Drawing on his own experiences in trauma surgery as an anaesthetist and intensive care expert, 'Extremes' is Kevin Fong's account of the way cutting-edge medicine is pushing the envelope of human survival.

    From Mary Lamb, sister of Charles, who in the throes of a nervous breakdown turned on her mother with a kitchen knife, to Freud, Jung, and Lacan, who developed the new women-centered therapies, Lisa Appignanesi’s research traces how more and more of the inner lives and emotions of women have become a matter for medics and therapists. Here too is the story of how over the years symptoms and diagnoses have developed together to create fashions in illness and how treatments have succeeded or sometimes failed. Mad, Bad, and Sad takes us on a fascinating journey through the fragile, extraordinary human mind.

    Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.

     A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation s disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

    Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities. . . .But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are--our appearance, our height, our penchants--in inconceivably subtle ways." Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors--using a word that once referred to kingdoms and estates--but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

    Exploring and participating in the cultures that have grown up around these drugs while consuming (or, in the case of caffeine, trying not to consume) them, Pollan reckons with the powerful human attraction to psychoactive plants. Why do we go to such great lengths to seek these shifts in consciousness, and then why do we fence that universal desire with laws and customs and fraught feelings?

    The Playbook not only takes the reader well beyond the basic ground rules of deliberate creation, as laid out in Excuse Me, but also does so in a uniquely entertaining manner.However, don't be fooled by the goofy, upbeat graphics. Whether The Playbook is to be used by groups or individuals, its overall content is designed to gently awaken and enhance the great Master in us all.While The Playbook holds within its unusual pages many more ideas and techniques than presented in Excuse Me, Your Life Is Waiting, it also holds a myriad of keys to enhance one's spiritual path, should any awakening soul be so inclined to accept them.

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.

    Violent and unattended deaths...suicide...forensics...viral pathology...crime scene myths...The stories behind Aftermath, Inc. are stranger than fiction, and utterly human and compelling. Like most people, true-crime writer Gil Reavill had never actually experienced a fresh crime scene. That is, until he met Tim Reifsteck and Chris Wilson, owners of Aftermath, Inc., a company in the new field of "bioremediation." In the mid-80s, when a sea change occurred in the way biohazard clean-up was handled, no one in traditional cleaning or janitorial services would come within ten feet of a blood-spattered crime scene. Into this void stepped lifelong friends Tim and Chris, who filled a desperate need by founding their company. For the guys of Aftermath, no crime scene is too bloody to clean. Aftermath, Inc. traces their history, introducing their clients and employees, and the cops, coroners, and detectives they encounter in their work. Gil goes on scene and works side by side with the Aftermath technicians. He tells the stories that led up to some of Aftermath's most grisly clean-up jobs, taking us on a journey through the suburban Midwest where the company is based, home to some of the quietest, calmest, most ordinary blocks in the world, which hide much darker undercurrents beneath. The issues that the Aftermath crew members face on a daily basis range from the mundane (What's the best way to suppress the urge to regurgitate?) to the lofty (How does being exposed to death on a daily basis alter one's personal philosophy?). Reavill approaches his task with respect and compassion, taking as his mantra a line from the Roman poet Terence-- "Nothing human is foreign to me."

    The first small cities formed not only the cradle of civilization, but the spawning ground for the earliest viral epidemics, the first opportunity for viruses to find a home in the human herd. This is a story of fear and ignorance, as everything from demons and the wrath of the gods to minority groups have been blamed for epidemics from smallpox to yellow fever to AIDS. It is a story of grief and heartbreak, as hundreds of thousands, sometimes millions, are wiped out in a single year. And it is a story of great bravery and sacrifice, as doctors and nurses put themselves in harm's way to combat yellow fever in Memphis and Ebola in Zaire, and as researchers risk their own lives to test theories of vaccines and the transmission of disease. Now, in Viruses, Plagues, and History, Michael B. A. Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity.Oldstone focuses his tale on a few of the most famous viruses humanity has battled, beginning with some we have effectively defeated, such as smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone -- more than were killed in all the wars of the twentieth century combined. The author presents a vivid account of the long campaign against the virus, the insightful work of Edward Jenner, who created the smallpox vaccine from cowpox virus in 1796, and the monumental efforts of D. A. Henderson and an army of W.H.O. health care workers to finally eradicate smallpox. The smallpox virus remains the only organism that we have deliberately pushed to complete extinction in the wild.Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola and other hemorrhagic fevers, which literally turn their victims' organs to a bloody pulp; the Hantavirus outbreaks in the southwestern United States and elsewhere; mad cow disease, a frightening illness made worse by government mishandling and secrecy; and, of course, AIDS, often called the plague of our time. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the deadly variant from 1918 -- a viral strain that killed over 20 million people in 1918-1919, more than twice the military and civilian casualties of the First World War -- will make a comeback.Viruses have enormous power. They have wiped out cities, brought down dynasties, and helped destroy civilizations. But, as Michael Oldstone reveals, scientific research has given us the power to tame many of these viruses as well. Viruses, Plagues, and History shows us the panorama of humanity's long-standing conflict with our unseen viral enemies, from our successes to our continuing struggles. Oldstone's book is a vivid history of a fascinating field, and a highly reliable dispatch from a worker on the frontiers of this ongoing campaign.

