We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    With a muckraker's passion, Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their efficacy. Tracing over three centuries of "cures" for madness, Whitaker shows how medical therapies have been used to silence patients and dull their minds. He tells of the eighteenth- and nineteenth-century practices of "spinning" the insane, extracting their teeth, ovaries, and intestines, and submerging patients in freezing water. The "cures" in the 1920s and 1930s were no less barbaric as eugenic attitudes toward the mentally ill led to brain-damaging lobotomies and electroshock therapy. Perhaps Whitaker's most damning revelation, however, is his report of how drug companies in the 1980s and 1990s skewed their studies in an effort to prove the effectiveness of their products. Based on exhaustive research culled from old patient medical records, historical accounts, numerous interviews, and hundreds of government documents, Mad in America raises important questions about our obligations to the mad, what it means to be "insane," and what we value most about the human mind.

    Many of the innovations that we think of as hallmarks of Western science had their roots in the Arab world of the middle ages, a period when much of Western Christendom lay in intellectual darkness. Jim al- Khalili, a leading British-Iraqi physicist, resurrects this lost chapter of history, and given current East-West tensions, his book could not be timelier. With transporting detail, al-Khalili places readers in the hothouses of the Arabic Enlightenment, shows how they led to Europe's cultural awakening, and poses the question: Why did the Islamic world enter its own dark age after such a dazzling flowering?

    After its founding in 509 BCE, Rome grew from an unremarkable Italian city-state to the dominant superpower of the Mediterranean world. Through it all, the Romans never allowed a single man to seize control of the state. Every year for four hundred years the annually elected consuls voluntarily handed power to their successors. Not once did a consul give in to the temptation to grab absolute power and refuse to let it go. It was a run of political self-denial unmatched in the history of the world. The disciplined Roman republicans then proceeded to explode out of Italy and conquer a world filled with petty tyrants, barbarian chieftains, and despotic kings.But the very success of the Republic proved to be its undoing. The republican system was unable to cope with the vast empire Rome ruled. Bankrolled by mountains of imperial wealth and without a foreign enemy to keep them united, ambitious Roman leaders began to stray from the republican austerity of their ancestors. Almost as soon as they had conquered the Mediterranean, Rome would become engulfed in violent political conflicts and civil wars that would destroy the Republic less than a century later.The Storm Before the Storm tells the story of the beginning of the end of the Roman Republic--the story of the first generation that had to cope with the dangerous new political environment made possible by Rome's unrivaled domination over the known world. The tumultuous years from 133-80 BCE set the stage for the fall of the Republic.The Republic faced issues like rising economic inequality, increasing political polarization, the privatization of the military, endemic social and ethnic prejudice, rampant corruption, ongoing military quagmires, and the ruthless ambition and unwillingness of elites to do anything to reform the system in time to save it--a situation that draws many parallels to present-day America. These issues are among the reasons why the Roman Republic would fall. And as we all know, those who do not learn from history are doomed to repeat it.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    It is told through the letters of Peter Abélard, a French philosopher and one of the greatest logicians of the twelfth century, and of his gifted pupil Héloïse. Through their impassioned writings unfolds the story of a romance, from its reckless, ecstatic beginnings through to public scandal, an enforced secret marriage and its devastating consequences. These eloquent and intimate letters express a vast range of emotions from adoration and devotion to reproach, indignation and grief, and offer a fascinating insight into religious life in the Middle Ages.This is the revised edition of Betty Radice's highly regarded translation, in which Michael Clanchy, the biographer of Abélard, updates the scholarship on the letters and the lovers. This volume includes Abélard's remarkable autobiography and his spiritual advice to Héloïse and her nuns, as well as a selection of the 'lost love letters' of Abélard and Héloïse, letters between Héloïse and Peter the Venerable, two of Abélard's hymns, a chronology, notes and maps.

