But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Lisa Seachrist Chiu has a smorgasbord of stories to tell about rare and not so rare genetic quirks. We read about the Dracula Gene, a mutation in zebra fish that causes blood cells to explode on contact with light, and suites of genes that also influence behavior and physical characteristics; the Tangier Island Gene, first discovered after physicians discovered a boy with orange tonsils (scientists now realize that the child's odd condition comes from an inability to process cholesterol); and Wilson's Disease, a gene defect that fails to clear copper from the body, which can trigger schizophrenia and other neurological symptoms, and can be fatal if left untreated. Friendlier mutations include the Myostatin gene, which allows muscles to become much larger than usual and enhances strength and the much-envied Cheeseburger Gene, which allows a lucky few to eat virtually anything they want and remain razor thin. While fascinating us with stories of genetic peculiarities, Chiu also manages to effortlessly explain much of the cutting-edge research in modern genetics, resulting in a book that is both informative and entertaining. It is a must read for everyone who loves popular science or is curious about the human body.

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.

    “Forget everything you think you know about genes, talent, and intelligence,” he writes. “In recent years, a mountain of scientific evidence has emerged suggesting a completely new paradigm: not talent scarcity, but latent talent abundance.” Integrating cutting-edge research from a wide swath of disciplines—cognitive science, genetics, biology, child development—Shenk offers a highly optimistic new view of human potential. The problem isn't our inadequate genetic assets, but our inability, so far, to tap into what we already have. IQ testing and widespread acceptance of “innate” abilities have created an unnecessarily pessimistic view of humanity—and fostered much misdirected public policy, especially in education. The truth is much more exciting. Genes are not a “blueprint” that bless some with greatness and doom most of us to mediocrity or worse. Rather our individual destinies are a product of the complex interplay between genes and outside stimuli-a dynamic that we, as people and as parents, can influence. This is a revolutionary and optimistic message. We are not prisoners of our DNA. We all have the potential for greatness.

    Each clique of scientists has a part of the story correct, but new evidence shows they are all fundamentally wrong.On the one side, we have academics highlighting the astonishing fossil record of China with multiple sites now producing modern human fossils aged between 80 - 120 thousand years, or older. Several extremely ancient fossil finds in China, including Dali, Maba and Jinniushan, place archaic Homo sapiens in this region up to 260,000 years ago.On the other side, we have scientists pointing to Africa's impressive fossil record with its evidence of potential ancestors going back around 6 million years. The evidence of extreme genetic diversity among Africans and the discovery of 300,000-year-old archaic Homo sapiens fossils in Morocco tends to further support the idea that humans came out from Africa. We can understand why both sides are so sure of their positions, and why the debate continues. While leading academics focussed on their own agendas, they overlooked significant evidence. Between the two poles of Out of Africa and Out of Asia Theory, exists a 'Middle Way'. The Forgotten Exodus: The Into Africa Theory of Human Evolution, reveals that within the known fossil record, the current genetic studies and recent paleoclimate models there is compelling evidence for a superior theory of human origins, representing a paradigm displacement.The Into Africa Theory does not dispute the evidence placing the earliest hominins in Africa.However, it does not agree with the consensus view that Homo sapiens emerged there first and later migrated to Eurasia.The Into Africa Theory recognises the extraordinary evidence for critical stages in our development occurring in East and Southeast Asia. It is abundantly clear that as a new concerted effort to gather and evaluate fossil evidence begins in earnest we see astonishing new discoveries. The Into Africa Theorydisputes the claims of Out of Africa and Out of Asia(or Europe) adherents over the starting point for the migration which populated Eurasia approximately 60,000 years ago and identifies the actual location.Amazing facts that you will encounter:-Homo heidelbergensis was not ancestral to modern humans -Denisovan fossils in Siberia carried DNAfrom Australian Aboriginals-An Indonesian supervolcano brought about the end for multiple hominin species-Climate catastrophe locked humans in Africa from 73,000 to 59,000 years ago-There is no African fossil DNA over 10,000 years in age-While supposedly isolated, Aboriginal Australians interbred with Denisovans 44,000 years agoYou will gain access to a long-forgotten conversation involving the famous evolutionary scientists Allan Wilson and Rebecca Cann, in which they admitted that their data suggested Aboriginal Australians were ancestral to all modern humans.Learn why the appearance of the haplogroups foundational to Eurasians, L3 and CT, had to come from a population incursion rather than an in-situ mutation.Explore the cutting-edge scientific findings of 2016 and 2017 alongside a broad range of anomalies long suppressed or ignored in academic circles.The Forgotten Exodus' author Bruce R. Fenton began his journey towards a new understanding of human origins after an expedition to a mysterious megalithic complex in the Ecuadorian Amazon. The Information Systems professional and lifelong scholar of ancient cultures, found himself tracing the threads of the human story across six continents and through 6,000,000 years of history. You will come away with a unique view of humanity and a sense of excitement for revelations still set to arrive. This book reminds all of us that we have a collective ability to overcome enormous obstacles.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

    A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.

