In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth.This spellbinding book is Dr. Henderson’s personal story of how he led the World Health Organization’s campaign to eradicate smallpox—the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century."In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished–and in just over ten years.The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it.New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis.This unique book is to be treasured—a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    Dr. Manheimer describes the plights of twelve very different patients--from dignitaries at the nearby UN, to supermax prisoners at Riker's Island, to illegal immigrants, and Wall Street tycoons.Manheimer was not only the medical director of the country's oldest public hospital for over 13 years, but he was also a patient. As the book unfolds, the narrator is diagnosed with cancer, and he is forced to wrestle with the end of his own life even as he struggles to save the lives of others.

    In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    Steven Hatch first came to Liberia in November 2013, to work at a hospital in Monrovia. Six months later, several of the physicians Dr. Hatch had mentored and served with were dead or barely clinging to life, and Ebola had become a world health emergency. Hundreds of victims perished each week; whole families were destroyed in a matter of days; so many died so quickly that the culturally taboo practice of cremation had to be instituted to dispose of the bodies. With little help from the international community and a population ravaged by disease and fear, the war-torn African nation was simply unprepared to deal with the catastrophe.A physician’s memoir about the ravages of a terrible disease and the small hospital that fought to contain it, Inferno is also an explanation of the science and biology of Ebola: how it is transmitted and spreads with such ferocity. And as Dr. Hatch notes, while Ebola is temporarily under control, it will inevitably re-emerge—as will other plagues, notably the Zika virus, which the World Health Organization has declared a public health emergency. Inferno is a glimpse into the white-hot center of a crisis that will come again.

    If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.The fascinating, true story of the world's deadliest disease.In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for "The New York Times," unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

    As an untried medical student studying the intersection of global health and communicable disease, Donaldson soon found himself in dangerous Sierra Leone, on the border of war-struck Liberia, where he struggled to control the spread of Lassa Fever. The words, “you know Lassa can kill you, don’t you?” haunted him each day. With the country in complete upheaval and working conditions suffering, he is forced to make life-and-death decisions alone as a never-ending onslaught of contagious patients flood the hospital. Soon however, he is not only fighting for others but himself when he becomes afflicted with a life threatening disease. The Lassa Ward is more than just an adventure story about the making of a physician; it is a portrait of the Sierra Leone people and the human struggle of those risking their daily comforts and lives to aid them.

    The most fatal virus known to science, rabies — a disease that spreads avidly from animals to humans — kills nearly one hundred percent of its victims once the infection takes root in the brain. In this critically acclaimed exploration, journalist Bill Wasik and veterinarian Monica Murphy chart four thousand years of the history, science, and cultural mythology of rabies. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh and often wildly entertaining look at one of humankind’s oldest and most fearsome foes.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Arthur Allen reveals a history of vaccination that is both illuminated with hope and shrouded by controversy - covering Jenner's discovery to Pasteur's vaccines for rabies and cholera, to those that safeguarded the children of the 20th century.

    A killer with little respect for class or wealth, cholera ravaged the squalid streets of Soho and rocked the great centers of Victorian power. In this gripping book, Sandra Hempel tells the story of John Snow, a reclusive doctor without money or social position, who—alone and unrecognized—had the genius to look beyond the conventional wisdom of his day and uncover the truth behind the pandemic. She describes how Snow discovered that cholera was spread through drinking water and how this subsequently laid the foundations for the modern, scientific investigation of today's fatal plagues. A dramatic account with a colorful cast of characters, The Strange Case of the Broad Street Pump features diversions into fascinating facets of medical and social history, such as Snow's tending of Queen Victoria in childbirth, Dutch microbiologist Leeuwenhoek's deliberate breeding of lice in his socks, Dickensian children's farms, and riotous nineteenth-century anesthesia parties. An afterword discusses the new threat of infectious diseases—including malaria, yellow fever, and cholera—with today's global warming. Copub: Granta

    Hilarious, horrifying and heartbreaking, this diary is everything you wanted to know – and more than a few things you didn't – about life on and off the hospital ward. As seen on ITV's Zoe Ball Book Club This edition includes extra diary entries and a new afterword by the author.

