Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book.

    Many books on the plague rely on statistics to tell the story: how many people died; how farm output and trade declined. But statistics can’t convey what it was like to sit in Siena or Avignon and hear that a thousand people a day are dying two towns away. Or to have to chose between your own life and your duty to a mortally ill child or spouse. Or to live in a society where the bonds of blood and sentiment and law have lost all meaning, where anyone can murder or rape or plunder anyone else without fear of consequence.In The Great Mortality, author John Kelly lends an air of immediacy and intimacy to his telling of the journey of the plague as it traveled from the steppes of Russia, across Europe, and into England, killing 75 million people—one third of the known population—before it vanished.

    Jack Geiger, M.D., New York Times Book Review

    But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed—major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey’s Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

    Through a freewheeling and candid conversation with his economist father, Ryoichi Mikitani, the two examine the issues facing Japan, and explore possible roadmaps to revitalization. How can Japan overhaul its economy, education system, immigration, public infrastructure, and hold its own with China? Their ideas include applying business techniques like Key Performance Indicators to fix the economy, using information technology to cut government bureaucracy, and increasing the number of foreign firms with a head office in Japan. Readers gain rare insight into Japan's future, from both academic and practical perspectives on the inside.Mikitani argues that Japan's tendency to shun international frameworks and hide from global realities is the root of the problem, while Mikitani Sr.'s background as an international economist puts the issue in perspective for a well-rounded look at today's Japan.Examine the causes of Japan's endless economic stagnation Discover the current efforts underway to enhance Japan's competitiveness Learn how free market "Abenomics" affected Japan's economy long-term See Japan's issues from the perspective of an entrepreneur and an economist Japan's malaise is seated in a number of economic, business, political, and cultural issues, and this book doesn't shy away from hot topics. More than a discussion of economics, this book is a conversation between father and son as they work through opposing perspectives to help their country find The Power to Compete.

    But how does virality actually work? In The Rules of Contagion, epidemiologist Adam Kucharski explores topics including gun violence, online manipulation, and, of course, outbreaks of disease to show how much we get wrong about contagion, and how astonishing the real science is.Why did the president retweet a Mussolini quote as his own? Why do financial bubbles take off so quickly? And why are disinformation campaigns so effective? By uncovering the crucial factors driving outbreaks, we can see how things really spread -- and what we can do about it.Whether you are an author seeking an audience, a defender of truth, or simply someone interested in human social behavior, The Rules of Contagion is an essential guide to modern life.

    Missing from these accounts is a consideration of the technologies behind the creation of the globalized economy. What makes it possible for us to move billions of tons of raw materials and manufactured goods from continent to continent? Why are we able to fly almost anywhere on the planet within twenty-four hours? In "Prime Movers of Globalization," Vaclav Smil offers a history of two key technical developments that have driven globalization: the high-compression non-sparking internal combustion engines invented by Rudolf Diesel in the 1890s and the gas turbines designed by Frank Whittle and Hans-Joachim Pabst von Ohain in the 1930s. The massive diesel engines that power cargo ships and the gas turbines that propel jet engines, Smil argues, are more important to the global economy than any corporate structure or international trade agreement. Smil compares the efficiency and scale of these two technologies to prime movers of the past, including the sail and the steam engine. The lengthy processes of development, commercialization, and diffusion that the diesel engine and the gas turbine went through, he argues, provide perfect examples of gradual technical advances that receive little attention but have resulted in epochal shifts in global affairs and the global economy.

    Jeffrey Sachs—celebrated economist, special advisor to the Secretary General of the United Nations, and author of the influential bestseller The End of Poverty—disagrees.  In his view, poverty is a problem that can be solved. With single-minded determination he has attempted to put into practice his theories about ending extreme poverty, to prove that the world's most destitute people can be lifted onto "the ladder of development." In 2006, Sachs launched the Millennium Villages Project, a daring five-year experiment designed to test his theories in Africa. The first Millennium village was in Sauri, a remote cluster of farming communities in western Kenya. The initial results were encouraging. With his first taste of success, and backed by one hundred twenty million dollars from George Soros and other likeminded donors, Sachs rolled out a dozen model villages in ten sub-Saharan countries. Once his approach was validated it would be scaled up across the entire continent. At least that was the idea. For the past six years, Nina Munk has reported deeply on the Millennium Villages Project, accompanying Sachs on his official trips to Africa and listening in on conversations with heads-of-state, humanitarian organizations, rival economists, and development experts. She has immersed herself in the lives of people in two Millennium villages: Ruhiira, in southwest Uganda, and Dertu, in the arid borderland between Kenya and Somalia. Accepting the hospitality of camel herders and small-hold farmers, and witnessing their struggle to survive, Munk came to understand the real-life issues that challenge Sachs's formula for ending global poverty.  The Idealist is the profound and moving story of what happens when the abstract theories of a brilliant, driven man meet the reality of human life.

    Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.

    Somewhere in nature, a killer virus is boiling up in the bloodstream of a bird, bat, monkey, or pig, preparing to jump to a human being. This not-yet-detected germ has the potential to wipe out millions of lives over a matter of weeks or months. That risk makes the threat posed by ISIS, a ground war, a massive climate event, or even the dropping of a nuclear bomb on a major city pale in comparison.In The End of Epidemics, Duke Global Health Institute faculty member and past Chair of the Global Health Council Dr. Jonathan D. Quick examines the eradication of smallpox and devastating effects of influenza, AIDS, SARS, Ebola, and other viral diseases . Analyzing local and global efforts to contain these diseases and citing firsthand accounts of failure and success, Dr. Quick proposes a new set of actions which he has coined "The Power of Seven," to end epidemics before they can begin. These actions include:- Spend prudently to prevent disease before an epidemic strikes, rather than spending too little, too late- Ensure prompt, open, and accurate communication between nations and aid agencies, instead of secrecy and territorial disputes- Fight disease and prevent panic with innovation and good sciencePractical and urgent, The End of Epidemics is crucial reading for citizens, health professionals, and policy makers alike.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Nuland tells the strange story of Ignác Semmelweis with urgency and the insight gained from his own studies and clinical experience. Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-nineteenth-century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately—childbed fever in Vienna all but disappeared—they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.