Genes, Peoples, and Languages


Luigi Luca Cavalli-Sforza - 1996
    Cavalli-Sforza and others have answered this question—anticipated by Darwin—with a decisive yes. Genes, Peoples, and Languages comprises five lectures that serve as a summation of the author's work over several decades, the goal of which has been nothing less than tracking the past hundred thousand years of human evolution.Cavalli-Sforza raises questions that have serious political, social, and scientific import: When and where did we evolve? How have human societies spread across the continents? How have cultural innovations affected the growth and spread of populations? What is the connection between genes and languages? Always provocative and often astonishing, Cavalli-Sforza explains why there is no genetic basis for racial classification.

What Is Life? with Mind and Matter and Autobiographical Sketches


Erwin Schrödinger - 1944
    The book was based on a course of public lectures delivered by Schrödinger in February 1943 at Trinity College, Dublin. Schrödinger's lecture focused on one important question: "how can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?" In the book, Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. In the 1950s, this idea stimulated enthusiasm for discovering the genetic molecule and would give both Francis Crick and James Watson initial inspiration in their research.

Rosalind Franklin and DNA


Anne Sayre - 1975
    In this classic work Anne Sayre, a journalist and close friend of Franklin, puts the record straight.

Saving Darwin: How to Be a Christian and Believe in Evolution


Karl W. Giberson - 2008
    Creationism and intelligent design are usually seen as the province of religious people, while evolution belongs to the scientists. More often than not, both camps see the other as "the enemy." But what about committed Christians who find something lacking in the ideas of both creationism and intelligent design? Can you still be a Christian and support the idea of evolution?Scientist Karl Giberson believes you can. Raised a fundamentalist and influenced as a boy by Henry Morris's creationist classic The Genesis Flood, Giberson firmly believed in creationism through his college years. But while working on his Ph.D. in physics, he began to doubt that science could have gotten everything as thoroughly wrong as the creationists suggested, and he gradually abandoned his creationist beliefs—but not his belief in Christianity. Through careful research, Giberson concluded that Christianity and evolution do not have to be incompatible. In Saving Darwin, Giberson paints a clear picture of the creation/evolution controversy and explores its intricate history, from Darwin to the current culture wars, carefully showing why—and how—it is possible to believe in God and evolution at the same time.

The Double Helix


James D. Watson - 1968
    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

Francis Crick: Discoverer of the Genetic Code


Matt Ridley - 2006
    Between 1953 and 1966 he made and led a revolution in biology by discovering, quite literally, the secret of life: the digital cipher at the heart of heredity that distinguishes living from non-living things -- the genetic code. His own discoveries -- though he always worked with one other partner and did much of his thinking in conversation -- include not only the double helix but the whole mechanism of protein synthesis, the three-letter nature of the code, and much of the code itself.Matt Ridley's biography traces Crick's life from middle-class mediocrity in the English Midlands, through a lackluster education and six years designing magnetic mines for the Royal Navy, to his leap into biology at the age of thirty-one. While at Cambridge, he suddenly began to display the unique visual imagination and intense tenacity of thought that would allow him to see the solutions to several great scientific conundrums -- and to see them long before most biologists had even conceived of the problems. Having set out to determine what makes living creatures alive and having succeeded, he immigrated at age sixty to California and turned his attention to the second question that had fascinated him since his youth: What makes conscious creatures conscious? Time ran out before he could find the answer.

Darwin and the Barnacle: The Story of One Tiny Creature and History's Most Spectacular Scientific Breakthrough


Rebecca Stott - 2003
    Pairing Charles Darwin and a rare species of barnacle as her unlikely protagonists, Rebecca Stott has written an absorbing work of history that guides readers through the treacherous shoals of nineteenth-century biology. Beginning her scientific detective story in the 1820s, even before Darwin's Beagle voyage, Stott examines the mystery of why Darwin waited over two decades between formulating his pivotal theory of natural selection and publishing it. Lavishly illustrated, filled with riddles and concepts that challenge our notion of Victorian science, Darwin and the Barnacle is a thrilling account of how genius proceeds through indirection—and how one small item of curiosity contributed to history's most spectacular scientific breakthrough.

Man & Horse: The Long Ride Across America


John Egenes - 2017
    With a hundred dollars in his pocket, a beat up cavalry saddle, and a faraway look in his eye, John Egenes saddled his horse Gizmo and started down the trail on an adventure across the North American continent. Their seven month journey took them across 11 states from California to Virginia, ocean to ocean.. As they left the pressing confinement of the city behind them, the pair experienced the isolation and loneliness of the southwestern deserts, the vastness of the prairie, and the great landscapes that make up America. Across hundreds of miles of empty land they slept with coyotes and wild horses under the stars, and in urban areas they camped alone in graveyards and abandoned shacks. Along the way John and Gizmo were transformed from inexperienced horse and rider to veterans of the trail. With his young horse as his spiritual guide John slowly began to comprehend his own place in the world and to find peace within himself. Full of heart and humor, Egenes serves up a tale that's as big as the America he witnessed, an America that no longer exists. It was a journey that could only have been experienced step by step, mile by mile, from the view between a horse's ears.

