An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

    Refusing to cave in to society's rules, Eleanor's exuberant style, wavering voice and lack of Hollywood beauty are fodder for the media.First Lady for thirteen years, Eleanor redefines and exploits this role to a position ofpower. Using her influence she champions for Jews, African Americans and women. Living through two world wars Eleanor witnesses thousands of graves, broken bodies and grieving families. After visiting troops in the Pacific she says:"If we don't make this a more decent world to live in I don't see how we can look these boys in the eyes."She defies a post-war return to status quo and establishes the Universal Declarationof Human Rights within the U.N. She earns her way to being named "First Lady of the World." The audacity of this woman to live out her own destiny challenges us to do the same. After all, it's not about Eleanor. Her story is history.  It's about us.

    There are treatments available that can halt, and in some cases, even reverse the aging process.But how do you know what treatments are best for you? Which of the hippest, hottest, and newest are fabulously effective and which are nothing more than new-age snake oil? Let us be your guides. Dr. and Mrs. Guinea Pig Present The Only Guide You'll Ever Need to the Best Anti-Aging Treatments will outline all the best techniques and treatments, from the so-new-you-haven t-heard-of-them-yet to the tried-and-true; from the perfectly legal to the are-you-trying-to-get-me-arrested; from the simple to the outrageous; and from the cheapest drugstore creams to the most complicated surgeries. We will provide you with the information and research you need to create your own, unique anti-aging plan to look and feel your best forever!"

    She knew instantly that her decision to work in general practice was the ‘biggest and worst mistake of her life’. Fortunately, however, this did not deter her from continuing in general practice, and this fascinating memoir (spanning half a century) is testament to her resilience and professionalism, as well as her pragmatic and charismatic personality. She shares real stories about real people in this intriguing book. Some stories are truly heart-breaking and will have you reaching for the tissues (such as the times when she has lost patients, and encountered and supported abused children and rape victims). But it isn’t all serious. There are lots of light-hearted and heart-warming moments too, such as the stories about Jessie-dog – her bodyguard when she made home visits, and the time when she helped a large (and desperately in need) family to get rehoused, and her time as a country GP. She also recalls with honesty and candidness, the prejudice and unimaginable pressure she had to contend with, as a young female GP in the 1960s. As well as a plethora of fascinating stories, experiences and case studies, this book also gives us, as 21st Century readers, a glimpse into the rapid changes in general practice and the NHS in general. Whether you’re in general practice, or you’re a medical professional, or you have a penchant for all kinds of autobiographies/memoirs, you will find this a thought-provoking and captivating book that’s impossible to put down. Take a peek at the ‘Look Inside’ feature now and be prepared to be instantly intrigued.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    Everyone said he was a good kid: a bit of a clown, maybe not too serious about his studies, but sweet and kind and quick to make friends. When, as a clean-cut teenager, he signed up with the army, the people of Reeds Springs, Missouri, expected to hear nothing but good things about R.J. and Lexie Mease's eldest son.It wouldn't work out that way. Darrell Mease would end up on the front lines of the Vietnam War and would come home a drug addict. Over the personally tumultuous, drifting decades that followed, he'd make a new name for himself in the Ozarks: as a tough drug dealer. Then, in 1987, he gunned down a 69-year-old meth kingpin, his wife, and their 20-year-old paraplegic grandson. After a desperate cross-country escape, he was captured, hauled back to Missouri, and sentenced to death for his crimes.In jail, Mease experienced a religious conversion, and he made a shocking prediction: he would be saved by miraculous intervention.No one believed it would happen. But it did. On January 27, 1999, Pope John Paul II visited St. Louis and spoke to Missouri's then-governor, Mel Carnahan. It was the same date that authorities had set for Mease's execution. The pope asked that he be spared. Carnahan agreed.

    Methland tells the story of Oelwein, Iowa (pop. 6,159), which, like thousands of other small towns across the country, has been left in the dust by the consolidation of the agricultural industry, a depressed local economy, and an out-migration of people. As if this weren t enough to deal with, an incredibly cheap, longlasting, and highly addictive drug has rolled into town.Over a period of four years, journalist Nick Reding brings us into the heart of Oelwein through a cast of intimately drawn characters, including: Clay Hallburg, the town doctor, who fights meth even as he struggles with his own alcoholism; Nathan Lein, the town prosecutor, whose caseload is filled almost exclusively with meth-related crime; and Jeff Rohrick, a meth addict, still trying to kick the habit after twenty years. Tracing the connections between the lives touched by the drug and the global forces that set the stage for the epidemic, Methland offers a vital and unique perspective on a pressing contemporary tragedy.

    At the moment, the scales are unfairly balanced and I just want things to be fair for my children, my grandchildren and future generations.’On 13 June 2020, Patrick Hutchinson, a black man, was photographed carrying a white injured man to safety during a confrontation in London between Black Lives Matter demonstrators and counter-protestors. The powerful image was shared and discussed all around the world.Everyone versus Racism is a poignant letter from Patrick to his children and grandchildren. Writing from the heart, he describes the realities of life as a black man today and why we must unite to inspire change for generations to come.

