Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    Divided into three sections – the movement, its fashion and advertising – the reader gains great insight into the artists and innovators that helped popularize the Art Deco movement, such as Georges Barbier, Erté, Cassandre and Paul Colin. While the main focus for this intriguing book is centred on graphic art, numerous examples of other forms of Art Deco are also featured. Nestled among the posters and paintings, sculpture, objets d'art and jewellery assert their similarity, whether through line, form or theme. These echoes serve to show the creativity fertility of the period as styles and ideas traversed artistic media.

    Readers also get the insider's take on:The smell of home-baked cookies on Main Street in the Magic KingdomThe Fountain of World Friendship in Epcot that contains water from rivers and oceans around the globeWalt Disney's opening day speech tapped out in Morse Code in FrontierlandThe eco-friendly benches (recycled milk jugs) in the Animal KingdomTwo versions of The Great Movie Ride at Disney's Hollywood StudiosComplete with secret tips from Disney's Imagineers, this book is the perfect in-park companion for Disney World fans.

     On the Camino: advice and information about what to expect on the Camino. Terrain, waymarkings, accommodation, food and drink, money matters, keeping in touch (telephone, internet, etc.), health – with advice on staying healthy and accessing the Spanish health service, Camino administration, etiquette and safety – staying safe and planning for any eventuality. The Caminos: information about the other Caminos, a list of books about the Caminos and pilgrim statistics, with the most popular starting points, nationalities, routes and busiest months. History: the History section aims to give you an understanding of the historical background to the Camino and the role it played in the foundation of modern Spain and Europe. It contains a history of Spain, and a history of the Camino from its beginnings to its revival, in the late 20th century. There’s also an account of life on the Camino in the middle-ages, the people who walked then, and the hardships and hazards they faced. Society, Culture & Environment: a brief outline of the fascinating mosaic that is modern Spain, its politics, cultures and peoples. The natural environment of northern Spain and the impact of the Camino on it. A description of the architectural styles and periods you’ll see along the Camino. Communicating: advice on making yourself understood and understanding others, with a Menu Guide and the most useful Spanish words and phrases for Camino life, plus a few phrases in Basque and Galician. Glossary: a concise reference for many Camino-related persons and things. This new edition, published in September 2013, has been extensively changed, updated and expanded based on feedback and criticisms received from readers over the past two years, and the author's experiences of walking various Caminos during that time. Most of the changes and additions are in the areas: - Packing, what to bring: with the different packing options listed in detail, and the pros and cons of different items explained. - A typical Camino day is described, from waking at the crack of dawn, to bedding down at nightfall. - There's detailed information about how Pilgrim Hostels work, and what it's like to stay in one. - Health: blisters, bedbugs, heatstroke, and other Camino hazards, are described with advice on avoiding them and dealing with them. Thanks to everybody for their feedback and their help with this new edition. ¡Buen Camino!

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    Thankfully, Mexico City: An Opinionated Guide for the Curious Traveler lends a thorough, guiding hand to help make the visitor's stay outstanding. Written by a longtime resident who knows the city inside and out, this travel guide delivers detailed walking tours of the city that include the most popular tourist sights as well as lesser-known spots. Johnston knows where to stay, what to do, and where to eat: everything from authentic market food to sophisticated Mexican cuisine.What began as a collection of notes to share with good friends is now available to every newcomer looking for a joyful, memorable stay in Mexico City."This is the guidebook that I want. Wonderfully written, airtight information, organized in the smartest possibly way. I can't imagine a better Mexico City guide for these times."-Tony Cohan, author of Mexican Days and On Mexican Time"Johnston is the friend you wish you had in every great city, toting you from palace to museum to park but never missing the exquisite pastelería, the grand hotel lobby or the clean public bathroom."-San Francisco Chronicle

    Rewind your Mickey Mouse watch back to the 1950s and travel with us through the decades as the wondrous story of Disneyland unfolds via fascinating, behind-the-pixie dust stories and incredible imagery. Like a visit to the park itself, it's a trip you'll never forget, ensuring that the spirit of Disneyland will remain--then, now, and forever. Filled with color photos of how the park looked at its opening and through the changes of the years up to the present day in 2005.

