Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    Evo Devo Evolutionary Developmental Biology is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

    Sachs is one of the world's most perceptive and original analysts of global development. In this major new work he presents a compelling and practical framework for how global citizens can use a holistic way forward to address the seemingly intractable worldwide problems of persistent extreme poverty, environmental degradation, and political-economic injustice: sustainable development.Sachs offers readers, students, activists, environmentalists, and policy makers the tools, metrics, and practical pathways they need to achieve Sustainable Development Goals. Far more than a rhetorical exercise, this book is designed to inform, inspire, and spur action. Based on Sachs's twelve years as director of the Earth Institute at Columbia University, his thirteen years advising the United Nations secretary-general on the Millennium Development Goals, and his recent presentation of these ideas in a popular online course, "The Age of Sustainable Development" is a landmark publication and clarion call for all who care about our planet and global justice.

    It contains sketches of orange growers, orange botanists, orange pickers, orange packers, early settlers on Florida's Indian River, the first orange barons, modern concentrate makers, and a fascinating profile of Ben Hill Griffin of Frostproof, Florida who may be the last of the individual orange barons. McPhee's astonishing book has an almost narrative progression, is immensely readable, and is frequently amusing. Louis XIV hung tapestries of oranges in the halls of Versailles, because oranges and orange trees were the symbols of his nature and his reign. This book, in a sense, is a tapestry of oranges, too—with elements in it that range from the great orangeries of European monarchs to a custom of people in the modern Caribbean who split oranges and clean floors with them, one half in each hand.

     "The genius of Hanson's fascinating, inspiring, and entertaining book stems from the fact that it is not about how all kinds of things grow from seeds; it is about the seeds themselves." -- Mark Kurlansky, New York Times Book Review We live in a world of seeds. From our morning toast to the cotton in our clothes, they are quite literally the stuff and staff of life: supporting diets, economies, and civilizations around the globe. Just as the search for nutmeg and pepper drove the Age of Discovery, coffee beans fueled the Enlightenment and cottonseed sparked the Industrial Revolution. Seeds are fundamental objects of beauty, evolutionary wonders, and simple fascinations. Yet, despite their importance, seeds are often seen as commonplace, their extraordinary natural and human histories overlooked. Thanks to this stunning new book, they can be overlooked no more. This is a book of knowledge, adventure, and wonder, spun by an award-winning writer with both the charm of a fireside story-teller and the hard-won expertise of a field biologist. A fascinating scientific adventure, it is essential reading for anyone who loves to see a plant grow.

    Dickson Despommier's visionary book provides a blueprint for securing the world's food supply and at the same time solving one of the gravest environmental crises facing us today."--StingImagine a world where every town has their own local food source, grown in the safest way possible, where no drop of water or particle of light is wasted, and where a simple elevator ride can transport you to nature's grocery store - imagine the world of the vertical farm.When Columbia professor Dickson Despommier set out to solve America's food, water, and energy crises, he didn't just think big - he thought up. Despommier's stroke of genius, the vertical farm, has excited scientists, architects, and politicians around the globe. Now, in this groundbreaking book, Despommier explains how the vertical farm will have an incredible impact on changing the face of this planet for future generations.Despommier takes readers on an incredible journey inside the vertical farm, buildings filled with fruits and vegetables that will provide local food sources for entire cities.Vertical farms will allow us to:- Grow food 24 hours a day, 365 days a year- Protect crops from unpredictable and harmful weather- Re-use water collected from the indoor environment- Provide jobs for residents- Eliminate use of pesticides, fertilizers, or herbicides- Drastically reduce dependence on fossil fuels- Prevent crop loss due to shipping or storage- Stop agricultural runoffVertical farms can be built in abandoned buildings and on deserted lots, transforming our cities into urban landscapes which will provide fresh food grown and harvested just around the corner. Possibly the most important aspect of vertical farms is that they can built by nations with little or no arable land, transforming nations which are currently unable to farm into top food producers. In the tradition of the bestselling The World Without Us, The Vertical Farm is a completely original landmark work destined to become an instant classic

