Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    . . on addiction.”—Ezra Klein, New York Times.“Accessible and enjoyable. The Craving Mind brilliantly combines the latest science with universal real-life experiences—from falling in love to spending too much time with our phones.”—Arianna Huffington We are all vulnerable to addiction. Whether it’s a compulsion to constantly check social media, binge eating, smoking, excessive drinking, or any other behaviors, we may find ourselves uncontrollably repeating. Why are bad habits so hard to overcome? Is there a key to conquering the cravings we know are unhealthy for us?   This book provides groundbreaking answers to the most important questions about addiction. Dr. Judson Brewer, a psychiatrist and neuroscientist who has studied the science of addictions for twenty years, reveals how we can tap into the very processes that encourage addictive behaviors in order to step out of them. He describes the mechanisms of habit and addiction formation, then explains how the practice of mindfulness can interrupt these habits. Weaving together patient stories, his own experience with mindfulness practice, and current scientific findings from his own lab and others, Dr. Brewer offers a path for moving beyond our cravings, reducing stress, and ultimately living a fuller life.

    In Mapping Cloud Nine, bestselling author and award-winning journalist Steven Kotler takes us on a heady thrill ride through the history of human potential—and how what we’ve learned so far might unlock even greater levels of creativity, performance, and meaning in our lives.From Nietzsche to now—a tour of human consciousnessIn this six-part audio program, Kotler bridges science and spirituality to explore how our understanding of peak experiences has evolved over time—from early inquiries into altered and mystical states; to the birth of positive psychology and research on high performers; to pioneering studies on meditation and near-death experiences; and into current explorations of psychedelics, flow states, and technological breakthroughs. A brilliant synthesizer and gifted storyteller, Kotler paints a compelling portrait of our greatest human potential, inspiring us to leverage this growing body of research and step into new realms of possibility. HIGHLIGHTS- The evolutionary impulse for altered states of mind—psychedelics throughout time- The neurobiology of flow states, mystical experiences, and hallucinations- The spiritual path and the high-performance path—are they one and the same?- Altered states lead to altered traits—the next wave of consciousness hacking- Why bridging the gap between science and spirituality leads to even greater breakthroughs- How you can leverage flow states for a more meaningful—and interesting—life

    Maybe before. Exponentially improving technologies such as solar, electric vehicles, and autonomous (self-driving) cars will disrupt and sweep away the energy and transportation industries as we know it. The same Silicon Valley ecosystem that created bit-based technologies that have disrupted atom-based industries is now creating bit- and electron-based technologies that will disrupt atom-based energy industries. Clean Disruption projections (based on technology cost curves, business model innovation as well as product innovation) show that by 2030: - All new energy will be provided by solar or wind. - All new mass-market vehicles will be electric. - All of these vehicles will be autonomous (self-driving) or semi-autonomous. - The new car market will shrink by 80%. - Even assuming that EVs don't kill the gasoline car by 2030, the self-driving car will shrink the new car market by 80%. - Gasoline will be obsolete. Nuclear is already obsolete. - Up to 80% of highways will be redundant. - Up to 80% of parking spaces will be redundant. - The concept of individual car ownership will be obsolete. - The Car Insurance industry will be disrupted. The Stone Age did not end because we ran out of rocks. It ended because a disruptive technology ushered in the Bronze Age. The era of centralized, command-and-control, extraction-resource-based energy sources (oil, gas, coal and nuclear) will not end because we run out of petroleum, natural gas, coal, or uranium. It will end because these energy sources, the business models they employ, and the products that sustain them will be disrupted by superior technologies, product architectures, and business models. This is a technology-based disruption reminiscent of how the cell phone, Internet, and personal computer swept away industries such as landline telephony, publishing, and mainframe computers. Just like those technology disruptions flipped the architecture of information and brought abundant, cheap and participatory information, the clean disruption will flip the architecture of energy and bring abundant, cheap and participatory energy. Just like those previous technology disruptions, the clean disruption is inevitable and it will be swift.

    Joe took toy soldiers to a whole new level by giving them the ability to pose via moveable parts, as well as interchangeable clothing and accessories, the business of creating pop sculpture icons for the mass market was off and running. Superheroes came next, followed by TV show and movie characters, most notably those from Star Wars. Today, action figures exist for sports stars, rock stars, even presidents.With today's blockbuster success of animated films, action figures and collectibles have become a behemoth industry--with a growing need for skilled artists who can bring these characters to life. So how do you get started?The trio of veteran industry insiders who authored this book take you on an incredibly thorough journey that begins with drawing conceptual drafts and continues through rough sculpting and honing the final product. Along the way, you'll learn how to research your character, shape casts from a variety of materials including wax and resin, make accessories, articulate characters so that they are poseable, paint them, and ultimately convince an art director to buy and manufacture them. Whether you want to make small PVC toys, collectible statues, or larger high-end collectibles, Pop Sculpture offers step-by-step demos and words of wisdom from the pros.

