Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    Why is glass see-through? What makes elastic stretchy? Why does a paper clip bend? Why does any material look and behave the way it does? These are the sorts of questions that Mark Miodownik a globally-renowned materials scientist has spent his life exploring In this book he examines the materials he encounters in a typical morning, from the steel in his razor and the graphite in his pencil to the foam in his sneakers and the concrete in a nearby skyscraper.

    In the clearest possible prose it differentiates the firmly established from the speculative and examines the claims of various fields such as string theory to approach a unified theory of everything. In doing so it challenges the orthodox consensus in those branches of cosmology, biology, and neuroscience that have ossified into dogma.Its striking analysis reveals underlying patterns of cooperation, complexification, and convergence that lead to the unique emergence in humans of a self-reflective consciousness that enables us to determine our future evolution.This groundbreaking book is destined to become a classic of scientific thinking.(67 black and white illustrations)

    It's ever-present. Without it, you would die in minutes. And it has an epic story to tell.In Caesar's Last Breath, New York Times bestselling author Sam Kean takes us on a journey through the periodic table, around the globe, and across time to tell the story of the air we breathe, which, it turns out, is also the story of earth and our existence on it.With every breath, you literally inhale the history of the world. On the ides of March, 44 BC, Julius Caesar died of stab wounds on the Senate floor, but the story of his last breath is still unfolding; in fact, you're probably inhaling some of it now. Of the sextillions of molecules entering or leaving your lungs at this moment, some might well bear traces of Cleopatra's perfumes, German mustard gas, particles exhaled by dinosaurs or emitted by atomic bombs, even remnants of stardust from the universe's creation.Tracing the origins and ingredients of our atmosphere, Kean reveals how the alchemy of air reshaped our continents, steered human progress, powered revolutions, and continues to influence everything we do. Along the way, we'll swim with radioactive pigs, witness the most important chemical reactions humans have discovered, and join the crowd at the Moulin Rouge for some of the crudest performance art of all time. Lively, witty, and filled with the astounding science of ordinary life, Caesar's Last Breath illuminates the science stories swirling around us every second.

    Authoritative and engaging, Paul Parsons takes us on a rollercoaster ride through billions of light years to tell the story of the Big Bang, from birth to death.13.8 billion years ago, something incredible happened. Matter, energy, space and time all suddenly burst into existence in a cataclysmic event that’s come to be known as the Big Bang. It was the birth of our universe. What started life smaller than the tiniest subatomic particle is now unimaginably vast and plays home to trillions of galaxies. The formulation of the Big Bang theory is a story that combines some of the most far-reaching concepts in fundamental physics with equally profound observations of the cosmos.From our realization that we are on a planet orbiting a star in one of many galaxies, to the discovery that our universe is expanding, to the groundbreaking theories of Einstein that laid the groundwork for the Big Bang cosmology of today – as each new discovery deepens our understanding of the origins of our universe, a clearer picture is forming of how it will all end. Will we ultimately burn out or fade away? Could the end simply signal a new beginning, as the universe rebounds into a fresh expanding phase? And was our Big Bang just one of many, making our cosmos only a small part of a sprawling multiverse of parallel universes?

    In The Life of the Cosmos, Smolin cuts the Gordian knot of cosmology with a simple, powerful idea: "The underlying structure of our world, " he writes, "is to be found in the logic of evolution." Today's physicists have overturned Newton's view of the universe, yet they continue to cling to an understanding of reality not unlike Newton's own - as a clock, an intricate mechanism, governed by laws which are mathematical and eternally true. Smolin argues that the laws of nature we observe may be in part the result of a process of natural selection which took place before the big bang. Smolin's ideas are based on recent developments in cosmology, quantum theory, relativity and string theory, yet they offer, at the same time, an unprecedented view of how these developments may fit together to form a new theory of cosmology. From this perspective, the lines between the simple and the complex, the fundamental and the emergent, and even between the biological and the physical are redrawn. The result is a framework that illuminates many intractable problems, from the paradoxes of quantum theory and the nature of space and time to the problem of constructing a final theory of physics. As he argues for this new view, Smolin introduces the reader to recent developments in a wide range of fields, from string theory and quantum gravity to evolutionary theory the structure of galaxies. He examines the philosophical roots of controversies in the foundations of physics, and shows how they may be transformed as science moves towardunderstanding the universe as an interrelated, self-constructed entity, within which life and complexity have a natural place, and in which "the occurrence of novelty, indeed the perpetual birth of novelty, can be understood."