    Yet they endlessy fascinate and continue to capture the public's attention with their strange charisma and deadly deeds. From Jack the Ripper to Ted Bundy and the Moors Murderers Ian Brady and Myra Hindley, these killers transfix us with their ability to commit utterly savage acts of cruelty and depravity. Only with modern police detection methods and psychological profiling, have these figures that have existed throughout human history finally been identified in the deadliest category: serial killers. These methods, the killers' characters and their crimes are described here in fascinating and terrifyingly gripping detail. The whole history of serial killers is brought to life in 50 chapters, including: Herman Webster Mudget, Devil in the White City John Christie, 10 Rillington Place murders Zodiac Killer Ian Brady and Myra Hindley, The Moors Murderers Ted Bundy Fred and Rosemary West Jeffrey Dahmer Aileen Wuornos Harold Shipman, Dr Death

    The internationally acclaimed “American with the Venetian heart,” Donna Leon, tells its fascinating story (The Washington Post).First used in medieval Venice as a deftly maneuverable getaway boat, the gondola evolved over the centuries into a floating pleasure palace, bedecked in silk, that facilitated the romantic escapades of the Venetian elite. Today, the gondola wears black—a gleaming, elegant hue, and is manned by robust gondolieri in black-and-white-striped shirts and straw hats.A tourist favorite, the gondola has never ceased to be a part of authentic Venice. Each boat’s 280 pieces are carefully fashioned in a maestro’s workshop—though Leon also recounts a tale of an American friend who attempted to make a gondola all on his own. The feat took five years and countless do-overs. But the gondola is a work of art well worth the labor. And once its arched prow pushes off from the dock, the single Venetian at its oar just might break out in a barcarole, a popular Italian boat song. The best of these songs, as timeless as the allure of the gondola itself, are compiled into an accompanying CD.

    In the early Christmas traditions of Europe, the Krampus was St. Nicholas' dark servant-a hairy, horned, supernatural beast whose pointed ears and long slithering tongue gave misbehavers the creeps! Whereas St. Nicholas would reward children who'd been good all year, those that had behaved badly were visited by the Krampus. This NEW and IMPROVED edition includes an introduction, a historical survey of the character, and over 180 lavish pre-World War 1 Krampus postcards. KRAMPUS: The Devil of Christmas is a lush, hair-raising collection guaranteed to give even Stephen King the creeps!

    Her father served in the military, and she traveled the world with him and her family. His assignments took them to Alaska, Virginia, Japan, Texas, and Germany, as part of the US Army's responsibilities in policing the world. This candid memoir recounts her family's life in new places and cultures following World War II. What was it like to be a child living in Japan seven years after the war? What was it like to be a thirteen-year-old living in Germany twelve years after the war? What was it like to grow up moving between cultures? This is the story of one family bound to service in the military at a time when the world was being redefined. For a young girl, it was the adventure of a lifetime as she learned the secrets of finding her own way in that new world. The author's story was informed by reading her father's diary, which offers up intimate and candid insight into the life of a typical soldier in a time of war. His entries describe his time serving aboard a battleship built for 800 soldiers--but carrying 6,000 to war. His tales--told from the perspective of a young soldier in southern England, Wales, and Scotland from 1943 to 1945--are glimpses into a life many will never know firsthand.

    In his analysis, Andrew Simms, director of the acclaimed think-and-do-tank the New Economics Foundation, and in association with tescopoly.org, tackles a subject that none of us can afford to ignore - what supermarkets in general, and Tesco in particular, are doing to the way we think we live our lives.

    You'll meet its people and their leaders, discover the differences and similarities between Arab and Western mindsets, and examine the wars and conflicts - including the Israeli-Palestinian turmoil - that led up to the current political situation. The Dummies Way * Explanations in plain English * Get in, get out information * Icons and other navigational aids * Tear-out cheat sheet * Top ten lists * A dash of humor and fun

    He returned with stories of exotic people, tremendous riches, and the most powerful ruler in the world – Kublai Khan. The explorer told of inventions ranging from gunpowder to paper money. The intellectual ferment and cultural diversity he described helped move Europe out of the Dark Ages and into the Renaissance. In his lifetime, people scoffed at his stories. But as this book explains, he changed the world.

    An earthen fill that carried the railroad over the creek could not withstand the power of the rising water, and Norfolk & Western passenger train Number Two plummeted into a hole in the earth. There in the valley beneath the shadow of the towering Peaks of Otter, passengers and crew scrambled from the wreckage and water in a life-or-death struggle. The best and worst of humanity were on display in the small hours of the night, as some worked heroically to rescue those trapped in the debris while others stood by concerned only for themselves. A terrible fire ensued, and those who remained trapped were consumed by the flames. The bloodied and battered survivors suffered through four more hours of isolation and torture in the rain alongside the burning wreckage before help would finally arrive.Written and extensively researched by the great-great grandson of the railroad section master at Thaxton, Lost at Thaxton tells the forgotten true story of one of the worst railroad accidents in the history of Virginia and the people who lived and died that night.