It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.David Quammen chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

    Eight years later, a schoolteacher who lived four miles away gave birth to a boy whose cherubic smile belied the fast growing tumors that soon riddled his face and chest. The doctors predicted he would not reach his first birthday. They were wrong, but that was only one of many surprises that would eventually come to light in Toms River, culminating in 2001 with a record legal settlement believed to top $35 million and an unprecedented government study confirming the existence of a long-suspected cluster of childhood cancer linked to polluted water and air. A detective story rooted in a scientific quest thousands of years old, Toms River is a tale of dumpers at midnight and deceptions in broad daylight, of corporate avarice and government neglect, and of a few brave individuals who would not keep silent.

    Kids typically no longer expect their lives to be better than their parents’ were. Dystopian scenarios loom ever larger in public consciousness as fisheries collapse, CO2 levels rise, and clouds of radioactive steam billow from “fail-safe” nuclear plants that failed. Despite the technological marvels of our age—or perhaps because of them—these are dark days.As comedian Louis C.K. put it, “Everything’s amazing, but nobody’s happy.”Even for the most fortunate among us, material abundance comes at a very high price. Facebook is a hollow replacement for face time. We produce more food than ever, but hunger and malnutrition are standard in most of the world while the rest of us stuff ourselves quite literally to death. Despair darkens ever more lives as rates of clinical depression and suicide continue their grim climb in the developed world. A third of all American children are obese or seriously overweight, and fifty four million of us are pre-diabetic. Pre-schoolers represent the fastest-growing market for anti-depressants, while the rate of increase of depression among children is over twenty percent, according to a recent Harvard study. Twenty four million American adults are thought to suffer from Post-Traumatic Stress Disorder—mostly attributable to the never-ending wars that have become part of modern life for the swelling underclass with few other employment opportunities.It’s common to wonder how an anthropologist from Mars would view our world or what sage advice an emissary from the future would bring back. But how would a time-traveler from our prehistoric past assess the lives we lead and the future prospects for the path we’re on? Such a visitor from 200 centuries ago would no doubt be impressed by much of what she found here. But once her amazement at iPhones, air travel, and liver transplants subsided, what would she make of our daily lives? Would she ultimately be more impressed by our advances or dismayed by what we’ve lost in our always accelerating rush toward the future?With faith in the future melting like an overheated glacier even as contentment with the present evaporates, it’s high time for a sober reassessment of the past. Ten thousand years since turning from the ancient path our ancestors trod forever, it’s time for a scientifically-informed, multidisciplinary look at the effects of this fateful divergence. It’s time to ask what may be the most subversive question of all: Are modern humans, even the most fortunate among us, living significantly better lives than our pre-civilized ancestors? Taken as a whole, is civilization a net gain for individual human beings?

    In The Ends of the World, Peter Brannen dives into deep time, exploring Earth’s past dead ends, and in the process, offers us a glimpse of our possible future.Many scientists now believe that the climate shifts of the twenty-first century have analogs in these five extinctions. Using the visible clues these devastations have left behind in the fossil record, The Ends of the World takes us inside “scenes of the crime,” from South Africa to the New York Palisades, to tell the story of each extinction. Brannen examines the fossil record—which is rife with creatures like dragonflies the size of sea gulls and guillotine-mouthed fish—and introduces us to the researchers on the front lines who, using the forensic tools of modern science, are piecing together what really happened at the crime scenes of the Earth’s biggest whodunits.Part road trip, part history, and part cautionary tale, The Ends of the World takes us on a tour of the ways that our planet has clawed itself back from the grave, and casts our future in a completely new light.

