The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    This staggering amount of information—unprecedented in history—can tell us a great deal about who we are—the fears, desires, and behaviors that drive us, and the conscious and unconscious decisions we make. From the profound to the mundane, we can gain astonishing knowledge about the human psyche that less than twenty years ago, seemed unfathomable.Everybody Lies offers fascinating, surprising, and sometimes laugh-out-loud insights into everything from economics to ethics to sports to race to sex, gender and more, all drawn from the world of big data. What percentage of white voters didn’t vote for Barack Obama because he’s black? Does where you go to school effect how successful you are in life? Do parents secretly favor boy children over girls? Do violent films affect the crime rate? Can you beat the stock market? How regularly do we lie about our sex lives and who’s more self-conscious about sex, men or women?Investigating these questions and a host of others, Seth Stephens-Davidowitz offers revelations that can help us understand ourselves and our lives better. Drawing on studies and experiments on how we really live and think, he demonstrates in fascinating and often funny ways the extent to which all the world is indeed a lab. With conclusions ranging from strange-but-true to thought-provoking to disturbing, he explores the power of this digital truth serum and its deeper potential—revealing biases deeply embedded within us, information we can use to change our culture, and the questions we’re afraid to ask that might be essential to our health—both emotional and physical. All of us are touched by big data everyday, and its influence is multiplying. Everybody Lies challenges us to think differently about how we see it and the world.

    There have been other books on Dr Morell's cocktail of treatments for Hitler and Goering's reliance on drugs, but Ohler's book is the first to show how the entire Nazi regime was permeated with drugs - cocaine, heroin, morphine and methamphetamines, the last of these crucial to troops' resilience and partly explaining German victory in 1940. Ohler is explicit that drugs cannot explain Third Reich ideology, but their promiscuous use impaired and confused decision-making, with drastic effects on Hitler and his entourage, who, as the war turned against Germany, took refuge in ever more poorly understood cocktails of stimulants. This chemical euphoria changes how we should think about the Nazi high command and its ability to understand the situation it found itself in by 1944-45. As such Blitzed will force a wider reinterpretation of several key events during the Second World War.

    Robert Oppenheimer, Freeman Dyson has composed an autobiography unlike any other. Dyson evocatively conveys the thrill of a deep engagement with the world-be it as scientist, citizen, student, or parent. Detailing a unique career not limited to his groundbreaking work in physics, Dyson discusses his interest in minimizing loss of life in war, in disarmament, and even in thought experiments on the expansion of our frontiers into the galaxies.

    It’s so bound up with our deepest feelings that emotional trauma causes it to change shape.Practising cardiologist Sandeep Jauhar beautifully weaves his own experiences with the defining discoveries of the past to tell the story of our most vital organ. He looks at some of the pioneers who risked their careers and their patients’ lives to better understand the heart. People like Daniel Hale Williams, who performed the world’s first documented heart surgery, and Wilson Greatbatch, who accidentally invented the pacemaker.Amid gripping scenes from the operating theatre, Jauhar interweaves stories about the patients he’s treated with the moving tale of his family’s own history of heart problems, from his grandfather’s sudden death in India – an event that sparked his life-long obsession – to the ominous signs of how he himself might die.He also confronts the limits of medical technology and argues that future progress will be determined more by how we choose to live rather than by any device we invent.

    It now has 600,000 to a million page hits daily. Every now and then, Munroe would get emails asking him to arbitrate a science debate. 'My friend and I were arguing about what would happen if a bullet got struck by lightning, and we agreed that you should resolve it . . . ' He liked these questions so much that he started up What If. If your cells suddenly lost the power to divide, how long would you survive? How dangerous is it, really, to be in a swimming pool in a thunderstorm? If we hooked turbines to people exercising in gyms, how much power could we produce? What if everyone only had one soulmate?When (if ever) did the sun go down on the British empire? How fast can you hit a speed bump while driving and live?What would happen if the moon went away?In pursuit of answers, Munroe runs computer simulations, pores over stacks of declassified military research memos, solves differential equations, and consults with nuclear reactor operators. His responses are masterpieces of clarity and hilarity, studded with memorable cartoons and infographics. They often predict the complete annihilation of humankind, or at least a really big explosion. Far more than a book for geeks, WHAT IF: Serious Scientific Answers to Absurd Hypothetical Questions explains the laws of science in operation in a way that every intelligent reader will enjoy and feel much the smarter for having read.

    Nearly a half-century after Neil Armstrong walked on the moon, these Space Barons-most notably Elon Musk and Jeff Bezos, along with Richard Branson and Paul Allen-are using Silicon Valley-style innovation to dramatically lower the cost of space travel, and send humans even further than NASA has gone. These entrepreneurs have founded some of the biggest brands in the world-Amazon, Microsoft, Virgin, Tesla, PayPal-and upended industry after industry. Now they are pursuing the biggest disruption of all: space. Based on years of reporting and exclusive interviews with all four billionaires, this authoritative account is a dramatic tale of risk and high adventure, the birth of a new Space Age, fueled by some of the world's richest men as they struggle to end governments' monopoly on the cosmos. The Space Barons is also a story of rivalry-hard-charging startups warring with established contractors, and the personal clashes of the leaders of this new space movement, particularly Musk and Bezos, as they aim for the moon and Mars and beyond.

