The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race


Walter Isaacson - 2021
    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

God's Hotel: A Doctor, a Hospital, and a Pilgrimage to the Heart of Medicine


Victoria Sweet - 2012
    Ballet dancers and rock musicians, professors and thieves-"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul.

Women in White Coats: How the First Women Doctors Changed the World of Medicine


Olivia Campbell - 2021
    In the early 1800s, women were dying in large numbers from treatable diseases because they avoided receiving medical care. Examinations performed by male doctors were often demeaning and even painful. In addition, women faced stigma from illness—a diagnosis could greatly limit their ability to find husbands, jobs or be received in polite society.Motivated by personal loss and frustration over inadequate medical care, Elizabeth Blackwell, Elizabeth Garrett Anderson and Sophia Jex-Blake fought for a woman’s place in the male-dominated medical field. For the first time ever, Women in White Coats tells the complete history of these three pioneering women who, despite countless obstacles, earned medical degrees and paved the way for other women to do the same. Though very different in personality and circumstance, together these women built women-run hospitals and teaching colleges—creating for the first time medical care for women by women.With gripping storytelling based on extensive research and access to archival documents, Women in White Coats tells the courageous history these women made by becoming doctors, detailing the boundaries they broke of gender and science to reshape how we receive medical care today.

Nisa: The Life and Words of a !Kung Woman


Marjorie Shostak - 1981
    This book is the story of the life of Nisa, a member of the !Kung tribe of hunter-gatherers from southern Africa's Kalahari desert. Told in her own words--earthy, emotional, vivid--to Marjorie Shostak, a Harvard anthropologist who succeeded, with Nisa's collaboration, in breaking through the immense barriers of language and culture, the story is a fascinating view of a remarkable woman.

Microbe Hunters


Paul de Kruif - 1926
    Gonzalez-Crussi, from the Introduction An international bestseller, translated into eighteen languages, Paul de Kruif’s classic account of the first scientists to see and learn about the microscopic world continues to fascinate new readers. This is a timeless dramatization of the scientists, bacteriologists, doctors, and medical technicians who discovered the microbes and invented the vaccines to counter them. De Kruif writes about how seemingly simple but really fundamental discovers of science—for instance, how a microbe was first viewed in a clear drop of rain water, and when, for the first time, Louis Pasteur discovered that a simple vaccine could save a man from the ravages of rabies by attacking the microbes that cause it.

Girl Sleuth: Nancy Drew and the Women Who Created Her


Melanie Rehak - 2005
    Eighty million books later, Nancy Drew has survived the Depression, World War II, and the sixties (when she was taken up with a vengeance by women’s libbers) to enter the pantheon of American girlhood. As beloved by girls today as she was by their grandmothers, Nancy Drew has both inspired and reflected the changes in her readers’ lives. Here, in a narrative with all the vivid energy and page-turning pace of Nancy’s adventures, Melanie Rehak solves an enduring literary mystery: Who created Nancy Drew? And how did she go from pulp heroine to icon?  The brainchild of children’s book mogul Edward Stratemeyer, Nancy was brought to life by two women: Mildred Wirt Benson, a pioneering journalist from Iowa, and Harriet Stratemeyer Adams, a well-bred wife and mother who took over as CEO after her father died. In this century-spanning story, Rehak traces their roles—and Nancy’s—in forging the modern American woman.

The Dinosaur Hunters


Deborah Cadbury - 2000
    The name dinosaur was coined in 1842 by an English anatomist Richard Owen, a highly ambitious, machiavellian schemer and villain of Deborah Cadbury's The Dinosaur Hunters: A True Story of Scientific Rivalry and the Discovery of the Prehistoric World. Her hero is Gideon Mantell, a practising doctor, who found and first described many of the bones of the beasts that subsequently became known as dinosaurs. Full of quotes from contemporary sources, The Dinosaur Hunters brilliantly evokes the Dickensian world of early Victorian science and society. From Mary Anning, the self-taught fossil hunter of Lyme Regis to the academic and deeply eccentric Dean Buckland of Oxford University, the story tells of reputations made and lost as self-help, self-promotion, over-wheening pride, folly and social climbing all played their part in the emerging story of the geological past. The dinosaurs, although central to the story, are also a vehicle for the much larger, more interesting and important story about the struggle to understand the meaning of fossils and what they tell us about prehistory. Deborah Cadbury, an award-winning TV science producer and acclaimed author of The Feminisation of Nature has thoroughly researched her topic and steeped herself in the intricacies of the scientific debates of the time. With black and white illustrations, extensive notes, a bibliography and index, the result is one of the best popular science histories. --Douglas Palmer.

Masters of Sex: The Life and Times of William Masters and Virginia Johnson, the Couple Who Taught America How to Love


Thomas Maier - 2009
    This critically acclaimed biography offers an unprecedented look at William Masters and Virginia Johnson, their pioneering studies on intimacy, and their lasting impact on the love lives of today's men and women.

Martha Washington: An American Life


Patricia Brady - 2005
    In place of the domestic frump of popular imagination, Patricia Brady resurrects the wealthy, attractive, and vivacious young widow who captivated the youthful George Washington. Here are the able landowner, the indomitable patriot (who faithfully joined her husband each winter at Valley Forge), and the shrewd diplomat and emotional mainstay. And even as it brings Martha Washington into sharper and more accurate focus, this sterling life sheds light on her marriage, her society, and the precedents she established for future First Ladies.