    Priestley represented a unique synthesis: by the 1780s, he had established himself as one of the world's most celebrated scientists, most prominent religious figures, and most outspoken political thinkers. Yet he would also have become one of the most hated men in all of his native England. When an angry mob burned down his house in Birmingham, Priestley and his family set sail for Pennsylvania.In the nascent United States, Priestley hoped to find the freedom to bridge the disciplines that had governed his life, to find a quiet lab and a receptive pulpit. Once he arrived, as a result of his close relationships with the Founding Fathers—Jefferson credited Priestley as the man who prevented him from abandoning Christianity—Priestley found himself at the center of what would go down as one of the seminal debates in American history. And as Johnson brilliant charts, Priestley exerted profound if little-known influence on the shape and course of this great experiment in nation-building.As in his most recent bestselling work, The Ghost Map, Steven Johnson here uses a dramatic historical story to explore themes that have long engaged him: innovation and the way new ideas emerge and spread, and the environments that foster these breakthroughs. As he did in Everything Bad is Good for You, he upsets some fundamental assumptions about the world we live in—namely, what it means when we invoke the Founding Fathers—and replaces them with a clear-eyed, eloquent assessment of where we stand today.

    

    In Enough Is Enough, Rob Dietz and Dan O’Neill lay out a visionary but realistic alternative to the perpetual pursuit of economic growth—an economy where the goal is not more but enough. They explore specific strategies to conserve natural resources, stabilize population, reduce inequality, fix the financial system, create jobs, and more—all with the aim of maximizing long-term well-being instead of short-term profits. Filled with fresh ideas and surprising optimism, Enough Is Enough is the primer for achieving genuine prosperity and a hopeful future for all.

    In 2001 a panel representing virtually all the world's governments and climate scientists announced that they had reached a consensus: the world was warming at a rate without precedent during at least the last ten millennia, and that warming was caused by the buildup of greenhouse gases from human activity. The consensus itself was at least a century in the making. The story of how scientists reached their conclusion--by way of unexpected twists and turns and in the face of formidable intellectual, financial, and political obstacles--is told for the first time in The Discovery of Global Warming, Spencer R. Weart lucidly explains the emerging science, introduces us to the major players, and shows us how the Earth's irreducibly complicated climate system was mirrored by the global scientific community that studied it. Unlike familiar tales of Science Triumphant, this book portrays scientists working on bits and pieces of a topic so complex that they could never achieve full certainty--yet so important to human survival that provisional answers were essential. Weart unsparingly depicts the conflicts and mistakes, and how they sometimes led to fruitful results. His book reminds us that scientists do not work in isolation, but interact in crucial ways with the political system and with the general public. The book not only reveals the history of global warming, but also analyzes the nature of modern scientific work as it confronts the most difficult questions about the Earth's future.

    We will soon be able to meet and exceed the basic needs of every man, woman and child on the planet. Abundance for all is within our grasp. This bold, contrarian view, backed up by exhaustive research, introduces our near-term future, where exponentially growing technologies and three other powerful forces are conspiring to better the lives of billions. An antidote to pessimism by tech entrepreneur turned philanthropist, Peter H. Diamandis and award-winning science writer Steven Kotler. Since the dawn of humanity, a privileged few have lived in stark contrast to the hardscrabble majority. Conventional wisdom says this gap cannot be closed. But it is closing—fast. The authors document how four forces—exponential technologies, the DIY innovator, the Technophilanthropist, and the Rising Billion—are conspiring to solve our biggest problems. Abundance establishes hard targets for change and lays out a strategic roadmap for governments, industry and entrepreneurs, giving us plenty of reason for optimism.Examining human need by category—water, food, energy, healthcare, education, freedom—Diamandis and Kotler introduce dozens of innovators making great strides in each area: Larry Page, Steven Hawking, Dean Kamen, Daniel Kahneman, Elon Musk, Bill Joy, Stewart Brand, Jeff Skoll, Ray Kurzweil, Ratan Tata, Craig Venter, among many, many others.