    In recent years, opponents of "Darwin’s dangerous idea" have mounted history’s most sophisticated and generously funded attack, claiming that evolution is "a theory in crisis." Ironically, these claims are being made at a time when the explosion of information from genome projects has revealed the most compelling and overwhelming evidence of evolution ever discovered. Much of the latest evidence of human evolution comes not from our genes, but from so-called "junk DNA," leftover relics of our evolutionary history that make up the vast majority of our DNA. Relics of Eden explores this powerful DNA-based evidence of human evolution. The "relics" are the millions of functionally useless but scientifically informative remnants of our evolutionary ancestry trapped in the DNA of every person on the planet. For example, the analysis of the chimpanzee and Rhesus monkey genomes shows indisputable evidence of the human evolutionary relationship with other primates. Over 95 percent of our genome is identical with that of chimpanzees and we also have a good deal in common with other animal species. Author Daniel J. Fairbanks also discusses what DNA analysis reveals about where humans originated. The diversity of DNA sequences repeatedly confirms the archeological evidence that humans originated in sub-Saharan Africa (the "Eden" of the title) and from there migrated through the Middle East and Asia to Europe, Australia, and the Americas. In conclusion, Fairbanks confronts the supposed dichotomy between evolution and religion, arguing that both science and religion are complementary ways to seek truth. He appeals to the vast majority of Americans who hold religious convictions not to be fooled by the pseudoscience of Creationists and Intelligent Design advocates and to abandon the false dichotomy between religion and real science. This concise, very readable presentation of recent genetic research is completely accessible to the nonspecialist and makes for enlightening and fascinating reading.

    Contrary to what the glossy magazines would have us believe, we do not enjoy potato chips because they crunch just like the insects our forebears snacked on. As Zuk argues, such beliefs incorrectly assume that we’re stuck—finished evolving—and have been for tens of thousands of years. She draws on fascinating evidence that examines everything from adults’ ability to drink milk to the texture of our ear wax to show that we’ve actually never stopped evolving. Our nostalgic visions of an ideal evolutionary past in which we ate, lived, and reproduced as we were “meant to” fail to recognize that we were never perfectly suited to our environment. Evolution is about change, and every organism is full of trade-offs.From debunking the caveman diet to unraveling gender stereotypes, Zuk gives an analysis of widespread paleofantasies and the scientific evidence that undermines them, all the while broadening our understanding of our origins and what they can really tell us about our present and our future.

    Life remains the only way to make life. Are we still missing a vital ingredient in its creation?      Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences. Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe. Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.

    But how did Watson and Crick do it—and why were they the ones who succeeded?In truth, the discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Each was fascinating and brilliant, with strong personalities that often clashed. Howard Markel skillfully re-creates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin—fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s, as the lone Jewish woman among young male scientists—who becomes a focal point for Markel.The Secret of Life is a story of genius and perseverance, but also a saga of cronyism, misogyny, anti-Semitism, and misconduct. Drawing on voluminous archival research, including interviews with James Watson and with Franklin’s sister, Jenifer Glynn, Markel provides a fascinating look at how science is done, how reputations are undone, and how history is written, and revised.A vibrant evocation of Cambridge in the 1950s, Markel also provides colorful depictions of Watson and Crick—their competitiveness, idiosyncrasies, and youthful immaturity—and compelling portraits of Wilkins, Pauling, and most cogently, Rosalind Franklin. The Secret of Life is a lively and sweeping narrative of this landmark discovery, one that finally gives the woman at the center of this drama her due.

    John Sanford, a retired Cornell Professor, shows in "Genetic Entropy and the Mystery of the Genome" that the "Primary Axiom" is false. The Primary Axiom is the foundational evolutionary premise -- that life is merely the result of mutations and natural selection. In addition to showing compelling theoretical evidence that whole genomes must in fact degenerate over time, this book strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process. This is an updated version of the October 2005 edition, which includes both a new appendix and glossary.

    Now, faced with the threat of nuclear weapons and the effects of climate change, it seems our innate tendencies for violence and invention have led us to a crucial fork in our road. Where did these traits come from? Are they part of our species immutable destiny? Or is there hope for our species’ future if we change? With fascinating facts and his unparalleled readability, Diamond intended his book to improve the world that today’s young people will inherit. Triangle Square’s The Third Chimpanzee for Young People is a book for future generation and the future they’ll help build.

    Would you want to know? Taking a uniquely intimate and cheeky approach to the personal genomics revolution, internationally acclaimed science writer Lone Frank swabs up her genetic code to explore who any of us are in the days when a catalogue of your full six billion DNA building blocks is available for $10,000 and the local Walgreens offers genetic screening tests to anyone. She challenges the august Nobel Prize winners and the hyperactive business mavericks who are pushing to map and decipher every fetus’s genome within the next decade. She tests the potential to detect diseases early, as well as our capacity to develop chronic anxieties when our DNA is seen as a death sentence. She ponders whether personality, including her own above-average irritability and non-conformity, can really be reduced to biochemistry. And she prods the psychologists who hope to uncover just how much or how little our environment will matter in the new genetic century — a quest made all the more gripping as Frank considers her family’s and her own struggles with depression. At turns compellingly candid and irreverently insightful, Frank provides the first truly personal account of the new science of consumer-led genomics — and to what extent our genes determine our destiny. Lone Frank is the author of The Neurotourist: Postcards from the Edge of Brain Science (ISBN 9781851687961). She holds a PhD in neurobiology and was previously a research scientist working in the biotechnology industry in the United States. An award-winning science journalist and TV documentary presenter, she has written for such publicationsn as Scientific American, Science, and Nature Biotechnology and is a frequent speaker at venues including Harvard Medical School, the Library of Congress, the Royal Society, and TED. Praise for The Neurotourist: “A fascinating exploration of the most intriguing brain experiments so far.” New Scientist “Riveting.” Rita Carter, author of Mapping the Mind