The Seven Daughters of Eve: The Science That Reveals Our Genetic Ancestry


Bryan Sykes - 2001
    News of both the Ice Man's discovery and his age, which was put at over five thousand years, fascinated scientists and newspapers throughout the world. But what made Sykes's story particularly revelatory was his successful identification of a genetic descendant of the Ice Man, a woman living in Great Britain today. How was Sykes able to locate a living relative of a man who died thousands of years ago?In The Seven Daughters of Eve, he gives us a firsthand account of his research into a remarkable gene, which passes undiluted from generation to generation through the maternal line. After plotting thousands of DNA sequences from all over the world, Sykes found that they clustered around a handful of distinct groups. Among Europeans and North American Caucasians, there are, in fact, only seven. This conclusion was staggering: almost everyone of native European descent, wherever they may live throughout the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve.Naming them Ursula, Xenia, Helena, Velda, Tara, Katrine, and Jasmine, Sykes has created portraits of their disparate worlds by mapping the migratory patterns followed by millions of their ancestors. In reading the stories of these seven women, we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, and how we are each living proof of the almost indestructible strands of DNA, which have survived over so many thousands of years. Indeed, The Seven Daughters of Eve is filled with dramatic stories: from Sykes's identification, using DNA samples from two living relatives, of the remains of Tsar Nicholas and Tsaress Alexandra, to the Caribbean woman whose family had been sold into slavery centuries before and whose ancestry Sykes was able to trace back to the Eastern coast of central Africa. Ultimately, Sykes's investigation reveals that, as a race, what humans have in common is more deeply embedded than what separates us.

Edison


Edmund Morris - 2019
    His invention of the first practical incandescent lamp 140 years ago so dazzled the world--already reeling from his invention of the phonograph and dozens of other revolutionary devices--that it cast a shadow over his later achievements. In all, this near-deaf genius ("I haven't heard a bird sing since I was twelve years old") patented 1,093 inventions, not including others, such as the X-ray fluoroscope, that he left unlicensed for the benefit of medicine.One of the achievements of this staggering new biography, the first major life of Edison in more than twenty years, is that it portrays the unknown Edison--the philosopher, the futurist, the chemist, the botanist, the wartime defense adviser, the founder of nearly 250 companies--as fully as it deconstructs the Edison of mythological memory. Edmund Morris, winner of the Pulitzer Prize and the National Book Award, brings to the task all the interpretive acuity and literary elegance that distinguished his previous biographies of Theodore Roosevelt, Ronald Reagan, and Ludwig van Beethoven. A trained musician, Morris is especially well equipped to recount Edison's fifty-year obsession with recording technology and his pioneering advances in the synchronization of movies and sound. Morris sweeps aside conspiratorial theories positing an enmity between Edison and Nikola Tesla and presents proof of their mutually admiring, if wary, relationship.Enlightened by seven years of research among the five million pages of original documents preserved in Edison's huge laboratory at West Orange, New Jersey, and privileged access to family papers still held in trust, Morris is also able to bring his subject to life on the page--the adored yet autocratic and often neglectful husband of two wives and father of six children. If the great man who emerges from it is less a sentimental hero than an overwhelming force of nature, driven onward by compulsive creativity, then Edison is at last getting his biographical due.

The Paper Garden: Mrs. Delany Begins Her Life's Work at 72


Molly Peacock - 2010
    At once a biography of an extraordinary 18th century gentlewoman and a meditation on late-life creativity, it is a beautifully written tour de force from an acclaimed poet. Mary Granville Pendarves Delany (1700-1788) was the witty, beautiful and talented daughter of a minor branch of a powerful family. Married off at 16 to a 61-year-old drunken squire to improve the family fortunes, she was widowed by 25, and henceforth had a small stipend and a horror of a marriage. She spurned many suitors over the next twenty years, including the powerful Lord Baltimore and the charismatic radical John Wesley. She cultivated a wide circle of friends, including Handel and Jonathan Swift. And she painted, she stitched, she observed, as she swirled in the outskirts of the Georgian court. In mid-life she found love, and married. Upon her husband's death 23 years later, she arose from her grief, picked up a pair of scissors and, at the age of 72, created a new art form, mixed-media collage. Over the next decade, Mrs Delany created an astonishing 985 botanically correct, breathtaking cut-paper flowers, now housed in the British Museum and referred to as the Botanica Delanica.Delicately, Peacock has woven parallels in her own life around the story of Mrs Delany's and, in doing so, has made this biography into a profound and beautiful examination of the nature of creativity and art.Gorgeously designed and featuring 35 full-colour illustrations, this is a sumptuous and lively book full of fashion and friendships, gossip and politics, letters and love. It's to be devoured as voraciously as one of the court dinners it describes.

The Emperor of All Maladies: A Biography of Cancer


Siddhartha Mukherjee - 2010
    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Your Inner Fish: a Journey into the 3.5-Billion-Year History of the Human Body


Neil Shubin - 2008
    By examining fossils and DNA, Shubin shows us that our hands actually resemble fish fins, our head is organized like that of a long-extinct jawless fish, and major parts of our genome look and function like those of worms and bacteria.Shubin makes us see ourselves and our world in a completely new light. Your Inner Fish is science writing at its finest-enlightening, accessible, and told with irresistible enthusiasm.

The Violinist's Thumb: And Other Lost Tales of Love, War, and Genius, as Written by Our Genetic Code


Sam Kean - 2012
    In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA.There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists. Kean's vibrant storytelling makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.