    Crafting an engrossing journey from the gushing Pennsylvania oil fields of the 1860s to today's fraught and fractious Middle East, Crude Volatility explains how past periods of stability and volatility in oil prices help us understand the new boom-bust era. Oil's notorious volatility has always been considered a scourge afflicting not only the oil industry but also the broader economy and geopolitical landscape; Robert McNally makes sense of how oil became so central to our world and why it is subject to such extreme price fluctuations.Tracing a history marked by conflict, intrigue, and extreme uncertainty, McNally shows how--even from the oil industry's first years--wild and harmful price volatility prompted industry leaders and officials to undertake extraordinary efforts to stabilize oil prices by controlling production. Herculean market interventions--first, by Rockefeller's Standard Oil, then, by U.S. state regulators in partnership with major international oil companies, and, finally, by OPEC--succeeded to varying degrees in taming the beast. McNally, a veteran oil market and policy expert, explains the consequences of the ebbing of OPEC's power, debunking myths and offering recommendations--including mistakes to avoid--as we confront the unwelcome return of boom and bust oil prices.

    Through a freewheeling and candid conversation with his economist father, Ryoichi Mikitani, the two examine the issues facing Japan, and explore possible roadmaps to revitalization. How can Japan overhaul its economy, education system, immigration, public infrastructure, and hold its own with China? Their ideas include applying business techniques like Key Performance Indicators to fix the economy, using information technology to cut government bureaucracy, and increasing the number of foreign firms with a head office in Japan. Readers gain rare insight into Japan's future, from both academic and practical perspectives on the inside.Mikitani argues that Japan's tendency to shun international frameworks and hide from global realities is the root of the problem, while Mikitani Sr.'s background as an international economist puts the issue in perspective for a well-rounded look at today's Japan.Examine the causes of Japan's endless economic stagnation Discover the current efforts underway to enhance Japan's competitiveness Learn how free market "Abenomics" affected Japan's economy long-term See Japan's issues from the perspective of an entrepreneur and an economist Japan's malaise is seated in a number of economic, business, political, and cultural issues, and this book doesn't shy away from hot topics. More than a discussion of economics, this book is a conversation between father and son as they work through opposing perspectives to help their country find The Power to Compete.

    Hazen writes of how the co-evolution of the geosphere and biosphere—of rocks and living matter—has shaped our planet into the only one of its kind in the Solar System, if not the entire cosmos.With an astrobiologist’s imagination, a historian’s perspective, and a naturalist’s passion for the ground beneath our feet, Hazen explains how changes on an atomic level translate into dramatic shifts in Earth’s makeup over its 4.567 billion year existence. He calls upon a flurry of recent discoveries to portray our planet’s many iterations in vivid detail. Through his theory of “co-evolution,” we learn how reactions between organic molecules and rock crystals may have generated Earth’s first organisms, which in turn are responsible for more than two-thirds of the mineral varieties on the planet.The Story of Earth is also the story of the pioneering men and women behind the sciences. Readers will meet black-market meteorite hawkers of the Sahara Desert, the gun-toting Feds who guarded the Apollo missions’ lunar dust, and the World War II Navy officer whose super-pressurized “bomb”—recycled from military hardware—first simulated the molten rock of Earth’s mantle. As a mentor to a new generation of scientists, Hazen introduces the intrepid young explorers whose dispatches from Earth’s harshest landscapes will revolutionize geology.

    Strevens calls this scientific code the iron rule of explanation, and reveals the way in which the rule, precisely because it is unreasonably close-minded, overcomes individual prejudices to lead humanity inexorably toward the secrets of nature.“With a mixture of philosophical and historical argument, and written in an engrossing style” (Alan Ryan), The Knowledge Machine provides captivating portraits of some of the greatest luminaries in science’s history, including Isaac Newton, the chief architect of modern science and its foundational theories of motion and gravitation; William Whewell, perhaps the greatest philosopher-scientist of the early nineteenth century; and Murray Gell-Mann, discoverer of the quark. Today, Strevens argues, in the face of threats from a changing climate and global pandemics, the idiosyncratic but highly effective scientific knowledge machine must be protected from politicians, commercial interests, and even scientists themselves who seek to open it up, to make it less narrow and more rational—and thus to undermine its devotedly empirical search for truth.Rich with illuminating and often delightfully quirky illustrations, The Knowledge Machine, written in a winningly accessible style that belies the import of its revisionist and groundbreaking concepts, radically reframes much of what we thought we knew about the origins of the modern world.