This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Working in the kitchens of the upper class, she left a trail of disease in her wake, until one enterprising and ruthless “medical engineer” proposed the inconceivable notion of the “asymptomatic carrier”—and from then on Mary Mallon was a hunted woman. In order to keep New York’s citizens safe from Mallon, the Department of Health sent her to North Brother Island where she was kept in isolation from 1907-1910. She was released under the condition that she never work as a cook again. Yet for Mary—spoiled by her status and income and genuinely passionate about cooking—most domestic and factory jobs were heinous. She defied the edict.Bringing early twentieth-century New York alive—the neighborhoods, the bars, the park being carved out of upper Manhattan, the emerging skyscrapers, the boat traffic—Fever is as fiercely compelling as Typhoid Mary herself, an ambitious retelling of a forgotten life. In the hands of Mary Beth Keane, Mary Mallon becomes an extraordinarily dramatic, vexing, sympathetic, uncompromising, and unforgettable character.

    Like something from a science fiction novel, doctors carefully injected viruses bearing healing genes into the DNA of Corey's eyes a few days later, Corey could see, his sight restored by gene therapy.THE FOREVER FIX is the first book to tell the fascinating story of gene therapy: how it works, the science behind it, how patients (mostly children) have been helped and harmed, and how scientists learned from each trial to get one step closer to its immense promise, the promise of a "forever fix," - a cure that, by fixing problems at their genetic root, does not need further surgery or medication.Told through the voices of the children and families who have been the inspiration, experimental subjects, and successes of genetic science, THE FOREVER FIX is compelling and engaging narrative science that tells explores the future of medicine as well as the families and scientists who are breaking new ground every day."

    It was stolen moments spent with the empowered literary characters of Jane Austen and Louisa May Alcott that helped her to imagine an alternative way of life. Trapped as a teenager in a sexually and emotionally dysfunctional marriage to a man she barely knew, the tension between Deborah’s desires and her responsibilities as a good Satmar girl grew more explosive until she gave birth at nineteen and realized that, for the sake of herself and her son, she had to escape.

    Croix. He went to America to pursue his education. Along the way he became one of the American Revolution’s most dashing—and unlikely—heroes. Adored by Washington, hated by Jefferson, Hamilton was a lightning rod: the most controversial leader of the American Revolution.She was the well-to-do daughter of one of New York’s most exalted families—feisty, adventurous, and loyal to a fault. When she met Alexander, she fell head over heels. She pursued him despite his illegitimacy, and loved him despite his infidelity. In 1816 (two centuries ago), she shamed Congress into supporting his seven orphaned children. Elizabeth Schuyler Hamilton started New York’s first orphanage. The only “founding mother” to truly embrace public service, she raised 160 children in addition to her own.With its flawless writing, brilliantly drawn characters, and epic scope, The Hamilton Affair will take its place among the greatest novels of American history.

    A heartbreaking, wry, brutally honest, and creative play on a personal ad—in which a dying wife encouraged her husband to go on and find happiness after her demise—the column quickly went viral, reaching more than five million people worldwide.In My Wife Said You May Want to Marry Me, Jason describes what came next: his commitment to respecting Amy’s wish, even as he struggled with her loss. Surveying his life before, with, and after Amy, Jason ruminates on love, the pain of watching a loved one suffer, and what it means to heal—how he and their three children, despite their profound sorrow, went on. Jason’s emotional journey offers insights on dying and death and the excruciating pain of losing a soulmate, and illuminates the lessons he learned.As he reflects on Amy’s gift to him—a fresh start to fill his empty space with a new story—Jason describes how he continues to honor Amy’s life and her last wish, and how he seeks to appreciate every day and live in the moment while trying to help others coping with loss. My Wife Said You May Want to Marry Me is the poignant, unreserved, and inspiring story of a great love, the aftermath of a marriage ended too soon, and how a surviving partner eventually found a new perspective on life’s joys in the wake of tremendous loss.

    We know, for example, that there are a few core truths to science of happiness. We know that being kind and altruistic makes us happy, that turning off devices, talking to people, forging relationships, living with meaning and delving into the concerns of others offer our best chance at achieving happiness. But how do we retain happiness? It often slips out of our hands as quickly as we find it. So, when we are exposed to, or learn, good things, how do we continue to burn with them?And more than that, when our world goes dark, when we're overwhelmed by illness or heartbreak, loss or pain, how do we survive, stay alive or even bloom? In the muck and grit of a daily existence full of disappointments and a disturbing lack of control over many of the things that matter most - finite relationships, fragile health, fraying economies, a planet in peril - how do we find, nurture and carry our own inner, living light - a light to ward off the darkness?Absorbing, achingly beautiful, inspiring and deeply moving, Julia Baird has written exactly the book we need for these times.