    Authors Barbara Ehrenreich and Deirdre English have never lost faith in science itself, but insist that we hold those who interpret it to higher standards. Women are entering the medical and scientific professions in greater numbers but as recent research shows, experts continue to use pseudoscience to tell women how to live. This edition of For Her Own Good provides today's readers with an indispensable dose of informed skepticism.

    A brilliantly creative work that established the reputation of Dutch historian John Huizinga (1872-1945), the book argues that the era of diminishing chivalry reflected the spirit of an age and that its figures and events were neither a prelude to the Renaissance nor harbingers of a coming culture, but a consummation of the old.Among other topics, the author examines the violent tenor of medieval life, the idea of chivalry, the conventions of love, religious life, the vision of death, the symbolism that pervaded medieval life, and aesthetic sentiment. We view the late Middle Ages through the psychology and thought of artists, theologians, poets, court chroniclers, princes, and statesmen of the period, witnessing the splendor and simplicity of medieval life, its courtesy and cruelty, its idyllic vision of life, despair and mysticism, religious, artistic, and practical life, and much more.Long regarded as a landmark of historical scholarship, The Waning of the Middle Ages is also a remarkable work of literature. Of its author, the New York Times said, "Professor Huizinga has dressed his imposing and variegated assemblage of facts in the colorful garments characteristic of novels, and he parades them from his first page to the last in a vivid style."An international success following its original publication in 1919 and subsequently translated into several languages, The Waning of the Middle Ages will not only serve as an invaluable reference for students and scholars of medieval history but will also appeal to general readers and anyone fascinated by life during the Middle Ages.

    In Elephants on Acid, Boese details the results of this scientific trial, as well as answers to the questions: Why can't people tickle themselves? Would the average dog summon help in an emergency? Will babies instinctually pick a well-balanced diet? Is it possible to restore life to the dead? Read on to find out...

    However, that's not to say that the Sumerians, Victorians, and every civilization in between and beyond have not tried, wielding their most formidable weapon: the law. At any given point in time, some forms of sex were condoned while others were punished mercilessly. Jump forward or backward a century or two (and often far less than that), and the harmless fun of one time period becomes the gravest crime in another. Sex and Punishment tells the story of the struggle throughout the millennia to regulate the most powerful engine of human behavior.Writer and lawyer Eric Berkowitz uses flesh-and-blood cases—much flesh and even more blood—to evoke the entire sweep of Western sex law, from the savage impalement of an Ancient Mesopotamian adulteress to the imprisonment of Oscar Wilde in 1895 for "gross indecency." The cast of Sex and Punishment is as varied as the forms taken by human desire itself: royal mistresses, gay charioteers, medieval transvestites, lonely goat-lovers, prostitutes of all stripes, London rent boys. Each of them had forbidden sex, and each was judged—and justice, as Berkowitz shows, rarely had much to do with it. With the light touch of a natural storyteller, Berkowitz spins these tales and more, going behind closed doors to reveal the essential history of human desire.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    But in this groundbreaking book, prize-winning historian Edith Sheffer exposes that Asperger was not only involved in the racial policies of Hitler’s Third Reich, he was complicit in the murder of children.As the Nazi regime slaughtered millions across Europe during World War Two, it sorted people according to race, religion, behavior, and physical condition for either treatment or elimination. Nazi psychiatrists targeted children with different kinds of minds—especially those thought to lack social skills—claiming the Reich had no place for them. Asperger and his colleagues endeavored to mold certain "autistic" children into productive citizens, while transferring others they deemed untreatable to Spiegelgrund, one of the Reich’s deadliest child-killing centers.In the first comprehensive history of the links between autism and Nazism, Sheffer uncovers how a diagnosis common today emerged from the atrocities of the Third Reich. With vivid storytelling and wide-ranging research, Asperger’s Children will move readers to rethink how societies assess, label, and treat those diagnosed with disabilities.

    Nuland tells the strange story of Ignác Semmelweis with urgency and the insight gained from his own studies and clinical experience. Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-nineteenth-century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately—childbed fever in Vienna all but disappeared—they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.