With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    From the start, the drug's manufacturer aggressively marketed its patented time-release formula as a breakthrough in the effort to reduce prescription drug abuse. It wasn't long, however, before thrill-seeking teenagers shattered that illusion of safety; by simply crushing an "Oxy," they were able to tap into a high so seductive it would come to dominate their lives. Some patients, seeking relief from pain, also found themselves drawn to the drug's dark side. Pain Killer takes readers on a journey of discovery that begins with the true story of Lindsay, a high-school cheerleader in Virginia who gets hooked on Oxys, and expands outward to explore the critical issues of legitimate pain management, prescription drug abuse, and how the misuse of science by the drug industry threatens the public good. With the fast-rising abuse of prescription drugs by young people ringing alarm bells within government, the how and why behind the OxyContin disaster is a gripping read not only for parents, but also for medical professionals, community leaders, business executives, and all those concerned with this crisis. The dangers described in Pain Killer also reverberate far beyond the threat from a single drug at a particular moment in time. The focus of our government's war on drugs has clearly misled many of us into thinking that only illegal drugs smuggled from beyond our borders can be abused. As Meier tells the dramatic story, some of the most deadly substances are produced and sold legally right here at home.THE EXTRAORDINARY AND TRUE STORY OF OXYCONTIN EQUAL PARTS crime thriller, medical detective story, and business exposé, Pain Killer takes a hard-hitting look at how a powerful drug touted as the salvation for millions triggered a national tragedy. At its inception, the legal narcotic OxyContin was seen as a pharmaceutical dream, a "wonder" drug that would herald a sea change in medical care while reaping vast profits for its maker. It did do that; but it also unleashed a public health crisis that cut a swath of despair and crime through unsuspecting small towns, suburbs, and cities across the country. As reports of OxyContin overdoses made front-page and network news, doctors, narcotics agents, regulators, industry executives, and lawmakers raced in, scrambling to slow the damage. Behind it all stood one of America's wealthiest families, and a drug company whose relentless promotion helped fuel the problem Written by award-winning journalist Barry Meier, whose special report in the New York Times triggered national interest in OxyContin, Pain Killer chronicles the rise of the multibillion dollar pain management industry and lays bare its excesses and abuses.

    These vast expanses provide a home to wildlife populations, a vital source of clean air and water, and a haven for recreation.Since its inception, however, America’s public land system has been embroiled in controversy—caught in the push and pull between the desire to develop the valuable resources the land holds or conserve them. Alarmed by rising tensions over the use of these lands, hunter, angler, and outdoor enthusiast Mark Kenyon set out to explore the spaces involved in this heated debate, and learn firsthand how they came to be and what their future might hold.Part travelogue and part historical examination, That Wild Country invites readers on an intimate tour of the wondrous wild and public places that are a uniquely profound and endangered part of the American landscape.

    But a young historical gastronomist named Sarah Lohman discovered that American food is united by eight flavors: black pepper, vanilla, curry powder, chili powder, soy sauce, garlic, MSG, and Sriracha. Lohman sets out to explore how these influential ingredients made their way to the American table. Eight Flavors introduces the explorers, merchants, botanists, farmers, writers, and chefs whose choices came to define the American palate.

    Unable to stand, barely able to think, he waited for hours in an emergency room before being correctly diagnosed and rushed into surgery. Over the next few days, as he clung to life and the first light of a new year came through his window, he found himself reflecting on the fragility of health, not recognized in America as a human right but without which all rights and freedoms have no meaning.And that was before the pandemic. We have since watched American hospitals, long understaffed and undersupplied, buckling under waves of coronavirus patients. The federal government made matters worse through willful ignorance, misinformation, and profiteering. Our system of commercial medicine failed the ultimate test, and thousands of Americans died.In this eye-opening cri de coeur, Snyder traces the societal forces that led us here and outlines the lessons we must learn to survive. In examining some of the darkest moments of recent history and of his own life, Snyder finds glimmers of hope and principles that could lead us out of our current malaise. Only by enshrining healthcare as a human right, elevating the authority of doctors and medical knowledge, and planning for our children's future can we create an America where everyone is truly free.

    Dr. George Parkman, a Brahmin who owned much of Boston’s West End, was last seen that afternoon visiting his alma mater, Harvard Medical School. Police scoured city tenements and the harbor, and offered hefty rewards as leads put the elusive Dr. Parkman at sea or hiding in Manhattan. But one Harvard janitor held a much darker suspicion: that their ruthless benefactor had never left the Medical School building alive.His shocking discoveries in a chemistry professor’s laboratory engulfed America in one of its most infamous trials: The Commonwealth of Massachusetts v. John White Webster. A baffling case of red herrings, grave robbery, and dismemberment—of Harvard’s greatest doctors investigating one of their own, for a murder hidden in a building full of cadavers—it became a landmark case in the use of medical forensics and the meaning of reasonable doubt. Paul Collins brings nineteenth-century Boston back to life in vivid detail, weaving together newspaper accounts, letters, journals, court transcripts, and memoirs from this groundbreaking case.Rich in characters and evocative in atmosphere, Blood Ivy explores the fatal entanglement of new science and old money in one of America’s greatest murder mysteries.