    Extraordinary." —Marlon James"Staccato prose and peripatetic storytelling combine the cadences of the Bible with an urgency reminiscent of James Baldwin in this powerfully emotional memoir." —BookPageThe testament of a boy and a generation who came of age as the world came apart—a generation searching for a new way to live.Casey Gerald comes to our fractured times as a uniquely visionary witness whose life has spanned seemingly unbridgeable divides. His story begins at the end of the world: Dallas, New Year's Eve 1999, when he gathers with the congregation of his grandfather's black evangelical church to see which of them will be carried off. His beautiful, fragile mother disappears frequently and mysteriously; for a brief idyll, he and his sister live like Boxcar Children on her disability checks. When Casey—following in the footsteps of his father, a gridiron legend who literally broke his back for the team—is recruited to play football at Yale, he enters a world he's never dreamed of, the anteroom to secret societies and success on Wall Street, in Washington, and beyond. But even as he attains the inner sanctums of power, Casey sees how the world crushes those who live at its margins. He sees how the elite perpetuate the salvation stories that keep others from rising. And he sees, most painfully, how his own ascension is part of the scheme.There Will Be No Miracles Here has the arc of a classic rags-to-riches tale, but it stands the American Dream narrative on its head. If to live as we are is destroying us, it asks, what would it mean to truly live? Intense, incantatory, shot through with sly humor and quiet fury, There Will Be No Miracles Here inspires us to question--even shatter--and reimagine our most cherished myths.

    Mary Neal's walk with God has been both ordinary and extraordinary, brimming with the gift and privilege of being touched by God in visible and very tangible ways. She is a practicing orthopaedic surgeon, a wife, and a mother who has experienced joy as well as great sorrow and death. She experienced life after death and, despite her scientific training, she believes the answer to each one of these questions is a definitive yes. She drowned on a South American river and went to Heaven. She conversed with angels. She returned to Earth, in part, to tell her story to others and help them find their way back to God. In this book , Dr. Neal shares the captivating details of her life in which she has experienced not just one miracle, but many. Her story is both compelling and thought provoking. Her experiences provide confirmation that miracles still occur, shows how God keeps His promises and why there is sufficient reason to live by faith. Dr. Neal's message is fundamentally one of hope.

    It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon.

    In 1895 her great-great aunt, Pauline Gross, a seamstress in Ann Arbor, Michigan, confided to a pathology professor at the local university that she expected to die young, like so many others in her family. Rather than dismiss her fears, the pathologist chose to enlist Pauline in the careful tracking of those in her family tree who had died of cancer. Pauline's premonition proved true--she died at 46--but because of her efforts, her family (who the pathologist dubbed 'Family G') would become the longest and most detailed cancer genealogy ever studied in the world. A century after Pauline's confession, researchers would identify the genetic mutation responsible for the family's woes. Now known as Lynch syndrome, the genetic condition predisposes its carriers to several types of cancer, including colorectal, endometrial, ovarian and pancreatic. In 2001, as a young mother with two sons and a keen interest in survival, Ami McKay was among the first to be tested for Lynch syndrome. She had a feeling she'd test positive: her mother's side of the family was riddled with early deaths and her own mother was being treated for the disease. When the test proved her fears true, she began living in "an unsettling state between wellness and cancer," and she's been there ever since. Intimate, candid, and probing, her genetic memoir tells a fascinating story, teasing out the many ways to live with the hand you are dealt.

    A lanky kid from Plano, Texas, is raised by a feisty, single parent who sacrifices for her son, who becomes one of our country's greatest athletes. Given that background, it is understandable why Armstrong was able to channel his boundless energy toward athletic endeavors. By his senior year in high school, he was already a professional triathlete and was training with the U.S. Olympic cycling developmental team. In 1993, Armstrong secured a position in the ranks of world-class cyclists by winning the World Championship and a Tour de France stage, but in 1996, he was diagnosed with testicular cancer. Armstrong entered an unknown battlefield and challenged it as if climbing through the Alps: aggressive yet tactical. He beat the cancer and proceeded to stun all the pundits by winning the 1999 Tour de France. In this memoir, Armstrong covers his early years swiftly with a blunt matter-of-factness, but the main focus is on his battle with cancer. Readers will respond to the inspirational recovery story, and they will appreciate the behind-the-scenes cycling information. After he won the Tour, his mother was quoted as saying that her son's whole life has been a fight against the odds; we see here that she was not exaggerating. Brenda Barrera

    Like when doctors prescribed morphine for crying infants. When snorting skull moss was a cure for a bloody nose. When consuming mail-order tapeworms was a latter-day fad diet. Or when snake oil salesmen peddled strychnine (used in rat poison) as an aphrodisiac in the '60s. Seamlessly combining macabre humor with hard science and compelling storytelling, Quackery is a visually rich and information-packed exploration of history's most outlandish cures, experiments, and scams.A humorous book that delves into some of the wacky but true ways that humans have looked to cure their ills. Leeches, mercury, strychnine, and lobotomies are a few of the topics that explore the lengths society has gone in the search for health.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Paul Seward leads us in his memoir through suspenseful diagnoses and explorations of anatomy. By his side, we learn to distinguish nursemaid's elbow from a true broken arm. We learn how our breathing and swallowing mechanisms resemble a practical joke.But when a baby’s heart stops and a young doctor forgets what to do, the situation is far from funny. Within the conditions of great stress and rapid decision-making that are routine in the ER, Dr. Seward shows us that physicians must be more than technicians of the body; they must be restorers of the human. Whether it is comforting anxious family or subjecting a distressed patient to tough procedures—resulting, once, in a patient’s punching our doctor—on every shift, a physician learns the difficult work of caring for strangers.Yet this is a physician who rejects doctor-as-god narratives. He highlights the essential role of nurses and other colleagues, including a pharmacist whose story is hard to forget. Throughout Patient Care, Dr. Seward reflects on how a life in medicine tests what it means to put ethics into practice.