    Half of all species could disappear by the end of the century, and scientists now concede that most of America’s endangered animals will survive only if conservationists keep rigging the world around them in their favor. So Mooallem ventures into the field, often taking his daughter with him, to move beyond childlike fascination and make those creatures feel more real. Wild Ones is a tour through our environmental moment and the eccentric cultural history of people and wild animals in America that inflects it—from Thomas Jefferson’s celebrations of early abundance to the turn-of the-last-century origins of the teddy bear to the whale-loving hippies of the 1970s. In America, Wild Ones discovers, wildlife has always inhabited the terrain of our imagination as much as the actual land.The journey is framed by the stories of three modern-day endangered species: the polar bear, victimized by climate change and ogled by tourists outside a remote northern town; the little-known Lange’s metalmark butterfly, foundering on a shred of industrialized land near San Francisco; and the whooping crane as it’s led on a months-long migration by costumed men in ultralight airplanes. The wilderness that Wild Ones navigates is a scrappy, disorderly place where amateur conservationists do grueling, sometimes preposterous-looking work; where a marketer maneuvers to control the polar bear’s image while Martha Stewart turns up to film those beasts for her show on the Hallmark Channel. Our most comforting ideas about nature unravel. In their place, Mooallem forges a new and affirming vision of the human animal and the wild ones as kindred creatures on an imperfect planet.With propulsive curiosity and searing wit, and without the easy moralizing and nature worship of environmental journalism’s older guard, Wild Ones merges reportage, science, and history into a humane and endearing meditation on what it means to live in, and bring a life into, a broken world.

    If your anxiety about global warming is dominated by fears of sea-level rise, you are barely scratching the surface of what terrors are possible. In California, wildfires now rage year-round, destroying thousands of homes. Across the US, "500-year" storms pummel communities month after month, and floods displace tens of millions annually.This is only a preview of the changes to come. And they are coming fast. Without a revolution in how billions of humans conduct their lives, parts of the Earth could become close to uninhabitable, and other parts horrifically inhospitable, as soon as the end of this century.In his travelogue of our near future, David Wallace-Wells brings into stark relief the climate troubles that await--food shortages, refugee emergencies, and other crises that will reshape the globe. But the world will be remade by warming in more profound ways as well, transforming our politics, our culture, our relationship to technology, and our sense of history. It will be all-encompassing, shaping and distorting nearly every aspect of human life as it is lived today.Like An Inconvenient Truth and Silent Spring before it, The Uninhabitable Earth is both a meditation on the devastation we have brought upon ourselves and an impassioned call to action. For just as the world was brought to the brink of catastrophe within the span of a lifetime, the responsibility to avoid it now belongs to a single generation.

    The most fatal virus known to science, rabies — a disease that spreads avidly from animals to humans — kills nearly one hundred percent of its victims once the infection takes root in the brain. In this critically acclaimed exploration, journalist Bill Wasik and veterinarian Monica Murphy chart four thousand years of the history, science, and cultural mythology of rabies. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh and often wildly entertaining look at one of humankind’s oldest and most fearsome foes.

    Mara Altman's volatile and apprehensive relationship with her body has led her to wonder about a lot of stuff over the years. Like, who decided that women shouldn't have body hair? And how sweaty is too sweaty? Also, why is breast cleavage sexy but camel toe revolting? Isn't it all just cleavage? These questions and others like them have led to the comforting and sometimes smelly revelations that constitute Gross Anatomy, an essay collection about what it's like to operate the bags of meat we call our bodies.Divided into two sections, "The Top Half" and "The Bottom Half," with cartoons scattered throughout, Altman's book takes the reader on a wild and relatable journey from head to toe—as she attempts to strike up a peace accord with our grody bits.With a combination of personal anecdotes and fascinating research, Gross Anatomy holds up a magnifying glass to our beliefs, practices, biases, and body parts and shows us the naked truth: that there is greatness in our grossness.