    Is it in our genes? The structure of our brains? Our genome may determine our eye color and even aspects of our personality. But our friendships, failures, and passions also shape who we are. The question is: how?Sebastian Seung, a dynamic professor at MIT, is on a quest to discover the biological basis of identity. He believes it lies in the pattern of connections between the brain’s neurons, which change slowly over time as we learn and grow. The connectome, as it’s called, is where our genetic inheritance intersects with our life experience. It’s where nature meets nurture.Seung introduces us to the dedicated researchers who are mapping the brain’s connections, neuron by neuron, synapse by synapse. It is a monumental undertaking—the scientific equivalent of climbing Mount Everest—but if they succeed, it could reveal the basis of personality, intelligence, memory, and perhaps even mental disorders. Many scientists speculate that people with anorexia, autism, and schizophrenia are "wired differently," but nobody knows for sure. The brain’s wiring has never been clearly seen.In sparklingly clear prose, Seung reveals the amazing technological advances that will soon help us map connectomes. He also examines the evidence that these maps will someday allow humans to "upload" their minds into computers, achieving a kind of immortality.Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are. Welcome to the future of neuroscience.

    Levitin shifts his keen insights from your brain on music to your brain in a sea of details.The information age is drowning us with an unprecedented deluge of data. At the same time, we’re expected to make more—and faster—decisions about our lives than ever before. No wonder, then, that the average American reports frequently losing car keys or reading glasses, missing appointments, and feeling worn out by the effort required just to keep up.But somehow some people become quite accomplished at managing information flow. In The Organized Mind, Daniel J. Levitin, PhD, uses the latest brain science to demonstrate how those people excel—and how readers can use their methods to regain a sense of mastery over the way they organize their homes, workplaces, and time.With lively, entertaining chapters on everything from the kitchen junk drawer to health care to executive office workflow, Levitin reveals how new research into the cognitive neuroscience of attention and memory can be applied to the challenges of our daily lives. This Is Your Brain on Music showed how to better play and appreciate music through an understanding of how the brain works. The Organized Mind shows how to navigate the churning flood of information in the twenty-first century with the same neuroscientific perspective.

    Even as they bring ease to our lives, these programs are stealing something essential from us.Drawing on psychological and neurological studies that underscore how tightly people’s happiness and satisfaction are tied to performing hard work in the real world, Carr reveals something we already suspect: shifting our attention to computer screens can leave us disengaged and discontented.From nineteenth-century textile mills to the cockpits of modern jets, from the frozen hunting grounds of Inuit tribes to the sterile landscapes of GPS maps, The Glass Cage explores the impact of automation from a deeply human perspective, examining the personal as well as the economic consequences of our growing dependence on computers.With a characteristic blend of history and philosophy, poetry and science, Carr takes us on a journey from the work and early theory of Adam Smith and Alfred North Whitehead to the latest research into human attention, memory, and happiness, culminating in a moving meditation on how we can use technology to expand the human experience.

    Tens of millions of people over several states are affected. For those without access to a generator, there is no running water, no sewage, no refrigeration or light. Food and medical supplies are dwindling. Devices we rely on have gone dark. Banks no longer function, looting is widespread, and law and order are being tested as never before.  It isn’t just a scenario. A well-designed attack on just one of the nation’s three electric power grids could cripple much of our infrastructure—and in the age of cyberwarfare, a laptop has become the only necessary weapon. Several nations hostile to the United States could launch such an assault at any time. In fact, as a former chief scientist of the NSA reveals, China and Russia have already penetrated the grid. And a cybersecurity advisor to President Obama believes that independent actors—from “hacktivists” to terrorists—have the capability as well. “It’s not a question of if,” says Centcom Commander General Lloyd Austin, “it’s a question of when.”  And yet, as Koppel makes clear, the federal government, while well prepared for natural disasters, has no plan for the aftermath of an attack on the power grid.  The current Secretary of Homeland Security suggests keeping a battery-powered radio.In the absence of a government plan, some individuals and communities have taken matters into their own hands. Among the nation’s estimated three million “preppers,” we meet one whose doomsday retreat includes a newly excavated three-acre lake, stocked with fish, and a Wyoming homesteader so self-sufficient that he crafted the thousands of adobe bricks in his house by hand. We also see the unrivaled disaster preparedness of the Mormon church, with its enormous storehouses, high-tech dairies, orchards, and proprietary trucking company – the fruits of a long tradition of anticipating the worst. But how, Koppel asks, will ordinary civilians survive?With urgency and authority, one of our most renowned journalists examines a threat unique to our time and evaluates potential ways to prepare for a catastrophe that is all but inevitable.

