This is the story of a fateful year that prefigured the events of 1776.In The Fever of 1721, Stephen Coss brings to life an amazing cast of characters in a year that changed the course of medical history, American journalism, and colonial revolution, including Cotton Mather, the great Puritan preacher, son of the president of Harvard College; Zabdiel Boylston, a doctor whose name is on one of Boston's grand avenues; James and his younger brother Benjamin Franklin; and Elisha Cooke and his protegee; Samuel Adams.During the worst smallpox epidemic in Boston history Mather convinced Doctor Boylston to try a procedure that he believed would prevent death--by making an incision in the arm of a healthy person and implanting it with smallpox. Inoculation led to vaccination, one of the most profound medical discoveries in history. Public outrage forced Boylston into hiding, and Mather's house was firebombed.A political fever also raged. Elisha Cooke was challenging the Crown for control of the colony and finally forced Royal Governor Samuel Shute to flee Massachusetts. Samuel Adams and the Patriots would build on this to resist the British in the run-up to the American Revolution. And a bold young printer James Franklin (who was on the wrong side of the controversy on inoculation), launched America's first independent newspaper and landed in jail. His teenage brother and apprentice, Benjamin Franklin, however, learned his trade in James' shop and became a father of the Independence movement.One by one, the atmosphere in Boston in 1721 simmered and ultimately boiled over, leading to the full drama of the American Revolution.

    From creating brand value to fine-tuning customer service, the folks running cartels have been attentive students of the strategy and tactics used by corporations such as Walmart, McDonald's, and Coca-Cola.     And what can government learn to combat this scourge? By analyzing the cartels as companies, law enforcers might better understand how they work—and stop throwing away 100 billion a year in a futile effort to win the “war” against this global, highly organized business.     Your intrepid guide to the most exotic and brutal industry on earth is Tom Wainwright. Picking his way through Andean cocaine fields, Central American prisons, Colorado pot shops, and the online drug dens of the Dark Web, Wainwright provides a fresh, innovative look into the drug trade and its 250 million customers.     The cast of characters includes “Bin Laden,” the Bolivian coca guide; “Old Lin,” the Salvadoran gang leader; “Starboy,” the millionaire New Zealand pill maker; and a cozy Mexican grandmother who cooks blueberry pancakes while plotting murder. Along with presidents, cops, and teenage hitmen, they explain such matters as the business purpose for head-to-toe tattoos, how gangs decide whether to compete or collude, and why cartels care a surprising amount about corporate social responsibility.More than just an investigation of how drug cartels do business, Narconomics is also a blueprint for how to defeat them.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    Writer Mikal Gilmore is his younger brother. In Shot in the Heart, he tells the stunning story of their wildly dysfunctional family: their mother, a blacksheep daughter of unforgiving Mormon farmers; their father, a drunk, thief, and con man. It was a family destroyed by a multigenerational history of child abuse, alcoholism, crime, adultery, and murder. Mikal, burdened with the guilt of being his father's favorite and the shame of being Gary's brother, gracefully and painfully relates a murder tale "from inside the house where murder is born... a house that, in some ways, [he has] never been able to leave." Shot in the Heart is the history of an American family inextricably tied up with violence, and the story of how the children of this family committed murder and murdered themselves in payment for a long lineage of ruin. Haunting, harrowing, and profoundly affecting, Shot in the Heart exposes and explores a dark vein of American life that most of us would rather ignore. It is a book that will leave no reader unchanged.

    Their name is synonymous with American royalty. Their commitment to public service is legendary. But, for all the successes, the family has been blighted by assassinations, fatal accidents, drug and alcohol abuse and sex scandals.To this day, the Kennedys occupy a unique, contradictory place in the world's imagination: at once familiar and unknowable; charmed and cursed. The Kennedy Curse is a revealing, fascinating account of America’s most famous family, as told by the world's most trusted storyteller.