    . . No scientist had seen a Blakiston’s fish owl so far south in a hundred years . . . When he was just a fledgling birdwatcher, Jonathan C. Slaght had a chance encounter with one of the most mysterious birds on Earth. Bigger than any owl he knew, it looked like a small bear with decorative feathers. He snapped a quick photo and shared it with experts. Soon he was on a five-year journey, searching for this enormous, enigmatic creature in the lush, remote forests of eastern Russia. That first sighting set his calling as a scientist.Despite a wingspan of six feet and a height of over two feet, the Blakiston’s fish owl is highly elusive. They are easiest to find in winter, when their tracks mark the snowy banks of the rivers where they feed. They are also endangered. And so, as Slaght and his devoted team set out to locate the owls, they aim to craft a conservation plan that helps ensure the species’ survival. This quest sends them on all-night monitoring missions in freezing tents, mad dashes across thawing rivers, and free-climbs up rotting trees to check nests for precious eggs. They use cutting-edge tracking technology and improvise ingenious traps. And all along, they must keep watch against a run-in with a bear or an Amur tiger. At the heart of Slaght’s story are the fish owls themselves: cunning hunters, devoted parents, singers of eerie duets, and survivors in a harsh and shrinking habitat.Through this rare glimpse into the everyday life of a field scientist and conservationist, Owls of the Eastern Ice testifies to the determination and creativity essential to scientific advancement and serves as a powerful reminder of the beauty, strength, and vulnerability of the natural world.

    But it’s also messy, fallible, and about 50,000 years out of date. We cling to superstitions, remember faces but not names, miss things sitting right in front of us, and lie awake at night while our brains endlessly replay our greatest fears. Idiot Brain is for anyone who has ever wondered why their brain appears to be sabotaging their life—and what on earth it is really up to.A Library Journal Science Bestseller and a Finalist for the Goodreads Choice Award in Science Technology.

    But, after a broken engagement and a broken heart, he desperately needed a change of scenery. The ambitious plan he cooked up went a bit overboard in that department; Knighton set out to visit every single one of America's National Parks, from Acadia to Zion. Leave Only Footprints is the memoir of his year spent traveling across the United States, a journey that yielded his "On the Trail" series, which quickly became one of CBS Sunday Morning's most beloved segments. In this smart, informative, and often hilarious book, he'll share how his journey through these natural wonders, unchanged by man, ended up changing his worldview on everything from God to politics to love and technology. Whether it's waking up early for a naked scrub in an Arkansas bathhouse or staying up late to stargaze along our loneliest highway, Knighton goes behind the scenery to provide an unfiltered look at America. In the tradition of books like A Walk in the Woods or Turn Right at Machu Picchu, this is an irresistible mix of personal narrative and travelogue-some well-placed pop culture references, too-and a must-read for any of the 331 million yearly National Parks visitors.

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    We meet people, date, get into and out of relationships, all with the hope of finding someone with whom we share a deep connection. This seems standard now, but it’s wildly different from what people did even just decades ago. Single people today have more romantic options than at any point in human history. With technology, our abilities to connect with and sort through these options are staggering. So why are so many people frustrated?Some of our problems are unique to our time. “Why did this guy just text me an emoji of a pizza?” “Should I go out with this girl even though she listed Combos as one of her favorite snack foods? Combos?!” “My girlfriend just got a message from some dude named Nathan. Who’s Nathan? Did he just send her a photo of his penis? Should I check just to be sure?” But the transformation of our romantic lives can’t be explained by technology alone. In a short period of time, the whole culture of finding love has changed dramatically. A few decades ago, people would find a decent person who lived in their neighborhood. Their families would meet and, after deciding neither party seemed like a murderer, they would get married and soon have a kid, all by the time they were twenty-four. Today, people marry later than ever and spend years of their lives on a quest to find the perfect person, a soul mate.For years, Aziz Ansari has been aiming his comic insight at modern romance, but for Modern Romance, the book, he decided he needed to take things to another level. He teamed up with NYU sociologist Eric Klinenberg and designed a massive research project, including hundreds of interviews and focus groups conducted everywhere from Tokyo to Buenos Aires to Wichita. They analyzed behavioral data and surveys and created their own online research forum on Reddit, which drew thousands of messages. They enlisted the world’s leading social scientists, including Andrew Cherlin, Eli Finkel, Helen Fisher, Sheena Iyengar, Barry Schwartz, Sherry Turkle, and Robb Willer. The result is unlike any social science or humor book we’ve seen before.In Modern Romance, Ansari combines his irreverent humor with cutting-edge social science to give us an unforgettable tour of our new romantic world.

    Here, Jenny Odell sends up a flare from the heart of Silicon Valley, delivering an action plan to resist capitalist narratives of productivity and techno-determinism, and to become more meaningfully connected in the process.