In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    Sour Diesel. Wax, shatter, and vapes. Marijuana has come a long way since its seedy days in the back parking lots of our culture. So has Howard S. Becker, the eminent sociologist, jazz musician, expert on “deviant” culture, and founding NORML board member. When he published Becoming a Marihuana User more than sixty years ago, hardly anyone paid attention—because most people didn’t smoke pot. Decades of Cheech and Chong films, Grateful Dead shows, and Cannabis Cups later, and it’s clear—marijuana isn’t just an established commodity, it’s an entire culture. And that’s just the thing—Becker totally called it: pot has everything to do with culture. It’s not a blight on culture, but a culture itself—in fact, you’ll see in this book the first use of the term “users,” rather than “abusers” or “addicts.” Come along on this short little study—now a famous timestamp in weed studies—and you will be astonished at how relevant it is to us today.             Becker doesn’t judge, but neither does he holler for legalization, tell you how to grow it in a hollowed-out dresser, or anything else like that for which there are plenty of other books you can buy. Instead, he looks at marijuana with a clear sociological lens—as a substance that some people enjoy, and that some others have decided none of us should. From there he asks: so how do people decide to get high, and what kind of experience do they have as a result of being part of the marijuana world? What he discovers will bother some, especially those who proselytize the irrefutably stunning effects of the latest strain: chemistry isn’t everything—the important thing about pot is how we interact with it. We learn to be high. We learn to like it. And from there, we teach others, passing the pipe in a circle that begins to resemble a bona fide community, defined by shared norms, values, and definitions just like any other community.             All throughout this book, you’ll see the intimate moments when this transformation takes place. You’ll see people doing it for the first time and those with considerable experience. You’ll see the early signs of the truths that have come to define the marijuana experience: that you probably won’t get high at first, that you have to hold the hit in, and that there are other people here who are going to smoke that, too.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    He did not crave my company, cling to and cuddle me endlessly. He showed no need to bond with me, his father, and we did not. He exhausted me, he frustrated me and he scared me. I came to dread coming home from work sometimes, or those moments when it was my turn to wrestle him into bed and begin the long struggle to settle him. I said things that will forever haunt me, like “What is wrong with that child?” and “Is he always going to be this annoying?” What I didn't know then was that he was autistic.When that realisation came, so did the beginning of my mission to understand my son, and to understand autism. This book chronicles that search for understanding and answers. It documents one parent’s attempts to come to terms with, and accept, his child. It is raw and real, sometimes confused and frightened but also, I’d like to think, written with warmth and love and an ability to smile through difficult times.This book is for anyone starting out on a pathway with their child that they did not expect. It’s also for people who, like me, are a little further down that road but still learning, still asking questions and still getting it wrong sometimes. You are not alone.

    In desperate attempts to cure their patients, physicians injected them with deadly medications, cut holes in their heads, and sterilized them. Years of insufficient funding caused the hospital to decay into a crumbling facility with too few staff, as seen in the 1975 film "One Flew Over the Cuckoo's Nest." Today, after a $360 million makeover, Oregon State Hospital is a modern treatment hospital for the state's civil and forensic mentally ill. In this compelling account of the institution's tragedies and triumphs, author Diane Goeres-Gardner offers an unparalleled look at the very human story of Oregon's historic asylum.

    Dick, Terence McKenna, and Robert Anton Wilson, High Weirdness charts the emergence of a new psychedelic spirituality that arose from the American counterculture of the 1970s. These three authors changed the way millions of readers thought, dreamed, and experienced reality—but how did their writings reflect, as well as shape, the seismic cultural shifts taking place in America?In High Weirdness, Erik Davis—America's leading scholar of high strangeness—examines the published and unpublished writings of these vital, iconoclastic thinkers, as well as their own life-changing mystical experiences. Davis explores the complex lattice of the strange that flowed through America's West Coast at a time of radical technological, political, and social upheaval to present a new theory of the weird as a viable mode for a renewed engagement with reality.

    He had, therefore, full opportunities of seeing the country and its life from various points of view. He has utilized his observations in an entertaining book. It is not — and does not pretend lo be — a scientific work, or technical in any sense. It gives, however, an excellent idea of conditions and ways of living in the Klondike at all seasons, and of the hardships which the pioneers had to undergo. Nothing but gold — the prospect of wealth — could induce men to live in such a climate, and to combat the many difficulties which it entails. Mr. Lynch, a Californian of means and position, arrived at Dawson in the summer of 1898. As the first discoveries of gold in the Klondike valley were made in August of 1896, Mr. Lynch found a mining town not two years old, unpaved and insanitary, crowded with adventurers of every nation, in fact still a typical “ tough" mining-camp, except that lawlessness and crime were sternly repressed by the vigilant Mounted Police. He spent the following winter in the town, making expeditions to the gold-bearing creeks, examining mines and studying the methods of working them. Early in the spring of 1899 he bought a claim which he believed would repay him and set himself at once to develop it thoroughly. During his stay he had seen Dawson transformed into a paved, sewaged, well built, well lighted city, and the streets, no longer thronged with rough-mannered miners and adventurers, had become the promenade of well dressed business men and ladies (real ladies !) intent on shopping. As one of the earliest of the new species of Klondike miner, he is able to give an account of the transition that took place, largely owing to the enterprise of men of his own stamp, and the book is an interesting addition to Klondike literature. Mr. Lynch's narrative is plainly written, in a way which leads one to believe in its substantial truth. It reads well, and brings out many points which will interest the miner, as well as the casual reader. He had confidence in the future of the country, and believed that it would hold a large population for many years, in spite of the drawbacks of climate.

