In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.

    And as outbreaks of COVID-19, Ebola, MERS, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza or coronavirus pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.

    But this isn't fantasy, this is hard fact.

    Head First Ajax gives you an up-to-date perspective that lets you see exactly what you can do--and has been done--with Ajax. With it, you get a highly practical, in-depth, and mature view of what is now a mature development approach. Using the unique and highly effective visual format that has turned Head First titles into runaway bestsellers, this book offers a big picture overview to introduce Ajax, and then explores the use of individual Ajax components--including the JavaScript event model, DOM, XML, JSON, and more--as it progresses. You'll find plenty of sample applications that illustrate the concepts, along with exercises, quizzes, and other interactive features to help you retain what you've learned.Head First Ajax covers:The JavaScript event modelMaking Ajax requests with XMLHTTPREQUEST objectsThe asynchronous application modelThe Document Object Model (DOM)Manipulating the DOM in JavaScriptControlling the browser with the Browser Object ModelXHTML FormsPOST RequestsXML Syntax and the XML DOM treeXML Requests & ResponsesJSON -- an alternative to XMLAjax architecture & patternsThe Prototype LibraryThe book also discusses the server-side implications of building Ajax applications, and uses a black box approach to server-side components.Head First Ajax is the ideal guide for experienced web developers comfortable with scripting--particularly those who have completed the exercises in Head First JavaScript--and for experienced programmers in Java, PHP, and C# who want to learn client-side programming.

    In The Beautiful Cure, leading immunologist Professor Daniel Davis describes the scientific quest to understand how it works – and how it is affected by stress, sleep, age and our state of mind – and explains how this knowledge is now unlocking a revolutionary new approach to medicine and well-being.The body's ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But within the last few years painstaking research has resulted in major advances in our understanding of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, it also plays a crucial role in our daily lives. Already we have found ways to harness these natural defences to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis and many age-related diseases, and we are starting to understand whether or not activities such as mindfulness might play a role in enhancing our physical resilience.Written by an expert at the forefront of this adventure, The Beautiful Cure tells a dramatic story of detective work and discovery, of puzzles solved and of the mysteries that remain, of lives sacrificed and saved, introducing the reader to this revelatory new understanding of the human body and what it takes to be healthy.

    The Quantum Rules is a different kind of physics book, as easy to read as a novel and directly relevant for everyday life issues that affect us all. It is not meant to dazzle you with unproven speculations that have no bearing on your life. Rather, The Quantum Rules will familiarize you with the important and established laws at the heart of physics, in a way never done before – by showing how the defining patterns of our lives, our behavior and our society already follow similar rules. Never took an interest in science before? No problem! you will still understand everything and find plenty to relate to. A scientist or a science junkie? You will find a different perspective on things you may already know. Best of all, you will discover how to have meaningful conversations about physics in a way that won’t make eyes glaze over, and in which all can gladly participate. The Quantum Rules also does something you would never expect from a book on physics – it makes you laugh, often. Its new and original take on established natural laws injects plenty of dry humor into this serious subject, by using life to explain physics and in turn using physics to understand life.

    From establishing routines, making schedules, and DIYing green cleaning solutions to help keep every area of your home neat, safe and spotless—find it all here.Learn the best seasons to tackle home projects, storage solutions to simplify the process, and sweet natural solutions for every room and fixture. This book will help you tackle every mess, stain, and dust-magnet, and keep things from getting out of hand in the future—all while being friendly to the environment and keeping toxic chemicals out of your home. Whether you’re a neat freak or new to the world of homekeeping, let Toni Hammersley be your guide to establishing routines, learning techniques and mastering the best home cleaning hacks out there. Learn what needs a deep-clean and how often, how to substitute essential oils and pantry basics for store-bought chemicals and what to do about the toughest homekeeping dilemmas. Soon you’ll find that no matter the number of pets, kids, or others in your home, cleanliness is easier than you ever imagined.

    It’s time we stand face-to-digital-face with the true powers and limitations of the algorithms that already automate important decisions in healthcare, transportation, crime, and commerce. Hello World is indispensable preparation for the moral quandaries of a world run by code, and with the unfailingly entertaining Hannah Fry as our guide, we’ll be discussing these issues long after the last page is turned.

    An individual's Decision Tree begins with genomics, where $400 and a test tube of spit provides a peek at how your DNA influences your health. It taps self-monitoring and collaborative health tools, where iPhone applications and next-generation monitoring gadgets can help individuals successfully change their behavior, once and for all. And it turns to new screening techniques that detect diseases like cancer and diabetes far earlier and with far better prospects for our health. Full of thoughtful, groundbreaking reporting on the impact personalized medicine will have on the average patient, The Decision Tree will show you how to take advantage of this new frontier in health care.