    This is the bloody saga of Beecher Island.Historian Dee Brown dramatically recounts the nine-day siege between Plains tribes and Major James William Forsyth’s scouts. Based on historical sources, the novel is told from a variety of viewpoints, including that of Lieutenant Frederick Beecher, still wounded from the Civil War and charged with clearing out American Indian settlements to make way for the Kansas Pacific Railroad. Beecher is joined by General Sheridan and Major Forsyth, as well as the scouts—from seasoned frontiersmen to young boys—employed to take part in the perilous mission. On the other side are the famous American Indian players in the battle: Turkey Leg and Roman Nose. With this complex assortment of characters, Brown vividly recreates the 1868 siege, as well as the competing worldviews of life on the prairies. This ebook features an illustrated biography of Dee Brown including rare photos from the author’s personal collection.

    You will rethink your entire perspective on the healthcare industry and their providers after reading this book. “Do yourself a favor and never give in to someone telling you that you need to smell something in the medical field.” -Nugget of wisdom from a trauma nurse. There is a lot about the healthcare industry and the medical profession, especially the workers that keep it functional that is unknown and shrouded in secrecy. If you’ve ever wondered how they deal with the things they’ve seen that will probably make you throw up your last meal and all the ones before that, then this book is for you. In Confessions of a Trauma Nurse, Arayah Sunshine gives a unique and rare peek into the daily activities of professionals in the healthcare industry with a fresh perspective never seen elsewhere or written down in this manner. Not for the weak-minded, this book gives a different spin on the realities of the medical profession. Taken from trauma nurses from different backgrounds with stories and anecdotes that will make you laugh, cringe-inducing horror stories, moments that will make you indignant and others that will bring you near tears, this book will take you on an emotional, yet insightful and enlightening roller coaster. Confessions of a Trauma Nurse is chock-full of lots of captivating thoughts, ideas, and comments that border deliciously on the edge of very dark humor. Some are as little as a sentence long, yet pack a punch so powerful that you will be thinking about them for hours, if not days. It also contains tips from the “pros” to avoid falling for the tricks and traps that healthcare providers set for themselves! But beware, once you’ve begun reading, you will not want to put this one down for even a minute, so make sure you’ve cleared your schedule for the day before delving into the psyche of trauma nurses. You might also want to make sure you can handle gross moments because this book contains a lot. If you’re a healthcare provider, then this is definitely a book you should add to your shelf. If you’re interested in the daily activities and thought processes of healthcare providers and trauma nurses, get this book. Scroll up and click the buy button now to get your copy of Confessions of a Trauma Nurse by Arayah Sunshine and get started on your way into the world of healthcare providers!

    Between the foolish and sometimes silly calls she goes on, are the heart-pounding serious cases that make every EMT anxious. And somehow, she still has time for a love life.

    The Wright Brothers is an historical narrative that draws on extensive archival materials, personal journals, and public records to tell the story of the Wright brothers as men of incredible character and determination along the road towards their significant contributions to aviation history. The summary parallels the structure of the book which is divided into three parts. The first part explores the period of the boys’ childhood through their work on flight testing various models of gliders. The second part picks up with the addition of the engine to the Wright planes and traces the brother’s work through the early stages of powered flight, roughly 1903 to 1908. Part three follows the brothers, now globally famous, through the years when they captured the most attention for their accomplishments. A central aspect of this historical account is the development of Orville and Wilbur Wright as individuals who showed fierce determination in the face of relentless setbacks. It also sheds light on their private nature and their deep bond as brothers. McCullough is a two time winner of the Pulitzer Prize for other historical works, Truman and John Adams. He also won the National Book Award twice and is a recipient of the Presidential Medal of Freedom. His educational background includes a degree in English Literature from Yale University. He is also a well-known narrator, as well as previous host of American Experience. Read more....

    But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

    Now Linwood was hauling fish guts to the woods for burial, answering distress calls from women in the ladies’ room who found themselves without toilet paper, and standing in leaky chest-waders pounding dock posts into the lake bottom.The chores weren’t so bad, especially when he could help his father, who had been a commercial artist before he bought his way into the tourist business. And in other ways, it was a good life for a boy. He had wheels (a John Deere riding mower), a small aluminum boat with a 9.5-horsepower outboard and only one speed (fast), and Chipper, a dog that chased boats the way other dogs chase cars, sometimes with catastrophically comic results. Linwood also had access to The Chart, a cottage reservations list that was, for him, a guide to the arrivals and departures of the guests’ teenaged daughters. Summer romances could be as intense as they were heartbreaking.When he was sixteen, an unexpected tragedy changed Linwood’s life again. His older brother, Rett, helped out as best he could, but he was wrestling with demons of his own – often withdrawing into his own complicated inner world. Linwood found an extended family in the resort’s guests, who lent him a hand, and shaped him into the man he would become. His mother’s eccentricities (she quit driving to shame the police for having given her a ticket) made Linwood’s new responsibilities heavier than they might otherwise have been. When he finally decided to move away from Green Acres to make a separate life, she made it as difficult as possible for him.In the midst of all this, Linwood found his vocation, and mentors, too, in Margaret Laurence, and in Kenneth Millar, who (under the pen name Ross MacDonald) wrote a highly successful series of detective novels.In this memoir, Linwood Barclay looks back with humour, sadness, and affection on the singular circumstances of his coming of age.