel my fear and desperation, and this is going to be a ride far more intense than any Stephen King novel. You might learn some shit along the way – but mostly I just want to not be so alone. I know a lot of people want to shut the door on the past and move on the future, but to that I say, “How can I?” When this thread of betrayal that this country has woven through me is sewn so deep? I think this is the only thing I can do that will help to set me free. And so, now that you’re warned, let’s begin.

    A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.

    In a clear and accessible style, Frank M. Snowden reveals the ways that diseases have not only influenced medical science and public health, but also transformed the arts, religion, intellectual history, and warfare. A multidisciplinary and comparative investigation of the medical and social history of the major epidemics, this volume touches on themes such as the evolution of medical therapy, plague literature, poverty, the environment, and mass hysteria. In addition to providing historical perspective on diseases such as smallpox, cholera, and tuberculosis, Snowden examines the fallout from recent epidemics such as HIV/AIDS, SARS, and Ebola and the question of the world’s preparedness for the next generation of diseases.

    . .Our health care system is in critical condition. Each year, fewer Americans can afford it, fewer businesses can provide it, and fewer government programs can promise it for future generations.We need a cure, and we need it now.Harvard Business School's Clayton M. Christensen--whose bestselling The Innovator's Dilemma revolutionized the business world--presents The Innovator's Prescription, a comprehensive analysis of the strategies that will improve health care and make it affordable.Christensen applies the principles of disruptive innovation to the broken health care system with two pioneers in the field--Dr. Jerome Grossman and Dr. Jason Hwang. Together, they examine a range of symptoms and offer proven solutions.YOU'LL DISCOVER HOW"Precision medicine" reduces costs and makes good on the promise of personalized careDisruptive business models improve quality, accessibility, and affordability by changing the way hospitals and doctors workPatient networks enable better treatment of chronic diseasesEmployers can change the roles they play in health care to compete effectively in the era of globalizationInsurance and regulatory reforms stimulate disruption in health care

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    The 10,000 Year Explosion: How Civilization Accelerated Human Evolution

    Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses —deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak.Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.” Warren Andiman, MD is professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health.