    Augustine equate nothingness with the Devil? What tortuous means did 17th-century scientists employ in their attempts to create a vacuum? And why do contemporary quantum physicists believe that the void is actually seething with subatomic activity? You’ll find the answers in this dizzyingly erudite and elegantly explained book by the English cosmologist John D. Barrow.Ranging through mathematics, theology, philosophy, literature, particle physics, and cosmology, The Book of Nothing explores the enduring hold that vacuity has exercised on the human imagination. Combining high-wire speculation with a wealth of reference that takes in Freddy Mercury and Shakespeare alongside Isaac Newton, Albert Einstein, and Stephen Hawking, the result is a fascinating excursion to the vanishing point of our knowledge.

    Twelve astronauts made this greatest of all journeys and were indelibly marked by it, for better or for worse. Journalist Andrew Smith tracks down the nine surviving members of this elite group to find their answers to the question "Where do you go after you've been to the Moon?"A thrilling blend of history, reportage, and memoir, Moondust rekindles the hopeful excitement of an incandescent hour in America's past and captures the bittersweet heroism of those who risked everything to hurl themselves out of the known world -- and who were never again quite able to accept its familiar bounds.

    We often overlook the historical link between mathematics and technological advances, says Stewart—but this connection is integral to any complete understanding of human history.Equations are modeled on the patterns we find in the world around us, says Stewart, and it is through equations that we are able to make sense of, and in turn influence, our world. Stewart locates the origins of each equation he presents—from Pythagoras's Theorem to Newton's Law of Gravity to Einstein's Theory of Relativity—within a particular historical moment, elucidating the development of mathematical and philosophical thought necessary for each equation's discovery. None of these equations emerged in a vacuum, Stewart shows; each drew, in some way, on past equations and the thinking of the day. In turn, all of these equations paved the way for major developments in mathematics, science, philosophy, and technology. Without logarithms (invented in the early 17th century by John Napier and improved by Henry Briggs), scientists would not have been able to calculate the movement of the planets, and mathematicians would not have been able to develop fractal geometry. The Wave Equation is one of the most important equations in physics, and is crucial for engineers studying the vibrations in vehicles and the response of buildings to earthquakes. And the equation at the heart of Information Theory, devised by Claude Shannon, is the basis of digital communication today.An approachable and informative guide to the equations upon which nearly every aspect of scientific and mathematical understanding depends, In Pursuit of the Unknown is also a reminder that equations have profoundly influenced our thinking and continue to make possible many of the advances that we take for granted.

    Army and Navy from small towns and elite colleges, more than ten thousand women served as codebreakers during World War II. While their brothers and boyfriends took up arms, these women moved to Washington and learned the meticulous work of code-breaking. Their efforts shortened the war, saved countless lives, and gave them access to careers previously denied to them. A strict vow of secrecy nearly erased their efforts from history; now, through dazzling research and interviews with surviving code girls, bestselling author Liza Mundy brings to life this riveting and vital story of American courage, service, and scientific accomplishment.

    Now, two science professors give us the tools to dismantle misinformation and think clearly in a world of fake news and bad data.It's increasingly difficult to know what's true. Misinformation, disinformation, and fake news abound. Our media environment has become hyperpartisan. Science is conducted by press release. Startup culture elevates bullshit to high art. We are fairly well equipped to spot the sort of old-school bullshit that is based in fancy rhetoric and weasel words, but most of us don't feel qualified to challenge the avalanche of new-school bullshit presented in the language of math, science, or statistics. In Calling Bullshit, Professors Carl Bergstrom and Jevin West give us a set of powerful tools to cut through the most intimidating data.You don't need a lot of technical expertise to call out problems with data. Are the numbers or results too good or too dramatic to be true? Is the claim comparing like with like? Is it confirming your personal bias? Drawing on a deep well of expertise in statistics and computational biology, Bergstrom and West exuberantly unpack examples of selection bias and muddled data visualization, distinguish between correlation and causation, and examine the susceptibility of science to modern bullshit.We have always needed people who call bullshit when necessary, whether within a circle of friends, a community of scholars, or the citizenry of a nation. Now that bullshit has evolved, we need to relearn the art of skepticism.

     Elinor Cleghorn became an unwell woman ten years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis.In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect. The result is an authoritative and groundbreaking exploration of the relationship between women and medical practice, from the wandering womb of Ancient Greece to the rise of witch trials across Europe, and from the dawn of hysteria as a catchall for difficult-to-diagnose disorders to the first forays into autoimmunity and the shifting understanding of hormones, menstruation, menopause, and conditions like endometriosis.Packed with character studies and case histories of women who have suffered, challenged, and rewritten medical orthodoxy--and the men who controlled their fate--this is a revolutionary examination of the relationship between women, illness, and medicine. With these case histories, Elinor pays homage to the women who suffered so strides could be made, and shows how being unwell has become normalized in society and culture, where women have long been distrusted as reliable narrators of their own bodies and pain. But the time for real change is long overdue: answers reside in the body, in the testimonies of unwell women--and their lives depend on medicine learning to listen.

    Yet in The Science of Interstellar, Kip Thorne, the physicist who assisted Nolan on the scientific aspects of Interstellar, shows us that the movie’s jaw-dropping events and stunning, never-before-attempted visuals are grounded in real science. Thorne shares his experiences working as the science adviser on the film and then moves on to the science itself. In chapters on wormholes, black holes, interstellar travel, and much more, Thorne’s scientific insights—many of them triggered during the actual scripting and shooting of Interstellar—describe the physical laws that govern our universe and the truly astounding phenomena that those laws make possible.Interstellar and all related characters and elements are trademarks of and © Warner Bros. Entertainment Inc. (s14).