    In late August 1619, a ship arrived in the British colony of Virginia bearing a cargo of twenty to thirty enslaved people from Africa. Their arrival led to the barbaric and unprecedented system of American chattel slavery that would last for the next 250 years. This is sometimes referred to as the country’s original sin, but it is more than that: It is the source of so much that still defines the United States. The 1619 Project: A New Origin Story builds on The New York Times Magazine’s award-winning “1619 Project,” which reframed our understanding of American history by placing slavery and its continuing legacy at the center of our national narrative. This book substantially expands on the original "1619 Project, "weaving together eighteen essays that explore the legacy of slavery in present-day America with thirty-six poems and works of fiction that illuminate key moments of oppression, struggle, and resistance. The essays show how the inheritance of 1619 reaches into every part of contemporary American society, from politics, music, diet, traffic, and citizenship to capitalism, religion, and our democracy itself. This legacy can be seen in the way we tell stories, the way we teach our children, and the way we remember. Together, the elements of the book reveal a new origin story for the United States, one that helps explain not only the persistence of anti-Black racism and inequality in American life today, but also the roots of what makes the country unique. The book also features an elaboration of the original project’s Pulitzer Prize–winning lead essay by Nikole Hannah-Jones on how the struggles of Black Americans have expanded democracy for all Americans, as well as two original pieces from Hannah-Jones, one of which makes a case for reparative solutions to this legacy of injustice.

    It was a bustling port city with a burgeoning African American middle class and a Fusionist government of Republicans and Populists that included black aldermen, police officers and magistrates. There were successful black-owned businesses and an African American newspaper, The Record. But across the state--and the South--white supremacist Democrats were working to reverse the advances made by former slaves and their progeny.In 1898, in response to a speech calling for white men to rise to the defense of Southern womanhood against the supposed threat of black predators, Alexander Manly, the outspoken young Record editor, wrote that some relationships between black men and white women were consensual. His editorial ignited outrage across the South, with calls to lynch Manly.But North Carolina's white supremacist Democrats had a different strategy. They were plotting to take back the state legislature in November "by the ballot or bullet or both," and then use the Manly editorial to trigger a "race riot" to overthrow Wilmington's multi-racial government. Led by prominent citizens including Josephus Daniels, publisher of the state's largest newspaper, and former Confederate Colonel Alfred Moore Waddell, white supremacists rolled out a carefully orchestrated campaign that included raucous rallies, race-baiting editorials and newspaper cartoons, and sensational, fabricated news stories.With intimidation and violence, the Democrats suppressed the black vote and stuffed ballot boxes (or threw them out), to win control of the state legislature on November eighth. Two days later, more than 2,000 heavily armed Red Shirts swarmed through Wilmington, torching the Record office, terrorizing women and children, and shooting at least sixty black men dead in the streets. The rioters forced city officials to resign at gunpoint and replaced them with mob leaders. Prominent blacks--and sympathetic whites--were banished. Hundreds of terrified black families took refuge in surrounding swamps and forests.This brutal insurrection is a rare instance of a violent overthrow of an elected government in the U.S. It halted gains made by blacks and restored racism as official government policy, cementing white rule for another half century. It was not a "race riot," as the events of November 1898 came to be known, but rather a racially motivated rebellion launched by white supremacists.In Wilmington's Lie, Zucchino uses contemporary newspaper accounts, diaries, letters and official communications to create a gripping and compelling narrative that weaves together individual stories of hate and fear and brutality. This is a dramatic and definitive account of a remarkable but forgotten chapter of American history.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

    A “spirit photographer,” William Mumler took portrait photographs that featured the ghostly presence of a lost loved one alongside the living subject. Mumler was a sensation: The affluent and influential came calling, including Mary Todd Lincoln, who arrived at his studio in disguise amidst rumors of séances in the White House.Peter Manseau brilliantly captures a nation wracked with grief and hungry for proof of the existence of ghosts and for contact with their dead husbands and sons. It took a circus-like trial of Mumler on fraud charges, starring P. T. Barnum for the prosecution, to expose a fault line of doubt and manipulation. And even then, the judge sided with the defense — nobody ever solved the mystery of his spirit photography. This forgotten puzzle offers a vivid snapshot of America at a crossroads in its history, a nation in thrall to new technology while clinging desperately to belief.

