But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Margulis to create a vivid new picture of the world that is crucial to our understanding of the future of the planet. Addressed to general readers, the book provides a beautifully written view of evolution as a process based on interdependency and the interconnectedness of all life on the planet.

    At just two years old, Nic experienced a searing pain that signaled the awakening of a new and deadly disease, one that would hurl Nic and his family up against the limits of modern medicine. For years, through false starts and failed cures, Nic holds on to life, buoyed up by his mother’s fierce drive to get him the care he needs. But when even the world’s experts are stumped by Nic’s illness, his doctors come up with a radical, long-shot plan: a step into the unknown. The next major scientific frontier, following the completion of the Human Genome Project, was to figure out how to use our new knowledge to save lives—to bring genomic or personalized medicine into reality. It’s a quest that is undertaken by researchers around the world. But it is only when geneticist Howard Jacob hears about young Nic that the finish line finally comes into sight: It’s no longer a race to make history. It’s a race to save this boy’s life. One in a Billion is an unforgettable tale of the lives that converged to launch a medical revolution. As pioneering geneticist Mary-Claire King pronounced upon learning Nic’s story: “It was as if one had heard about Case Zero of AIDS and the cure, all at once.”

    It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes.This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children.Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

    

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

    In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.David Quammen chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

    LikeWhen does a bee go through metamorphosis?Why does a queen bee sometimes leave her hive?And where does all this honey come from, anyway?!But Nyuki’s biggest question is, “What is this inner voice I hear, and why does it tell me to go forth to adventure?Follow Nyuki on a lifelong journey as she annoys her sisters, avoids predators, and learns to trust her inner voice as she masters the way of the hive.And if you still have questions at the end, the back of the book uncovers even more mysteries about the lives of these incredible insects!

    r/K Theory examines how all populations tend to adopt one of two psychologies as a means of adapting their behavior to the presence or absence of environmental resources. The two strategies, termed r and K, each correlate perfectly with the psychologies underlying Liberalism and Conservatism.One strategy, named the r-strategy, imbues those who are programmed with it to be averse to all peer on peer competition, embrace promiscuity, embrace single parenting, and support early onset sexual activity in youth. Obviously, this mirrors the Liberal philosophy's aversion to individual Darwinian competitions such as capitalism and self defense with firearms, as well as group competitions such as war. Likewise, Liberalism is tolerant of promiscuity, tolerant of single parenting, and more prone to support early sex education for children and the sexualization of cultural influences. Designed to exploit a plethora of resources, one will often find this r-type strategy embodied within prey species, where predation has lowered the population's numbers, and thereby increased the resources available to it's individuals.The other strategy, termed the K-strategy, imbues those who pursue it with a fierce competitiveness, as well as tendencies towards abstinence until monogamy, two-parent parenting, and delaying sexual activity until later in life. Obviously, this mirrors Conservatism's acceptance of all sorts of competitive social schemes, from free market capitalism, to war, to individuals owning and carrying private weapons for self defense. Conservatives also tend to favor abstinence until monogamy, two parent parenting with an emphasis upon "family values," and children being shielded from any sexualized stimuli until later in life. This strategy is found most commonly in species which lack predation, and whose population's have grown to the point individuals must compete with each other for the limited environmental resources that they are rapidly running out of.Meticulously substantiated with the latest research in fields from neurobiology to human behavioral ecology, this work offers an unprecedented view into not just what governs our political battles, but why these battles have arisen within our species in the first place. From showing how these two strategies adapt in other more complex species in nature, to examining what genetic and neurostructural mechanisms may produce these divergences between individuals, to showing what this theory indicates our future may hold, this work is the most thorough analysis to date of just why we have two political ideologies, why they will never agree, and why we will tend to become even more partisan in the future.