    Norco ’80 tells the story of how five heavily-armed young men—led by an apocalyptic born-again Christian—attempted a bank robbery that turned into one of the most violent criminal events in U.S. history, forever changing the face of American law enforcement. Part action thriller and part courtroom drama, Norco ’80 transports the reader back to the Southern California of the 1970s, an era of predatory evangelical gurus, doomsday predictions, megachurches, and soaring crime rates, with the threat of nuclear obliteration looming over it all. A group of landscapers transforms into a murderous gang of bank robbers armed to the teeth with military-grade weapons. Their desperate getaway turned the surrounding towns into war zones. When it was over, three were dead and close to twenty wounded; a police helicopter was forced down from the sky, and thirty-two police vehicles were destroyed by thousands of rounds of ammo. The resulting trials shook the community to the core, raising many issues that continue to plague society today: from racism and the epidemic of post-traumatic stress disorder within law enforcement to religious extremism and the militarization of local police forces.

    On March 25, 1911, as workers were getting ready to leave for the day, a fire broke out in the Triangle Shirtwaist factory in New York’s Greenwich Village. Within minutes it spread to consume the building’s upper three stories. Firemen who arrived at the scene were unable to rescue those trapped inside: their ladders simply weren’t tall enough. People on the street watched in horror as desperate workers jumped to their deaths. The final toll was 146 people—123 of them women. It was the worst disaster in New York City history.

    In fact, your body is actually endowed with many self-defense measures to hold on to fat. For example, fat can use stem cells to regenerate; increase our appetite if it feels threatened; and use bacteria, genetics, and viruses to expand itself. The secret to losing twenty pounds? You have to work with your fat, not against it. Tara explains how your fat influences your appetite and willpower, how it defends itself when attacked, and why it grows back so quickly. The Secret Life of Fat brings cutting-edge research together with historical perspectives to reveal fat’s true identity: an endocrine organ that, in the right amount, is critical to our health. Fat triggers puberty, enables our reproductive and immune systems, and even affects brain size.Although we spend $60 billion annually fighting fat, our efforts are often misinformed and misdirected. Tara expertly illustrates the complex role that genetics, hormones, diet, exercise, and history play in our weight, and The Secret Life of Fat sets you on the path to beat the bulge once and for all.

    Lyme disease, and SARS. According to Walters, we are not only victims of these emerging diseases; we are helping exacerbate their creation and spread.

    It continued in Moscow, where Browder made his fortune heading the largest investment fund in Russia after the Soviet Union's collapse. But when he exposed the corrupt oligarchs who were robbing the companies in which he was investing, Vladimir Putin turned on him and, in 2005, had him expelled from Russia. In 2007, a group of law enforcement officers raided Browder's offices in Moscow and stole $230 million of taxes that his fund's companies had paid to the Russian government. Browder's attorney Sergei Magnitsky investigated the incident and uncovered a sprawling criminal enterprise. A month after Sergei testified against the officials involved, he was arrested and thrown into pre-trial detention, where he was tortured for a year. On November 16, 2009, he was led to an isolation chamber, handcuffed to a bedrail, and beaten to death by eight guards in full riot gear. Browder glimpsed the heart of darkness, and it transformed his life: he embarked on an unrelenting quest for justice in Sergei's name, exposing the towering cover-up that leads right up to Putin. A financial caper, a crime thriller, and a political crusade, Red Notice is the story of one man taking on overpowering odds to change the world.