What Stars are Made of: The Life of Cecilia Payne-Gaposchkin


Donovan Moore - 2020
    Cecilia Payne-Gaposchkin, a tireless innovator who correctly theorized the substance of stars, was one of them.It was not easy being a woman of ambition in early twentieth-century England, much less one who wished to be a scientist. Cecilia Payne-Gaposchkin overcame prodigious obstacles to become a woman of many firsts: the first to receive a PhD in astronomy from Radcliffe College, the first promoted to full professor at Harvard, the first to head a department there. And, in what has been called “the most brilliant PhD thesis ever written in astronomy,” she was the first to describe what stars are made of.Payne-Gaposchkin lived in a society that did not know what to make of a determined schoolgirl who wanted to know everything. She was derided in college and refused a degree. As a graduate student, she faced formidable skepticism. Revolutionary ideas rarely enjoy instantaneous acceptance, but the learned men of the astronomical community found hers especially hard to take seriously. Though welcomed at the Harvard College Observatory, she worked for years without recognition or status. Still, she accomplished what every scientist yearns for: discovery. She revealed the atomic composition of stars―only to be told that her conclusions were wrong by the very man who would later show her to be correct.In What Stars Are Made Of, Donovan Moore brings this remarkable woman to life through extensive archival research, family interviews, and photographs. Moore retraces Payne-Gaposchkin’s steps with visits to cramped observatories and nighttime bicycle rides through the streets of Cambridge, England. The result is a story of devotion and tenacity that speaks powerfully to our own time.

Lise Meitner: A Life in Physics


Ruth Lewin Sime - 1996
    Braving the sexism of the scientific world, she joined the prestigious Kaiser Wilhelm Institute for Chemistry and became a prominent member of the international physics community. Of Jewish origin, Meitner fled Nazi Germany for Stockholm in 1938 and later moved to Cambridge, England. Her career was shattered when she fled Germany, and her scientific reputation was damaged when Hahn took full credit—and the 1944 Nobel Prize—for the work they had done together on nuclear fission. Ruth Sime's absorbing book is the definitive biography of Lise Meitner, the story of a brilliant woman whose extraordinary life illustrates not only the dramatic scientific progress but also the injustice and destruction that have marked the twentieth century.

The Emperor of All Maladies: A Biography of Cancer


Siddhartha Mukherjee - 2010
    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Patient H.M.: A Story of Memory, Madness, and Family Secrets


Luke Dittrich - 2016
    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer


Robert Bazell - 1998
    The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

The Physics of Life: The Evolution of Everything


Adrian Bejan - 2016
    Bejan explores controversial and relevant issues such as sustainability, water and food supply, fuel, and economy, to critique the state in which the world understands positions of power and freedom. Breaking down concepts such as desire and power, sports health and culture, the state of economy, water and energy, politics and distribution, Bejan uses the language of physics to explain how each system works in order to clarify the meaning of evolution in its broadest scientific sense, moving the reader towards a better understand of the world's systems and the natural evolution of cultural and political development. What Life Is argues that the evolution phenomenon is much broader and older than the evolutionary designs that constitute the biosphere, empowering readers with a new view of the globe, revealing that the urge to have better ideas has the same physical effect as the urge to have better laws and better government. This is evolution explained loudly but also elegantly, forging a path that flows sustainability.

Possessing Genius: The True Account of the Bizarre Odyssey of Einstein's Brain


Carolyn Abraham - 2002
    He seized the opportunity to do something "noble." Using an electric saw, Harvey sliced through the skull and gingerly removed the organ that would both define and haunt the rest of his life. Harvey struck a controversial deal with Einstein's family to keep the brain, swearing to safeguard it from souvenir hunters and publicity seekers, and to make it available only for serious scientific inquiry. Not a neuroscientist himself, he became the unlikely custodian of this object of intense curiosity and speculation, and the self-styled bulwark against the relentless power of Einstein's growing celebrity. Bridging the post-war era and the new millennium, Possessing Genius is the first comprehensive account of the circuitous path the brain took with Harvey during the decades it remained in his possession. Harvey permitted Einstein's gray matter to be sliced, diced, probed, prodded, and weighed by those hoping to solve the enigma and locate the source of genius itself. The brain was more than a subject of scientific investigation, it was a kind of holy relic; the history of its adventures since 1955 reflects the vicissitudes and vanities underpinning what we believe makes us human. Abraham has gathered together all of the fascinating details and documents of the brain's saga--including previously unpublished correspondence between Harvey and Otto Nathan, the executor of Einstein's estate—and from them woven a story that is both deeply engrossing and highly illuminating.