    Based in the latest research in neuroscience, this audiobook offers dozens of little things you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life.Depression doesn't happen all at once. It starts gradually and builds momentum over time. If you go through a difficult experience, you may stop taking care of yourself. You may stop exercising and eating healthy, which will end up making you feel even worse as time goes on. You are caught in a downward spiral, but you may feel too tired, too overwhelmed, and too scared to try and pull yourself back up. The good news is that just one small step can be a step in the right direction.In The Upward Spiral, neuroscientist Alex Korb demystifies the neurological processes in the brain that cause depression and offers effective ways to get better "one little step at a time". In the book, you'll discover that there isn't "one big solution" that will solve your depression. Instead, there are dozens of small, practical things you can do to alleviate your symptoms and start healing. Some are as simple as relaxing certain muscles to reduce feelings of anxiety, while others involve making small efforts toward more positive social interactions. Small steps in the right direction can have profound effects giving you the power to literally "reshape" your brain.Like most people, you probably didn't wake up one day and find yourself completely depressed. Instead, it probably happened over time, as a series of reactions to difficult situations and negative thinking. But if you are ready to reverse the trajectory of your depression and find lasting happiness, this book will show you how.

    But while this medieval medicine now seems archaic, it also made a critical contribution to modern science.Medieval Bodies guides us on a head-to-heel journey through this era’s revolutionary advancements and disturbing convictions. We learn about the surgeons who dissected a living man’s stomach, then sewed him up again; about the geographers who delineated racial groups by skin color; and about the practice of fasting to gain spiritual renown. Encompassing medicine and mysticism, politics and art—and complete with vivid, full-color illustrations—Medieval Bodies shows us how it felt to live and die a thousand years ago.

    And many are so, so tired … But women's pain is all too often dismissed, their illnesses misdiagnosed or ignored. In medicine, man is the default human being. Any deviation is atypical, abnormal, deficient.'Fourteen years after being diagnosed with endometriosis, Gabrielle Jackson couldn't believe how little had changed in the treatment and knowledge of the disease. In 2015, her personal story kick-started a worldwide investigation into the disease by The Guardian; thousands of women got in touch to tell their own stories and many more read and shared the material. What began as one issue led Jackson to explore how women - historically and through to the present day - are under-served by the systems that should keep them happy, healthy and informed about their bodies.Pain and Prejudice is a vital testament to how social taboos and medical ignorance keep women sick and in anguish. The stark reality is that women's pain is not taken as seriously as men's. Women are more likely to be disbelieved and denied treatment than men, even though women are far more likely to be suffering from chronic pain.In a potent blend of personal memoir and polemic, Jackson confronts the private concerns and questions women face regarding their health and medical treatment. Pain and Prejudice, finally, explains how we got here, and where we need to go next.

    It is William Nolen's story of his transformation from student to practitioner, from a brash medical school graduate to a surgeon possessing skill and judgment. And, as happens in the best memoirs, with his brilliant flash of self-discovery William Nolen illuminates the world outside himself.First published in 1970, The Making of a Surgeon received critical acclaim and touched a world audience. The book's universal themes propelled it to the rarefied heights of a best seller. In this reprinted edition, with a foreword by the author's daughter, his classic returns.

    With enormous tasks, like installing a lift, plus the beginnings of lifelong traditions, this much-anticipated follow-up includes many firsts for the Strawbridge family. As Dick and Angel recount stories of the next two years at the château, we start to understand the true extent of the work and skill that it has taken to make this incredible house into a much-loved home.With never-before-told stories of remarkable discoveries, amazing transformations and once-in-a-lifetime celebrations, this book is sure to delight and inspire in equal measure!