    In this brilliant history of the phenomenon, Richardson shares debutantes’ own words—from diaries, letters, and interviews—throughout her vivid telling, beginning in Henry VIII’s era, sweeping through Queen Elizabeth I’s court, crossing back and forth the Atlantic to colonial Philadelphia, African American communities, Jane Austen’s England, and Mrs. Astor’s parties, ultimately arriving at the contemporary New York Infirmary and International balls.Whether maligned for its archaic attitude and objectification of women or praised for raising money for charities and providing a necessary coming-of-age ritual, the debutante tradition has more to tell us in this entertaining and illuminating book.

    But the Secret Service wasn't always so troubled.The Secret Service was born in 1865, in the wake of the assassination of Abraham Lincoln, but its story begins in earnest in 1963, with the death of John F. Kennedy. Shocked into reform by their failure to protect the president on that fateful day, this once-sleepy agency was rapidly transformed into a proud, elite unit that would finally redeem themselves in 1981 by valiantly thwarting an assassination attempt against Ronald Reagan. But this reputation for courage and efficiency would not last forever. By Barack Obama's presidency, the Secret Service was becoming notorious for break-ins at the White House, an armed gunman firing at the building while agents stood by, a massive prostitution scandal in Cartagena, and many other dangerous lapses.To expose the these shortcomings, Leonnig interviewed countless current and former agents who risked their careers to speak out about an agency that's broken and in desperate need of a reform.

    From its inception as a "Poor House" dispensing free medical care to indigents, Chicago's Cook County Hospital has been both a renowned teaching hospital and the healthcare provider of last resort for the city's uninsured. COUNTY covers more than thirty years of its history, beginning in the late 1970s when the author began his internship, to the "Final Rounds" when the enormous iconic Victorian hospital building was replaced and hundreds of former trainees gathered to bid it an emotional farewell.Ansell writes of the hundreds of doctors who went through the rigorous training process with him, sharing his vision of saving the world and of resurrecting a hospital on the verge of closing. Radical Medicine is about people, from Ansell’s mentors, including the legendary Quentin Young, to the multitude of patients whom he and County’s medical staff labored to diagnose and heal. It is a story about politics, from contentious union strikes to battles against “patient dumping”, and public health, depicting the AIDS crisis and the opening of County’s HIV/AIDS clinic, the first in the city.Finally, it is about a young man’s medical education in urban America, a coming-of-age story set against a backdrop of race, segregation and poverty.

    Our bodies are hardwired for sweets, so food giants have developed fifty-six types of sugar to add to their products, creating in us the expectation that everything should be cloying; we've evolved to prefer fast, convenient meals, hence our modern-day preference for ready-to-eat foods. Moss goes on to show how the processed food industry--including major companies like Nestlé, Mars, and Kellogg's--has tried not only to evade this troubling discovery about the addictiveness of food but to actually exploit it. For instance, in response to recent dieting trends, food manufacturers have simply turned junk food into junk diets, filling grocery stores with "diet" foods that are hardly distinguishable from the products that got us into trouble in the first place. As obesity rates continue to climb, manufacturers are now claiming to add ingredients that can effortlessly cure our compulsive eating habits. An account of the legal battles, insidious marketing campaigns, and cutting-edge food science that have brought us to our current public health crisis, Moss lays out all that the food industry is doing to exploit and deepen our addictions, and shows us why what we eat has never mattered more.From the #1 New York Times bestselling author of Salt Sugar Fat comes a powerful exposé of how the processed food industry exploits our evolutionary instincts, the emotions we associate with food, and legal loopholes in their pursuit of profit over public health.

    Her father's hidden liquor bottles, the strange cancers in children in the neighborhood, the truth about what was made at Rocky Flats (cleaning supplies, her mother guessed)—best not to inquire too deeply into any of it.But as Iversen grew older, she began to ask questions. She learned about the infamous 1969 Mother's Day fire, in which a few scraps of plutonium spontaneously ignited and—despite the desperate efforts of firefighters—came perilously close to a "criticality," the deadly blue flash that signals a nuclear chain reaction. Intense heat and radiation almost melted the roof, which nearly resulted in an explosion that would have had devastating consequences for the entire Denver metro area. Yet the only mention of the fire was on page 28 of the Rocky Mountain News, underneath a photo of the Pet of the Week. In her early thirties, Iversen even worked at Rocky Flats for a time, typing up memos in which accidents were always called "incidents."And as this memoir unfolds, it reveals itself as a brilliant work of investigative journalism—a detailed and shocking account of the government's sustained attempt to conceal the effects of the toxic and radioactive waste released by Rocky Flats, and of local residents' vain attempts to seek justice in court. Here, too, are vivid portraits of former Rocky Flats workers—from the healthy, who regard their work at the plant with pride and patriotism, to the ill or dying, who battle for compensation for cancers they got on the job.Based on extensive interviews, FBI and EPA documents, and class-action testimony, this taut, beautifully written book promises to have a very long half-life.