    ClarkeSpace was one of the most fiercely fought battlegrounds of the Cold War, the Moon its ultimate beachhead.In this dual autobiography, Apollo 15 commander David Scott and cosmonaut Alexei Leonov, the first man to ever walk in space, recount their exceptional lives and careers spent on the cutting edge of science and space exploration—and their participation in the greatest technological race ever—to land a man on the Moon.With each mission fraught with perilous tasks, and each space program touched by tragedy, these parallel tales of adventure and heroism read like a modern-day thriller. Cutting fast between their differing recollections, this book reveals, in a very personal way, the drama of one of the most ambitious contests ever embarked on by man, set against the conflict that once held the world in suspense: the clash between Communism and Western democracy.Through the men's memoirs, their courage, passion for exploration, and determination to push themselves to the limit, emerge not only through their triumphs but also through their perseverance in times of extraordinary difficulty and danger."Two Sides of the Moon is unique among space histories. If you are looking for a balanced, interesting, and personal account of the American and Soviet space programs during the 1960s and 1970s this is it."---Astronomy magazine

    Here he explains how our image of the world has changed throughout centuries. Fom Aristotle to Albert Einstein, Michael Faraday to the Higgs boson, he takes us on a wondrous journey to show us that beyond our ever-changing idea of reality is a whole new world that has yet to be discovered.

    However, while physicists celebrated these momentous discoveries—which presaged the era of big science and nuclear bombs—Europe was moving inexorably toward totalitarianism and war. In April of that year, about forty of the world’s leading physicists—including Werner Heisenberg, Lise Meitner, and Paul Dirac—came to Niels Bohr’s Copenhagen Institute for their annual informal meeting about the frontiers of physics. Physicist Gino Segrè brings to life this historic gathering, which ended with a humorous skit based on Goethe’s Faust—a skit that eerily foreshadowed events that would soon unfold. Little did the scientists know the Faustian bargains they would face in the near future. Capturing the interplay between the great scientists as well as the discoveries they discussed and debated, Segrè evokes the moment when physics—and the world—was about to lose its innocence.

    The universe is all about extremes, and in this engaging and thought-provoking book, astronomer Bryan Gaensler gives a whirlwind tour of the galaxies, with an emphasis on its fastest, hottest, heaviest, brightest, oldest, densest, and even loudest elements. From supernova explosions a billion times brighter than the sun to an asteroid the size of a beach ball, Extreme Cosmos offers a fascinating, fresh, and informed perspective of the remarkable richness of the universe, and the incredible physics that modern astronomy has revealed.

    Over the last three decades the theory has been repeatedly revised to address such issues as how galaxies and stars first formed and why the expansion of the universe is speeding up today. Furthermore, an explanation has yet to be found for what caused the Big Bang in the first place.In Endless Universe, Paul J. Steinhardt and Neil Turok, both distinguished theoretical physicists, present a bold new cosmology. Steinhardt and Turok “contend that what we think of as the moment of creation was simply part of an infinite cycle of titanic collisions between our universe and a parallel world” (Discover). They recount the remarkable developments in astronomy, particle physics, and superstring theory that form the basis for their groundbreaking “Cyclic Universe” theory. According to this theory, the Big Bang was not the beginning of time but the bridge to a past filled with endlessly repeating cycles of evolution, each accompanied by the creation of new matter and the formation of new galaxies, stars, and planets.Endless Universe provides answers to longstanding problems with the Big Bang model, while offering a provocative new view of both the past and the future of the cosmos.  It is a “theory that could solve the cosmic mystery” (USA Today).

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

    Titan Unveiled is one of the first general interest books to reveal the startling new discoveries that have been made since the arrival of the Cassini-Huygens mission to Saturn and Titan.Ralph Lorenz and Jacqueline Mitton take readers behind the scenes of this mission. Launched in 1997, Cassini entered orbit around Saturn in summer 2004. Its formidable payload included the Huygens probe, which successfully parachuted down through Titan's atmosphere in early 2005, all the while transmitting images and data--and scientists were startled by what they saw. One of those researchers was Lorenz, who gives an insider's account of the scientific community's first close encounter with an alien landscape of liquid methane seas and turbulent orange skies. Amid the challenges and frayed nerves, new discoveries are made, including methane monsoons, equatorial sand seas, and Titan's polar hood. Lorenz and Mitton describe Titan as a world strikingly like Earth and tell how Titan may hold clues to the origins of life on our own planet and possibly to its presence on others.Generously illustrated with many stunning images, Titan Unveiled is essential reading for anyone interested in space exploration, planetary science, or astronomy.-- "Lunar and Planetary Information Bulletin"

    . . and then broke? How would you survive? Could you improve on humanity's original timeline? And how hard would it be to domesticate a giant wombat? With this book as your guide, you'll survive--and thrive--in any period in Earth's history. Bestselling author and time-travel enthusiast Ryan North shows you how to invent all the modern conveniences we take for granted--from first principles. This illustrated manual contains all the science, engineering, art, philosophy, facts, and figures required for even the most clueless time traveler to build a civilization from the ground up. Deeply researched, irreverent, and significantly more fun than being eaten by a saber-toothed tiger, How to Invent Everything will make you smarter, more competent, and completely prepared to become the most important and influential person ever.