    He’s a sociopath. And your boss, teacher, and colleague? They may be sociopaths too.We are accustomed to think of sociopaths as violent criminals, but in The Sociopath Next Door, Harvard psychologist Martha Stout reveals that a shocking 4 percent of ordinary people—one in twenty-five—has an often undetected mental disorder, the chief symptom of which is that that person possesses no conscience. He or she has no ability whatsoever to feel shame, guilt, or remorse. One in twenty-five everyday Americans, therefore, is secretly a sociopath. They could be your colleague, your neighbor, even family. And they can do literally anything at all and feel absolutely no guilt. How do we recognize the remorseless? One of their chief characteristics is a kind of glow or charisma that makes sociopaths more charming or interesting than the other people around them. They’re more spontaneous, more intense, more complex, or even sexier than everyone else, making them tricky to identify and leaving us easily seduced. Fundamentally, sociopaths are different because they cannot love. Sociopaths learn early on to show sham emotion, but underneath they are indifferent to others’ suffering. They live to dominate and thrill to win. The fact is, we all almost certainly know at least one or more sociopaths already. Part of the urgency in reading The Sociopath Next Door is the moment when we suddenly recognize that someone we know—someone we worked for, or were involved with, or voted for—is a sociopath. But what do we do with that knowledge? To arm us against the sociopath, Dr. Stout teaches us to question authority, suspect flattery, and beware the pity play. Above all, she writes, when a sociopath is beckoning, do not join the game. It is the ruthless versus the rest of us, and The Sociopath Next Door will show you how to recognize and defeat the devil you know.

    Their father had gone to sea the previous Friday, the boys told their neighbours, and their mother was visiting her family in Liverpool. Over the next ten days Robert and Nattie spent extravagantly, pawning their parents' valuables to fund trips to the theatre and the seaside. But as the sun beat down on the Coombes house, a strange smell began to emanate from the building. When the police were finally called to investigate, the discovery they made sent the press into a frenzy of horror and alarm, and Robert and Nattie were swept up in a criminal trial that echoed the outrageous plots of the 'penny dreadful' novels that Robert loved to read. In The Wicked Boy, Kate Summerscale has uncovered a fascinating true story of murder and morality - it is not just a meticulous examination of a shocking Victorian case, but also a compelling account of its aftermath, and of man's capacity to overcome the past.

    Governments spend millions on a losing war against it, yet it's still the drug of choice in the West. How did the cocaine economy become so massive? Who keeps it running behind the scenes?In Cocaine Nation, Tom Feiling travels the trade routes from Colombia via Miami, Kingston and Tijuana to London and New york. he meets Medellin hitmen, U.S. kingpins, Brazilian traffickers, and talks to soldiers and narcotics officers who fight the gangs and cartels. He traces cocaine's progress from legal 'pick-me-up' to luxury product to global commodity, looks at legalization programs in countries such as Switzerland, and shows how America's anti-drugs crusade is actually increasing demand. Cutting through the myths about the white trade, this is the story of cocaine as it's never been told before.

    Cory Franklin. Filled with stories of strange medical cases and unforgettable patients culled from a thirty-year career in medicine, Cook County ICU offers readers a peek into the inner workings of a hospital. Author Dr. Cory Franklin, who headed the hospital’s intensive care unit from the 1970s through the 1990s, shares his most unique and bizarre experiences, including the deadly Chicago heat wave of 1995, treating some of the first AIDS patients in the country before the disease was diagnosed, the nurse with rare Munchausen syndrome, the first surviving ricin victim, and the famous professor whose Parkinson’s disease hid the effects of the wrong medication. Surprising, darkly humorous, heartwarming, and sometimes tragic, these stories provide a big-picture look at how the practice of medicine has changed over the years, making it an enjoyable read for patients, doctors, and anyone with an interest in medicine.

    In the early 1800s, women were dying in large numbers from treatable diseases because they avoided receiving medical care. Examinations performed by male doctors were often demeaning and even painful. In addition, women faced stigma from illness—a diagnosis could greatly limit their ability to find husbands, jobs or be received in polite society.Motivated by personal loss and frustration over inadequate medical care, Elizabeth Blackwell, Elizabeth Garrett Anderson and Sophia Jex-Blake fought for a woman’s place in the male-dominated medical field. For the first time ever, Women in White Coats tells the complete history of these three pioneering women who, despite countless obstacles, earned medical degrees and paved the way for other women to do the same. Though very different in personality and circumstance, together these women built women-run hospitals and teaching colleges—creating for the first time medical care for women by women.With gripping storytelling based on extensive research and access to archival documents, Women in White Coats tells the courageous history these women made by becoming doctors, detailing the boundaries they broke of gender and science to reshape how we receive medical care today.