      Leonard Mlodinow takes us on a passionate and inspiring tour through the exciting history of human progress and the key events in the development of science. In the process, he presents a fascinating new look at the unique characteristics of our species and our society that helped propel us from stone tools to written language and through the birth of chemistry, biology, and modern physics to today’s technological world.   Along the way he explores the cultural conditions that influenced scientific thought through the ages and the colorful personalities of some of the great philosophers, scientists, and thinkers: Galileo, who preferred painting and poetry to medicine and dropped out of university; Isaac Newton, who stuck needlelike bodkins into his eyes to better understand changes in light and color; and Antoine Lavoisier, who drank nothing but milk for two weeks to examine its effects on his body. Charles Darwin, Albert Einstein, Werner Heisenberg, and many lesser-known but equally brilliant minds also populate these pages, each of their stories showing how much of human achievement can be attributed to the stubborn pursuit of simple questions (why? how?), bravely asked.  The Upright Thinkers is a book for science lovers and for anyone interested in creative thinking and in our ongoing quest to understand our world. At once deeply informed, accessible, and infused with the author’s trademark wit, this insightful work is a stunning tribute to humanity’s intellectual curiosity.  (With black-and-white illustrations throughout.)

    In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past. Journeying to far-flung Siberian locales in search of ice age bones and delving into her own research--as well as those of fellow experts such as Svante Paabo, George Church, and Craig Venter--Shapiro considers de-extinction's practical benefits and ethical challenges. Would de-extinction change the way we live? Is this really cloning? What are the costs and risks? And what is the ultimate goal?Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms. But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem.Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.

    

    This elegant, humane, and engaging book "captures what we know of the development of what makes us human" (Nature).Visit Armand Marie Leroi on the web: http: //armandleroi.com/index.htmlStepping effortlessly from myth to cutting-edge science,

    But, as it turns out, 'time immemorial' may not have been all that long ago. To tell us the story of our ancestry, journalist Tony Joseph goes 65,000 years into the past—when a band of modern humans, or Homo sapiens, first made their way from Africa into the Indian subcontinent. Citing recent DNA evidence, he traces the subsequent large migrations of modern humans into India—of agriculturalists from Iran between 7000 and 3000 BCE and pastoralists from the Central Asian Steppe between 2000 and 1000 BCE, among others. As Joseph unravels our history using the results of genetic and other research, he takes head-on some of the most controversial and uncomfortable questions of Indian history: Who were the Harappans? Did the 'Aryans' really migrate to India? Are North Indians genetically different from South Indians? And are the various castes genetically distinct groups? This book relies heavily on path-breaking DNA research of recent years. But it also presents earlier archaeological and linguistic evidence—all in an entertaining and highly readable manner. A hugely significant book, Early Indians authoritatively and bravely puts to rest several ugly debates on the ancestry of modern Indians. It not only shows us how the modern Indian population came to be composed as it is, but also reveals an undeniable and important truth about who we are: we are all migrants. And we are all mixed.

    Gases and dust particles ejected into the atmosphere changed weather patterns around the world, resulting in the infamous ''year without a summer'' in North America, food riots in Europe, and a widespread cholera epidemic. And the gloomy weather inspired Mary Shelley to write the gothic novel Frankenstein.This book tells the story of nine such epic volcanic events, explaining the related geology for the general reader and exploring the myriad ways in which the earth's volcanism has affected human history. Zeilinga de Boer and Sanders describe in depth how volcanic activity has had long-lasting effects on societies, cultures, and the environment. After introducing the origins and mechanisms of volcanism, the authors draw on ancient as well as modern accounts--from folklore to poetry and from philosophy to literature. Beginning with the Bronze Age eruption that caused the demise of Minoan Crete, the book tells the human and geological stories of eruptions of such volcanoes as Vesuvius, Krakatau, Mount Pel�e, and Tristan da Cunha. Along the way, it shows how volcanism shaped religion in Hawaii, permeated Icelandic mythology and literature, caused widespread population migrations, and spurred scientific discovery.From the prodigious eruption of Thera more than 3,600 years ago to the relative burp of Mount St. Helens in 1980, the results of volcanism attest to the enduring connections between geology and human destiny.