    Their visionary answers flow from the frontiers of psychology, philosophy, economics, physics, sociology, and more. Surprising and enlightening, these insights will revolutionize the way you think about yourself and the world.Contributors include:Daniel Kahneman on the “focusing illusion”Jonah Lehrer on controlling attentionRichard Dawkins on experimentationAubrey De Grey on conquering our fear of the unknownMartin Seligman on the ingredients of well-beingNicholas Carr on managing “cognitive load”Steven Pinker on win-win negotiatingDaniel Goleman on understanding our connection to the natural worldMatt Ridley on tapping collective intelligenceLisa Randall on effective theorizingBrian Eno on “ecological vision”J. Craig Venter on the multiple possible origins of life  Helen Fisher on temperamentSam Harris on the flow of thoughtLawrence Krauss on living with uncertainty

     In this decentralization manifesto, futurist Max Borders shows that humanity is already building systems that will “underthrow” great centers of power. Exploring the promise of a decentralized world, Borders says we will: - Reorganize to collaborate and compete with AI; - Operate within networks of superior collective intelligence; - Rediscover our humanity and embrace values for an age of connection. With lively prose, Borders takes us on a tour of modern pagan festivals, cities of the future, and radically new ways to organize society. In so doing, he examines trends likely to revolutionize the ways we live and work. Although the technological singularity fast approaches, Borders argues, a parallel process of human reorganization will allow us to reap enormous benefits. The paradox? Our billion little acts of subversion will help us lead richer, healthier lives—and avoid the robot apocalypse.

    Out of the exploratory instincts that allowed our ancestors to prosper hundreds of thousands of years ago, humans developed a cognitive style that Mlodinow terms elastic thinking, a unique set of talents that include neophilia (an affinity for novelty), schizotypy (a tendency toward unusual perception), imagination and idea generation, and divergent and integrative thinking. These are the qualities that enabled innovators from Mary Shelley to Miles Davis, from the inventor of jumbo-sized popcorn to the creators of Pok'mon Go, to effect paradigm shifts in our culture and society. In our age of unprecedented technological innovation and social change, it is more important than ever to encourage these abilities and traits.How can we train our brains to be more comfortable when confronting change and more adept at innovation? How do our brains generate new ideas, and how can we nurture that process? Why can diversity and even discord be beneficial to our thought process? With his keen acumen and quick wit, Leonard Mlodinow gives us the essential tools to harness the power of elastic thinking in an endlessly dynamic world.Includes a Bonus PDF of Exercises

    In the forty-eight brief chapters of Feeling & Knowing, and in writing that remains faithful to our intuitive sense of what feeling and experiencing are about, Damasio helps us understand why being conscious is not the same as sensing, why nervous systems are essential for the development of feelings, and why feeling opens the way to consciousness writ large. He combines the latest discoveries in various sciences with philosophy and discusses his original research, which has transformed our understanding of the brain and human behavior. Here is an indispensable guide to understand­ing how we experience the world within and around us and find our place in the universe.

    And there is no more accomplished and accessible guide than renowned neuroscientist David Eagleman to help us understand the nature and changing texture of that fabric. With his hallmark clarity and enthusiasm he reveals the myriad ways that the brain absorbs experience: developing, redeploying, organizing, and arranging the data it receives from the body's own absorption of external stimuli, which enables us to gain the skills, the facilities, and the practices that make us who we are. Eagleman covers decades of the most important research into the functioning of the brain and presents new discoveries from his own research as well: about the nature of synesthesia, about dreaming, and about wearable devices that are revolutionizing how we think about the five human senses. Finally, Livewired is as deeply informative as it is accessible and brilliantly engaging.

    In How to Create a Mind, Kurzweil presents a provocative exploration of the most important project in human-machine civilization—reverse engineering the brain to understand precisely how it works and using that knowledge to create even more intelligent machines.Kurzweil discusses how the brain functions, how the mind emerges from the brain, and the implications of vastly increasing the powers of our intelligence in addressing the world’s problems. He thoughtfully examines emotional and moral intelligence and the origins of consciousness and envisions the radical possibilities of our merging with the intelligent technology we are creating.Certain to be one of the most widely discussed and debated science books of the year, How to Create a Mind is sure to take its place alongside Kurzweil’s previous classics which include Fantastic Voyage: Live Long Enough to Live Forever and The Age of Spiritual Machines.