    Braided with that history is the moving story of Powers's beloved son Kevin--spirited, endearing, and gifted--who triumphed even while suffering from schizophrenia until finally he did not, and the story of his courageous surviving son Dean, who is also schizophrenic.A blend of history, biography, memoir, and current affairs ending with a consideration of where we might go from here, this is a thought-provoking look at a dreaded illness that has long been misunderstood.

    Martin Lee and Bruce Shlain's exhaustively researched and astonishing account—part of it gleaned from secret government files—tells how the CIA became obsessed with LSD as an espionage weapon during the early 1950s and launched a massive covert research program, in which countless unwitting citizens were used as guinea pigs. Though the CIA was intent on keeping the drug to itself, it ultimately couldn't prevent it from spreading into the popular culture; here LSD had a profound impact and helped spawn a political and social upheaval that changed the face of America. From the clandestine operations of the government to the escapades of Timothy Leary, Abbie Hoffman, Ken Kesey and his Merry Pranksters, Allen Ginsberg, and many others, Acid Dreams provides an important and entertaining account that goes to the heart of a turbulent period in our history.Also called: Acid Dreams. The Complete Social History of LSD: The CIA, The Sixties, and Beyond

    But what is Prozac—a medication, or a mental steroid? A cure for depression, or a drug that changes personality? Reported to turn shy people into social butterflies and to improve work performance, memory, even dexterity, does Prozac work on character rather than illness? Are you using it "cosmetically," to make people more attractive? More energetic, more socially acceptable? And what does it tell us about the nature of character and the mutability of self?

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Marcia Angell had a front-row seat on the appalling spectacle of the pharmaceutical industry. She watched drug companies stray from their original mission of discovering and manufacturing useful drugs and instead become vast marketing machines with unprecedented control over their own fortunes. She saw them gain nearly limitless influence over medical research, education, and how doctors do their jobs. She sympathized as the American public, particularly the elderly, struggled and increasingly failed to meet spiraling prescription drug prices. Now, in this bold, hard-hitting new book, Dr. Angell exposes the shocking truth of what the pharmaceutical industry has become–and argues for essential, long-overdue change.Currently Americans spend a staggering $200 billion each year on prescription drugs. As Dr. Angell powerfully demonstrates, claims that high drug prices are necessary to fund research and development are unfounded: The truth is that drug companies funnel the bulk of their resources into the marketing of products of dubious benefit. Meanwhile, as profits soar, the companies brazenly use their wealth and power to push their agenda through Congress, the FDA, and academic medical centers.Zeroing in on hugely successful drugs like AZT (the first drug to treat HIV/AIDS), Taxol (the best-selling cancer drug in history), and the blockbuster allergy drug Claritin, Dr. Angell demonstrates exactly how new products are brought to market. Drug companies, she shows, routinely rely on publicly funded institutions for their basic research; they rig clinical trials to make their products look better than they are; and they use their legions of lawyers to stretch out government-granted exclusive marketing rights for years. They also flood the market with copycat drugs that cost a lot more than the drugs they mimic but are no more effective.The American pharmaceutical industry needs to be saved, mainly from itself, and Dr. Angell proposes a program of vital reforms, which includes restoring impartiality to clinical research and severing the ties between drug companies and medical education. Written with fierce passion and substantiated with in-depth research, The Truth About the Drug Companies is a searing indictment of an industry that has spun out of control.

      AA has become so infused in our society that it is practically synonymous with addiction recovery. Yet the evidence shows that AA has only a 5–10 percent success rate—hardly better than no treatment at all. Despite this, doctors, employers, and judges regularly refer addicted people to treatment programs and rehab facilities based on the 12-step model.   In The Sober Truth, acclaimed addiction specialist Dr. Lance Dodes exposes the deeply flawed science that the 12-step industry has used to support its programs. Dr. Dodes analyzes dozens of studies to reveal a startling pattern of errors, misjudgments, and biases. He also pores over the research to highlight the best peer-reviewed studies available and discovers that they reach a grim consensus on the program’s overall success.   But The Sober Truth is more than a book about addiction. It is also a book about science and how and why AA and rehab became so popular, despite the discouraging data. Dr. Dodes explores the entire story of AA’s rise, from its origins in early fundamentalist religious and mystical beliefs to its present-day place of privilege in politics and media.  The Sober Truth includes true stories from Dr. Dodes’s thirty-five years of clinical practice, as well as firsthand accounts submitted by addicts through an open invitation on the Psychology Today website. These stories vividly reveal the experience of walking the steps and attending some of the nation’s most famous rehabilitation centers.  The Sober Truth builds a powerful response to the monopoly of the 12-step program and explodes the myth that these programs offer an acceptable or universal solution to the deeply personal problem of addiction. This book offers new and actionable information for addicts, their families, and medical providers, and lays out better ways to understand addiction for those seeking a more effective and compassionate approach to this treatable problem.

    For over a decade Philippe Bourgois and Jeff Schonberg followed a social network of two dozen heroin injectors and crack smokers in the San Francisco drug scene, accompanying them as they scrambled to generate income through burglary, larceny, panhandling, recycling, and day labor. Righteous Dopefiend interweaves stunning black-and-white photography with vivid dialogue, oral biography, detailed field notes, and critical theoretical analysis to viscerally illustrate the life of a drug addict. Its gripping narrative develops a cast of characters around the themes of violence, racism and race relations, sexuality, trauma, embodied suffering, social inequality, and power relations. The result is a dispassionate chronicle of fixes and overdoses; of survival, loss, caring, and hope rooted in the drug abusers’ determination to hang on for one more day, through a "moral economy of sharing" that precariously balances mutual solidarity and interpersonal betrayal.