    Who Owns the Future? is his visionary reckoning with the most urgent economic and social trend of our age: the poisonous concentration of money and power in our digital networks.Lanier has predicted how technology will transform our humanity for decades, and his insight has never been more urgently needed. He shows how Siren Servers, which exploit big data and the free sharing of information, led our economy into recession, imperiled personal privacy, and hollowed out the middle class. The networks that define our world—including social media, financial institutions, and intelligence agencies—now threaten to destroy it.But there is an alternative. In this provocative, poetic, and deeply humane book, Lanier charts a path toward a brighter future: an information economy that rewards ordinary people for what they do and share on the web.

    Increasingly, the decisions that affect our lives--where we go to school, whether we can get a job or a loan, how much we pay for health insurance--are being made not by humans, but by machines. In theory, this should lead to greater fairness: Everyone is judged according to the same rules.But as mathematician and data scientist Cathy O'Neil reveals, the mathematical models being used today are unregulated and uncontestable, even when they're wrong. Most troubling, they reinforce discrimination--propping up the lucky, punishing the downtrodden, and undermining our democracy in the process.

    Essinger, a master story-teller, describes how Joseph-Marie Jacquard's loom enabled the silk-weavers of Lyons to weave fabrics 25 times faster than had previously been possible. The device used punched cards, which stored instructions for weaving whatever pattern or design was required. Thesecards can very reasonably be described as the world's first computer programs. Indeed, Essinger shows through a series of remarkable and meticulously researched historical connections--connections never before investigated--that the Jacquard loom kick-started a process of scientific evolution whichwould lead directly to the development of the modern computer. The book examines a wealth of extraordinary links between the nineteenth-century world of weaving and today's computer age: for example, modern computer graphics displays are based on exactly the same principles as those employed inJacquard's special woven tableaux. Jacquard's Web also introduces some of the most colorful and interesting characters in the history of science and technology: the modest but exceptionally dedicated Jacquard himself; the brilliant but temperamental Victorian polymath Charles Babbage, who dreamed ofa cogwheel computer operated using Jacquard cards; and the imaginative and perceptive Ada Lovelace, Lord Byron's only legitimate daughter. Attractively illustrated and compellingly narrated, Jacquard's Web is an engaging and delightful volume. It is an impressive case of historical detective work, one that will leave the reader mesmerized.

    Digital technologies—with hardware, software, and networks at their core—will in the near future diagnose diseases more accurately than doctors can, apply enormous data sets to transform retailing, and accomplish many tasks once considered uniquely human.In The Second Machine Age MIT’s Erik Brynjolfsson and Andrew McAfee—two thinkers at the forefront of their field—reveal the forces driving the reinvention of our lives and our economy. As the full impact of digital technologies is felt, we will realize immense bounty in the form of dazzling personal technology, advanced infrastructure, and near-boundless access to the cultural items that enrich our lives.Amid this bounty will also be wrenching change. Professions of all kinds—from lawyers to truck drivers—will be forever upended. Companies will be forced to transform or die. Recent economic indicators reflect this shift: fewer people are working, and wages are falling even as productivity and profits soar.Drawing on years of research and up-to-the-minute trends, Brynjolfsson and McAfee identify the best strategies for survival and offer a new path to prosperity. These include revamping education so that it prepares people for the next economy instead of the last one, designing new collaborations that pair brute processing power with human ingenuity, and embracing policies that make sense in a radically transformed landscape.A fundamentally optimistic book, The Second Machine Age alters how we think about issues of technological, societal, and economic progress.

    Packed with art and advice from Marc Taro Holmes, artist and co-founder of Urbansketchers.org, this self-directed workshop shows you how to draw inspiration from real life and bring that same excitement into your sketchbook. Inside you'll fi nd everything you need to tackle subjects ranging from still lifes and architecture to people and busy street scenes.15 step-by-step demonstrations cover techniques for creating expressive drawings using pencil, pen and ink, and watercolor.Expert tips for achieving a balance of accuracy, spontaneity and speed.Practical advice for working in the field, choosing subjects, coping with onlookers, capturing people in motion and more.Daily exercises and creative prompts for everything from improving essential skills to diverse approaches, such as montages, storytelling portraits and one-page graphic novels.Whether you are a habitual doodler or a seasoned artist, The Urban Sketcher will have you out in the world sketching from the very first page. By completing drawings on the spot, in one session, you achieve a fresh impression of not just what you see, but also what it feels like to be there . . . visual life stories as only you can experience them.

    Kai-Fu Lee—one of the world’s most respected experts on AI and China—reveals that China has suddenly caught up to the US at an astonishingly rapid and unexpected pace.In AI Superpowers, Kai-Fu Lee argues powerfully that because of these unprecedented developments in AI, dramatic changes will be happening much sooner than many of us expected. Indeed, as the US-Sino AI competition begins to heat up, Lee urges the US and China to both accept and to embrace the great responsibilities that come with significant technological power.Most experts already say that AI will have a devastating impact on blue-collar jobs. But Lee predicts that Chinese and American AI will have a strong impact on white-collar jobs as well. Is universal basic income the solution? In Lee’s opinion, probably not.  But he provides a clear description of which jobs will be affected and how soon, which jobs can be enhanced with AI, and most importantly, how we can provide solutions to some of the most profound changes in human history that are coming soon.