    We are most familiar with the viruses that give us colds or the flu, but viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long, in fact, that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in caves miles underground.This fascinating book explores the hidden world of viruses—a world that we all inhabit. Here Carl Zimmer, popular science writer and author of Discover magazine’s award-winning blog The Loom, presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate for years to come. In this eye-opening tour of the frontiers of biology, where scientists are expanding our understanding of life as we know it, we learn that some treatments for the common cold do more harm than good; that the world’s oceans are home to an astonishing number of viruses; and that the evolution of HIV is now in overdrive, spawning more mutated strains than we care to imagine.The New York Times Book Review calls Carl Zimmer “as fine a science essayist as we have.” A Planet of Viruses is sure to please his many fans and further enhance his reputation as one of America’s most respected and admired science journalists.

    . . . The only crime equaling inhumanity is the crime of indifference, silence, and forgetting.—James OrbinskiIn 1988, James Orbinski, then a medical student in his twenties, embarked on a year-long research trip to Rwanda, a trip that would change who he would be as a doctor and as a man. Investigating the conditions of pediatric AIDS in Rwanda, James confronted widespread pain and suffering, much of it preventable, much of it occasioned by political and economic corruption. Fuelled by the injustice of what he had seen in Rwanda, Orbinski helped establish the Canadian chapter of Médecins Sans Frontières (Doctors Without Borders/MSF). As a member of MSF he travelled to Peru during a cholera epidemic, to Somalia during the famine and civil war, and to Jalalabad, Afghanistan.In April 1994, James answered a call from the MSF Amsterdam office. Rwandan government soldiers and armed militias of extremist Hutus had begun systematically to murder Tutsis. While other foreigners were evacuated from Rwanda, Orbinski agreed to serve as Chef de Mission for MSF in Kigali. As Rwanda descended into a hell of civil war and genocide, he and his team worked tirelessly, tending to thousands upon thousands of casualties. In fourteen weeks 800,000 men, women and children were exterminated. Half a million people were injured, and millions were displaced. The Rwandan genocide was Orbinski’s undoing. Confronted by indescribable cruelty, he struggled to regain his footing as a doctor, a humanitarian and a man. In the end he chose not to retreat from the world, but resumed his work with MSF, and was the organization’s president when it was awarded the Nobel Peace Prize in 1999.An Imperfect Offering is a deeply personal, deeply political book. With unstinting candor, Orbinski explores the nature of humanitarian action in the twenty-first century, and asserts the fundamental imperative of seeing as human those whose political systems have most brutally failed. He insists that in responding to the suffering of others, we must never lose sight of the dignity of those being helped or deny them the right to act as agents in their own lives. He takes readers on a journey to some of the darkest places of our history but finds there unimaginable acts of courage and empathy. Here he is doctor as witness, recording voices that must be heard around the world; calling on others to meet their responsibility.Ummera, ummera–sha is a Rwandan saying that loosely translated means ‘Courage, courage, my friend–find your courage and let it live.’ It was said to me by a patient at our hospital in Kigali. She was slightly older than middle aged and had been attacked with machetes, her entire body rationally and systematically mutilated. Her face had been so carefully disfigured that a pattern was obvious in the slashes. I could do little more for her at that moment than stop the bleeding with a few sutures. We were completely overwhelmed. She knew and I knew that there were so many others. She said to me in the clearest voice I have ever heard, “Allez, allez. Ummera, ummera-sha”–‘Go, go. Courage, courage, my friend–find your courage and let it live.’—From An Imperfect Offering

    Now, in her unsparing and illuminating account of this global disease, she describes how international health experts, governments, and ordinary Africans have struggled to understand the rapid and devastating spread of the disease in Africa, and traces the changes wrought by new medical developments and emerging political realities. It is an account of scientific discovery and intrigue with implications far beyond the fight against one tragic disease. The AIDS epidemic is partly a consequence of the rapid transition of African societies from an agrarian past to an impoverished present. Millions of African people have yet to find a place in an increasingly globalized world, and their poverty and social dislocation have generated an earthquake in gender relations that deeply affects the spread of HIV. But Epstein argues that there are solutions to this crisis, and some of the most effective ones may be simpler than many people assume. Written with conviction, knowledge, and insight, Why Don't They Listen? will change how we think about the worst health crisis of the past century, and our strategies for improving global public health.